• Journal of Korean Ophthalmic Optics Society
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• v.12 no.4
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• pp.91-94
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• 2007

This research was investigated to find out the examinees' refractive problems within heterophoria using Torrington method. The number of subjects ware approximately 327 and subjects were sourced from the 12th grade student at high school in Kwang-Ju city. Result obtained shows 21.4% of emmetropia and 78.6% of ametropia. Most of refractive errors were myopia and due to it's condition, frequency of ametropia and emmetropia at the similar rate. However, one that consist of refractive problems, it's myopia contains 74.9% of heterophoria. Due to emmetropia, horizontal heterophoria have 45.7% of exophoria and 4.3% of esophoria. Myopia shows 11.4% of esophoria and 63.5% of exophoria. Hozizonda heterophoria shows 5.7% of emmetropia and myopia of 22.4%, than average of esophoria shows $4.3P{\Delta}$ and case of myopia, it was $3.4P{\Delta}$. Case of Exphoria, emmetropia have $8.8P{\Delta}$ and within myopia $8.0P{\Delta}$. Vertical heterophoria owns $2.2P{\Delta}$ within emmetropia and case of myopia $4.3P{\Delta}$ was shown. Which shows myopia result value higher than emmetropia.

• Journal of Korean Ophthalmic Optics Society
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• v.18 no.2
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• pp.117-123
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• 2013

Purpose: The aim of this study was to propose effective data for the clinical examinations of binocular vision by comparative analysis of measuring the near horizontal phoria according to accommodative stimulations. Methods: It carried out near horizontal phorias, targeting 104 college students (50 males and 54 females) aged between 19 and 24 ($20.27{\pm}1.31$). It made a comparative analysis of changes in near horizontal phoria according to accommodative stimulations by using the von Graefe, Maddox rod and the Howell phoria methods respectively. We have also investigated the AC/A ratio in all phoria groups. Results: As the additional lenses were changed to the negative (-) diopter, the near horizontal phoria changed to the esodeviation. At this time, the rate of change in the section signifies the AC/A ratio, and the values were not consistent based on the evaluating methods or on each section. The AC/A ratio of the esophoria group appeared the largest value in all groups. As a result of analyzing AC/A ratio at the exophoria group using the von Graefe method, the AC/A ratio was $1.568{\pm}1.937$ ${\Delta}/D$ on the additional lenses +2.00 D and $2.527{\pm}2.253$ ${\Delta}/D$ on the additional lenses -1.00 D and at the esophoria group using the Howell phoria method, the AC/A ratio was $5.521{\pm}1.337$ ${\Delta}/D$, $5.593{\pm}1.623$ ${\Delta}/D$ on the additional lenses +2.00 D, +1.00 D and $4.687{\pm}1.643$ ${\Delta}/D$ on the additional lenses -2.00 D. These were significant differences statistically. Conclusions: In the exophoria group, when the (-) lenses were added, the averages of the AC/A ratio were shown to be high but in the esophoria group, when the (+) lenses were added, the of AC/A ratio was high.

• Journal of Radiation Protection and Research
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• v.26 no.2
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• pp.59-66
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• 2001

It is a hot issue to determine the spatial location and shape of tumor boundary in fractionated stereotactic radiotherapy (FSRT). We could get consecutive transaxial plane images from the phantom (paraffin) and 4 patients with brain tumor using helical computed tomography(HCT). K-means classification algorithm was adjusted to change raw data pixel value in CT images into classified average pixel value. The classified images consists of 5 regions that ate tumor region (TR), normal region (NR), combination region (CR), uncommitted region (UR) and artifact region (AR). The major concern was how to separate the normal region from tumor region in the combination area. Relative average deviation analysis was adjusted to alter average pixel values of 5 regions into 2 regions of normal and tumor region to define maximum point among average deviation pixel values. And then we drawn gross tumor volume (GTV) boundary by connecting maximum points in images using semi-automatic contour method by IDL(Interactive Data Language) program. The error limit of the ROI boundary in homogeneous phantom is estimated within ${\pm}1%$. In case of 4 patients, we could confirm that the tumor lesions described by physician and the lesions described automatically by the K-mean classification algorithm and relative average deviation analyses were similar. These methods can make uncertain boundary between normal and tumor region into clear boundary. Therefore it will be useful in the CT images-based treatment planning especially to use above procedure apply prescribed method when CT images intermittently fail to visualize tumor volume comparing to MRI images.

