• Analytical Science and Technology
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• v.22 no.1
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• pp.101-108
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• 2009

The bioequivalence of two pioglitazone tablets, Actos$^{(R)}$ tablet (Takeda Chemical Industries, reference drug) and Pioglitazone tablet (Boryung Company, test drug) was evaluated according to the guidelines of Korea Food and Drug Administration. Twenty-eight healthy male Korean volunteers received each medicine (pioglitazone dose of 30 mg) in a $2{\times}2$ crossover study with one week washout interval. After drug administration, blood samples were collected at specific time intervals from 0-36 hours. The plasma concentrations of pioglitazone were determined by high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). The total chromatographic run time was 5 min and calibration curves were linear over the concentration range of 5-2000 ng/mL for pioglitazone. The method was validated for selectivity, sensitivity, linearity, accuracy and precision. The pharmacokinetic parameters were determined from the plasma concentration-time profiles of both formulations. The primary calculated pharmacokinetic parameters were compared statistically to evaluate bioequivalence between the two preparations. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for Pioglitazone tablet and Actos$^{(R)}$ tablet were log0.9422~log1.1040 and log0.9200~log1.1556, respectively. Based on the statistical considerations, we can conclude that the test drug, Pioglitazone tablet was bioequivalent to the reference drug, Actos$^{(R)}$ tablet.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2002.06a
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• pp.123-137
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• 2002

생물정보공학을 위한 학문적/실용적 접근은 전산학, 생물학, 유전공학, 수학/통계학등이 유기적으로 통합되어 이루어져야 한다. 그러나 각계의 전문가가 서로의 특정 지식을 활용하기 위한 물리적인 기반이 갖추어져 있지 않은 상태에서는 각 분야의 전문적 지식 활용이 용이하지 않다. 현재의 의료 서비스 제공자/병원이 가진 방대한 의료 데이터를 생물정보공학 령역에서 활용할 수 있도록 해야 하고, 진료 데이터에 근거한 유전적 정보 분석을 위해 생물학 전문가들이 생성하는 인간 질병에 관한 유전적 분석, 연구 결과를 다시 의료 서비스 제공자에게 돌려주는 순환적 사이클이 필요하고, 이러한 순환적 사이클 지원자는 정보 기술이라고 생각한다. 인간 질병 극복과 좀 더 나은 진료, 예방책을 제공할 수 있도록 생물정보공학, 의료정보학, 컴퓨터과학의 통합 활용 목표를 설정할 수 있다. 각계의 전문가가 지식을 공유할 수 있고 기존의 병원 시스템 및 유전 연구소 등의 시스템을 통합하여 유기적으로 엮음으로써 데이터를 의미 있게 해석하고 공유할 수 있도록 지원하는 프레임워크가 절실히 요구된다. 본 세미나에서는 의료정보학과 생물정보공학에서 활용하는 시스템 통합, 전문 지식의 통합적 활용을 위해 각 전문가를 대신하는 에이전트로 구성된 멀티에이전트 플랫폼을 제시하여, 각 분야가 갖는 전문성 확보, 광고, 유기적 연결을 멀티에이전트 시스템에게 위임함으로써 각 영역에서 서비스 할 수 있는 내용과 서비스 제공 주체인 각계의 전문가 집단을 유기적으로 통합하고자 한다. 의료 영역에서 이루어진 의료 영상 통신 시스템 (Picture Archiving and Communication Systems), 의료 정보 표준화를 위한 HL7 (Health Level 7)에 대해서 경북대학교 지능정보 연구실에서 연구, 개발한 내용을 발표한다. 의료 정보 시스템과 생물학 영역의 유전체 정보 데이터베이스 시스템 사이에 의미 있는 데이터 전송, 지식 획득을 위해 정보 기술 분야에서 활용해야 할 영역으로 XML Web Services, Multi-agent Systems, 전문가 컴뮤니티를 위한 그룹웨어 연구 개발에 관해 사례 중심으로 발표한다.

