• The Journal of the Society of Korean Medicine Diagnostics
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• v.12 no.1
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• pp.42-62
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• 2008

Objectives: It is well known that some parameters of the photoplethysmogram (PPG) acquired by time domain contour analysis can be used as markers of vascular aging. But the previous studies that have been performed for frequency domain analysis of the PPG to date have provided only restrictive and fragmentary information. The aim of the present investigation was to determine whether the harmonics extracted from the PPG using a fast Fourier transformation could be used as an index of vascular aging. Methods: The PPG was measured in 600 recruited subjects for 30 second durations, To grasp the gross age-related change of the PPG waveform, we grouped subjects according to gender and age and averaged the PPG signal of one pulse cycle. To calculate the conventional indices of vascular aging, we selected the 5-6 cycles of pulse that the baseline was relatively stable and then acquired the coordinates of the inflection points. For the frequency domain analysis we performed a power spectral analysis on the PPG signals for 30 seconds using a fast Fourier transformation and dissociated the harmonic components from the PPG signals. Results: A final number of 390 subjects (174 males and 216 females) were included in the statistical analysis. The normalized power of the harmonics decreased with age and on a logarithmic scale reduction of the normalized power in the third (r=-0.492, P<0.0001), fourth (r=-0.621, P<0.0001) and fifth harmonic (r=-0.487, P<0.0001) was prominent. From a multiple linear regression analysis, Stiffness index, reflection index and corrected up-stroke time influenced the normalized power of the harmonics on a logarithmic scale. Conclusions: The normalized harmonic power decreased with age in healthy subjects and may be less error prone due to the essential attributes of frequency domain analysis. Therefore, we expect that the normalized harmonic power density can be useful as a vascular aging marker.

• Proceedings of the Korea Information Processing Society Conference
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• 2015.10a
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• pp.949-951
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• 2015

본 연구는 맥파속도를 측정 하는데 간단한 방법으로 1채널 심전도 데이터와 4채널 광전식 용적맥파를 이용하여 취득한 데이터를 분석하는 알고리즘을 제안한다. 심전도의 R 피크점과 좌우 지첨, 족첨에서 발생하는 4 채널 맥파신호간 시간차를 이용하여 맥파 전달시간을 구하고 팔, 다리 길이로 나눠서 맥파전달속도를 구한다. 알고리즘은 심전도 R 피크점 검출, 4 채널 맥파에서의 피크점 검출 이후 검출된 피크정보를 이용하여 맥파의 시작지점인 기시점을 검출하는 간단한 방법을 개발하였고, 4 가지 맥파형태에 검출알고리즘을 적용하여 검증 하였다. 본 연구에서 개발한 방법으로 간단히 맥파속도를 측정하여 동맥경화나 고혈압, 당뇨 등 심혈관 관련 연구의 기반이 될 수 있을 것으로 사료된다.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.41 no.5
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• pp.65-70
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• 2004

In this paper, we present a new methodology to analyze the characteristic of artery by using 4 channels photoplethysmograpy. The proposed parameter is a time difference of pulse transit time(PTT) between Pulse waves at finger site and at toe site. To verify the usefulness of the developed system volume pulse waves on 4 sites were measured simultaneously for total 51 normal subjects (male 26 and female 25) aged from 9 to 83 years old. And then correlations between the analysis parameters and age were evaluated by using linear regression analysis method. As the result of experiments, the change of parameter was found according to ages. The result of regression analysis about relationships between the parameter and ages for n=51, the coefficient of correlation of non-normalized data has 0.79770 in left side and 0.80599 in right side and the coefficient of correlation of normalized data by height has 0.81345 in left side and 0.81605 in right side.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.11 no.1
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• pp.48-60
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• 2007

Palpation of the pulse has been used in Korean traditional medicine since ancient times to assess physical health. Pulse wave contour may be obtained by measuring arterial pressure or blood volume change of skin. The latter is called as Photoplethysmography(PPG) or digital volume pulse(DVP). The PPG signal is measured by a device comprising an infrared light sourece and a photodetector. Although less widely used, this technique deserves further consideration because of its simplicity and ease of use. The contour of the PPG is formed as a result of a complex interaction between the left ventricle and the systemic circulation. It usually exhibits an early systolic peak and an early diastolic peak. the first peak is formed mainly by pressure trasmitted along a direct path from the left ventricle to the finger. The second peak is formed in part by pressure transmitted along the aorta and large arteries to sites of impedance mismatch in the lower body. The contour of the PPG is sensitive to changes in arterial tone and is influenced by ageing and large artery stiffness. Measurements taken directly from the PPG or from its second derivative can be used to assess these properties. In some mathematical approaches, the extraction of periodic components using frequency analysis was tried to analysis of the PPG. But we don't understand yet what kind of factor in the cardiovascular system or human body is related with the respective specific Fourier components of PPG. This review describes the background to measurement principles, representative contour, contour analysis and frequency domain analysis of PPG, and current and future.

