• Tuberculosis and Respiratory Diseases
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• v.42 no.2
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• pp.142-148
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• 1995

Background: Despite modern diagnostic, staging, and therapeutic advances, esp. with molecular biologic techniques, the 5-year survival rate of all cases of lung cancer does not exceed 15%. Also, the incidence of lung cancer of both sex in Korea is increasing year by year and the lung cancer is one of the leading causes of cancer death. Therefore, it is strongly needed to develop the new combination of treatment modalities including neoadjuvant chemotherapy and to identify tumor specific characteristics with staging or prognostic markers. Here we present the clinical significance of several biologic tumor markers to use as a prognostic markers in patients with non-small cell lung cancers. Method: The survival has correlated with the expressibility of proliferative cell nuclear antigen (PCNA), epidermal growth factor receptor(EGFR), p53 and/or blood group antigen A(BGAA) using immunohistochemistry in 46 patients with non-small cell lung cancers. Results: 1) The expression rates of PCNA, EGFR, p53 and BGAA were 80.6%, 61.3%, 45.9% and 64.3%, respectively and those were not correlated to cell types or clinical stges. 2) The expression of BGAA was correlated with better survival in median survival and in 2-year survival rate and that of PCNA was correlated with worse survival in median survival and 2-year survival rate. 3) The expression of EGFR or p53 was not valuable to predict prognosis in non-small cell lung cancers. 4) With simultaneous applications of PCNA, EGFR and p53 immunostain, the patients with 2 or more negative expressions showed better prognosis than the patients with 2 or more positive expressions. Conclusion: It is suggested that the expression of blood group antigen may be a positive prognostic factor and that of PCNA may be a negative prognostic factor. Also, the combination of expressions of PCNA, EGFR and p53 may be used as a negative prognostic factor.

• Journal of the Korean Institute of Landscape Architecture
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• v.52 no.2
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• pp.79-95
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• 2024

The purpose of this study was to find the changes in the habitat of wild birds caused by climate change in urban rivers and protected areas that greatly require ecological functions. In the future, this study can be used as a management index to protect the urban river ecosystem and maintain the health of sustainable urban rivers, thereby ensuring biodiversity. The Tancheon Ecological and Landscape Conservation Area, selected as a target site, has been affected by climate change. The four seasons of Korea have a distinct temperate climate, but the average annual temperature in Seoul has risen by 2.4-2.8℃ over the last 40 years. Winter temperatures tended to gradually increase. Precipitation, which was concentrated from June to August, is now changing into localized torrential rain and a uniform precipitation pattern of several months. Climate change causes irregular and unforeseen features. Climate change has been shown to have various effects on urban river ecosystems. The decrease in the area of water surface and sedimentary land impacted river shape change and has led to large-scale terrestrialization. Plants showed disturbance, and the vegetation was simplified. The emergence of national climate change indicator species, the development of foreign herbaceous plants, the change of dry land native herbaceous species, and wet intelligence vegetation were developed. Wild birds appeared in the territory of winter-summer migratory. In addition, species change and the populations of migratory birds also occurred. It was judged that fluctuations in temperature and precipitation and non-predictive characteristics affect the hydrological environment, plant ecology, and wild birds connecting with the river ecosystem. The results of this study were to analyze how climate change affects the habitat of wild birds and to develop a management index for river ecological and landscape conservation areas where environmental and ecological functions in cities operate. This study can serve as a basic study at the level of ecosystem services to improve the health of urban rivers and create a foundation for biodiversity.

• Korean Journal of Environmental Biology
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• v.19 no.4
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• pp.239-247
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• 2001

