• Journal of Korean Medicine Rehabilitation
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• v.18 no.3
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• pp.19-39
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• 2008

Objectives : It has been reported that CG was effective in decreasing injury to neural tissues. To investigate neural responses in the injured spinal cord, an extract of CG was examined to determine its effect on neural responses in the injured spinal cords of rats. Methods : After CG treatment was applied to the spinal cord of rats given a contusion injury, the re-growth responses of injured neural tissues and corticospinal tract axons was observed by measuring the number of GAP-43, Cdc2, and phospho-Erk1/2 proteins, CST axons, GFAP-stained astrocytes, and Glial scarring in the injured spinal cord. Results : Levels of GAP-43, Cdc2, and phospho-Erk1/2 proteins were found to have increased in the injured spinal cord region. The number of GFAP-stained astrocytes also increased within and around the injury cavity. Glial scarring, which was identified by CSPG immunofluorescence staining, was reduced by CG treatment. Anterograde tracing by Dil dye showed that the elongation of the CST axons in the dorso-medial white matter area was almost completely prevented at the injury site. Collateral sprouting was observed in the spinal cord rostrally close to the injury site, and CG treatment further increased axonal arborization in the corresponding region. In vivo migration of CST axons and astrocytes using an implanted polymer tube system showed more of an increase in enhanced migration of axons and astrocytes in CG-treated group compared to the injury control group. Conclusions : These results suggest that CG activated neural responses - including astrocyte migration - and promotes axonal regenerative activity in the injured spinal cord area.

• Journal of Veterinary Clinics
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• v.15 no.2
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• pp.378-385
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• 1998

Chloramphenicol주사에 의한 좌골신경손상을 유발한 후 Prednisolone을 이용한 약물처치군, 전침군 및 전침과 약물을 병용한 군에서 각각 회복속도를 비교하였다. 정상보행 횟수, pinching을 통한 감각신경의 통감반응,그리고 병리조직소견 등을 죠사한 결과를 요약 하면 다음과 같다. Enrofloxacin, cefazolin, cephalexin, penicillin 등의 좌골신경주위 주사게 서는 신경마비가 관찰되지 않았으나 chloramphenicol을 주사할 경우에는 좌골신경손상으로 인한 편측성 후지마비가 유발되어 knuckling 반응을 보였다. Chloramphenicol을 투여한후 좌골신경손상에 대한 각 처치에서 정상보행 횟수는 8-12주까지는 침술처치군이 약간 중가하 였으나, 처리군간 유의성은 관찰되지 않았다. 실험기간동안 chloramphenicol 에 의한 신경손 상에 대한 각 처치군별 병리조직 소견은 호전양상이 관찰되지 아니하였다.

• Journal of Sasang Constitutional Medicine
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• v.11 no.2
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• pp.283-299
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• 1999

1. Purpose : Systemic injection of kainic acid in experimental animals induces the limbic seizure and structural damages in hippocampus and amygdala which resembles the changes in human temporal lobe epilepsy. The author performed this study to investigate the neuroprotective effects of Yuldahansotang, on the neurotoxicity induced by kainic acid in the hippocampus in rats. 2. Method : Kainic acid was administered intraperitoneally. And feeding with Yuldahansotang for 3 weeks after kainic acid administration. Seizure were induced in male mice (kainate 10-40 mg/kg i.p) and animals were sacrified at various time-points after injection. The experimental animals were sacrificed at 1, 2, 3day and 1, 3weeks while Yuldahansotang administrations. Seizure were graded using a behavioral scale developed in our laboratory. c-fos belong to immediate early genes(IEGs) known to have rapid and brief responses. And neuronal injury was assayed by examining DNA fragmentation using in situ nick translation histochemistry. 3. Results & Conclusion : Seizure severity paralled kainate dosage. At higher doses DNA fragmentation is seen mainly in hippocampus in area CA3, and variable in CA1, thalamus, amygdala within 24 h, is maximal within 72 h, and is large gene by 7 days after administration of kainate. And we can't see the expression of DNA fragmentation and c-fos in the mice what feeded by Yuldahansotang after 7 days from kainic acid administration. It is consequently suggested that Yuldahansotang may attenuate the kainic acid-induced neuronal degeneration and increase the immunoreactivity of hippocampus in mouse.

