• Science of Emotion and Sensibility
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• v.7 no.2
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• pp.179-186
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• 2004

Acute spinal cord injury can produce neurologic injury with many physical, psychological and social ramifications. It has been shown that two separate components combine to produce neurologic damage in acute spinal cord injury : the primary and secondary injuries. The primary mediators of spinal cord injury include the actual mechanical tissue disruption which is a passive process that occurs immediately following the trauma. A secondary injury cascade follows which appears mediated by cellular and molecular processes working through complex mechanisms. Both the primary and secondary injury cascades produce cell death both in neuronal and supporting cell tissues. Recovery from central nervous system(CNS) disorders is hindered by the limited ability of the vertebrate CNS to regenerate injured cells, replace damaged myelin sheath, and re-establish functional neuronal connections. Of many CNS disorders including multiple sclerosis, stroke, and other trauma, spinal cord injury is one of the important diseases because of the direct association with the functional loss of the body. Previous studies suggest that substantial recovery of function might be achieved through regeneration of lost neuronal cells and remyelination of intact axon in spinal cord injury which is occurred frequently. As a therapeutic approach in spinal cord injury, recently, cell transplantation provides a potential solution for the treatment of spinal cord injury. This review describes the characteristics of spinal cord injury and presents some evidence supporting functional recovery after cell transplantation following spinal cord injury.

• The Journal of the Korea Contents Association
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• v.10 no.4
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• pp.206-215
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• 2010

This study was designed to investigate the effects of mild hypothermia and Aquatic exercise on function Activity after experimental Spinal Cord Injury(SCI) rats. Experimental groups were divided into the control group (non-treatment after SCI induction), group I(hypothermia after SCI induction), group II(exercise after SCI induction), group III(hypothermia and exercise after SCI induction). After operation, rats were examined neurological motor behavior test at 3, 7, 14, 21 days and Immunohistochemical assessment at 3, 7, 21 days.Each other 14 days were a statistically significant difference between control group and group II, III(p<.001) in BBB scale, between control group and group III(p<.05) in grid walk test. In mmunohistochemical assessment, there was appeared highest express in group III. Based on these results, mild hypothermia and exercise was effected functional Activity after SCI.

• Proceedings of the Korean Society of Computer Information Conference
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• 2009.01a
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• pp.467-472
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• 2009

최근 장애인에 대한 사회적 배려 및 관심이 높아지면서 장애인을 위한 각종 보조기구가 많이 개발되고 있다. 대부분의 청각, 시각, 정아 장애인들은 정자, 수화 등을 통해 타인과의 의사소통이 가능하며, 또한 이들을 위한 많은 보조기구가 개발되어 큰 도움을 받고 있지만 척수 손상 환자들을 위한 보조기구는 전무한 실정이다. 이에 본 논문에서는 척수 손상 환자를 위해 들숨, 날숨 기반으로 각종 기기(컴퓨터, 휠체어, 콘센트 등)들을 작동시키며, 또한 입력된 분자를 음성으로 출력할 수 있는 시스템을 설계하고 구현하여 척수 손상 환자들이 최소한의 도움으로 독립적인 활동이 가능하도록 하였다.

• Journal of Korean Medicine Rehabilitation
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• v.18 no.3
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• pp.19-39
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• 2008

Objectives : It has been reported that CG was effective in decreasing injury to neural tissues. To investigate neural responses in the injured spinal cord, an extract of CG was examined to determine its effect on neural responses in the injured spinal cords of rats. Methods : After CG treatment was applied to the spinal cord of rats given a contusion injury, the re-growth responses of injured neural tissues and corticospinal tract axons was observed by measuring the number of GAP-43, Cdc2, and phospho-Erk1/2 proteins, CST axons, GFAP-stained astrocytes, and Glial scarring in the injured spinal cord. Results : Levels of GAP-43, Cdc2, and phospho-Erk1/2 proteins were found to have increased in the injured spinal cord region. The number of GFAP-stained astrocytes also increased within and around the injury cavity. Glial scarring, which was identified by CSPG immunofluorescence staining, was reduced by CG treatment. Anterograde tracing by Dil dye showed that the elongation of the CST axons in the dorso-medial white matter area was almost completely prevented at the injury site. Collateral sprouting was observed in the spinal cord rostrally close to the injury site, and CG treatment further increased axonal arborization in the corresponding region. In vivo migration of CST axons and astrocytes using an implanted polymer tube system showed more of an increase in enhanced migration of axons and astrocytes in CG-treated group compared to the injury control group. Conclusions : These results suggest that CG activated neural responses - including astrocyte migration - and promotes axonal regenerative activity in the injured spinal cord area.