• The Journal of Korean Medicine
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• v.29 no.2
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• pp.60-70
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• 2008

Objectives: The aim of the present investigation was to determine whether the finger photoplethysmography (PPG) of the young will become analogous to those of the old when the PPG harmonic components in the young decrease. Methods: The PPG was measured in 46 old men (21 males and 25 females) over the age of 60 years and 10 young men (5 males and 5 females). We acquired the representative pulse waveform of old men by averaging the PPG waveforms measured in the old men. after the PPG harmonic components in the young men were diminished with notch filtering, we compared the representative pulse waveform of old men and those of the young men. Results: The PPG waveform of the young males became analogous to the representative pulse waveform of the old as the PPG harmonic components in the young were diminished with notch filtering. Especially after the second harmonic component in the young was diminished with notch filtering, increase of the Pearson's correlation coefficient was prominent. On the other hand, the Pearson's correlation coefficient between the PPG waveforms of the young females and that of the old deceased after the second harmonic component diminished in the young. Conclusions: Decrease of the second harmonic component may be a precondition of typical age-related change of the pulse waveform in the healthy male.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.11 no.2
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• pp.1-12
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• 2007

Objectives: The aim of the present investigation was to determine whether the finger photoplethysmographic waveform of a healthy young man will become analogous to those of healthy old men when the photoplethysmographic harmonic components in the young man decrease. Methods and Results: The finger photoplethysgmoraphy was measured in 21 old men over the age of 60 years and a young men. We acquired the representative pulse waveform of old man by averaging the finger photoplethysmographic waveforms measured in the old men. after the photoplethysmographic harmonic components in the young man were diminished with notch filtering, we compared the representative pulse waveform of old man and the pulse waveforms of which the harmonic components decreased in the young man. The finger photoplethysmographic waveform of the young man became analogous to those of the old men as the photoplethysmographic harmonic components in the young man were diminished with notch filtering. Conclusions: Decrease of the second harmonic component may be a precondition of typical age-related change of the pulse waveform.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.11 no.1
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• pp.82-104
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• 2007

Purpose: We performed this study to examine the effect of controlled respiration on cardiovascular system in healthy adult subjects using impedance cardiography and photoplethysmography. Materials and Methods: This study had performed on 74 subjects, which were healthy men and women without a experience of respiration practice. Using the instruments for impedance cardiography and photoplethysmography, parameters of each subject had been measured after each controlled respirations which were natural respiration, controlled natural respiration (I:E=1.1.6), longer inspiration(I:E=3:3), and longer expiration(I:E=2:4). The measured parameters of impedance cardiography and photoplethysmography were processed statistically by one-way repeated ANOVA. Results: 1. HR and CI of impedance cardiography were decreased significantly during controlled respiration comparing with the result of basal state(the state of enough break). There was no significant difference among the results of controlled respiration. 2. PEP of impedance cardiography had no significant difference among the result of basal state and the results of controlled respiration(p=0.059). 3. VI of impedance cardiography had significant differences among the result of basal state and the results of controlled respiration, and decreased continuously through the controlled respiration. 4. b/a of photoplethysmography had no significant difference among the result of basal state and the results of controlled respiration(p=0.554). 5. c/a of photoplethysmography were decreased significantly during controlled respiration comparing with the result of basal state. There was no significant difference among the results of controlled respiration. 6. d/a of photoplethysmography had significant differences among the results of the controlled respiration decreasing continuously through the controlled respiration and had no significant difference between the result of basal state and the result of natural respiration. 7. AGI of photoplethysmography had significant differences among the result of basal state and the results of the controlled respiration increasing continuously through the controlled respiration. Conclusion: We had examined the effects of controlled respirations on cardiovascular system in multiple points of view. The effects of controlled respirations on cardiovascular system can't be explained in a simple way, as the cardiovascular system is controlled by many factors. Therefore, more physiological parameters must be measured in the future study on the effect of the controlled respiration on human cardiovascular system.