• Journal of the Korean Society of Food Science and Nutrition
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• v.33 no.6
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• pp.965-972
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• 2004

In the present study, it is observed that Monascus diet may have a hepatoprotective effect on the liver damage induced by bromobenzene in rats. By treatment with bromobenzene (400 mg/kg, i.p.) once a day for 3 consecutive days, the liver damage was reduced in rats fed 2% Monascus diet, based on the liver functional and histopathological findings. Furthermore, retreatment of bromobenzene to the animals with damaged liver showed higher decreasing rate of hepatic glutathione content and increasing rate of cytochrome P450 dependent aniline hydroxylase activity at 4 h in rats fed 2% Monascus diet than those fed STD diet, and V$_{max}$ in glutathione S-transferase was higher in liver of rats fed 2% Monascus diet than those fed STD diet. On the other hand, activities of antioxidant enzymes such as hepatic glutathione S-transferase, catalase and superoxide dismutase were generally higher both in bromobenzene and 2% Monascus diet treated group than those fed STD diet. In conclusion, the rats fed 2% Monascus diet showed lower liver damage than those fed STD diet, which may be due to the acceleration of bromobenzene metabolism and detoxication of oxygen free radicals.s.

• Journal of Korean Foot and Ankle Society
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• v.1 no.1
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• pp.59-64
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• 1997

The aims of free tissue transplantation to the injured foot are to cover the exposed blood vessels, nerves, muscles, tendons and bones, to clear up infection, to lessen the morbidity, to shorten the hospitalization, and to prepare for further surgical procedures when no local or transpositioning flaps are available. Authors have carried out free flap transplantation in 13 cases of crushing injury, osteomyelitis and electrical burn in the foot at Chonbuk National University Hospital from June 1992 through May 1996. The results were as follows : 1. 9 cases of 13 (69%) were sustained from the traffic accident. 2. The dorsalis pedis free flap transplantation has been performed most frequently in 5 cases (38.5%), followed gracilis muscle flap in 4 cases(30.7%), rectus abdominis muscle flap in 2 cases(15.4%), latissimus dorsi muscle flap and upper arm flap in 1 each. 3. 6 muscle flaps were covered with split thickness skin graft 20 days after microsurgical anastomosis. 4. All of 13 cases were survived after microsurgical procedure and showed excellent coverage in the foot.

• Journal of the korean academy of Pediatric Dentistry
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• v.35 no.1
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• pp.11-17
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• 2008

The purpose of this study was to investigate early histological changes and calcitonin gene-related peptide (CGRP) expression in the dental pulp of the rat after Er:YAG laser preparation. Occlusal cavities were prepared in the upper first molars using either Er:YAG laser and conventional bur. At 48 hours after cavity preparation, the teeth were processed for hematoxylin-eosin stain and CGRP immunohistochemistry. The results were as follows : 1. The cavity floor by Er:YAG laser preparation was more irregular shape compared with those by bur preparation and there are some cracks in the directions of dentinal tubules. 2. There were more inflammatory cell infiltration and disruption of odontoblast in the dental pulp by Er:YAG laser preparation in comparison with the dental pulp by bur preparation. 3. CGRP expression in the pulp tissue by both Er:YAG laser and bur preparations were increased and higher than in the normal pulp. The expression pattern of CGRP was more strong in the pulp by Er:YAG laser preparation. These results indicate that Er:YAG laser is useful in the operative dentistry such as caries removal and cavity preparation if properly applied.