• Journal of The Korean Association For Science Education
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• v.6 no.2
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• pp.63-72
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• 1986

과학교육은 학생들이 장차 과학 기술분야의 직업을 추구하도록 하는 것을 그 중요한 결실의 하나로 잡고 있다. 현재 한국은 과학과 기술의 발전을 교육의 주요목표의 하나로 삼고 있으며, 정부에서는 보다 많은 영재를 과학 기술분야로 유치하려고 여러 가지 정책을 펴고 있다. 그러나 이러한 정책도 결국은 학생이 과학 기술분야로 모여들지 않으면 그 효과가 없게 된다. 그런 점에서 학생들이 어떤 이유로 과학 기술분야를 선택하는지 혹은 기피하는지 그 원인을 아는 것을 중요한 과제라고 할 수 있다. 본 연구는 과학 및 기술분야의 직업을 갖게 되는데 결정적인 역할을 하는 고교생의 문 이과반 선택에 있어 그 진로결정에 영향을 주는 제 요인들을 규명하는데 목적을 두고있다. 연구대상은 대구시내외 남 녀 고교 1학년생 109명(문과 56명, 이과 53명)이었으며 조사방법은 설문지법을 사용하였다. 조사결과는 학생들의 문 이과반 선택에는 장래직업, 대학전공, 적성, 학과목에 대한 능력, 흥미 선호도, 가족 및 주위의 권유 등이 주요요인임을 보여주고 있다. 그중 문과를 지원한 학생들은 대체적으로 자신의 적성 이과과목에 대한 능력부족 인식, 내신 및 학력고사에서의 성적취득용이성 등 주로 자신의 내적 동기와 관련된 요인들을 들고 있는데 비해, 이과를 지원한 학생들은 밝은 직업전망, 가족 및 주위의 권유 등 외적인 동기도 큰 작용을 하고 있음을 보여 대조를 이루고 있다. 또 문과를 지원한 학생은 이과가 공부하기가 어렵고 성적을 올리기도 힘들어 이과를 기피한 경향을 보이는데 반해 이과 지원자는 문과를 기피하여 이과로 왔다는 응답은 별로 없는 점이 대조를 보였다. 본 논문은 이러한 결과가 던져주는 시사점과 과학교육의 개선책에 관한 제언을 제시하면서 결론을 맺고 있다.

• Convergence Security Journal
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• v.14 no.6_1
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• pp.113-120
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• 2014

Recent changes made lack of volunteers is ready for a lot of the black students lack basic physical fitness and to increase this by itself is a lot to announce the final selection from the first notes, the secondary Fitness NCO selection process and interview process. The trend of course, but also to life as a career soldier passed the sergeant exam showed the important need is ready to run out of the old basic fundamentals that can be said that a lot of beginners executives. Therefore, we propose an appropriate national security with the mental and physical knowledge that our military needs the basic data ingest through analysis of model train to make excellent NCO personnel by fitness programs.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.9 no.5
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• pp.1479-1486
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• 2008

Recently, the number of applicants for the engineering college is gradually decreased all over the nation. Additionally, the concerns of fall of freshman mathematical ability are raised due to the incomplete high school education. Therefore, the local universities endeavor in order to improve the quality of mathematics education, and study the countermeasure against the crisis. As part of these efforts, Sang-Myung University founds the innovation center for engineering education. The center derives several ideas in order to enhance the mathematics education quality. In this paper, the enhancement plans for the mathematics education in Sang-Myung University are proposed. Results in this paper will be helpful for other university to enhance the mathematics education as reference materials.

• Journal of Yeungnam Medical Science
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• v.11 no.1
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• pp.30-34
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• 1994

Local anesthetics produce pain during infiltration into skin. The relationship between local anesthetic-induced pain and pH of the local anesthetic solution has not been fully investigated. Commercial preparation of local anesthetics are prepared as acidic solutions of the salts to promote solubility and stability. And the acidity of local anesthetic solition may be related with the pain during infiltration of the solutione. So, we tried to neutralize the lidocaine hydrochloride solution which is one of the most frequently used local anesthetic agent. Sodium bicarbonate was used for neutralization. Sodium bicarbonate was mixed with lidocaine hydrochloride until the resulting pH of the solution become 7.4 which is identical to the acidity of body fluid. To identify the effect of neutralized lidocaine solution, we had a course of double blind test to 6 volunteers. Both forearm of each volunteer were injected with neutralized lidocaine and plain one, and the degree of pain was estimated by each volunteers. According to subjective description by the volinteers, everyone felt neutralized lidocaine injection site was less painful than plain lidocaine. We concluded that we could reduce pain from infiltration of lidocaine hydrochloride by neutralization of the anesthetic solution with sodium bicarbonate.

