• Journal of Periodontal and Implant Science
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• v.35 no.1
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• pp.153-161
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• 2005

파이브로넥틴은 세포외기질에 존재하는 당단백질로 세포의 부착, 이동, 성장 및 분화에 관여하며, 섬유아세포 성장인자는 세포의 증식 이동 및 분화에 영향을 주는 중요한 성장인자로 알려져 있다. 최근 연구에 의하면, 파이브로넥틴은 조골세포의 타이태늄 임플란트 표면으로 이주와 증식 및 골생성을 촉진하며, 섬유아세포 성장 인자는 파이브로넥틴에 상승작용을 한다고 보고된 바 있다. 이 실험의 목적은 파이브로넥틴 및 섬유아세포 성장인자의 복합 단백질을 이용하여 타이태늄 임플란트의 골 반응을 알아보는 것이다. 체중 2.5 kg 내외의 건강한 18 마리의 웅성가토를 준비하여 무균 사육하였고, 순수 타이태늄을 절삭가공하여 직경 3.5mm, 길이 6mm 의 machined surface를 지니는 screw type 의 임플란트를 준비하였다. 사람의 유전자를 기초로, 유전자 재조합법을 통해, 적절한 primer를 이용하여 얻은 섬유아세포 성장인자를 파이브로넥틴 III 형 분절의 9-10 번 도메인에 결합시켜 얻은 복합 단백질을 준비된 임플란트에 표면처리하여 실험군으로 하였고, 표면처리하지 않은 임플란트를 대조군으로 하여, 가토의 좌우 경골에 각각 2 개씩의 임플란트를 식립하였다. 4주 후, 가토를 희생시켜 각 경골 당 한 개의 임플란트에서 뒤틀림 제거력을 측정하였고 나머지 임플란트 식립 부위 에서는 경골을 포함하는 조직표본을 제작하였다. 조직표본상에서 골접촉이 가장 좋은 3 개의 나사산의 길이를 측정하고, 나사와 접촉하는 골의 길이를 측정하여 골-임플란트 접촉도를 구하고, 같은 부위에서 나사산 사이의 면적과 골이 차지하는 면적을 비교하여 골생성률을 얻었다. 실험군과 대조군의 결과는 Student t-test 를 이용하여 신뢰도 95% 수준에서 통계학적 유의성을 검정하였다. 파이브로넥틴과 섬유아세포 성장인자의 복합 단백질로 표면처리된 임플란트와 표면처리를 하지 않은 임플란트는 뒤틀림 제거력에서는 통계적 유의성이 나타나지 않았으나, 골-임플란트 접촉도와 골생성률에서 복합 단백질로 처리된 임플란트가 통계적으로 유의하게 높은 결과를 보였다. 이상의 연구결과로, 섬유아세포 성장인자와 파이브로넥틴 복합 단백질로 처리한 타이태늄 임플란트가 주변 골 형성을 촉진시켜, 골유합을 증진시킴을 알 수 있었다. 따라서, 복합 단백질이 타이태늄 임플란트의 성공률을 높이기 위한 표면개질 물질로 이용될 가능성을 확인할 수 있었다.

• Journal of Dental Rehabilitation and Applied Science
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• v.38 no.4
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• pp.204-212
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• 2022

Purpose: The aim of this study was to compare changes of bite force, occlusal contact area, and dynamic functional occlusion analysis after occlusal stabilization splint therapy during sleep for one month in a patient with bruxism. Materials and Methods: From October 2021 to July 2022, sleep bruxism of 30 patients who visited the Department of Oral Medicine at Yonsei University College of Dentistry Hospital were recruited. The participants were divided into two groups: using an occlusal stabilization splint during sleep (treatment; n = 15) and not using an occlusal stabilization splint (control; n = 15). Before using the occlusal stabilization splint and one month after, bite force, occlusal contact area and dynamic functional occlusion analysis (ratio of left/right bite forces, average bite forces, maximum bite forces, and maximum contact areas during lateral and anterior and posterior mandibular movements) were performed. Results: There was no difference in bite force and occlusal contact area between the treatment group using the occlusal stabilization splint and the control group not using the occlusal stabilization splint during sleep for one month. However, there were significant differences in the average bite force and maximum bite force in the lateral and anterior and posterior mandibular movements and the maximum contact areas in the anterior and posterior mandibular movements. Conclusion: The occlusal stabilization splint is helpful for sleep bruxism patients who lateral and anterior and posterior mandibular movements. In addition, further studies are needed a double-blind study with a large population.

