• Journal of Korean Biological Nursing Science
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• v.23 no.3
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• pp.199-207
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• 2021

Purpose: The purpose of this study was to investigate effects of NXP031, an inhibitor of oxidation by specifically binding to the complex of DNA aptamer/vitamin C, on dopaminergic neurons loss and the reaction of microglia in an animal model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced subchronic Parkinson's disease (PD). Methods: A subchronic PD mouse model was induced via an intraperitoneal (IP) injection of MPTP 30 mg/kg per day for five days. NXP031 (vitamin C/aptamer at 200 mg/4 mg/kg) and vitamin C at 200 mg/kg were administered via IP injections at one hour after performing MPTP injection. This process was performed for five days. Motor function was then evaluated with pole and rotarod tests, after which an immunohistochemical analysis was performed. Results: NXP031 administration after MPTP injection significantly improved motor functions (via both pole and rotarod tests) compared to the control (MPTP injection only) (p<.001). NXP031 alleviated the loss of dopaminergic neurons in the substantia nigra (SN) and striatum caused by MPTP injection. It was found to have a neuroprotective effect by reducing microglia activity. Conclusion: NXP031 can improve impaired motor function, showing neuroprotective effects on dopaminergic neurons in the SN and striatum of MPTP-induced subchronic Parkinson's disease mouse model. Results of this study suggest that NXP031 has potential in future treatments for PD and interventions for nerve recovery.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.43 no.12
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• pp.1054-1061
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• 2015

Navigation accuracy, integrity, and safety of commercial Unmanned Aerial Vehicle (UAV) is becoming crucial as utilization of UAV in commercial applications is expected to increase. Recently, the concept of Local-Area Differential GNSS (LADGNSS) which can provide navigation accuracy and integrity of UAV was proposed. LADGNSS can provide differential corrections and separation distances for precise and safe operation of the UAV. In order to derive separation distances between UAVs, modeling of Flight Technical Error (FTE) is required. In most cases, FTE for civil aircraft has been assumed to be zero-mean normal distribution. However, this assumption can cause overconservatism especially for UAV, because UAV may use control and navigation equipments in wider performance range and follow more diverse path than standard airway for civil aircraft. In this research, flight experiments were carried out to understand the characteristics of FTE distribution. Also, this paper proposes to use Johnson distribution which can better describe heavy-tailed and skewed FTE data. Futhermore, Kolmogorov-Smirnov and Anderson-Darling tests were conducted to evaluate the goodness of fit of Johnson model.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.10 no.3
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• pp.133-146
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• 2015

This study is to investigate the causal relationship between exchange hedge and the net income of the shipbuilder through the unit root test and co-integration and vector autoregressive model(Vector Autoregressive Model: VAR). First, quarter net income of shipbuilders to order a unit root tests from 2000 to 2013 was used as a value after the Johnson transformation. In the same period, the return on bond futures(KTBF), three years bond yield(KTB3Y), America-Korea exchange differences are weekly data for each quarterly difference in value was converted by utilization, shipbuilding shares after log transformation which it was used. Also, structural change point investigation analysis to verify that looked to take advantage of the structural changes occur in the exchange hedge strategies affecting net income in the shipbuilding industry. Between the exchange hedge and net income of shipbuilders in structural change points detection and analysis showed that structural changes occur starting in 2004. In other words, strategy of shipbuilders about exchange hedge has occurred from "passive exchange hedge" to "active exchange hedge". The exchange hedge of the Korea shipbuilders through the estimation of the VAR was able to grasp that affect the profitability of mutual shipbuilders. Macroeconomic variables and stock prices could also check to see that affected the net income of the shipbuilding industry.

• Research in Community and Public Health Nursing
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• v.8 no.2
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• pp.277-288
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• 1997

