• Proceedings of the Korean Society of Medical Physics Conference
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• 2003.09a
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• pp.60-60
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• 2003

목적 : 감마나이프 치료계획용 소프트웨어인 감마플렌에서 처방선량을 계산하는 단위와 실제 시간을 설정하는 하드웨어인 조정판의 시간설정 단위의 차이에 의한 실제 처방선량에 끼치는 영향을 계산하였다. 대상 및 방법 : 감마나이프는 주어진 4 개의 헬멧을 가지고 최소 한번 또는 최대 20 번 이상의 방사선 조합으로 한번에 많은 방사선을 목표물에 조사한다. 감마나이프 방사선 수술을 위한 치료계획용 소프트웨어인 감마플렌 5.32에서는 처방선량에 대한 치료시간을 최대 지점 또는 지정하는 지점에 규격화하여 소숫점 두 자리 즉 0.6 초까지 계산한다. 그러나 실제 치료를 위한 조정판의 시간설정은 모델 B 에서는 소숫점 한자리까지 가능하게 되어있다. 그러므로 모델 B를 사용하는 기관의 치료계획 컴퓨터인 감마플렌에서는 소숫점 한자리로 만들기 위해 반올림과 내림을 하게 되며 이것을 프린트하여 사용하게 된다. 실제 임상에서 멀티삿에 대한 반올림과 내림에 대한 효과를 선량으로 환산하여 처방선량에 끼치는 영향을 연구하였다. 치료 계획에 서 처방선량을 입력한 후 계산된 각 조사에 대한 소숫점 두자리 시간을 화면에 표시한 후 스냅tit으로 스크린 캡쳐하여 프린트하였으며, 소숫점 한자리로 된 최종 치료계획을 프린트하여 서로 비교 계산하였다. 결과 : 20 여명의 환자에 대한 치료 결과에 대한 분석은 조사의 수나 처방선량에 관계하지 않고 우연히 올림이 많으냐 내림이 많으냐에 의존하였다. 최대지점에 대하여 분석한 결과는 -0.48부터 +0.47로 -2%부터 +1.9%의 정도로 영향을 끼쳤다. 결론 : 반올림과 내림의 결과는 처방선량을 줄일 수도 있고 늘일 수도 있었다. 그러나 이 연구는 최대선량 지점에 대해 비교를 하였으나 실제로는 각 조사의 위치가 서로 다르므로 영향은 이보다 훨씬 적을 것으로 생각되어 소숫점 한자리로 치료하여도 무방할 것으로 보인다.mm, AP 방향에서는 2.1$\pm$0.82 mm이었다. 그리고 복부의 later의 방향에서는 7.0$\pm$2.1 mm, AP 방향에서는 6.5$\pm$2.2 mm 이었다. 또한 표적 위치측정을 위해서 환자의 피부에 임의의 가상표적을 부착하고 CT 촬영한 영상결과, 프레임으로 가상표 적에 대한 위치를 정확히 파악할 수 있었다. 결론 : 제작된 프레임을 적용하여 방사선투과율 측정실험, 환자 외부자세에 대한 오차 측정실험, 가상표적 위치측정 실험 등을 수행하였다. 환자 외부자세에 대한 오차 측정실험 경우, 더 많은 Volunteer를 적용하여 보다 정확한 오차 측정실험이 수행되어야 할 것이며 정확한 표적 위치 측정실험을 위해서 내부 마커를 삽입한 환자를 적용한 임상실험이 수행되어야 할 것이다. 또한 위치결정에서 획득한 좌표값의 정확성을 알아보기 위해서 팬톰을 이용한 방사선조사 실험이 추후에 실행되어져야 할 것이다. 그리고 제작된 프레임에 Rotating X선 시스템과 내부 장기의 움직임을 계량화하고 PTV에서의 최적 여유폭을 설정함으로써 정위 방사선수술 및 3 차원 업체 방사선치료에 대한 병소 위치측정과 환자의 자세에 대한 setup 오차측정 결정에 도움이 될 수 있을 것이라고 사료된다. 상대적으로 우수한 것으로 나타났으며, 혼합충전재는 암모니아의 경우 코코넛과 펄라이트의 비율이 7：3인 혼합 재료 3번과 소나무수피와 펄라이트의 비율이 7：3인 혼합 재료 6번에서 다른 혼합 재료에 비하여 우수한 것으로 나타났다. 4. 코코넛과 소나무수피의 경우 암모니아 가스에 대한 흡착 능력은 거의 비슷한 것으로 사료되며, 코코넛의 경우 전량을 수입에 의존하고 있다는 점에서 국내 조달이 용이하며, 구입 비용도 적게 소요되는 소나무수피를 사용하는 것이 경제적이라고 사료된다. 5. 마지막으로