• Journal of Life Science
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• v.19 no.10
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• pp.1489-1494
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• 2009

This study was designed to investigate the effects of swimming and minocycline on motor function recovery and Bcl-2 expression after spinal cord injury (SCI) in rats. After operation, neurological motor behavior test (BBB scale) on days 1, 4, 7, 10, and 14 were tested. Western blot and immunohistochemical assessment (Bcl-2) were performed on day 14. BBB scale started to show a statistically significant difference on day 7 (p<0.05). On day 14, it showed the most significant (p<0.05) difference. Expression of Bcl-2 increased in all the experimental groups. In particular, the highest expression of Bcl-2 appeared in the swimming and minocycline groups. Based on these results, minocycline and swimming were the most effective factors in the motor behavior function and immunohistochemical assessment of SCI rats.

• Physical Therapy Korea
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• v.6 no.4
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• pp.30-35
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• 1999

본 증례연구는 복합손상을 가진 척수손상환자의 재활치료과정을 소개하여 유사한 사례의 치료에 도움이 되고자 하는 것이다. 증례연구의 대상자인 26세의 남자환자는 흉수 4번 완전손상과 사고 당시 전기화상에 의한 좌측하박 절단과 우측손의 정중신경이 마비되었다. 치료초기에는 일상생활동작 검사에서 MBI (Modified Barthel Index) 점수가 22점으로 독립적으로 가능한 것은 거의 없었고, 기능적으로도 모든 도움이 필요한 상태였으나 재활치료결과 독립적으로 가능한 기능수행 능력은 돌아눕기, 일어나 앉기, 침상에서 의자차로 이동하기, 의자차 굴리기였고 제한적이기는 하지만 독립적으로 가능한 일상생활동작은 식사, 상의 입기, 의자차와 같은 높이의 이동 등이 가능하여 MBI 점수가 47점을 나타내었다. 이 환자의 초기의 장기치료목표는 전동 의자차를 이용하여 보호자의 도움을 줄이는 것이었다. 그러나 환자가 익숙하게 의지를 사용하였으며 일반 의자차 사용을 위해 필요한 만큼의 근력증가가 있었고, 의자차에 앉은 상태의 균형감각이 증가하여 목표를 수정하여 일반 의자차를 사용하도록 하였다. 환자 본인이 가지고 있는 재활 잠재력을 최대로 이끌어낼 수 있도록 유도한 결과 부분적으로 제한이 있었지만 실내에서는 의자차를 이용하여 독립적인 생활이 가능하였다.

• Journal of the Korean Society of Physical Medicine
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• v.7 no.1
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• pp.119-124
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• 2012

목적 : 본 연구는 척수손상환자들 중 신체활동 정도가 급격하게 차이 나는 운동 선수군과 비선수군의 일상생활동작과 골밀도를 비교 분석하는데 그 목적이 있다. 방법 : 본 연구를 위해 20명(선수 10명, 비선수 10명)의 SCI 환자가 실험에 참가하였다. 골밀도 측정을 위해 이중에너지 방사선골밀도 측정기(Lunar Prodigy, GE Healthcare. England)를 이용하여 종골부위(calcaneus)의 골밀도를 측정하였다. 척수손상환자의 일상 생활 기능을 측정하기 위해 자조관리(self care), 호흡과 괄약근 조절 (respiration and sphincter management task), 이동(transfer)의 세 영역으로 나누어진 SCIM II(Spinal Cord Injury Measurement II)을 이용하였다. 척수손상환자들 중 운동 선수군과 비운동 선수군의 일상생활 동작과 골밀도를 비교 하기 위해 SPSS 14.0 통계 프로그램의 independent t-test를 이용하여 통계분석을 실시하였고 일상생활 동작과 골밀도의 상관관계는 Pearson correlation을 실시하였다. 유의수준은 ${\alpha}$=.05로 통계처리 하였다. 결과 : 검사 결과 선수군이 비선수군보다 통계적으로 유의하게 큰 SCIM 점수와 T-score를 보여주었다. 결론 : 일상생활동작을 측정하기 위하여 SCIM II(SpinalCordIndependenceMeasureII) 척도를 사용하였는데 선수군이 비선수군에 비해 유의하게 높은 SCIM II 총점을 나타내어 운동을 통한 훈련이 척수손상환자의 기능적 활동을 향상시킬 수 있다고 사료된다. 그리고 골밀도 측정 결과 선수군이 비선수군에 비해 통계적으로 유의하게 높은 골밀도를 나타내었다. 이 역시 강도 높은 훈련이 척수손상환자에게 나타날 수 있는 신체구성을 강화시켜줄 수 있을 것으로 사료된다. 운동을 통한 재활 중에서 그 강도가 높을수록 신체의 구성적, 기능적 측면 뿐 아니라 신경의 가소성 측면에서도 증가를 기대해 볼 수 있을 것으로 판단된다.