• Journal of Korean Ophthalmic Optics Society
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• v.9 no.2
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• pp.361-370
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• 2004

The purpose of this study was to evaluate the outcome and Factors that influence the quantity of Phoria in the low correction and perfect correction. Also the coincidence with the opticenter and the pupillary distance was a principal factor that influence the quantity of Phoria. Thereupon, this study is attributed to promote the perfect Phoria test. The subjects for this study were 120 persons(240 eye) in myopic refractive errors. ISP/WIN program was used for the data analysis. The collected data was analyzed by descriptive statistics and Spearman's correlation coefficient. The results of this study were as follows: 1. The prism pattern was difference between low correction and perfect correction in the Phoria test. The proportion of orthophoria was changed from 10.0% to 12.5%, exophoria was changed from 67.5% to 62.5%, and esophoria was changed from 22.0% to 32.5%, respectively. 2. The average of optical center distance and pupillary distance were 31.70mm and 31.49 mm, respectively. 3. Among the 120 myopic glasses wearers, the distance between optical centers was coincided with the pupillary distance in 37.5%, and discrepant in 62.5%. 4. For the patients who were coincided with the pupillary distance, the proportion of exophoria decreased 53.33%, esophoria increased 20.0%. 5. For the changing of the quantity of Phoria in the low correction, the degree of exophoria decreased 1.11 prism diopters in the perfect correction, esophoria increased 0.39 prism diopters.

• Progress in Medical Physics
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• v.14 no.3
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• pp.167-174
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• 2003

In the radiation treatment planning (RTP) process, especially for stereotactic radiosurgery (SRS), knowing the exact volume and shape and the precise position of a lesion is very important. Sometimes X-ray projection images, such as angiograms, become the best choice for lesion identification. However, while the exact target position can be acquired by bi-projection images, 3D target reconstruction from bi-projection images is considered to be impossible. The aim of this study was to reconstruct the 3D target volume from multiple projection images. It was assumed that we knew the exact target position in advance, and all processes were performed in Target Coordinates, where the origin was the center of the target. We used six projections: two projections were used to make a Reconstruction Box and four projections were for image acquisition. The Reconstruction Box was made up of voxels of 3D matrices. Projection images were transformed into 3D in this virtual box using a geometric back-projection method. The resolution and the accuracy of the reconstructed target volume were dependent on the target size. An algorithm was applied to an ellipsoid model and a horseshoe-shaped model. Projection images were created geometrically using C program language, and reconstruction was also performed using C program language and Matlab ver. 6(The Mathwork Inc., USA). For the ellipsoid model, the reconstructed volume was slightly overestimated, but the target shape and position proved to be correct. For the horseshoe-shaped model, reconstructed volume was somewhat different from the original target model, but there was a considerable improvement in determining the target volume.

• Investigative Magnetic Resonance Imaging
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• v.12 no.2
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• pp.89-99
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• 2008

Imaging assessment of prostate cancer is one of the most difficult sections of oncology imaging. Detecting, localizing and staging of the primary prostate cancer by preoperative imaging are still challenging for the radiologist. Magnetic resonance (MR) imaging provides excellent soft tissue contrast and is widely used for solid organ imaging, but results of preoperative imaging of the prostate gland with conventional MR imaging is unsatisfactory. Positron emission tomography and computed tomography (PET/CT) is the cornerstone in oncology imaging, but some limitations prohibit the assessment of primary prostate cancer with PET or PET/CT. Recent studies to overcome these insufficient accuracies of imaging evaluation of primary prostate cancers with advanced MR techniques and PET and PET/CT are reported. In this article, we review the imaging findings of prostate cancer on variable modalities, focused on MR imaging and PET/CT.

• Journal of the Korean Society of Radiology
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• v.10 no.3
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• pp.201-206
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• 2016

Social interest in breast cancer has increased. The most basic exams for diagnosis include breast X-ray and breast ultrasound. In particular, breast microcalcification requires histological diagnosis, and breast microcalcification biopsy is commonly performed. Therefore, this study aimed to analyze and assess X-ray guided biopsy (needle localized open biopsy) and ultrasound guided biopsy (sono guided core needle biopsy), which are basics in diagnosis of microcalcification. Targeting 241 cases in which magnification mammography was performed for patients who visited the hospital due to breast microcalcification, age distribution and the location of lesions were analyzed in X-ray guided biopsy and ultrasound guided biopsy. By classifying exams performed after magnification mammography, the frequencies of X-ray guided biopsy and ultrasound guided biopsy were analyzed, and malignant and benign results were confirmed. The results showed that 64 cases(26.6%) were X-ray guided biopsy, which was 5.4 times higher than 12 cases(4.9%) of ultrasound guided biopsy. Due to development of ultrasound equipments, stereotactic vacuum-assisted biopsy, etc. the methods of histological diagnosis of microcalcification have become diverse, but when considering characteristics and limitations of each exam, X-ray guided biopsy is thought to be most accurate and useful.