• Investigative Magnetic Resonance Imaging
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• v.11 no.2
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• pp.103-109
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• 2007

To develop an advanced non-linear curve fitting (NLCF) algorithm for performing dynamic susceptibility contrast study of the brain. The first pass effects give rise to spuriously high estimates of $K^{trans}$ for the voxels that represent the large vascular components. An explicit threshold value was used to reject voxels. The blood perfusion and volume estimation were accurately evaluated in the $T2^*$-weighted dynamic contrast enhanced (DCE)-MR images. From each of the recalculated parameters, a perfusion weighted image was outlined by using the modified non-linear curve fitting algorithm. The present study demonstrated an improvement of an estimation of the kinetic parameters from the DCE $T2^*$-weighted magnetic resonance imaging data with using contrast agents.

• Investigative Magnetic Resonance Imaging
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• v.11 no.2
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• pp.110-118
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• 2007

Purpose: The objective of this work to construct eigenvalue maps that have information of magnitude of three primary diffusion directions using diffusion tensor images. Materials and Methods: To construct eigenvalue maps, we used a 3.0T MRI scanner. We also compared the Moore-Penrose pseudo-inverse matrix method and the SVD (single value decomposition) method to calculate magnitude of three primary diffusion directions. Eigenvalue maps were constructed by calculating of magnitude of three primary diffusion directions. We did investigate the relationship between eigenvalue maps and fractional anisotropy map. Results: Using Diffusion Tensor Images by diffusion tensor imaging sequence, we did construct eigenvalue maps of three primary diffusion directions. Comparison between eigenvalue maps and Fractional Anisotropy map shows what is difference of Fractional Anisotropy value in brain anatomy. Furthermore, through the simulation of variable eigenvalues, we confirmed changes of Fractional Anisotropy values by variable eigenvalues. And Fractional anisotropy was not determined by magnitude of each primary diffusion direction, but it was determined by combination of each primary diffusion direction. Conclusion: By construction of eigenvalue maps, we can confirm what is the reason of fractional anisotropy variation by measurement the magnitude of three primary diffusion directions on lesion of brain white matter, using eigenvalue maps and fractional anisotropy map.

• Fire Science and Engineering
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• v.32 no.2
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• pp.67-72
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• 2018

A fire shutter is installed to prevent the movement of fire or smoke when a fire occurs inside a building. Fire shutters have access doors for passengers. On the other hand, the present fire shutter door display regulation is only required to be displayed in a different color from the surroundings. Hence, the risk of people not being able to recognize the door of the fire shutter is quite high, and the danger increases further in a smoke situation. Therefore, this study attempted to find a way to mark a fire shutter door that can be recognized even when smoke is spreading. First, a preliminary questionnaire was used to draw three factors to mark the fire shutter door (sign, door background, and edge). The experiment type was set by combining 5 colors for the three derived factors. The experiment was conducted on a total of 122 male and female participants. The results showed that a yellow background, red sign, and red edge have the highest awareness in a normal visual field without smoke. This was also the same in the field of view in the case of a fire with smoke, but the red background, yellow sign, and yellow edge were most noticeable in the case of dark smoke.

