• Science of Emotion and Sensibility
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• v.1 no.1
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• pp.59-67
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• 1998

뇌전위에서 개인차가 없는 일반적인 규칙ㅇ르 지닌 두개의 정보 변수, 즉 ILF와 IHF를 발견하였다. 이러한 일반성을 지닌 정보 변수가 청각, 후각, 촉각 자극에 의해 유발된 쾌하거나 불쾌한 감성 상태를 구분할 수 있으며 전두엽에서 그 경향이 두드러짐을 확인하였다. 전두엽의 뇌전위에서 감성 자극이 주어지가 전과 자극이 주어지는 동안의 ILF, IHF값을 정규화함으로써 새로운 변수, Relative Quantified Emotional State(RQES)를 구현하였다. RQES는 쾌, 중립, 불쾌한 감성의 정도를 선형적으로 정량화하였다. 따라서 하나의 전극으로 측정한 전두엽부분의 뇌전위로부터 RQES값을 계산하면 인간의 쾌, 불쾌 감성을 신뢰도있게 정량화 할 수 있다.

• KIPS Transactions on Software and Data Engineering
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• v.3 no.10
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• pp.451-456
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• 2014

The correlations between electroencephalographic (EEG) spectral power and emotional responses during affective sound clip listening are important parameters. Hemispheric asymmetry in prefrontal activation have been proposed in two decades ago, as measured by power value, is related to reactivity to affectively pleasure audio stimuli. In this study, we designed an emotional audio stimulus experiment in order to verify frontal EEG asymmetry by analyzing Event-related Spectral Perturbation (ERSP) results. Thirty healthy college male students volunteered the stimulus experiment with the standard IADS(International Affective Digital Sounds) clips. These affective sound clips are classified in three emotion states, high pleasure-high arousal (happy), middle pleasure-low arousal (neutral) and low pleasure-high arousal (fear). The analysis of the data was performed in both theta (4-8Hz) and alpha (8-13Hz) bands. ERSP maps in the alpha band revealed that there are the stronger power responses of high pleasure (happy) in the right frontal lobe, while the stronger power responses of middle-low pleasure (neutral and fear) in the left frontal lobe. Moreover, ERSP maps in the theta band revealed that there are the stronger power responses of high arousal (fear and happy) in the left pre-frontal lobe, while the stronger responses of low arousal (neutral) in the right pre-frontal lobe. However, the high pleasure emotions (happy) can elicit greater relative right EEG activity, while the low and middle pleasure emotions (fear and neutral) can elicit the greater relative left EEG activity. Additionally, the most differences of theta band have been found out in the medial frontal lobe, which is proved as the frontal midline theta. And there are the strongest responses of happy sounds in the alpha band around the whole frontal regions. These results are well suited for emotion recognition, and provide the evidences that theta and alpha powers may have the more important role in the emotion processing than previously believed.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2002.11a
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• pp.205-208
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• 2002

본 연구에서는 단순노무직, 판매직, 전문직에 종사하는 피험자를 대상으로 100%의 basil oil, lavender oil, lemon oil, jasmine oil, ylang-ylang oil (KIMEX co. Ltd, Korea), skatole (TAKASAGO co. Ltd, Japan)등 총 6가지 종류의 천연향에 대한 두뇌의 정보량 흐름을 파악하기 위해 상호 정보량을 검토하였다. 그 결과, 전문직에서는 상호 정보량의 유의한 변화가 전두엽 사이(F3F4)에서 나타난 반면, 단순노무직과 판매직에서는 전두엽(F3F4), 두정엽(P3P4), 측두엽(T5T6) 사이에서 모두 나타났다. 두 직종과 비교하여 전문직이 주로 외부 자극에 대한 고차원적 기능을 담당하는 전두엽영역의 정보량에서 유의한 변화를 보인 것은 향을 전문적으로 구분하고, 확인하는 그들의 직업적 특성을 반영한 결과라 추측된다. 또한, 단순노무직과 달리, 전문직과 판매직은 선호도가 낮은 향에서 상호 정보량이 증가하는 경향을 보여, 향 관련 종사자들의 선호도와 상호 정보량간의 관련성을 시사하였다.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2002.11a
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• pp.128-131
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• 2002

