• Journal of Convergence for Information Technology
• /
• v.10 no.8
• /
• pp.179-186
• /
• 2020

The purpose of this study was to investigate the effects on the bio signal of brain waves and pulse waves using acupressure thermal bed combined with acupressure and thermal therapy. Forty healthy adults were divided into 20 experimental groups using combinatorial stimulation beds and 20 non-irritating controls. As a result of the experiment, the EEG was significantly increased in the delta wave and theta wave in the experimental group, and the alpha wave and beta wave decreased significantly. The pulse wave increased the parasympathetic activity index in the experimental group and the heart rate decreased. There was no difference in the control group. This change in EEG can be seen as a combination stimulation bed having a sleep-inducing effect, and a change in pulse wave can seen as having a relaxing effect. This study is expected to be used as basic data for the development of various combination stimulators and functional bed products.

• Proceedings of the Korean Aquaculture Society Conference
• /
• 2003.10a
• /
• pp.21-21
• /
• 2003

경골어류의 뇌하수체에서는 두 종류의 생식선자극호르몬 (FSH, LH)이 생산되며, 이 호르몬들은 공통적인 α 쇄와 특이적인 β 쇄를 가진다. 연어과 어종들에서, FSH는 난황형성과 정자형성의 역할을 하며, LH는 배우자의 최종성숙을 조절한다. 냉수성 고유어종인 열목어 (Brachymystax lenok)의 멸종을 방지하고 종묘생산을 원활히 하기 위하여 먼저 열목어의 GTHα, FSHβ 및 LHβ 쇄를 cloning하여 염기서열을 결정하였다. 열목어 GTHα, FSHβ 및 LHβ의 cDNA는 산천어의 해당 cDNA와 높은 상동성 (각각 84, 95, 98%)을 보였다. 다음으로 기능적인 생식선자극호르몬을 제작하기 위해서 2개의 쇄를 single-strand로 연결하여 진핵세포를 숙주로하는 시스템에서 생식선자극호르몬을 생산할 수 있는 구조체인 FSHβ-GTHα (235 amino acids) 와 LHβ-GTHα (240 amino acids)를 각각 재조합하였다. 또한 각각의 융합단백질 생산용 구조체의 3'-말단에는 단백질추출이 용이하도록 histidine×6 구조를 첨가하였다. 이상의 단일쇄 FSH와 LH 유전자재조합 산물을 포유동물 유래의 세포 (CHO-K1)에 liposome chemical을 사용하여 유전자도입 후 세포에서 분비되는 단백질을 모니터링하였다. 배지를 부분정제한 후 SDS-PACE로 조사한 결과, LH 재조합 유전자를 도입한 후 48-60 시간째에 약 25 kDa의 단백질로서 관찰되었다. 현재 FSH 재조합 유전자에 대해서도 조사중이며, 향후 이를 재료로 하여 기능형 생식선자극호르몬을 생산하고 추출하기 위한 연구가 계속적으로 수행 될 것이다.

• Science of Emotion and Sensibility
• /
• v.24 no.4
• /
• pp.107-116
• /
• 2021

This study aims to investigate the effect of multisensory stimulation on relieving the stress experienced by drivers. The photoplethysmograms (PPGs) of 30 healthy subjects were measured, and their subjective response to stressful situations and normal driving were evaluated. The subjects underwent nonstimulation and multisensory stimulation in stressful driving situations. Heart rate estimation from the PPG was collected via an ear-type sensor to reduce movement noise. The signals acquired were sampled at 200 Hz using BIOPAC PPG100C. Heart rate variability (HRV) was analyzed to compare the effect of multisensory stimulation on stress situations. In the multisensory stimulation, blue, green, and yellow were used for the visual sensory system; white, pink, and brown noises were used for the auditory sensory system; and lavender, lemon, and rosemary were used for the olfactory sensory system. No difference was observed in the subjective evaluation; however, the HRV results showed an increased HF (%) and decreased LF (%) and LF/HF (%) in the multisensory stimulation (e.g., green, pink noise, and rosemary) when compared to the nonstimulation.

• Journal of Veterinary Clinics
• /
• v.31 no.2
• /
• pp.77-84
• /
• 2014

The present study evaluated that responses of peripheral and bone marrow depends on the frequency of recombinant human granulocyte colony-stimulating factor (rhG-CSF) administration in dogs. The rhG-CSF has been revealed that have a beneficial effect for dogs with myelosuppression secondary to chemotherapy or radiation but there were no studies about the frequency of administration in dogs. In this research, rhG-CSF was administrated $5{\mu}g/kg$ subcutaneously for each two-dogs group as follows: (1) every day for trial, (2) every other day for trial, (3) every third day for trial. The peripheral blood analysis including direct microscopic differential counts of one hundred cells was performed every day. Bone marrow aspiration was performed before administration of rh G-CSF, on the day of 0, 3, 9 and when the WBC counts were decreased within the normal range (day 12 or 13). Rh G-CSF was well-tolerated and showed no side effects in all dogs. According to the present study, $5{\mu}g/kg$ administration of rhG-CSF have cell-specific, frequency-related effect on bone marrow and peripheral blood. Furthermore, the effects of rhG-CSF administration on bone marrow sustained during the study and prolonged at least 3 days after discontinuing of rhG-CSF treatment.

