• Proceedings of the Korean Nutrition Society Conference
• /
• 1995.11b
• /
• pp.55-55
• /
• 1995

• The korean journal of orthodontics
• /
• v.26 no.5 s.58
• /
• pp.535-546
• /
• 1996

The purpose of this study was to classify mandibular dental arch forms based on Raberin's method, and to compare Raberin's arch forms with that of the Korean's, and to designate arch form of bracket level according to distance between cusp tip and buccal surface of bracket level. The sample consisted of 159 mandibular dental casts showing normal occlusion which was taken from 62 males and 97 females of the Korean, aging from 13 to 25 years. The model was taken by X-ray. The landmarks were cusp points which expressed the mandibular dental arch line of cusp tips and buccal points which were measured from cusp tips to buccal surfaces of bracket level. The landmarks on the film were digitized, and measurements and statistics were performed. The results were as follows; 1. The models were classified as type 1, type 2, type 3, type 4 and type 5 by the author, and polynomial functions of the six degree and R-square values were calculated using statistical method, and each calculated equations explained each group with the least R-square value of 0.97, and each arch forms' were plotted. 2. The distribution of type 1 was $17.6\%$, type 2 $20.8\%$, type 3 $20.8\%$, type 4 $16.3\%$ and type 5 $24.5\%$. 3. The Korean arch form was characterized by larger width, smaller height compared to the French arch form. 4. The designated arch form of bracket level, viz the distance between cusp point and buccal point was calculated. The distance between cusp point and buccal point of incisor was 1mm, canine 1.9mm, first premolar 2.5mm, second premolar 2.6mm, first molar 2.7mm and second molar 2.7mm.

• Journal of Hospice and Palliative Care
• /
• v.13 no.2
• /
• pp.81-88
• /
• 2010

Purpose: This study was conducted to study the attitude of Korean lawyers toward withdrawal of life sustaining treatment, and compare and analyze different types of their attitudes. Methods: Research design of this project was Q methodology approach. The study population was 24 lawyers, aged from 32 to 69 years. Q sample to investigate the attitude of the lawyers toward withdrawal of life sustaining treatment included 34 statements obtained from literatures, TV debate, and depth interviews of 5 lawyers among the lawyers included. After listening to the purpose and method of the study, the 24 lawyers agreed to fill out a survey asking sociodemographic information, and the information was distributed in 9 scale Q-sample. Results: The collected data were processed through QUANL PC program and sorted into 5 types as follows: The first type was 'Choosing to withdraw life sustaining treatment', the second 'Withholding life sustaining treatment' regardless of the cost, the third is neutral type that claims that humans have the right to decide the death and life, and demands the proper legalization to protect such rights, the fourth type agrees to withdrawal of life sustaining treatment, nevertheless, admits that one has a rigt to withhold one's own life treatment, categorized as self contradiction type. The fifth type believed that 'Life and death are providential' with the faith, therefore, such authority to decide life and death belongs to God, but not human beings. Conclusion: In conclusion, the lawyer's attitudes toward withdrawal of life sustaining treatment were grouped into five different types as follows: 'Choosing to withdraw life sustaining treatment', 'Withholding life sustaining treatment', 'Demanding legalization', 'Self contradiction type', and 'Life and death are providential'.

• Childhood Kidney Diseases
• /
• v.13 no.1
• /
• pp.1-13
• /
• 2009

Type 1 diabetes mellitus commonly occurs in childhood and adolescence, although the prevalence of type 2 diabetes mellitus in these age groups is now being increased in the western world and Korea. Diabetic nephropathy developing in 15-25% of subjects with type 1 diabetes mellitus and in similar or higher percentage of type 2 diabetes mellitus patients is the leading cause of end-stage renal disease worldwide. Although prepubertal diabetic duration may contribute less to the development of microvascular complications than pubertal and postpubertal duration, diabetic nephropathy in susceptible patients almost certainly begins soon after disease onset and may accelerate during adolescence, leading to microalbuminuria or incipient DN. Type 1 diabetes is commonly associated with a period of hyperfiltration followed by the development of persistent microalbuminuria after as little as 7-10 years of type 1 diabetes. Microalbuminuria is associated with pathologic lesions that are so advanced as to overlap with those seen in patients with overt proteinuria and declining kidney function, therefore, microalbuminuria currently considered the best clinical indicator of overt diabetic nephropathy risk. This review covers the natural history and renal manifestations of diabetic nephropathy in children and adolescents.

