• The Korean Society of Law and Medicine
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• v.21 no.1
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• pp.223-259
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• 2020

With COVID-19 spreading rapidly around the world, research and development issues on treatments and vaccines for the virus are of high interest. Among them, Remdesivir was the first to show noticeable therapeutic effects and began clinical trials, with each country authorizing the use of the drug through emergency approval. However, Gilead Co., Ltd., the developer of Remdesivir, received a lot of criticism from civic groups for submitting the application for the marketing authorization as an orphan drug. This is because when a new drug got a marketing authorization as an orphan drug could be granted an exclusive status for seven year. The long-term exclusive status of an orphan drug comes from the policy purpose of motivating pharmaceutical companies to develop treatment opportunities for patients suffering from rare diseases, which was not appropriate to apply to infectious disease treatments. This paper provides a review of the problems and improvement directions of the domestic system through comparative legal consideration against the United States, Europe and Japan for the statutes which give exclusive status to medicines. The domestic system has a fundamental problem that it does not have explicit provisions in the statute in the manner of granting exclusive status, and that it uses the review system to give it exclusive status indirectly. In addition, in the case of orphan drugs, the "Rare Diseases Management Act" and the "Regulations on Examination of Items Permission and Reporting of Drugs" provide overlapping review periods, and despite the relatively long monopoly period, there seems to be no check clause to recover exclusive status in the event of a change in circumstances. Given that biopharmaceuticals are difficult to obtain patents, the lack of such provisions is a pity of domestic legislation, although granting exclusive rights may be a great motivation to induce drug development. In the United States, given that the first biosimilar also has a one-year monopoly period, it can be interpreted that domestic legislation is quite strictly limited to granting exclusive status to biopharmaceuticals. The need for improvement of the domestic system will be recognized in that it could undermine local pharmaceutical companies' willingness to develop biopharmaceuticals in the future, and in that it is also necessary to harmonize international regulations. Taking advantage of the emergence of COVID-19 as an opportunity, we look again at the problems of the domestic system that grants exclusive rights to medicines and hope that an overall revision of the relevant legislation will be made to establish a unified legal basis.

• Korean Security Journal
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• no.25
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• pp.1-25
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• 2010

This research aims to provide a solution for the improvement of private security according to the change in criminal environment. The main cause of crime can be found in the anti-functional dimensions including value set disorder, social phenomenon variation, information-based, globalization and urbanization. In this environment, the private security sector has dramatically increased in a quantitative viewpoint, but it is insufficient in a qualitative viewpoint. This paper recognized this problem and demonstrates a solution for improvement through classifying elements of private security into relevant legislation, education institutions, security companies and security associations. The analysis result is a follows: First, motivation and satisfaction rate of escort and security related major has shown to be high. However, respondents evaluated the guard educational institution negatively. Second, the motivation of entering into the private security sector for internal staffs has shown to be positive and sound. However, the job satisfaction rate has shown to be low due to excessive competition, negative perception of occupation and low earning. Third, respondents gave an average mark to the Security Association's management and operation. In addition, the mutual-aid project received the same mark. Negative feedbacks were given to the protection of member's interest and to association operation and policy, while positive feedbacks were given to the degree of member's cooperation towards association policies.

• Management & Information Systems Review
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• v.33 no.5
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• pp.85-95
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• 2014

This paper suggested an efficient mathematical model for strategic alliance of liner shipping companies. Even though a few previous research papers proposed the mathematical models for container slot chartering and allocation under liner shipping, those models were nonlinear and very difficult to solve. So their models had limits to apply them to real world problems. On the other hand, the model suggested in this paper is easy to solve and apply to real world problems because it is a integer linear programming model. This paper tried to apply the model to the same example problem as used in existing research paper. Excel add-in program, Premium Solver Platform was used to solve the problem and the optimal allocation and slot chartering for containers were able to be found easily. The result also showed that the total container shipping cost for applying the strategic alliance model was reduced compared to non-strategic alliance model.