• 대한생식의학회:학술대회논문집
• /
• 2007.06a
• /
• pp.145-145
• /
• 2007

• Journal of the Institute of Electronics Engineers of Korea SP
• /
• v.44 no.2 s.314
• /
• pp.46-54
• /
• 2007

In current printer industry, four or more colorants are added for color gamut extension because the gamut of printer is smaller than other devices. However, these additional colorants make a redundancy problem that several combinations of colorants reproduced same color stimulus in colorimetric inverse characterization process. Thus, we propose a method of colorimetric inverse characterization using color correlation between colorant's amount. First, for analyzing the combination of colorants which represent the same color stimulus, we estimate the color stimulus for all combination of colorants by Cellular Yule-Nielsen Spectral Neugebauer printer model. The combination of colorants which has higher color correlation factor comparing combinations of colorant around itself in color space is selected. It can reduced the color difference from the tetrahedral interpolation process which is estimation of the output value(colorants combination) for arbitrary input(color stimulus). The selected combinations of colorants and their color stimulus are stored to the lookup table. In experiment, the CMYKGO printer was used. As a result, the dark region of color gamut was extended and the color tone was more naturally represented.

• Proceedings of the Costume Culture Conference
• /
• 2003.04a
• /
• pp.72-73
• /
• 2003

본 연구는 간호사복의 색상 및 문양에 따른 이미지를 분석하고, 색상과 문양이 조합을 이루었을 때 어떤 이미지로 통합되는지를 규명하고, 피험자에 따라 이미지지각의 차이를 알아보는데 목적이 있었다. 연구방법으로는 준실험 연구방법으로 피험자간 설계를 하였으며, 피험자는 대전, 충남지역의 대학생을 대상으로 시행하여 통계에 적합한 739부를 사용하였다. 연구에 사용된 자극물은 간호사복 catalog에서 선택한 모델에게, 색상(흰색, 분홍색, 하늘색, 녹색, 베이지색)과 문양(무지, 줄, 꽃)을 조합한 총 13개의 자극물을CAD simulation으로 제작했다. (중략)

• Science of Emotion and Sensibility
• /
• v.15 no.1
• /
• pp.149-160
• /
• 2012

The relative effects of individual differences in cultural orientation (individualism vs. collectivism) and locus of control (LOC: internal vs. external control beliefs) combination types on global/local processing were compared by manipulating the compound stimulus types (arrows or letters), and the stimulus-stimulus congruence. The results can be summarized as followings. First, consistent with previous research on global/local processing of the compound stimuli, reaction time (RT) for global stimuli than for local stimuli, and that in the stimulus-stimulus congruent condition than in the stimulus-stimulus incongruent condition was faster. Second, faster RT was found in the compound arrows condition than in the compound letters. Third, individual difference in LOC, rather than that in the cultural orientations, appeared to be related to global precedence effect, when the compound letters were presented. These results indicated that the individual's LOC rather than cultural orientation can increase the size of the global precedence effect, which might be involved in the stage of cognitive analysis than that of feature detection.

• Proceedings of the Korean Society for Cognitive Science Conference
• /
• 2005.05a
• /
• pp.223-227
• /
• 2005

시각 자극의 운동 방향을 파악하는 것은 시각의 주요 기능 가운데 하나이다. 동일한 망막상의 영상 운동은 다양한 조합의 시각 자극의 운동 벡터와 눈 운동의 벡터의 합으로 발생할 수 있는데, 이렇게 망막 정보가 애매한 경우에도 불구하고 시각 자극의 움직임을 정확하게 파악하며, 이것은 시지각의 안정성을 돕는 망막 이외의 정보가 통합된 결과이다. 본 발표는 이러한 정보 중에 하나인 도약 안구 운동에 즈음하여 제시되는 시자극 운동의 지각 과정에서 안구 운동 정보의 역할을 결정한 실험의 결과에 관한 것이다. 도약 안구 운동의 발생 전후에 제시된 자극의 속성에 대한 판단은, 자극의 속성과 도약 안구 운동 방향에 따라 일정한 방식으로 조절되는 것을 관찰하였다. 이러한 시각 운동의 지각 왜곡을 일으키는 신경 기전은 일차 시각 피질에서 일어날 가능성이 있는 것으로 생각된다.

• Proceedings of the Korean Society of Applied Pharmacology
• /
• 1993.04a
• /
• pp.66-66
• /
• 1993

혈액 세포 형성 과정인 조혈 작용은 콜로니 자극인자 (Colony Stimulating Factor, CSF)라 불리는 몇 종류의 당 단백질에 의해 조절된다. 이들 자극인자 중, GM-CSF는 다계통에 작용하는 조절인자로서 과립구와 거식세포의 생성을 조절한다고 알려져 있다 한편 GM-CSF는 생체내에서 백혈구의 형성을 조절하는 인자이기 때문에 골수이식을 한 환자 및 화학요법이나 방사선 치료를 받는 암환자에게서 발생하는 백혈구의 감소현상을 완화시키는 역할을 한다. 혈액의 보조화와 관련하여 의학적 효능을 나타낼 것으로 간주되는 GM-CSF를 유전자 재조합 기술로 효모에서 발현, 정제하여 물리화학적 특성 및 역가를 측정하는 것이 이 연구의 기본목적이다.