• The korean journal of orthodontics
• /
• v.26 no.2 s.55
• /
• pp.187-196
• /
• 1996

Underlying malocclusions and dentofacial deformities are often related to variations in the craniofacial development. Type I and type II collagens are considered the major collagens of bone and cartilage respectively. Monitoring the patterns of those protein expressions during development will Provide a basis for the understanding of normal and abnormal growths. This study was undertaken to investigate the morphogenetic changes and the expression patterns of type I and II collagen proteins involved in the developing mandible of human embryos and fetuses. 50 embryos and fetuses were studied with Hematoxylin and Eosin, Alcian, blue-PAS, Masson Trichrome, md Immunohistochemical stains. The results were as follows : 1. A 13.5 mm embryo showed the stomatodeum with dental lamina, maxillary and mandibular processes. Meckel's cartilage appeared in the mandibular arch of a 20.5 mm embryo. New bone formation was bilaterally initiated at the outer side of middle portion of Meckel's cartilage of 22-38 mm embryos. 2. Meckel'cartilage was resorbed at the 15th week fetus. The endochondral ossification was observed where there was direct replacement of cartilage by bone. Meckel'cartilage disappeared and membraneous ossification were observed at the 25th week. 3. Before the appearance of Meckel's cartilage, the expression of type I collagen was moderate at the odontogenic epithelium of maxillary & mandibular process, but mild for the expression of type II collagen. 4. During the appearance of Meckel's cartilage and new bone formation, the immunoactivity of type II collagen was more expressed than type I collagen at the Meckel's cartilage and new bone. 5. During intrarmembranous bone formation, the expression of type II collagen was rare in the bony trabeculae. There was a switch for the expression of collagens from type II to type I during the appearance of Meckel's cartilage.

• Journal of The Korean Society of Inherited Metabolic disease
• /
• v.16 no.1
• /
• pp.34-41
• /
• 2016

Adult-onset type II citrullinemia (CTLN2) is characterized by episodes of neurologic symptoms associated with hyperammonemia leading to disorientation, irritability, seizures, and coma. CTLN2 is distinct from classical citrullinemia, which is caused by a mutation of the argininosuccinic acid synthetase (ASS) gene. The serum citrulline level is elevated, while the activity of ASS in liver tissue is decreased. CTLN2 is known to have a poor prognosis if the proper treatment is not taken. We reported a female aged 37 years who developed recurrent attacks of altered consciousness, aberrant behavior, and vomiting. We initially suspected the patient had CTLN2 because of the signs of hyperammonemic encephalopathy, such as altered mentality, memory disturbance, and aberrant behaviors provoked by exercise-induced stress and excessive intravenous amino acid administration. Through her peculiar diet preferences and laboratory findings that included hyperammonemia and citrullinemia, we diagnosed the patient as CTLN2, and SLC25A13 sequencing revealed known compound heterozygous mutations (IVS11+1G>A, c.674C> A). Her parents were heterozygous carriers, and we identified that her older sister had the same mutations. The older sister had not experienced any episodes of hyperammonemia, but she had peculiar diet preferences. The patient and her sister have been well with conservative management. When considering the clinical course of CTLN2, it was meaningful that the older sister could be diagnosed early in an asymptomatic period and that preemptive treatment was employed. Through this case, CTLN2 should be considered in adults who present symptoms of hyperammonemic encephalopathy without a definite etiology. Because of its rare incidence and similar clinical features, CTLN2 is frequently misdiagnosed as hepatic encephalopathy, and it shows a poor prognosis due to the lack of early diagnosis and proper treatment. A high-carbohydrate diet, which is usually used to treat other urea cycle defects, can also exaggerate the clinical course of CTLN2, so proper metabolic screening tests and genetic studies should be performed.