향 관련 직업을 중심으로 한 연구에는 유기 화학적 냄새에 폭로된 종사자를 대상으로 그들의 작업환경 개선을 주된 목적으로 실시되어져왔으나 천연향 자극에 대한 연구는 전무한 상태이다. 본 연구에서는 화장품 관련 전문직과 화장품 판매직을 대상으로 100%의 basil oil, lavender oil, lemon oil, jasmine oil, ylang-ylang oil (KIMEX co. Ltd, Korea), skatole (TAKASAO co. Ltd, Japan)등 6종 향 자극에 대한 EEG, 주관평가에 대해 알아보았다. 그 결과, 전문직에서 선호도가 높은 향은 Fz와 F3에서, 선호도가 낮은 향은 P4에서 $\alpha$/$\beta$비가 증가하는 경향을 나타냈다. 상호 정보량에 대해서는 두 직업 모두 선호도가 낮은 향에 대한 상호 정보량이 선호도가 높은 향에 비해 더 많았다. 특히 화장품 관련 전문직에서는 전두엽의 상호 정보량이 증가하는 경향이 확인되었다. 이상에서 판매직과 비교하여 전문직은 천연향 자극이 감성효과가 아닌 외부자극에 대한 고차원적 기능을 담당하는 전두엽 영역과 관련된 지성효과로 작용함을 알 수 있었다.

• Korean Journal of Biological Psychiatry
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• v.9 no.2
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• pp.95-102
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• 2002

Objectives:Abnormalities in the frontal lobe have been consistently suggested in the pathophysiology of depression. The purpose of this review is to discuss the relationship between the frontal lobe and depression. Methods:Recent researches on the frontal lobe in depression were reviewed and abnormalities in this region were considered within the context of modern functional neuroanatomy. Results:This paper reviewed evidence strongly implicating the frontal lobe as a key brain structure in depression. Conclusion:Taken together, these abnormalities in the function of the frontal lobe implicate interconnected neural circuits in depression and offer suggestions for the themes of future research and treatment. Further research is needed to investigate the association between emotion and the brain in the paradigm of "affective neuroscience".

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.11
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• pp.5311-5316
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• 2012

Single Photon Emission Computed tomography(SPECT) was performed on 13 healthy adults (average age: 39) to investigate the changes of cerebral blood flow according to brain imaging analysis algorithm. The acquired images were filtered and reconstructed through Filtered Back Projection (FBP) and Ordered Subset Expectation Maximization (OSEM). The brain distribution data of radiopharmaceuticals were compared using Statistical Parametric Mapping (SPM), and the changes of blood flow was expressed in Cluster. As a result, uptake rate was increased in Sub-gyral, Sub-Lobar, Extra-Nuclear, Limbic lobe and Cingulate Gyrus, while uptake rate was decreased in Middle frontal gyrus, Inferior Frontal Gyrus and Precentral Gyrus. The discriminable SPM was shown according to cerebral blood flows in Cluster by the reconstruction algorithm.

• The Korean Journal of Nuclear Medicine
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• v.29 no.3
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• pp.294-306
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• 1995

There has recently been increasing interest in the use of NMDA receptor antagonists as potential neuroprotective agents for the treatment of ischemic stroke. To evaluate the neuroprotective effect of the selective non-competitive NMDA receptor antagonist MK-801 in focal cerebral ischemia, local cerebral glucose utilization (ICGU) was examined in 15 neuroanatomically discrete regions of the conscious rat brain using the 2-deoxy-D[$^{14}C$] glucose quantitative autoradiographic technique 24 hr after left middle cerebral artery occlusion (MCAO). Animals received MK-801 (5 mg/kg i.v.) or saline vehicle before (20-30 min) or after (30 min) MCAO. Both pretreatment and posttreatment of MK-801 increased occluded/non-occluded ICGU ratio in 7 and 5 of the 15 regions measured, respectively (most notably in cortical structures). Following MK-801 pretreatment, there was evidence of widespread increases in ICGU not only in the non-occluded hemisphere (12 of the 15 areas studied) but also in the occluded hemisphere (13 of the 15 areas studied), while MK-801 postreatment did not significantly increase ICGU both in the normal and occluded hemispheres. These data indicate that MK-801 has a neuroprotective effect in focal cerebral ischemia and demonstrate that MK-801 provides widespread alterations of glucose utilization in conscious animals.

• Journal of Chest Surgery
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• v.34 no.7
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• pp.574-577
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• 2001

A 54-year-old homosexual man was diagnosed as human immunodeficiency virus-1-positive in 1992. He was admitted to a tertiary hospital in March, 2000 because of right flank pain, fever and intermittent cough. A chest roentgenogram showed right-sided pleural effusion, and closed thoracostomy was performed for drainage Salmonella species and Escherichia coli were isolated from the pleural fluid. In spite of 6 weeks of antibiotic treatment, fever did not subside and the general condition gradually deteriorated, and under the diagnosis of lung abscess with empyema thoracis, right pleuropneumonectomy was performed. The general condition improved postoperatively until day 10 when he showed sudden change in mental status to stuporous and developed focal seizure. Brain CT showed multiple abscesses in right frontal and left frontotemporal lobes and he expired on postoperative day 14.