• 재활복지
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• v.22 no.4
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• pp.83-102
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• 2018

The purpose of this study is to provide basic data for effective management and prevention of chronic diseases and secondary complications as elderly spinal cord injuries(SCI). The subjects were 200 spinal cord injuries admitted to S hospital from April, 2013 to April, 2018. We investigated the occurrence of chronic diseases and secondary complication through medical records. The results showed that SCI were affected chronic diseases and secondary complications over 50years. The prevalence of chronic diseases and secondary complications over 50 years of age had the odds ratio 11.8 times higher in hypertension and 6.7 times diabetes mellitus. Secondary complications had the odds ratio Osteoporosis 7.5 times, Pneumonia 5.2 times, and central pain 0.4 times. We suggest that continuous management and service of chronic diseases and secondary complications of elderly SCI are necessary. It will be necessary to expand the target population and to study various characteristics including.

• Journal of Chest Surgery
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• v.35 no.4
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• pp.255-260
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• 2002

Paraplegia remains unresolved as the most dreaded operative complication with surgical treatment of descending thoracic and thoracoabdominal aortic diseases. In this study, the neuroprotective effect of trimetazidine that has been used clinically for ischemic heart disease was investigated in a rabbit spinal cord ischemia model. Material and Method: Thirty-three New Zealand white rabbits were randomized as follows: control group undergoing abdominal aortic occlusion but receiving no pharmacologic intervention(Group 1, n= 17); TMZ group(Group 2, n= 16) receiving 3 mg/kg trimetazidine intravenously before the occlusion of the aorta. Ischemia was induced by clamping the abdominal aorta just distal to the left renal artery for 30 minutes. Neurologic status was assessed at 2, 24, and 48 hours after the operation according to the modified Tarlov scale, then the lumbosacral spinal cord was processed for histopathologic examinations 48 hours after the final assessment. Result: The average motor function score was significantly higher in the TMZ group(3.20 $\pm$ 0.77 vs 1.13 $\pm$ 1.25 at 2 hours, 3.50 $\pm$ 0.76 vs 1.45 $\pm$ 1.57 at 24 hours, and 3.91 $\pm$ 0.30 vs 1.86 $\pm$ 1.86 at 48 hours after operation; p value$\leq$0.05). Histologic observations were correlated with the motor scores. Conclusion: The results suggested that trimetazidine reduced spinal cord injury during aortic clamping and that it may have clinical utility for the thoracoabdominal aortic surgery:

• The Journal of Korean society of community based occupational therapy
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• v.2 no.1
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• pp.97-104
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• 2012

Objective : This research was conducted in order to identify the influence of leisure activity by the spinal cord injury(SCI) on quality of life and present it as evidence for occupational therapy intervention. Methods : The experiment was conducted from October 2010 to March 2011 and was subjected 120 SCI of 9 administration. In use of SPSS 12, 94 samples from 120 SCI were analysis by freqency analysis, T-test and One-way ANOVA. Results : The satisfaction of leisure depending on SCI level and level of paralysis had a significant differences statistically(p< .05). Conclusion : From the research, it was identified that satisfaction of leisure can be improve depending on the level of injury and classification of paralysis, and leisure activity is related to the satisfaction of leisure and quality of life.