The purpose of this study is to identify the behavioral subsystems of the obese adult and contribute to the utility of Johnson's Behavioral System Model. The subjects were 167 obese adults in out-patients clinics of 2 hospitals and health clinics for 4 companies. These data were collected by a structured questionnaire with 52 items from July 1 to Sep. 30, 1995. The instrument used for this study was modified from the DBSM -self reporting instrument (1983) and Grubbs(1980)'s. The reliability of this method was cronbach's ${\alpha}$=.8476 and the construct validity of it was accepted by using a factor analysis. These data were analyzed by frequency, percentage, mean, standard deviation, factor analysis, pearson's correlation coefficient, Kruskal-Wallis with an SPSS PC+ Program. The results of this study were as follows: 1. The 9 behavioral subsystems of the obese were indentified : sex-related, attachment-affiliative I(social), dependency, ingestive, eliminative, restorative, aggressive-protective, attachment-affiliative and II (familial), an achievement behavioral subsystem. 2. Out of 9 subsystems, the highest significant positive correlation between dependency and acheivement subsystem was found(r=.5357, p<.01), The next, attachment-affiliative I and attachment-affiliative II subsystem was correlated significantly (r=.4526, p<.01). Significant positive correlations among sex-related, achivement, attachment-affiliative I, II, dependency, restorative, and aggressive-protective subsystems were found. But, ingestive and eliminative subsystems were not correlated with the above seven subsystems significantly, only the positive correlation between the ingestive and eliminative subsystems was found. 3. The explained variance of the 9 subsystems was explained as 56.1% out of a total of one. The sex-related subsystem was the first factor explaining 16.3% of the total variance and then the next 8 factors which resulted in 39.8%. According to the results of this study, the suggestions were as follows: 1. In the nursing practice, nursing assessmentand intervention of the obese should be in cluded not only in ingestive and eliminative subsystems but also in sex-related, attachment-affiliative I, dependency, restorative, aggressive-protective, attachment -affiliative II, and achievement behavioral subsystem. 2. Concerning instruments, some items to measure the eliminative, dependency, and aggressive-protective behavioral subsystems with relatively reliability are needed. 3. Johnson's concept of a dependency subsystem should be clarified. 4. Correlation among the 7 subsystems, and the ingestive and eliminative subsystems should be clarified.

• Journal of Korean Philosophical Society
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• v.144
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• pp.51-82
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• 2017

In Meditation II, Descartes questions "sed quid igitur sum" ("But what then am I?"). To this question to rule our essence, A. Clark insists that "We are soft selves". The idea by Clark is a spontaneous conclusion of the extended mind theory stating that cognitive process, cognitive state, and self may be extended over biological organisms. However, it seems that it is difficult for the extended self to have the qualifications as a moral agent. There have been disputes about expandability of cognitive process and cognitive state, but there have not been many disputes about the possibility of accountability of behavior by the extended self. First of all, in this thesis, it will be revealed that the extended self through the analysis of metaphorical theories and the ontological essence of agent and behavior by G. Lakoff and M. Johnson is just metaphorical rhetoric, which is not suitable for rational comprehension of ontological essence of agent and behavior. Moreover, the analysis of problem about artificial moral agent (AMA) proposes the "Strong First-person Viewpoint" as a requirement of the agent. Finally, the concept of extended self will be shown to be unsuitable for theoretical explanation of us, and the concept of human person will be proposed as an alternative solution.

• Korean Journal of Comparative Education
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• v.28 no.5
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• pp.47-69
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• 2018

The purpose of this study is to classify the lifelong learning policy implementation process of lifelong learning in Korea according to the policy making decision models and to suggest developmental tasks. Korea's lifelong learning policy came to a full-fledged start with the enactment of the Lifelong Education Act in 2000. The Lifelong Education Act proposed the establishment of an open educational system as a strategy to realize the lifelong learning society. According to the Lifelong Education Act, the Korean government has developed several lifelong education policies such as providing learning opportunity for the underprivileged, facilitating lifelong learning city project, building lifelong learning culture, recognizing of experiential learning result, funding lifelong learning hub university, launching lifelong learning supporting administrative etc. The Korean lifelong system is characterized as Allison's (1971) governmental/bureaucratic, Ziegler and Johnson's (1972) legislative, Griffin's(1987) social control and Green's (2000) state-led models which make policy through the coordination between the government and the parliament and control bureaucratic power and educational qualifications. Lifelong learning policies should be managed in terms of supply and demand at the learning market. In addition, the state has to strengthen lifelong learning through supporting NGOs' activities and adult learners' tuition fee for the disadvantaged group of people.

• Composites Research
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• v.36 no.3
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• pp.199-204
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• 2023

A combination of a metallic mesh and an adhesive layer of metallic particle/epoxy composite was introduced as an intermediate layer to enhance the adhesion between cold-sprayed particles and fiber-reinforced composites (FRCs). Aluminum was considered for both the metallic particles in the adhesive and the metallic mesh. To predict the mechanical characteristics of the intermediate bond layer under a high strain rate, the properties of the adhesive layer needed to be calculated or measured. Therefore, in this study, the Al particle/epoxy adhesive was homogenized by using a rule of mixture. To verify the homogenization, the penetration depth, and the thickness decrease after the cold spray deposition from the undeformed surface, was monitored with FE analysis and compared with experimental observation. The comparison displayed that the penetration depth was comparable to the diameters of one cold spray particle, and thus the homogenization approach can be reasonable for the prediction of the stress level of particulate polymer composite interlayer under a high strain rate for cold spray processing.