• Journal of Periodontal and Implant Science
• /
• v.36 no.2
• /
• pp.409-425
• /
• 2006

치주질환의 병원균은 세포벽의 항원에 의하여 조직내 존재하는 mononuclear phagocytes가 활성화되어 cytokine들이 생성됨 으로써 치주 결체조직의 파괴를 진행시킨다. 이런 관련된 cytokine들은 순차적으로 상주하는 치은세포 및 대식세포가 Matrix metalloproteinase 합성을 하도록 유도하여 조직파괴를 시작한다. 이들 Matrix metalloproteinase중 MMP-2, MMP-9 (Gelatinase A,B)는 type IV collagen 및 변성된 interstitial collagen을 파괴하며 치주환자의 치은 열구액, 치은조직, 타액 네에서 높게 보고 되어왔다. 당뇨병은 치주질환의 위험요소중 하나로 달뇨 환자에서는 치주질환의 유병율이 일반인에 비해 높고 치주질환의 중증도도 더 심하여 진행도 빠르다고 알려져 있다. 그 병리 기전 중 하나로는 당뇨 환자에서는 치은 열구액 내 중성구 유래의 Matrix metalloproteinase의 활성 증가 및$TNF-{\alpha}$ 의 활성 증가가 추정되고 있다. 본 실험에서는 제2형 당뇨병 환자와 비당뇨 환자들에서 만성 치주염 부위의 치은 및 건강한 치은에서 염증매개체 중 하나인 MMP-2, MMP-9 및 $TNF-{\alpha}$ 의 발현에 대해 상호 비교 분석함으로서 염증, 혈당이 미치는 영향을 밝히고 제 2형 당뇨병 환자에서 심한 치주조직 파괴의 기전을 연구하고자 하였다. 경북대학교병원 치주과 내원환자 중 제2형 당뇨병 환자와 비당뇨 환자들 및 치주질환이 없는 건강인 대조군을 대상으로 여러 가지 환자요소, 임상 치주상태를 기록하고, 전신적으로 건강한 환자의 건강한 부위(n=8,Group 1), 전신적으로 건강한 환자으 만성 치주염 부위(n=8, Group 2), 제2형 당뇨병 환자의 만성 치주염 부위 (n=8,Group 3)에서 각각 변연치은을 채득하고 액화질소에 급속 동결하였다. Western blotting을 이용하여 각 조직 내 MMP-2, MMP-9 및 $TNF-{\alpha}$ 의 발현을 관찰, densitometer를 이용하여 상대적 발현을 정량, 각 조직의${\beta}-actin$을 이용하여 표준화하여 실험군과 대조군들의 평균치를 비교하였다. 비당뇨 환자들의 만성 치주염 부위 및 제2형 당뇨병 환자의 만성 치주염 부위에서 모두 건강 대조군에 비해 MMP-2와 MMP-9 의 발현이 증가되었다. 또한 MMP-2와 MMP-9는 2형 당뇨 환자의 만성 치주염 부위가 비당뇨 환자의 만성 치주염 부위보다 증가된 발현양상을 보였으며, $TNF-{\alpha}$ 발현 비교시 각 군간 유의성 있는 변화는 없었으나 2형 당뇨환자군에서 MMP-2 및 MMP-9의 증가와 함께 다소 증가 양상을 보였다. 결론적으로 본 실험에서 MMP-2 및 MMP-9의 증가가 만성 치주염 및 2형 당뇨 환자에서의 만성치주염에서 비당뇨환자 보다 MMP-2, MMP-9의 증가양상을 보여 주었으며 $TNF-{\alpha}$ 가 2형 당뇨환자의 만성치주염 진행과정에 기여인자로써 역할을 하는 것으로 생각된다.