• Journal of Intelligence and Information Systems
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• v.9 no.3
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• pp.137-153
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• 2003

Comparison shopping is the most popular functionality in the e-Marketplace. Most of their revenue has been generated kent the Internet advertisement, but the ad earning was declined as the ad costing per action method widespread. Seller less familiar to the customer shrinks from chances for advertising and exposing their products. So, we need an efficient methodology subject to the seller's ad budget and other constraints, and it also has to increase comparison broker's earning in the e-Marketplace. Our research proposed and developed an ad planning methodology using comparison challenge approach which can be applied by 3$^{rd}$ party comparison brokers. Comparison challenge planning is organized with challenge policy of competitor level, product level and specification level. With that policies and basic challenge propositions, we measure the quantified value of functional distance between the specifications of my product and competitor's product. My product challenges the comparison using the comparative ad format to the similar but inferior competitor's product based on quantified valuation. Comparison challenge planning system has two phases of comparative value generation and optimization. We developed a prototype system and applied it to the desktop PC market of five major manufacturers. Our performance was emphasized by comparing to other comparative ad methods such as random display method and minimum distance method..

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.1
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• pp.148-154
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• 2020

This study examines room assignments to improve accessibility in a university dormitory depending on the student grade, taking into account frequency of using a certain common space. An integer programming model is presented to minimize the total moving distance from the common space to the students' rooms for accessibility. The model also constrains the maximum capacity of a room, and disallows different grade students to be assigned to the same room. This model is similar to a facility location problem used widely in the supply chain management field. Applying our optimization model to a small group at the dormitory of Unversity A as the case study, our results indicate that lower grade students are assigned rooms closer to the common space due to their higher frequency of using that space to guarantee high accessibility. Moreover, if higher grade students are prioritized to select their rooms, we suggest an objective function that imposes a penalty in cases when lower grade students select rooms with priority. Based on the results obtained, we propose assigning rooms to students in a dormitory by considering their complex requirements and convenience to use the common space.

• Cross-Cultural Studies
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• v.25
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• pp.483-527
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• 2011

The main focus of this dissertation is the comparative research of Korean and Chinese adjectives. With the comparison and contrast of the concepts, features and usages of Korean and Chinese adjectives, we have concluded some similarities and differences. The aim is to help Chinese learners who study Korean better understand the features of Korean adjectives and use them more easily. Korean belongs to 阿?泰?族 and expresses meanings with pronunciation; however, Chinese belongs to ?藏?族 and expresses meanings with characters. There are many similarities between those two languages that look completely different, such as pronunciation and grammar at some extent. Even the Chinese words in Korean are quite similar to Chinese. However, the two languages are very different from each other, from the detailed grammatical view. For instance, the auxiliary word in Korean and Chinese is completely different. Then, Korean has a concept: ?尾that does not exist in Chinese at all. Especially, about categories of words, it is very important and difficult to distinguish adjective and verb for the Chinese Korean-learners. One reason of the challenge is that some Korean adjectives are categorized as verbs in Chinese. For example, "like", "dislike", "fear" in Korean are "psychological adjective" however, they are "psychological verb" in Chinese. The differences in categorization always mislead learners in understanding whole articles. At the same time, they cause more problems and difficulties in learning other grammatical items for Chinese Korean-learners. Based on that, the dissertation is helpful for Chinese learners who are studying Korean. Starting from the most basic concepts, the second chapter focuses on analyzing the similarities and differences between Korean and Chinese adjectives. The correct understanding of adjective is the basis of accurate learning of it. With the comparison of concepts and primary comprehension of adjective, the third chapter analyzes in detail about the features of Korean and Chinese adjective from grammar and meaning. Based on those features, we analyze the detailed usages of Korean and Chinese adjective in articles; especially we provide the detailed explanations of adjective changes in different tense and ?尾 changes in using with noun and verb. The fourth chapter emphasizes the similarities and differences of adjective meanings in Korean and Chinese. We have provided the comparative analyses from six different views, which could be helpful for Chinese Korean-learners. Until now, there are few comparative studies of Korean and Chinese adjectives. About this dissertation, some limitations also exist in such an area. However, we hope it could provide some help for Chinese Korean-learners, and more profound research will be developed in the future.