• Journal of the Korean Society for Nondestructive Testing
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• v.22 no.4
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• pp.361-368
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• 2002

The aim of this study was to investigate the effect of preprocessing the transmitted energy spectrum data on development of a robust model to predict the sugar content in intact apples. The spectrum data were measured from 120 Fuji apple samples conveying at the speed of 2 apples per second. Computer algorithms of preprocessing methods such as MSC, SNV, first derivative, OSC and their combinations were developed and applied to the raw spectrum data set. The results indicated that correlation coefficients between the transmitted energy values at each wavelength and sugar contents of apples were significantly improved by the preprocessing of MSC and SNV in particular as compared with those of no-preprocessing. SEPs of the prediction models showed great difference depending on the preprocessing method of the raw spectrum data, the largest of 1.265%brix and the smallest of 0.507% brix. Such a result means that an appropriate preprocessing method corresponding to the characteristics of the spectrum data set should be found or developed for minimizing the prediction errors. It was observed that MSC and SNV are closely related to prediction accuracy, OSC is to number of PLS factors and the first derivative resulted in decrease of the prediction accuracy. A robust calibration model could be d3eveloped by the combined preprocessing of MSC and OSC, which showed that SEP=0.507%brix, bias=0.0327 and R2=0.8823.

• Journal of Korea Water Resources Association
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• v.51 no.2
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• pp.99-107
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• 2018

This study was to evaluate the stream depletion due to groundwater pumping from 17 wells near the Anseongcheon upper stream using the Baalousha's analytical solution (2012) which directly considers stream width and streambed hydraulic conductivity. The input hydraulic values of aquifer and streambed were obtained from the pumping tests and seepage experiments. The estimated streamflow depletion rates divided by pumping rate (dimensionless stream depletion) showed a range from 0.23 to 0.89 for 5 year pumping. In particular, the results revealed that the groundwater pumping has insignificant effects on streamflow when the stream depletion factor (SDF) is higher than 1,000 with values of dimensionless stream depletion lower than 0.4. A more simple Hunt's solution (1999) also applied to the same wells, and the results showed that the difference between the dimensionless stream depletions calculated by using both solutions could be negligible. From the comparison of the Baalousha's solution (2012) with the Hunt's solution (1999) with total 3,000 cases of simulations with combinations of various aquifer and stream properties, the stream-well distance should be more longer than stream width for reducing the discrepancy between both solutions.

• Health Policy and Management
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• v.1 no.1
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• pp.116-135
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• 1991

Few studies have been conducted on the detailed routes of medical care utilization under the National Health Insurance. This study was undertaken to identify the utilization patte군 of health care facilities among industrial workers and their dependents. One of the largest health insurance association was purposively chosen for this objective. The association had 345, 757 members as of 31 December, 1990. The study sample of 297, 948 subjects have been drawn from the membership pool on the basis of their continuous membership status during 1 January through 31 December 1990. This study has tried to identify differential utilization patterns between acute and chronic conditions, and among standard income classes. All the diagnoses were recoded in a manner to achieve the objective of this study. As for acute diseases, most age group had used one medical facility as much as by 60% except the age group of 1-4, This young age group had used over three different health facilities as much as by 10.9-15.8%. The finding suggests that some policy measures by sought for remedying the excessive/inappropriate use of services. In addition, mid-income classes(between 17 and 48) were more likely to use multiple sources of care than lower income classes(between 1 and 16) and upper income classes(above 49). This study has revealed that chronic cases are more likely to pursue multiple sources of care, however those with chronic conditions tend to use single health facility more than those with acute conditions(67.9% versus 52.4%). As many as 12.2% have visited more than three health facilities in chronic conditions, but 5.9% for acute conditions. The most likely source of care was primary clinics for both acute and chronic conditions. Compared with the role of general hospital, small-size hospitals found to play a minimal role in the care and referral of patients. This indicates the need of strengthening the function of small-size hospitals. While a minor cross utilization of western medicine and pharmacy was noted, no significant boundary crossing was identified between western medicine and oriental medicine, or between pharmacy and oriental medicine. It is too early to confirm that whether there is substitutability or cross utilization among these alternative sources of care. A further study is needed to identify these relationship.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.28 no.2
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• pp.209-218
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• 1995