• 방재와보험
• /
• s.112
• /
• pp.51-58
• /
• 2006

지난 호에 이어 이번 호에는 SFPE 방화공학핸드북의 제4부, 제9장 및 제11장에서 설명하고 있는 내화피복 강부재와 내력 목재 부재의 내화성능 계산방법에 대해서 소개하고, 제3부, 제11장에서 다루는 개방형 탄화수소 화재의 복사열선속을 계산하는 방법과, 이러한 복사열선속의 인체 위험성(제2부, 제6장)에 대해 소개한다

• 한국신재생에너지학회:학술대회논문집
• /
• 2010.11a
• /
• pp.150.1-150.1
• /
• 2010

가스 하이드레이트는 물분자와 저분자량의 가스분자가 고압과 저온에서 수소결합을 이루며 형성되는 결정성 화합물을 말한다. 최근 가스 하이드레이트의 물리적 특성과 형성 원리를 이용하여 다양한 분야로의 적용 연구가 수행되고 있는데 이의 효과적 달성을 위해서는 가스 하이드레이트의 상평형 연구가 필수적이다. 기존에 수행되는 상평형 실험 방법은 온도의 변화에 따라 하이드레이트를 해리시키고 압력의 변곡점을 찾는 것으로 최소 24시간이 소요되지만, 본 연구진이 제안하는 QCM을 이용한 방법은 1 ng의 무게에 1 Hz의 변화를 나타내는 수정진동자의 민감성을 이용한 것으로 약 2~3시간 내에 상평형 실험을 수행할 수 있고, 하이드레이트의 기억효과(Memory Effect)를 이용하여 연속적인 상평형 실험도 가능하다. 본 연구에서는 QCM 반응기의 원리 및 실험 방법에 대하여 설명하고 열역학적 촉진제를 첨가한 상평형 실험결과를 제시함으로써 상대적으로 저렴한 가격으로 다양한 촉진제와 억제제 첨가 시 나타나는 상평형 효과를 빠른 시간 내에 선별할 수 있는 방법으로 QCM을 이용한 방법을 제안하고자 한다.

• Journal of the Korean hospital association
• /
• v.25 no.10 s.238
• /
• pp.45-61
• /
• 1996

일본의료법의 기본적인 내용은 1948년 제정 당시 그대로 이어서 인구의 고령화,질병구조의 변화,의학기술의 진보에 충분히 대응할수 없다는 문제점이 지적되어 왔다. 이에따라 1985년 의료계획의 창설을 골자로 하는 제1차 개정이 행하여 졌다. 이 개정은 의료공급체제 개혁에의 제1보로써 제1차 개정이라고 불려지고 1992년 행해진 제2차개정은 이에 계속된 제도개혁으로 지금까지 전혀 손대지 않았던 의료시설 기능의 세분화와 체계화에 깊이 손을 댄것으로써 앞으로의 병의원 경영에 있어서 커다란 전화점이 될 것이다. 제2차 개정의 목적은 양질의 의료를 효율적으로 제공하는 의료공급 체제의 확보에 있다. 개정의 주요 포인트는 특정기능 병원과 요양형병상군의 제도화이다. 지금까지 병원이라고 하면 모두 똑같은 체제이었으나 제2차 의료법의 개정으로 병원의 기능에 적합한 인원과 구조설비를 갖추는 것이 가능하게 되었다. 이번호에서는 1992년 4월 개정된 의료법의 내용과 배경을 설명하고 의료법 개정에 즈음하여 행해진 진료수가의 개정내용을 설명한 후에 차기 의료법 개정의 방향을 전망해 본다