• Journal of Korea Entertainment Industry Association
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• v.15 no.4
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• pp.337-347
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• 2021

This study is a qualitative study conducted to provide basic data for therapists working in long-term care hospitals to improve their countermeasure strategies for new infectious diseases and improvement of the treatment room infection management system, and to help therapists understand their infection management work. Colaizzi's phenomenological research method was applied as the research method. Telephone interviews were conducted with nine occupational therapists and physical therapists working in nursing hospitals. The contents of the interview were recorded with the consent of the study subjects, and additional confirmation was received by email. The recorded content was analyzed after transcription, and the meaning and nature of the experience coping with COVID-19 were described. The content was organized into 6 themes, 17 main meaning and 49 meaning units. In accordance with the COVID-19 situation, the infection control system has been strengthened by reinforcing infection control education in nursing hospitals, practicing infection control, and supervising infection control outside business hours. It was found that the treatment environment was changed due to the restriction of treatment activities by practicing distancing in the treatment room, adjusting rest and meal times during working hours, and strengthening infection control. In addition, the therapist's role has been expanded and the paradigm of treatment has changed, such as considering the untact intervention, and they have experienced cohort quarantine, pre-tested for COVID-19, vaccinations, and side effects from COVID-19. However, due to the infection work, the therapist's work burden is increased, and the person is experiencing fear, depression, and work stress from the spread of COVID-19. They were also aware of the need for nursing hospital care personnel support, such as guaranteeing rest after vaccination and providing infection control tools and equipment. The results of this study are expected to be used as basic data for human and physical support for the development of infectious disease response strategy programs in nursing hospital treatment rooms and for infection control in nursing hospitals.

• Journal of the Korea Computer Graphics Society
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• v.23 no.3
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• pp.1-8
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• 2017

In this paper, we introduce a technique to retarget human motion data to the humanoid body in a constrained environment. We assume that the given motion data includes detailed interactions such as holding the object by hand or avoiding obstacles. In addition, we assume that the humanoid joint structure is different from the human joint structure, and the shape of the surrounding environment is different from that at the time of the original motion. Under such a condition, it is also difficult to preserve the context of the interaction shown in the original motion data, if the retargeting technique that considers only the change of the body shape. Our approach is to separate the problem into two smaller problems and solve them independently. One is to retarget motion data to a new skeleton, and the other is to preserve the context of interactions. We first retarget the given human motion data to the target humanoid body ignoring the interaction with the environment. Then, we precisely deform the shape of the environmental model to match with the humanoid motion so that the original interaction is reproduced. Finally, we set spatial constraints between the humanoid body and the environmental model, and restore the environmental model to the original shape. To demonstrate the usefulness of our method, we conducted an experiment by using the Boston Dynamic's Atlas robot. We expected that out method can help the humanoid motion tracking problem in the future.

• Korean Chemical Engineering Research
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• v.48 no.6
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• pp.757-762
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• 2010

Since the quality and performance of medicinal products are heavily dependent upon the size, shape and polymorphism of active pharmaceutical ingredients(APIs), their crystallization has been regarded as one of the most important pharmaceutical processes. In this study, NIR-based inline measurements were employed to monitor key attributes of API particles real-time during the crystallization process. Principal component analysis(PCA) method was selected to correlate inline NIR spectra while the well-known aspirin was studied as a model drug. According to our characterization results, the ratio of ethanol to acetone did not cause any change in polymorphism, but resulted in a significant difference in the nucleation time, crystal growth and crystal shape. These phenomenological changes were well correlated with the PCA's implications. It turned out that the NIR-based inline monitoring technology can be employed well in observing and predicting key quality attributes such as crystal size during pharmaceutical crystallization processes.

• Journal of The Korean Association For Science Education
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• v.10 no.1
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• pp.1-8
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• 1990

Mechanical CAI Program was developed for university science student The program was mainly aimed for individual study. The program was written in BASIC and construct 130s flams. This project was supproted by Ministry of Education research fund. Summary of this study is as follows. 1. The program consisted of main, pretest, tutorial, final, and several other routines for program control. 2. This program written in BASIC. 3. 20 flames for pretest routine, 90 flames for tutorial routine, 20 flames for final test routine were developed. 4. The expected rate of achivement for final test was set 80%. 5. Average mark of final test was 70.2 point through the all course of program. This means that program was constructed of well.