• The Journal of the Korean dental association
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• v.54 no.10
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• pp.811-819
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• 2016

Panfacial fracture is extremely difficult to manage facial injuries but concomitant injuries and severe complications including facial esthetic and functional problems can make it harder. Thorough evaluation and closed co-work with other specialists is needed when reduction and fixation cannot be achieved quickly. Emergency bony support and soft tissue key suture provide the patients with airway integrity, hard and soft tissue vitality. A systemic treatment plan must be made by 3D CT image. This plan include airway management for surgery, sequence of reduction and fixation, approach method, soft tissue resuspension and reconstruction of lost tissue like inferior orbital wall, zygomaic buttress and soft tissue. From known to unknown structures, accurate reduction and fixation will provide proper occlusion, facial projection, width, hight and function. Consideration about facial retaining ligaments must be given to prevent soft tissue sagging.

• Journal of Life Science
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• v.17 no.11
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• pp.1571-1575
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• 2007

This research was carried out to investigate the effects of Hambag mushroom on the oxidative stress in diabetic rats, Sprague-Dawley. The diabetic rats induced by streptozotocin were fed with hambag mushroom-powder(G. frondosa) for 6 weeks. For the level of oxidative stress in liver and pancreas tissues, it was studied by measuring LPO (lipid oxide) level as an indicator of lipid peroxidation, XOD(xanthine oxidase) as one of important sources for free radicals and the levels of GSH and GST as anti-oxidant systems. Also, as an indicator of liver damaged by oxidative stress, the activities of serum ALT and AST were measured. It was observed that the levels of ALT, AST, LPO and XOD were higher by about two times in both tissues from diabetic rats than in those from control rats. This indicates that the oxidative stress induced by diabetes caused the tissues damages. However, these levels were decreased in the tissues from rats with hambag mushroom-powder. Futhermore, the activity of GST were higher in both tissues from diabetic rats fed with hambag mushroom-powder than in those from diabetic rats. Thus, it is considered that the hambag mushroom-powder decreases the level of oxidative stress by increasing activity of anti-oxidant system such as GSH and GST. It is suggested that the hambag mushroom-powder can be useful for preventing the tissues damaged by diabetes-induced oxidative stress.

• Ceramist
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• v.7 no.1
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• pp.11-20
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• 2004

오늘날 고령화와 사고의 증가 및 삶의 질이 향상됨에 따라 생체재료에 대한 관심과 수요는 매우 커지고 있다. 오래전부터 인체의 손상된 부위를 자가이식(autograft)이나 동물을 통한 이종이식(allograft)으로 일부 대체 하였지만, 그 수요와 쓰임에는 많은 한계가 있었다. 생체재료 (biomaterials)는 사고나 질병에 의해 손상된 인체의 조직이나 장기를 대체하거나 그 기능을 회복하기 위해 사용되는 재료를 말한다. 1) 생체재료로서 세라믹스(생체 세라믹스 bioceramics)는 1970년대부터 일부 임플란트 (implant)용으로 쓰이기 시작했으며 현재는 치과(dentistry)및 정형외과(orthopaedics) 분야에서 그 쓰임과 규모는 실로 막대하다. 최근에 생명공학(biotechnology)의 발달과 더불어 생체재료나 조직공학(tissue engineering) 분야가 새롭게 대두되면서, 생체세라믹스를 개발하고자 하는 노력은 선진국을 중심으로 이루어지며, 국내에서도 관심이 집중되고 있다.(중략)

• Journal of the Korea Institute of Building Construction
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• v.24 no.3
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• pp.297-308
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• 2024

This study presents a novel approach for evaluating fire-induced damage depth in concrete. The methodology leverages the principle that exposure to high temperatures causes internal expansion within concrete, leading to increased voids and microcracks in the damaged zones. This heightened porosity results in greater absorption rates compared to undamaged areas. By immersing fire-damaged concrete samples in water and subsequently monitoring the drying process, the depth of damage can be assessed. Differences in drying rates and color variations between damaged and undamaged areas serve as visual indicators for determining the extent of the damage. Experimental results from this water immersion method revealed damage depths of 38.7mm and 37.5mm for two different concrete mixtures. These measurements notably surpass the damage depths estimated using traditional phenolphthalein-based methods. This discrepancy suggests that utilizing the absorption rate principle, which is directly linked to the physical changes caused by thermal expansion, offers a more accurate and sensitive assessment of fire damage depth compared to methods relying solely on the presence of Portlandite for colorimetric indication.