• Journal of Korean Tunnelling and Underground Space Association
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• v.18 no.2
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• pp.213-220
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• 2016

The needs for the utilization of space in the urban ara due to the increasing population and traffic volume. A Double-deck tunnel can be an appropriate solution. Geosynthetics are inevitably installed between ground and tunnel lining, therefore, geosynthetic-soil interface is also comprises. Dynamic shear behavior of geosynthetic-soil interface affects the dynamic behavior of tunnel, and experimental study is required since the behavior is very complicated. In this study, chemical factors such as acid and basic element in the groundwater and temperature are considered in the laboratory test. Multi-purpose Interface Apparatus(M-PIA) is utilized and submerging periods are 60 and 960 days. Consequently, dynamic shear degradation of geosynthetic-soil interface considering chemical and thermal factors are verified.

• Journal of Korean Tunnelling and Underground Space Association
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• v.19 no.2
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• pp.249-263
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• 2017

The expansion behavior of inflatable steel pipe rockbolt shows geometric nonlinearity due to its ${\Omega}-shaped$ section. Previous studies on the anchoring behavior of inflatable steel pipe rockbolt were mainly performed using theoretical method. However, those studies oversimplified the actual behavior by assuming isotropic expansion of inflatable steel pipe rockbolt. In this study, the anchoring behavior of the inflatable steel pipe rockbolt were investigated by the numerical method considering the irregularity of pipe expansion and other influencing factors. The expansion of inflatable steel pipe rockbolt, the contact stress distribution and the change of the average contact stress and the contact area during installation were analyzed. The contact stresses were developed differently depending on the constitutive behavior of rocks. Small contact stresses occurred in steel pipes installed in elasto-plastic rock compared to steel pipes installed in elastic rock. Also, the anchoring behaviors of the inflatable steel pipe rockbolt were different according to the stiffness of the rock. The steel pipe was completely unfolded in the case of the stiffness smaller than 0.5 GPa, but it was not fully unfolded in the case of the stiffness larger than 0.5 GPa for the given analysis condition. When the steel pipe is completely unfolded, the contact stress increases as the rock stiffness increases. However, the contact stress decreases as the rock stiffness increases when the steel pipe is not fully expanded.

• Journal of Biomedical Engineering Research
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• v.21 no.3 s.61
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• pp.295-301
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• 2000

It is known that among many factors, relative micromotion at bone/implant interfaces can hinder bone ingrowth into surface pores of an implant. Loading conditions, mechanical properties of spinal materials, friction coefficients at the interfaces and geometry of spinal segments would affect the relative micromotion and spinal stability. A finite clement model of the human lumbar spine segments (L4-L5) was constructed to investigate the mechanical sensitivity at the interfaces between bone and cage. Relative micromotion. Posterior axial displacement. bone stress, cage stress and friction force were predicted in changes of friction coefficients, loading conditions. bone density and age-related material/geometric properties of the spinal segments. Relative micromotion (slip distance in a static loading means relative micromotion in routine activity) at the interfaces increased significantly as the mechanical properties of cancellous bone, annulus fibers or/and ligaments decrease or/and as the friction coefficient at the interfaces decreases. The contact normal force at the interfaces decreased as cancellous bone density decreases or/and as the friction coefficient increases A significant increase of slip distance at anterior annulus occurred with an addition of torsion to compressive preload. Relative micromotion decreased with an increase of disc area. In conclusion. relative micromotion, stress response. Posterior axial displacement and contact normal force are sensitive to the friction coefficient of the interfaces, bone density, loading conditions and age-related geometric/material changes.