• Progress in Medical Physics
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• v.18 no.3
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• pp.179-185
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• 2007

The purpose of this study is to investigate the spectra of a magnetic resonance spectroscopy (MRS) in accordance with the variance of TE and the volumes of metabolites in a localized voxel for the quality assurance using a designed single voxel spectroscopy QA phantom. Because a cone-shade phantom is designed as the volume of metabolite in a localized voxel is changeable, we try to analyze the peaks of each metabolite (NAA, Cr, Cho, Lac, etc.) in accordance with metabolite volume in a localized voxel as well as echo time (TE). All data were obtained using a 3T MRI/MRS machine and analyzed using $jMRUI^{(R)}$. The results of this study show that TE is in inverse proportion to the noise of MRS and the longer TE and the less metabolite volume in the localized voxel, the peak intensities of each metabolite decrease. In case of the lactate, its peak was observed on the all TE only if the greatest metabolite is included in the localized voxel. Then, the intensity of a metabolite is more sensitive to the metabolite volume in the localized voxel than the TE. These obtained in vitro MRS data is provide the guideline that is important for in vivo metabolite quantification. But, in the edge of cone-shape vial air bubbles were observed and spectrum could not obtained. Therefore our cone-shape MRS phantom needs to be modified in order to solve these problems.

• The Korean Journal of Nuclear Medicine
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• v.28 no.3
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• pp.364-370
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• 1994

The purpose of this study is to evaluate the clinical application of the no carrier added $[^{51}Cr]Cr(III)$-EDTA complexes, produced at Korea Cancer Center Hospital. The $[^{51}Cr]Cr(III)$-EDTA complexes, usefut for measurement of GFR were prepared at room temperature in the presence of bicarbonate catalysts. The radiochemical purity of $[^{51}Cr]Cr(III)$-EDTA was over 99% by paper electrophoresis. The time activity curves were obtained by counting the blood samples from 5 volunteers and counting the head and neck regions with whole body counter after injection of the $^{51}Cr$-EDTA, respectively. After the nonlinear regression, the area under curve was obtained. The plasma clearance of the $^{51}Cr$-EDTA was calculated with injected dose/AUC. The clearance rate calculated with the head and neck counting data was in good agreement with the result from the plasma sample radioactivity at 1-3 hrs after injection. From this result, the counting of head and neck region and the nonlinear regression by 2-compartment model could be applied for the measurement of the clearance rate. Using MIRD system, the absorbed radiation dose was calculated by residence $time{\times}S$. The absorbed whole body radiation dose was negligibly small.

• The Korean Journal of Nuclear Medicine
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• v.33 no.1
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• pp.84-93
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• 1999

Purpose: We investigated the direct labeling method of antibody with $^{99m}Tc$ and $^{188}Re$ and examined the stability and function of these labeled compounds in in vitro and in vivo. Materials and Methods: Disulfide bond of nonspecific human IgG was reduced to -SH group by 2-mercaptoethanol. Stannous ion was used to reduce $^{99m}Tc$ and $^{188}Re$. The stability of $^{99m}Tc$-IgG and $^{188}Re$-IgG was estimated upto 24 hrs. Biodistribution was evaluated in abscess bearing rats at 4 and 24 hr post-injection of $^{99m}Tc$ or $^{188}Re$ labeled IgG. Results: The number of -SH group per reduced IgG molecule was 2.34. The labeling yield of $^{99m}Tc$-IgG and $^{188}Re$-IgG were 90% and 95%, respectively The stability of $^{99m}Tc$-IgG at 1, 4, 6 and 24 hr was 91%, 83%, 78%, 7% and that of $^{188}Re$-IgG at 1, 4, 16 and 24 hr was 94%, 80%, 47%, 42%, respectively. At 4 hr post-injection of $^{99m}Tc$-IgG, high uptake was found on kidney, blood, stomach and abscess ($9.42{\pm}0.68,\;1.43{\pm}0.24,\;0.86{\pm}0.18,\;0.72{\pm}0.10$ %ID/g, respectively). The uptakes at 24 hr were kidney, abscess,.itomach, and blood in descending order. In case of $^{188}Re$-lgG, high uptake at 4 hr post injection appeared on kidney, blood, abscess and stomach ($3.92{\pm}0.62,\;1.32{\pm}0.08,\;0.88{\pm}0.01,\;0.26{\pm}0.06$, respectively). The uptakes at 24 hr were kidney, abscess, blood and stomach in descending order. The abscess to blood uptake ratio of $^{99m}Tc$-IgG was 0.5 at 4 hr and 2.02 at 24 hr and that of $^{188}Re$-IgG was 0.67 and 1.29. Conclusion: $^{99m}Tc$-IgG and $^{188}Re$-IgG canbe labeled efficiently with direct labeling method. However, $^{99m}Tc$-IgG and $^{188}Re$-IgG, labeled with direct method, was unstable. Further study is needed to enhance the stability of the antibody labeling.