• 생물정신의학
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• 제8권1호
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• pp.147-152
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• 2001

Objective : It has been thought that estrogen has neuroleptic like effect in women schizophrenic patients. This study aimed to investigate neuroleptic side-effects severity in women with schizophrenia and to investigate their putative association with variations in sex steroids over menstrual cycle. Based on the estrogen theory, The author hypothesized that parkinsonian side-effects would be exacerbated when estrogen levels were high. Method : 26 schizophrenic women were assessed using the ESRS(Extrapyramidal Symptom Rating Scale) and estrogen analysis. Tests were conducted twice, in the mid luteal and mid follicular phase. Result : It was hypothesized that high level of estrogen would lead to an exacerbation of parkinsonian side-effects but the results indicated that parkinsonian side effects decreased overall when estrogen levels were high. This effects were more marked for the group taking typical neuroleptics than those taking atypical neuroleptics. Conclusion : The results of this study suggest that estrogen and progesteron may reduce the severity of neuroleptic induced extrapyramidal side effects over menstrual cycle in women with schizophrenia. It was concluded that estrogen has different effects on dopamine dynamics in the mesolimbic and mesostriatal pathways according to estrogen, progesteron, catecol estrogen, prolactine.

• 동의신경정신과학회지
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• 제20권2호
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• pp.207-216
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• 2009

Objectives : Schizophreniform Disorder can be put as pre-stage of Schizophrenia, which is known as one of the most common mental disorder. Many studies have shown that Antipsychotic Treatment for Schizophrenia has many side effects such as EPS(Extrapyramidal Symptoms), and recently it has been found that even Non-Antipsychotic Treatment has side effects such as weight gain. This clinical study was aimed to search the therapeutic effects of Oriental medicine in Schizophreniform Disorder, and in reducing the side effects of Western medicine. Methods : We treated the patient diagnosed as Schizophreniform Disorder, whose chief complaint was auditory hallucination, with herbal medicine and acupuncture. Improvement in her clinical symptoms were recorded daily. We also used Emotional Freedom Techniques to control her anxiety effectively. Results : Auditory hallucination and extrapyramidal symptoms such as tremor disappeared. The patient's anxiety was controlled by Emotional Freedom Techniques effectively. Conclusions : From the above results, we conclude that Oriental medical treatment is effective in treating clinical symptoms of Schizophreniform Disorder, as well as in reducing the side effects of Western medicine.