• Tunnel and Underground Space
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• v.26 no.5
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• pp.409-417
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• 2016

The shale gas is emerging as one of the oil and gas resources which can replace the traditional oil and gas resources. As the shale layer where the shale gas is deposited has low permeability, the hydrofracturing method is required to improve the productivity. This study is designed to conduct the laboratory hydrofracturing test on the samples which are modeled after the drilling hole having the general drilling hole and spiral groove. And compare the initial fracturing pressure and fluid contact between them in order to the result of the hydrofracturing depending on the shape of the drilling hole. In addition, the results were compared with the numerical modeling values from 3DEC and they were also compared with the data from the advance researches. It was found from the study that rather than the contact area of the high pressures water, the force concentration depending on the form of guide hole was more effective in the hydrofracturing.

• Journal of Korea Soil Environment Society
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• v.4 no.3
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• pp.95-104
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• 1999

Comparative biodegradation studies of liquid and solid alkanes and of two different solid alkanes were conducted by an isolated Acinetobacter sp., which degraded crude oil alkanes simultaneously. for the determination of degradation mechanism of hydrophobic crude oil constituents. Also a model oil experimental system composed of a solid alkane. heneicosane, as a substrate and a non-degradable non-aqueous phase liquid. pristane, as an oil matrix was established and studied. It was proposed that the Acinefobacter sp. utilized hydrophobic substrates directly on the surface of them with no difference in the degradation rates between the liquid and solid alkanes. On the basis of the results from the heneicosane/pristane system which imitates crude oil matrix containing solid constituents. the crude oil matrix was considered to reduce the bioavailability of contained substrates by reducing the specific surface area of substrates to contact with microorganisms.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.10 no.1
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• pp.39-45
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• 2009

The CRT(Cathode Ray Tube) displays have been substituted for FPDs(Flat Panel Displays) such as LCD(Liquid Crystal Display) and PDP(Plasma Display Panel) because they have a convex surface, large volume and heavy weight. The productivity of FPDs is greatly dependent on the area of thin glass panel with $0.6{\sim}0.8mm$ thickness because FPDs are manufactured by cutting a large-scaled thin glass panel with patterns to the required product dimensions. So FPD's industries are trying to increase the area of thin glass Panel. Through FEM(Finite Element Method) analysis and fluid analysis, we developed an non-contact and air-floating conveyor system which consists of transport-module, distributor, horizontal/vertical changer and controller for the 7th generation glass panel (2,200mm in width, 1,870mm in length and 0.7mm in thickness). The design technology developed in this study can be effectively applied to a conveyor system for a larger-scaled thin glass panel.

• Journal of the Korean Geotechnical Society
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• v.19 no.5
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• pp.59-67
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• 2003

In this study, the change in hydraulic conductivity according to the changes in the contact area, aperture, confining pressure and temperature was observed to improve the reliability of the analysis of underground water flow. Also, the mechanical and thermal properties of domestic crystalline rocks in a great depth were obtained. It was found that the averaged intial aperture ranged from 544.33${\mu}{\textrm}{m}$ to 898.62${\mu}{\textrm}{m}$ and it followed a log-normal distribution. The hydraulic conductivity decreased with the increase of normal stress on the fracture surface and the hydraulic conductivity decreased as temperature increased. The change in hydraulic conductivity was strongly correlated with the change in contact area. It was verified by experiments that hydraulic conductivity was inversely proportional to the contact area. The measured mechanical and thermal properties were very close to the existing typical properties of domestic granites.

• Journal of Sensor Science and Technology
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• v.3 no.3
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• pp.9-15
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• 1994

Catalytic combustible gas sensors were fabricated by using ${\gamma}-Al_{2}O_{3}$ with large surface area and noble metal catalysts. The optimum conditions for ${\gamma}-Al_{2}O_{3}$ fabrication were investigated by DT/TGA and XRD analyses and it was found that fabricated ${\gamma}-Al_{2}O_{3}$ had superior value as surface area of $215.5m^{2}/g$. Gas sensors were manufactured and tested to inflammable gases by using Pt coil as a heater and temperature sensing part, fine ${\gamma}-Al_{2}O_{3}$ powder as a bead material and Pt, Pd noble metal powder as a catalyst. From the results, fabricated sensor showed good sensitivity to LPG and LNG of 20mV/l000ppm, 6.5mV/l000ppm respectively.