• Pediatric Infection and Vaccine
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• v.28 no.3
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• pp.149-159
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• 2021

Purpose: Antibiotic exposure during pregnancy may affect the fetus and newborn in many ways. This study investigated the impact of prenatal antibiotic exposure duration on neonatal outcomes in very preterm (VP) or very low birth weight (VLBW) infants. Methods: From September 2015 to December 2020, preterm infants with gestational age less than 32 weeks or with a BW less than 1,500 g who were admitted to the neonatal intensive care unit, and their mothers were enrolled. Prenatal antibiotic exposure was defined as antibiotics received by mothers before delivery, and the patients were categorized into the non-antibiotic group, short-duration (SD; ≤7 days) group, or long-duration (LD; >7 days) groups. Results: A total of 93 of 145 infants were exposed to prenatal antibiotics, among which 35 (37.6%) were in the SD group and 58 (62.4%) were in the LD group. Infants in the LD group had a significantly higher birth weight-for-gestational-age (BW/GA) Z-score than those in the non-antibiotic group, even after the adjustment for confounding factors (beta, 0.258; standard error, 0.149; P<0.001). Multivariate logistic regression analysis showed that prolonged prenatal antibiotic exposure was independently associated with death (adjusted odds ratio [aOR], 8.926; 95% confidence interval [CI], 1.482-53.775) and composite outcomes of death, necrotizing enterocolitis (NEC), and late-onset sepsis (LOS) (aOR, 2.375; 95% CI, 1.027-5.492). Conclusions: Prolonged prenatal antibiotic exposure could increase the BW/GA Z-score and the risk of death and composite outcomes of death, NEC, and LOS in VP or VLBW infants.

• Journal of Nutrition and Health
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• v.55 no.5
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• pp.572-586
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• 2022

Purpose: This study examined the factors that may affect the growth status of preterm infants. Methods: This study included 91 preterm infants born at <37 weeks of gestation (22.9-36.9 weeks of gestation), including 48 (52.7%) males and 43 (47.3%) females. Diet-related data were collected through parental questionnaires, and growth-related data, such as height and weight, were collected through the hospital medical records. Results: No significant difference in weight and growth was observed between early and late preterm infants. On the other hand, smaller averages of all weight z-score (recent weight at 40 weeks of gestation) included lower birth weight, height, and head circumference. On the other hand, infants' birth weight, height, and head circumference in the weight z-score of <0 (<50% in the age-weight growth chart) was smaller than those in the weight z-score of ≥0. Furthermore, neonatal intensive care unit (NICU) hospitalization period and NICU discharge were shorter with growth cessation age in weight z-score of <0. The weight growth velocity was associated with gestational age, birth weight, and medical treatment in the NICU. Thus, parents of preterm infants with low growth rates prefer more community care services for their children. Conclusion: Birth weight, age of preterm infants, and medical treatment in the NICU were factors related to early birth weight growth. Following NICU discharge, poor intake and intake issues were associated with poor growth after 40 weeks of gestation. Therefore, monitoring the growth of preterm infants requires continuous active involvement and supports for growth-promoting factors after NICU discharge.

• Proceedings of the Korean Society of Food and Cookery Science Conference
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• 2003.10a
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• pp.1-4
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• 2003

일반적으로 영유아기 라고 하면 출생 후 학령기 이전까지의 시기를 말하나 여기서는 출생 후 약 2년까지의 시기에 대하여 집중적으로 거론하고자 한다. 이 시기의 아기들, 특히 만 1세 이전의 영아들은 신체적, 정서적으로 일생을 통해 가장 변화의 폭이 큰 성장 곡선을 그리면서 성장한다. 이러한 급격한 성장은 단지 키나 체중 등에만 국한되는 것이 아니라 신체내 모든 조직의 구성이나 기능 둥에도 해당되며, 소화 생리를 포함한 생리적, 면역학적 기능과 기계적 운동 기능 등이 다양하게 포함된다. (중략)

• 대한예방의학회:학술대회논문집
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• 2002.10a
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• pp.374-375
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• 2002

• Environmental Mutagens and Carcinogens
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• v.7 no.2
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• pp.72-84
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• 1987

어미쥐에 유발시킨 납중독이 새끼쥐의 특정 중추신경계에 미치는 신경독성의 선택성 여부를 알아보고자 하였다. 특정 신경계의 한 예로 모노아민성 신경계를 선택하여 납중독의 지표로 모노아민성 신경계의 효소인 MAO(monoamine oxidase)의 활성을 측정하였으며 비특정조직에의 지표로 Na+.K+-ATPase의 활성을 측정하였다. 임신한 Wistar계 어미쥐에게 임신전기간에 걸쳐 0.05 혹은 0.2% 초산납(PbAc2)용액을 식수로 공급하여 간접적으로 태아에 납중독을 유발시켰다. 새끼쥐는 출생직후 정상 식수를 공급해 주었다. 2, 4, 6 및 8주된 새끼쥐의 MAO 및 Na+.K+-ATPase활성을 대뇌, 간뇌, 중뇌, 뇌교-연수 및 소뇌 등 다섯부위에서 각기 측정하였다.

• Proceedings of the Korean Society of Embryo Transfer Conference
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• 2003.10a
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• pp.129-129
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• 2003

• 대한예방의학회:학술대회논문집
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• 2004.10a
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• pp.38.2-38.2
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• 2004

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.7 no.1
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• pp.113-122
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• 1996

장애복지 선진국의 통계에 의하면 감음성 난청아의 약 80%가 중도(severe, 71-90dB, WHO 분류)와 최중도(profound, 91dB이상, WHO 분류) 난청이라고 한다. 출생 이전 및 출생시(선천성)에, 또는 2세 이전의 전언어기부터 청력을 않은 감음성 난청아 중에서, 청력 손상 정도가 심한 중도 이상인 경우에는 음성언어능력의 발달을 기대할 수 없는 것으로 간주되어, 즘은 의미에서의 구화에 의한 의사소통 내지 일반교육장에서의 교육도 불가능한 것으로 여겨져 왔다. (중략)

• The Korea Swine Journal
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• v.6 no.11 s.63
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• pp.117-120
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• 1984

• 가정의 벗
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• v.34 no.7 s.395
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• pp.20-20
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• 2001