• Radiation Oncology Journal
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• v.18 no.4
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• pp.277-282
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• 2000

Purpose : Though It has been known that the to tolerance of the liver to external beam irradiation depends on the irradiated volume and dose, few data exist which Quantify this dependence. However, recently, with the development of three dimensional (3-D) treatment planning, have the tools to Quantify the relationships between dose, volume, and normal tissue complications become available. The objective of this study is to investigate the relationships between normal tissue complication probabili쇼 (WCP) and the risk of radiation hepatitis for patients who received variant dose partial liver irradiation. Materials and Methods : From March 1992 to December 1994, 10 patients with hepatoma and 10 patients with bile duct cancer were included in this study. Eighteen patients had normal hepatic function, but 2 patients (prothrombin time 73$\%$, 68$\%$) had mild liver cirrhosis before irradiation. Radiation therapy was delivered with 10MV linear accelerator, 180$\~$200 cGy fraction per day. The total dose ranged from 3,960 cGy to 6,000 cGy (median dose 5,040 cGy). The normal tissue complication probability was calculated by using Lyman's model. Radiation hepatitis was defined as the development of anicteric elevation of alkaline phosphatase of at least two fold and non-malignant ascites in the absence of documented progressive. Results: The calculated NTCP ranged from 0.001 to 0.840 (median 0.05). Three of the 20 patients developed radiation hepatitis. The NTCP of the patients with radiation hepatitis were 0.390, 0.528, 0.844(median : 0.58$\pm$0.23), but that of the patients without radiation hepatitis ranged fro 0.001 to 0.308 (median .0.09$\pm$0.09). When the NTCP was calculated by using the volume factor of 0.32, a radiation hepatitis was observed only in patients with the NTCP value more than 0.39. By contrast, clinical results of evolving radiation hepatitis were not well correlated with NTCP value calculated when the volume factor of 0.69 was applied. On the basis of these observations, the volume factor of 0.32 was more correlated to predict a radiation hepatitis. Conclusion : The risk of radiation hepatitis was increased above the cut-off value. Therefore the NTCP seems to be used for predicting the radiation hepatitis.

• Radiation Oncology Journal
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• v.19 no.2
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• pp.87-94
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• 2001

Purpose : To evaluate the role of LINAC-based stereotactic radiosurgery (SRS) in the management of meningiomas, we reviewed clinical response, image response, neurological deficits for patients treated at our institution. Methods and materials : Between February 1995 and December 1999, twenty-six patients were treated with SRS. Seven patients had undergone prior resection. Nineteen patients received SRS as the initial treatment. There were 7 male and 19 female patients. The median age was 51 years (range, $14\~67\;years$). At least one clinical symptom presented at the time of SRS in 17 patients and cranial neuropathy was seen in 7 patients. The median tumor volume was $4.7\;cm^3\;(range,\;0.7\~16.5\;m^3)$. The mean marginal dose was 15 Gy (range, $10\~20\;Gy$), delivered to the $80\%$ isodose surface (range, $46\~90\%$). The median clinical and imaging follow-up periods were 27 months (range, 1-71 months) and 25 months (range, $1\~52\;months$), respectively. Results : Of 14 patients who had clinical follow-up of one year or longer, thirteen patients $(93\%)$ were improved clinically at follow-up examination. Clinical symptom worsened in one patient at 4 months after SRS as a result of intratumoral edema, who underwent surgical resection at 7 months. OF 14 patients who had radiologic follow-up of one year or longer, tumor volume decreased in 7 patients $(50\%)$ at a median of 11 months (range, $6\~25\;months$), remained stable in 6 patients $(43\%)$, and increased in one patient $(7\%)$, who underwent surgical resection at 44 months. New radiation-induced neurological deficits developed in six patients $(23\%)$. Five patients $(19\%)$ had transient neurological deficits, completely resolved by conservative treatment including steroid therapy. Radiation-induced brain necrosis developed in one patient $(3.8\%)$ at 9 months after SRS who followed by surgical resection of tumor and necrotic tissue. Conclusions : LINAC-based SRS proves to be an effective and safe management strategy for small to moderate sized meningiomas, inoperable, residual, and recurrent, but long-term follow-up will be necessary to fully evaluate its efficacy. To reduce the radiation-induced neurological deficit for large size meningioma and/or in the proximity of critical and neural structure, more delicate treatment planning and optimal decision of radiation dose will be necessary.