The Herbal Vegetation on Running Waterside in the Main Stream of Genmho River, Daegu and Gyeongsanbuk-do, Korea was investigated by the methodology from June to August of 1994 and analyzed distribution characteristics of vegetation that was related Water Environment. The vegetation is divided into 6 communities of Persicaria sieboldi-Persicaria hydropiper community, Persicaria thunbergii community, Impatiens textori community, Zizania latifoloa community, Phragmites communis community and Echinochloa crus-galli var. oryzicola community. A BOD and COD that indicate degree of contamination in water were showed 0.9 ppm and 1.6 ppm at upstream and 15.9 ppm and 24.8 ppm at downstream, respectively. The distribution patterns of vegetation have dominated by Impatiens textoricommunity in the upstream, by Persicaria sieboldi-Persicaria hydropiper community from upstream to mid-upstream, by Persicaria thunbergii community from upstream to midstream, by Zizania latifoloa community from nidstream to mid-downstream and by Phragmites communis community and Echinochloa crus-galli var. oryzicola community from mid-downstream to downstream. Especially, I suggested that Persicaria sieboldi-Persicaria hydropiper community and Persicaria thunbergii community will use as biotic indicator in water environment.

• Korean Journal of Environmental Biology
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• v.21 no.3
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• pp.257-261
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• 2003

Population of small mammals (Apodemus agrarius and Crocidura lasiura) was monitored to identify the bioaccumulation of heavy metals in Gumho river basin around Daegu city. The small mammals were captured during 28 of May~12 of June, 2002. The techniques of live-trapping and snap-trapping were applied to capture the animals. A total of 39 animals were captured among which 53.3% (16130) of population were reached to breeding. Heavy metals (Cu, Pb, Zn, Cd) were analyzed. According to the analysis of heavy metal elements, Zn was more accumulated in kidney (6.83 mg $kg^{-1}$) than in liver (3.66). However, the accumulation of Cu was higher in liver than in kidney. Even though this site was relatively away from major industrial zones, heavy metals were wide spread along the stream of Gumbo River. This is the first quantitative study of small mammal bioaccumulation of heavy metals in Korea so that further research should be followed in other industrial areas that heavy metals were widely dispersed.

• The Journal of the Korea institute of electronic communication sciences
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• v.15 no.3
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• pp.563-572
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• 2020

Tidal flats provide important indicators that inform the condition of the environment, so we need to monitor them systematically. Currently, the projects to monitor tidal flats by periodically observing the creatures in tidal flats are underway. Still, it is done in a way that people observe directly, so it is not systematic and efficient. In this paper, we propose a background modeling method for tidal flat images that can be applied to a system that automatically monitors creatures living in tidal flats using sensor network technology. The application of sensor network technology makes it difficult to collect enough images due to the limitation of transmission capacity. Therefore, in this paper, we propose a method to effectively model the background and generate foreground maps by reflecting the characteristics of tidal flat images in the situation where the number of images to be used for analysis is small. Experimental results show that the proposed method models the background of a tidal flat image easily and accurately.

• Korean Journal of Biological Psychiatry
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• v.19 no.1
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• pp.29-37
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• 2012

The loudness dependence of the auditory evoked potential (LDAEP) has been proposed as a valid biomarker of central serotoninergic activity in humans. The specificity and sensitivity of the LDAEP to changes in serotonergic neurotransmission have recently been explored in many studies about pharmacology and genetics. The majority of evidence for an association between the LDAEP and serotonin activity has come from animal studies. Genetic association studies with the LDAEP have provided conflicting reports with additional evidence outlining sensitivity to other neurotransmitter systems including the dopamine and glutamatergic systems. The LDAEP has been revealed to reflect the pathophysiology of various psychiatric illnesses. There is supporting evidence that major psychiatric disorders have differential LDAEP activities. Overall, the LDAEP shows strong evidence as a potential predictor of antidepressant treatment response. It need to be explored whether the LDAEP could be a biological marker of various psychiatric diseases and treatment prediction of antidepressants and serotonin related drugs.

• Journal of the Korean Society of Food Culture
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• v.4 no.4
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• pp.417-424
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• 1989

The volatile constituents of Mugwort seeds were extracted by simultaneous steam distillation-extraction apparatus, and analyzed by combined GC and GC-MS. Of the 73 compounds identified from Mugwort seed extract, the main volatile compounds were campher (14.242%), borneol(12.812%), 1.8-cineol(6.437%) and terpinen-4-ol(1.185%) comprising about 35%. Effect of the volatile constituents (champher, borneol, 1.8-cineol, terpinen-4-ol and essential oil) on the growth of Microorganism (B. subtilis, E. coli, S. cerevisiae, L. mesenteroides, L. Plantarum, A. oryzae). Of the volatile compounds had a antibiological effect, terpinen-4-ol was the most effective in volatile compound.

