• Korean Journal of Social Welfare
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• v.16
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• pp.1-24
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• 1990

• Investigative Magnetic Resonance Imaging
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• v.4 no.1
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• pp.52-57
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• 2000

Purpose : The purpose of this study was to investigate the pattern of cerebral response to motor tasks in patients with schizophrenia compared with normal subjects using functional MRI. Materials and methods ; Nine right handed-schizophrenic patients and six right-handed normal subjects were included. We used right hand movement as task. Series of 120 consecutive echo-planar images per section were acquired during three cycles of task and rest activations. Lateralization index of cortical response was measured and compared between patients and normal subjects. Results ; Right hand motor task was associated with greater activation in left sensorimotor cortex than the right in normal subjects. Schizophrenia patients showed relatively decreased activation in left cortex and increased activation in right cortex compared with normal subjects. In one patient, reversed lateralization was noted. Conclusion : Normal hemispheric asymmetry of cortical response to motor task was found in different pattern in schizophrenia. Our result is consistent with functional disturbance of motor circuitry in this disorder. Functional MRI will play an important role in diagnosis and research of this disorder.

• The Journal of the Korea Contents Association
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• v.19 no.9
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• pp.430-440
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• 2019

This study analyzed the moderating effect of mindfulness on the relationship between college students' mental health and college life adjustment. The study subjects were 246 college students. Data were analyzed using ANOVA, Pearson's correlation analysis, and multiple regression analysis. The results of this study were as follows. First, the group with high satisfaction regarding their major showed significantly higher mindfulness and college life adjustment than the group with low satisfaction. Second, ta negative correlation was found between mental health(hypochondriasis, depression, psychopathic deviate, paranoia, schizophrenia, introversion) and mindfulness. Third, a significant negative correlation was found between mental health (depression, psychopathic deviate, paranoia, psychasthenia, schizophrenia, introversion) and college life adjustment. Fourth, mindfulness positively impacted college life adaptation. Fifth, mindfulness also had a significant moderating effect on the relationship between mental health (depression, psychopathic deviate, psychasthenia, schizophrenia, introversion) and college life adjustment. Thus, this study focused on the role and importance of mindfulness as a way to improve mental health and adjustment among college students.

• Korean Journal of Biological Psychiatry
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• v.2 no.1
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• pp.131-139
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• 1995

Clozapine, on atypical antipsychotic drug, has been estimated to be a major improvement in the treatment-refractory schizophrenic patients. We evaluated the clozapine efficacy in the treatment of schizophrenic patients who are refractory to classic neuroleptics. The patients were assigned in a prospective, open, comparative trial for 12 weeks. Following an dose titration, 33 inpatients with treatment-refractory schizophrenia diagnosed according to DSM-III-R were given a clozapine(N=17, approximate 300-600mg/day) or haloperidol(N=16, approximate 20-30 mg/day) for 12 weeks. The clinical state was assessed before treatment, and 1st, 4th, 8th and 12th week during treatment using Brief Psychiatric Rating Scale(BPRS) and Positive and Negative Syndrome Scale(PANSS). Assessment of side effects were mode weekly using Simpson-Angus Scale for Extrapyramidal Side Effects and Adverse Events-Somatic Symptoms. Clozapine produces significant improvement than haloperidol on the BPRS and PANSS scores. 77% (13/17) of the clozapine-treated patients were categorized as responders, who showed at least 20% decrease in total BPRS scores, compared with 31% (5/16) of haloperidol-treated patients. Extrapyramidal side effects occurred in only one patient in clozapine group, but nine patients in haloperidol group. Salivation, sleepiness, constipation and hypotension were most frequent adverse effects observed in clozapine group. There was no significant changes in total WBC and neutrophil during clozapine treatment. These findings suggest that clozapine is on effective antipsychotic drug for the Korean treatment-refractory schizophrenic patients, who are nonresponsive to or unable to tolerate classcal antipsychotic drugs due to extrapyramidal side effects.

• Korean Journal of Biological Psychiatry
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• v.3 no.2
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• pp.211-215
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• 1996

The present study investigated the associations between CT measures and obstetric complications and family history of major mental illnesses. We had the hypothesis of diosthesis-stress model in the etiology of schizophrenia. We had the following findings. 1) Family history of major mental illnesses is inversely related to obstetric complications. 2) Prefrontal sulcal widening and family history of schizophrenia. are inversely related. 3) In female but not in male patients those with family history of schizophrenia tended to have less prefrontal sulcal widening and ventricular brain ratio. These results suggest that more genetic factors contribute to structural brain abnormalities in female than in male patients.

• Journal of Yeungnam Medical Science
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• v.10 no.2
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• pp.544-549
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• 1993

The authors have experienced a case of organic mental disorder with bilateral frontal lobe atrophy in a 36-year-old man. He showed negative symptoms of schizophrenia such as anhedonia, social withdrawal, flat affect, poverty of thought.

• The Korean Nurse
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• v.26 no.3 s.141
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• pp.65-68
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• 1987

• 한국사회복지학회:학술대회논문집
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• 2007.04a
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• pp.351-357
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• 2007

• 한국사회복지학회:학술대회논문집
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• 2007.04a
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• pp.359-366
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• 2007

• 한국사회복지학회:학술대회논문집
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• 2008.04a
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• pp.285-291
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• 2008