• Korean Journal of Ecology and Environment
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• v.52 no.3
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• pp.274-283
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• 2019

Beta diversity is an efficient means of assessing the spatial variation in community composition among sites. To present fish community variation and LCBD (Local Contribution to Beta Diversity) among sites in stream, 6 sampling sites were selected in Cheonggye stream. Fish communities, environmental and habitat variables were collected at sites from April 2014 to October 2015. We used the total variance of the fish community data table (site-by-species community table) based on different forms, presence-absence, abundance, and Hellinger transformation, to estimate and compare beta diversity and LCBD. Fish community data table transformed by Hellinger distance showed the higher values of beta diversity than presence-absence and abundance data table. A similar patterns of LCBD were observed with presence-absence and Hellinger transformed data table. Low value of beta diversity calculated by community data table with abundance was due to the non-normality of fish assemblage data. Additionally, correlation coefficients were calculated to evaluate the relationships among LCBD, community indices and physicochemical variables. LCBD showed negative correlation coefficients with Shannon diversity. Overall, application of beta diversity analysis is an efficient method of addressing spatial variation of fish communities and ecological uniqueness of the sites in stream.

• Proceedings of the Korean Nuclear Society Conference
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• 1996.05d
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• pp.253-258
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• 1996

원자로의 가동 중지 중이나 재장전시 원자로가 설치되어 있는 수조의 냉각수가 증기발생기 안으로 유입되는 것을 막는 장비로써 노즐댐을 사용한다. 현재의 노즐댐은 알루미늄 재질로 그 무게가 무거워 노즐댐 작업자가 취급하기 어렵다. 이 노즐댐의 경량화와 동시에 구조적 강도를 증가시키기 위해서 비강성이 높은 탄소섬유 강화 복합재료와 굽힘 강성 및 전단강성을 증가시키기 위하여 벌집구조(honeycomb)의 알루미늄을 사용하여 KAERI 노즐댐-II를 설계하였다. 노즐댐에 발생하는 응력 해석을 통하여 중앙판과 측면판의 변위가 충분히 작은 값을 가지면서 파괴지수도 충분히 작은 값이 되는 탄소섬유의 적층각도를 구하였으며, 중앙판은 ［$\pm$15］로 적층하고 측면판은 ［$\pm$45 ］로 적층 하였다. 그리고 각 판의 최대 파괴지수는 중앙판의 경우 0.32, 측면판의 경우 0.27 이었고 최대변위는 각각 3.1mm, 2.7mm로 노즐댐을 사용할 때 예상되는 하중에 대하여 노즐댐의 구조적 건전성을 입증하였다.

• The Transactions of the Korean Institute of Electrical Engineers
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• v.40 no.4
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• pp.402-406
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• 1991

In this paper, we find a set of conditions on weights under which a recursive weighted median filter preserves monotone or localy monotone sequence and under which any input sequence converges to a locally monotone sequence after a finite number of passes.

• Journal of the Korean Geotechnical Society
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• v.20 no.6
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• pp.5-10
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• 2004

The earth pressure coefficient at rest for clayey soils in the one-dimensional state, $K_0$ obtained from the triaxial test is not correct in principle because the seepage flow is radial and the displacement of soil elements is three-dimensional. Measurements of the earth pressure and the pore water pressure during one-dimension consolidation in the consolidometer ring are presented. The earth pressure and pore water pressure are measured directly by a circular part of the consolidometer ring of a floating type at its mid height. A plastic clay showed $K_0$=0.5 irrespective of pressure in the consolidometer ring.

• Radiation Oncology Journal
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• v.21 no.4
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• pp.276-282
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• 2003

Purpose: Although high-dose-rate intracavitary radiotherapy (HDR ICR) has been used in the treatment of cervical cancer, the potential for increased risk of late complication, most commonly in the rectum, is a major concern. We have previously reported on 136 patients treated with HDR brachytherapy between 1995 and 1999. The purpose of this study is to upgrade the previous data and confirm the correlation between late rectal complication and rectal dose in cervix cancer patients treated with HDR ICR. Materials and Methods: A retrospective analysis was peformed for 222 patients with cevix cancer who were treated for curative intent with external beam radiotherapy (EBRT) and HDR ICR from July 1995 to December 2001. The median dose of EBRT was 50.4 (30.6$\~$56.4) Gy with a daily fraction size 1.8 Gy. A total of six fractions of HDR ICR were given twice weekly with fraction size of 4 (3$\~$5.5) Gy to A point by Iridium-192 source. The rectal dose was calculated at the rectal reference point using the barium contrast criteria. in vivo measurement of the rectal dose was peformed with thermoluminescent dosimeter (TLD) during HDR ICR. The median follow-up period was 39 months, ranging from 6 to 90 months. Results: Twenty-one patients (9.5$\%$) experienced late rectal bleeding, from 3 to 44 months (median, 13 months) after the completion of RT. The calculated rectal doses were not different between the patients with rectal bleeding and those without, but the measured rectal doses were higher in the complicated patients. The differences of the measured ICR rectal fractional dose, ICR total rectal dose, and total rectal biologically equivalent dose (BED) were statistically significant. When the measured ICR total rectal dose was beyond 16 Gy, when the ratio of the measured rectal dose to A point dose was beyond 70$\%$, or when the measured rectal BED was over 110 Gy$_{3}$, a high possibility of late rectal complication was found. Conclusion: Late rectal complication was closely correlated with measured rectal dose by in vivo dosimetry using TLD during HDR ICR. If data from in vivo dosimetry shows any possibility of rectal bleeding, efforts should be made to reduce the rectal dose.