• Korean Journal of Organic Agriculture
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• v.25 no.4
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• pp.875-901
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• 2017

Although some skeptical views arguing that the impact of organic farming is quite limited to sustainable biodiversity, the organic agriculture has been generally accepted to have positive effects on various properties of soils not only on biophysical and ecological properties but also on biodiversity of the field. Therefore, this field investigation has been conducted to examine the effect of organic farming, relative to conventional agriculture, through a comparative investigations of the two systems for conserving local biodiversity of invertebrate animals. For this research, organic and conventional farming locations matched with both of a paddy field and a upland fields in Goesan-gun province (Chungcheongbuk-do, South Korea) were selected to compare the species richness of invertebrate biodiversity as follows: location OP (Organic Paddy field), location OU (Organic Upland field), location CP (Conventional Paddy field), and location CU (Conventional Upland field). Among 249 species collected, the numbers of species collected in the locations practicing organic farming were greater than the locations practicing conventional farming both in paddy fields (104 vs. 84 species) and upland fields (108 vs. 77 species). Changes in species richness can be shown in the selected locations depending on the agriculture system with organic (50 species) or conventional (44 species) farming systems in the paddy fields, similarly with organic (42 species) or conventional (35 species) farming in the upland fields, respectively. Our present research clearly shows that a wide range of taxa, including insects, spiders and other invertebrates, benefit from organic management through increases in abundance or species richness. It has been also identified that four orders (Hemiptera, Diptera, Hynemoptera, and Araneae) that are largely intrinsic to organic paddy field, and another three orders (Hemiptera, Coleoptera, and Araneae) that are particularly beneficial for organic crop field regime.

• Journal of Environmental Impact Assessment
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• v.24 no.5
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• pp.420-431
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• 2015

As biodiversity and climate change have become main issues in recent times, the role of the forest ecosystem has been more important and forest conservation has been highlighted. The purpose of this study is to estimate forest area with high conservation values in Gapyung-gun by considering forest ecosystem services. The indicators of biodiversity, climate regulation, and water regulation were selected for assessment in this study. To assess biodiversity, habitat structural features and distribution characteristics of species were analyzed. Climate regulation and water regulation were assessed through analysis of carbon absorption volume and water storage. The result showed that, 50.1% of the forests in Gapyung-gun had high conservation values. The results were verified by comparing them with distribution tendencies of other environmental maps, which represent forest ecological values, and showed similar distribution tendencies. The study was conducted on only Gapyung-gun in Korea; however, the methods used in this study could be utilized for assessment of other areas to identify forests with high conservation values.

• Korean Journal of Environmental Biology
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• v.32 no.4
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• pp.389-394
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• 2014

This study was conducted to find out the soil $CO_2$ emission characteristic due to rain fall pattern and intensity changes. Using Automatic Opening and Closing Chambers (AOCCs), we have measured annual soil respiration changes in Pinus koraiensis plantation at Seoul National University experimental forest in Mt. Taehwa. In addition, we have monitored heterotrophic respiration at trenching sites ($4{\times}6m$). Based on the one year data of soil respiration and heterotrophic respiration, we observed that 24% of soil respiration was derived from root respiration. During the rainy season (end of July to September), soil respiration at trenching site and trenching with rainfall interception site were measure during portable soil respiration analyzer (GMP343, Vaisala, Helsinki, Finland). Surprisingly, even after days of continuous heavy rain, soil water content did not exceed 20%. Based on this observation, we suggest that the maximum water holding capacity is about 20%, and relatively lower soil water contents during the dry season affect the vital degree of trees and soil microbe. As for soil respiration under different rain intensity, it was increased about 14.4% under 10 mm precipitation. But the high-intensity rain condition, such as more than 10 mm precipitation, caused the decrease of soil respiration up to 25.5%. Taken together, this study suggests that the pattern of soil respiration can be regulated by not only soil temperature but also due to the rain fall intensity.