Bacteriophage T7 gene 2.5 protein, a single-stranded DNA binding protein, has been implicated in T7 DNA replication, recombination, and repair. Purified gene 2.5 protein has been shown to interact with the phage encoded gene 5 protein (DNA polymerase) and gene 4 proteins (helicase and primase) and stimulates their activities. Genetic analysis of T7 phage defective in gene 2.5 shows that the gene 2.5 protein is essential for T7 DNA replication and growth. T7 phage that contain null mutants of gene 2.5 were constructed by homologous recombination. These mutant phage $(T7\Delta2.5)$ cannot grow in Escherichia coli. After infection of E. coli with $T7\Delta2.5$, host DNA synthesis is shut off, and $T7\Delta2.5$ DNA synthesis is reduced to less than $1\%$ of wild-type phage DNA synthesis (Kim and Richardson, 1993, Proc. Natl. Aca. Sci. USA, 90, 10173-10177). A truncated gene 2.5 protein $(GP2.5-\Delta21C)$ deleted the 21 carboxyl terminal amino acids was constructed by in vitro mutagenesis. $GP2.5-\Delta21C$ cannot substitute for wild-type gene 2.5 protein in vivo; the phage are not viable and exhibit less than $1\%$ of the DNA synthesis observed in wild-type phage-infected cells. $GP2.5-\Delta21C$ has been purified to apparent homogeneity from cells overexpressing its cloned gene. Purified $GP2.5-\Delta21C$ does not physically into「act with T1 gene 4 protein as measured by affinity chromatography and immunoblot analysis. The mutant protein cannot stimulate T7 gene 4 protein activity on RNA-primed DNA synthesis and primer synthesis. These results suggest that C-terminal domain of gene 2.5 protein is essential for protein-protein interactions.

• Journal of the Korea Computer Graphics Society
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• v.20 no.1
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• pp.1-11
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• 2014

Patients with cerebral palsy or arthritis have deformities in lower limb which cause unstable gait or posture and pains. Surgeons perform a deformity correction osteotomy with surgical plan. But sometimes they find the unexpected angular or rotational deformation after surgery. The problems are that there is no method to predict the result of a surgical plan and also there are so many factors to must consider in surgical planning step such as clinical measurements, rotation angle, wedge angle, morphology of lower limb, etc. This paper presents new methods for planning the deformity correction osteotomy efficiently. There are two approaches based on the 3D mesh model and the accurate assessment of the patient's lower limb. One is the manual pre-simulation of surgery using forward kinematics. And the other is the automatic surgical planning using inverse kinematics and nonlinear optimization. Using these methods, we can predict and verify the results of various surgical treatments and also we can find a more effective surgical plan easily compared to conventional methods.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.11
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• pp.86-93
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• 2020

The demand for maintenance in Korea infrastructure facilities constructed since the 1970s has increased significantly compared to the demand for new construction. Moreover, after the Gyeongju and Pohang earthquakes, seismic performance evaluation, repair, and retrofitting projects have been carried out. Therefore, in this study, a specimen was designed following the L-type GFRP Plate Externally Bonded Retrofit method, one among other retrofit methods. The L-type GFRP Plate was bonded to the specimen by epoxy and a washered steel nail. A four-point bending test was performed to confirm the strengthening effect of the Externally Bonded Retrofit method using an L-type GFRP Plate. The strengthening effect of the L-type GFRP plate was proven experimentally, and the behavior of the beam designed following the L-type GFRP Plate Externally Bonded Retrofit method was evaluated according to Korea's "Design Manual & Specification for Strengthening of RC Structures by Advanced Composites System". Furthermore, the effectiveness of the bonding method, a combination of epoxy and washered steel nail, was also checked. The results showed that the design, according to the guidelines mentioned above, predicted the strength of the member well, but the failure mode did not satisfy the design assumption because of unexpected damage to the GFRP plate due to the fixing method, washered steel nail.