• Biomolecules & Therapeutics
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• 제10권1호
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• pp.59-69
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• 2002

Recently, recombinant human erythropoietin (rHu-EPO) has been used to treat various types of anemia. YHB216 is a new rHu-EPO developed by Yuhan Research Institute. In this study, we investigated the single dose and 4-week repeated dose toxicity of YHB216 in Beagle dogs. In the single dose toxicity study, YHB216 was administered intravenously at single dose levels of 0 and 25,000 IU/kg to dogs (2 dogs/sex/group). There were no treament-related changes in survivals, clinical signs, body weight gain, hematological values, blood chemical values, and necropsy finding during experimental period. In the repeated dose toxicity study, YHB216 was administered intravenously to dogs for 4 weeks at the dose levels of 0, 100, 500, and 2,500IU／kg (3 dogs/sex／group). There were no toxicologically significant changes in clinical signs, body weights, food and water consumptions, ophthalmoscopy, urinalysis and blood chemistry. There were increased values of red blood cell, hemoglobin, and hematocrit at all treated groups. Spleen revealed increased weight and extramedullary hematopoiesis at 500 IU/kg or more. These changes are all considered to be Pharmacology-related effects and were recovered after 4-week recovery period. From these results, it is concluded that LD50 value was above 25,000 IU/kg in the single dose toxicity study of YHB216 in dogs and the no observed adverse effect level (NOAEL) was 100 IU/kg day in the repeated dose toxicity study of YHB216 in dogs.

• 기록학연구
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• 제54호
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• pp.5-44
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• 2017

본 연구는 기록학 이론의 하나인 원질서 존중원칙에 대한 다양한 담론을 논하고 개인기록에 대한 적용의 실효성을 고찰하는 데 목적이 있다. 이를 위해, 연구는 적용과 실효성의 측면에서 개인, 가족 문서의 맥락성을 위한 이론과 관련된 문헌을 분석하며, 노근리 아카이브의 사례를 통해 원질서 존중 원칙의 실질적 적용을 고찰한다. 노근리 수집물은 정은용, 정구도 가족이 축적하고 생산해온 기록으로부터 시작된다. 본 논문에서는 개인 기록물에서 시작되는 노근리디지털아카이브의 정리를 위해 연구팀이 고민하고 탐구해온 내용을 소개한다. 이에 본 연구는 원질서 존중 원칙의 실질적 영향과 적용을 노근리 기록의 사례를 통해, 살펴보고 이론의 의미를 재구성해보고자 한다.