• Parasites, Hosts and Diseases
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• v.23 no.1
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• pp.24-32
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• 1985

The worm development and egg laying pattern of Echinostoma hortense (Trematoda; Echinosto-matidae) were studied in albino rats and the brief clinical course was observed in human volunteers. A total of 21 rats were infected with 20~69 metacercariae each and two humans were with 7 and 27 metacercariae, which were collected from the loaches. For recovery of worms, the rats were sacrificed at irregular intervals from the 6th to 150th day after infection and the human volunteers were treated with praziquantel and purged with magnesium salt on the 26~27th day. The stools of the rats and humans were examined for the eggs. The results were as follows: 1. The worm recovery rate from the rats was not affected by the increase of infection time but varied individually; 9.1~50.0% (31.1 % in average). From humans, 14.3% and 37.0% (32.4% in average) of challenged were recovered. 2. In the rats, it was revealed that the worms rapidly grew for the first 14 days to become 7.59mm in average length and 1.17mm in average width but the growth became much slower thereafter until the 150th day; 7.95mm in length on the 21 th day, 9.04mm on the 28th day, 10.21mm on the 49th day and 12. 62mm on the 150th day. During the early stage of infection, the growth of genital organs (male or female) was expressed as sigmoid curves whereas non-genital organs (such as suckers) was simply as straight lines. 3. The prepatent period of this fluke was 10~12 days in the rats and 16~17 days in men. After the start of oviposition, the egg production by the worms remarkably increased, reached maximum on the 32~33th day, followed by decrease thereafter. The maximum value of E.P.G./worm was 390. 4. The major subjective symptoms in human volunteers were abdominal pain and diarrhea during the early stage of infection. The results show that human is as susceptible as the rats to E. hortense infection and the amount of egg production in the rats is greatly affected by the age of worms.

• Journal of Oral Medicine and Pain
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• v.32 no.3
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• pp.337-346
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• 2007

This study aimed to evaluate a relation of bruxism with clinical effects of botulinum toxin type A(BTX-A) injection. 5 bruxers and 5 nonbruxers with bilateral masseter hypertrophy were participated in this study. After injecting 25 unit of BTX-A(Allergen Inc, $Botox^{(R)}$) into each masseter muscle, the thickness of masseter(Mm) and anterior temporalis(Ta) muscles was measured by ultrasonography and the maximum bite force was evaluated during a 9-month period. Self-estimation on the recovery of occlusal force during mastication was done as well. Regardless of presence of bruxsim, all subjects showed significantly reduced Ms thickness(p<0.001) and maximum bite force at $1^{st}$ molars(p=0.027) with their peak at 3 months after injection, which then started to return. No significant difference was observed in Ta thickness and the bite force at the central incisors. While self-estimated occlusal force was the least at 2 weeks after injection and then rapidly returned to the baseline level with full recovery at the time of 6 to 9 months after injection, the maximum bite force measured by bite force recorder did not recover the original value, particularly in the nonbruxer group. It is assumed that nocturnal bruxism can influence recovery of atrophic masseter and decreased occlusal force due to BTX-A injection. These findings suggest a need of occlusal appliance to control bruxism or clenching habit for longer clinical effect of BTX-A injection.

• Journal of Gifted/Talented Education
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• v.15 no.1
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• pp.37-48
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• 2005

Comparing to the other subject, the relationship among physics contents is strong from the perspective of knowledge order as grades go up. That is, The things already that students learned, are learning and will learn are closed related from grade to grade. We expect students to be proactive and creative in studying physics, which is the goal of 21th century, analyzing their knowledge structure based on the knowledge order through assessment. Especially, using computer system, we provide students with substantial feedback for the assessment as well as objective validity is increased along with speedy and exact process in a bid to help students' mathematical understanding grow. This paper seeks to analyze the data from assessment applying knowledge spaces of the scientifical gifted in selective examination and to applicate on development of evaluation method.

• Journal of the Korean Society for information Management
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• v.25 no.2
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• pp.143-155
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• 2008

Authoritative as well as objective information on ranking or dominant research areas of academic departments/schools in a certain discipline is essential for the graduate school applicants. In this study, we performed an informetric analysis to identify dominant research areas in the top 10 U.S. LIS schools. We used two different datasets of research productivity and research interests of the LIS faculty. The correspondence analysis method was employed to graphically display the association between research areas and the LIS schools. We found that the research Productivity data collected from SSCI database generated a very informative map presenting which research areas were dominant in which LIS schools. We also found that for the two most productive suhject areas in LIS over the past 10-year period, the proportion of research articles in information retrieval decreased to a great extent in the recent 5-rear period, whereas that of information seeking behavior showed an almost same degree of increase.