• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2001.05a
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• pp.219-224
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• 2001

본 연구에서는 개인의 성격이 소리자극에 의하여 유도되는 감성에 미치는 영향을 조사하기 위하여 대학생 450명(남자: 210명)을 대상으로 행동활성화체계(BAS)와 행동억제체계(BIS) 민감성의 고저에 따라 두 집단을 추출하여 안정상태에서 전전두엽(PFC)의 비대칭적 활성화를 측정한 뒤, 긍정감성과 부정감성을 각각 유발하는 소리들을 제시하여 느끼는 감성에 대한 심리반응 변화를 평가하고 이에 따른 전전두엽의 비대칭적 활성화의 변화를 관찰하였다. 긍정감성과 부정감성을 유도하는 소리는 명상음악과 소음을 각각 사용하였으며 안정상태와 음향청취상태에서의 전전두엽 영역 활성화를 관찰하기 위하여 F7와 F8 부위에서 EEG의 알파밴드(8-13 Hz) 활성도를 분석하였다.

• The Korean Journal of Nuclear Medicine
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• v.36 no.2
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• pp.91-101
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• 2002

Purpose : The aim of this study was to identify the brain areas in which reductions of regional cerebral blood flow (rCBF) were correlated with decline of general mental function, measured by Mini-Mental State Examination (MMSE). Materials and Methods : Tc-99m HMPAO brain SPECT was peformed in 9 probable AD patients at the initial and follow-up periods of 1.8 years (average) after the first study. MMSE scores were also measured in both occasions. The mean MMSE score of the initial study 16.4 (range: 5 - 24) and the mean MMSE score of the follow-up was 8.1 (range: 0 - 17). Each SPECT image was normalized to the cerebellar activity and a correlation analysis was peformed between the level of rCBF in AD patients and the MMSE scores by voxel-based analysis using SPM99 software. Results : Significant correlation was found between the blood-flow decrease in left inferior prefrontal region (BA 47) and left middle temporal legion (BA 21) and the MMSE score changes. Additional areas such as anterior and posterior cingulate cortices, precuneus, and bilateral superior and middle prefrontal regions showed the similar trends. Conclusions : A relationship was found between reduction of regional cerebral blood flow in left prefrontal and temporal areas and decline of cognitive function in Alzheimer's disease(AD) patients. This voxel-based analysis is useful in evaluating the progress of cognitive function in Alzheimer's disease.