• Radiation Oncology Journal
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• v.24 no.2
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• pp.149-155
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• 2006

Meningeal hemangiopericytoma (HPC) is an uncommon dura-based tumor and can recur not only locally but also distantly in the neural axis or extraneural sites. We report our experience of radiation therapy, one preoperative and one elective postoperative, In two patients with meningeal HPC and reviewed the role of radiation therapy. A 41-year-old man (Case 1) presented with a 3-month history of headache and right hemiparesis. The mass was nearly unresectable at the first and second operation and diagnosed as meningeal HPC. Preoperative radiation therapy was given with a total dose of 55.8 Gy/31 fractions to the large residual mass of left frontoparietal area. Follow-up computerized tomography (CT) showed marked regression of tumor after radiation therapy. The third operation was peformed to remove the residual tumor at 6 months after the radiation therapy and a $2{\times}2cm$ sized tumor was encountered. The mass was totally removed. The serial follow-up CT showed no evidence of recurrence and he is alive without distant metastasis for 4 years and 10 months after the first operation. A 45-year-old woman (Case 2) presented with suddenly developed headache and visual impairment. Tumor mass occupying right frontal lobe was removed with the preoperative diagnosis of meningioma. It was totally removed with attached sagittal sinus and diagnosed as meningeal HPC. Elective postoperative radiation therapy was peformed to reduce local recurrence with a total dose of 54 Gy/30 fractions to the involved area of right frontal lobe. She is alive for 5 years maintaining normal activity without local recurrence and distant metastasis.

• Nuclear Medicine and Molecular Imaging
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• v.42 no.3
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• pp.192-200
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• 2008

To evaluate the hemodynamic changes and the predictive factors of the clinical outcome in pediatric patients with moyamoya disease, we analyzed pre/post basal/acetazolamide stress brain perfusion SPECT with automated volume of interest (VOIs) method. Methods: Total fifty six (M:F = 33:24, age $6.7{\pm}3.2$ years) pediatric patients with moyamoya disease, who underwent basal/acetazolamide stress brain perfusion SPECT within 6 before and after revascularization surgery (encephalo-duro-arterio-synangiosis (EDAS) with frontal encephalo-galeo-synangiosis (EGS) and EDAS only followed on contralateral hemisphere), and followed-up more than 6 months after post-operative SPECT, were included. A mean follow-up period after post-operative SPECT was $33{\pm}21$ months. Each patient's SPECT image was spatially normalized to Korean template with the SPM2. For the regional count normalization, the count of pons was used as a reference region. The basal/acetazolamide-stressed cerebral blood flow (CBF), the cerebral vascular reserve index (CVRI), and the extent of area with significantly decreased basal/acetazolamide- stressed rCBF than age-matched normal control were evaluated on both medial frontal, frontal, parietal, occipital lobes, and whole brain in each patient's images. The post-operative clinical outcome was assigned as good, poor according to the presence of transient ischemic attacks and/or fixed neurological deficits by pediatric neurosurgeon. Results: In a paired t-test, basal/acetazolamide-stressed rCBF and the CVRI were significantly improved after revascularization (p<0.05). The significant difference in the pre-operative basal/acetazolamide-stressed rCBF and the CVRI between the hemispheres where EDAS with frontal EGS was performed and their contralateral counterparts where EDAS only was done disappeared after operation (p<0.05). In an independent student t-test, the pre-operative basal rCBF in the medial frontal gyrus, the post-operative CVRI in the frontal lobe and the parietal lobe of the hemispheres with EDAS and frontal EGS, the post-operative CVRI, and ${\Delta}CVRI$ showed a significant difference between patients with a good and poor clinical outcome (p<0.05). In a multivariate logistic regression analysis, the ${\Delta}CVRI$ and the post-operative CVRI of medial frontal gyrus on the hemispheres where EDAS with frontal EGS was performed were the significant predictive factors for the clinical outcome (p =0.002, p =0.015), Conclusion: With probabilistic map, we could objectively evaluate pre/post-operative hemodynamic changes of pediatric patients with moyamoya disease. Specifically the post-operative CVRI and the post-operative CVRI of medial frontal gyrus where EDAS with frontal EGS was done were the significant predictive factors for further clinical outcomes.