• Radiation Oncology Journal
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• v.24 no.1
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• pp.44-50
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• 2006

Puroose: This study evaluated the late rectal complications in cervix cancer patients following treatment with external beam radiotherapy (EBRT) and high dose rate intracavitary radiation (HDR ICR). The factors affecting the risk of developing late rectal complications and its incidence were analyzed and discussed. Materials and Methods: The records of 105 patients with cervix cancer who were treated with radical radiotherapy using HDR ICR between July, 1995 and December, 2001 were retrospectively reviewed. The median dose of EBRT was 50.4Gy $(41.4{\sim}56.4 Gy)$ with a daily fraction size of 1.8Gy. A total of $5{\sim}7$ (median: 6) fractions of HDR ICR were given twice weekly with a fraction size of $4{\sim}5 Gy$ (median: 4Gy) to A point using an Ir (Iridium)-192 source. The median dose of ICR was 24 Gy $(20{\sim}35 Gy)$. During HDR ICR, the rectal dose was measured in vivo by a semiconductor dosimeter. The median follow-up period was 32 months, ranging from 5 to 84 months. Results: Of the 105 patients, 12 patients (11%) developed late rectal complications: 7 patients with grade 1 or 2, 4 patients with grade 3 and 1 patient with grade 4. Rectal bleeding was the most frequent chief complaint. The complications usually began to occur $5{\sim}32$ (median: 12) months after the completion of radiotherapy. Multivariate analysis revealed that the measured cumulative rectal BED over 115 Gy3 (Deq over 69 Gy) and the depth (D) of a 5 Gy isodose volume more than 50 mm were the independent predictors for late rectal complications. Conclusion: With evaluating the cumulative rectal BED and the depth of a 5 Gy isodose volume as predictors, we can individualize treatment planning to reduce the probability of late rectal complications.

• Analytical Science and Technology
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• v.19 no.3
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• pp.203-210
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• 2006

The determination of trace selenium in milk powder has been studied by octopole reaction cell(ORC)-ICP-MS. The interferences by polyatomic ions and other concomitant molecular species could be removed remarkably by using $H_2$ as reaction gas in ORC. Compared to the normal mode (no cell gas), the $H_2$ cell gas mode improved the accuracy and precision. The quantitative result was average 102.7% and it was slightly higher than certified standard value of milk powder and the RSD was 7.6%.

• Proceedings of the Korea Water Resources Association Conference
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• 2022.05a
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• pp.352-352
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• 2022

수위자료는 기초 수문자료의 하나로서 자료 수집시 이에 대한 품질관리가 반드시 필요하다. 이 과정에서 이상치 여부를 점검하여 이상치로 확인된 경우 소거하거나 수정하는 등의 처리를 해야 한다. 수위자료의 이상치 점검에는 다양한 방법이 있지만 아직 일반화된 방법은 없다. 이에 다양한 방법에 대한 적용가능성을 평가해 볼 필요가 있다. Hampel 필터는 신호처리 시 신호의 이상치를 찾아 보완하려고 개발된 필터이다. 시계열자료에서 이상치를 감지하는 고전적인 접근 방법은 이동평균과 이동표준편차를 이용하는 것이지만 고전적인 이동평균과 이동표준편차는 이상치의 영향을 받는다. 이에 따라 이상치의 추정이 어렵게 되는 경우가 있다. 이에 반하여 Hampel 필터는 이동평균 및 이동표준편차 대신 중앙값과 중앙값 절대편차(Median Absolute Deviation; MAD)를 이용함으로써 더 나은 결과를 얻을 수 있다. Hampel 필터는 신호처리용으로 개발되었기 때문에 부드러운 Sine 곡선에 적합할 것으로 보이며, 이미 하천수위 변화보다는 부드러운 변화를 보이는 저수지수위의 이상치를 점검하기 위해 사용되고 있다. 하지만 변화가 급격하고 첨두가 발생하는 하천의 수위에 대해서도 적용할 수 있는지에 대해서는 평가가 필요하다. 이에 본 연구에서는 신호처리에 사용되는 Hampel 필터를 이용하여 수위자료의 이상치 점검에 적용하고 과거 자료에 기록된 실제 이상치 자료와 비교하여 그 성능을 평가해 보았다.