• The Journal of the Korean bone and joint tumor society
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• v.14 no.1
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• pp.33-43
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• 2008

Purpose: To evaluate the clinical usability of reconstructive methods, and how to select flap after wide excision of malignant soft tissue tumor in ankle and foot. Materials and Methods: The 15 cases shown in the 14 patients (In case of a male patient, reconstruction was performed two times due to local recurrence.) with malignant soft tissue tumor in ankle and foot, who underwent reconstruction after wide excision from March 2000 until March 2007. Oncologic, surgical and functional results were evaluated. Results: The method of reconstruction used were anterolateral thigh perforator flap (5cases), Reversed superficial sural artery flap (4 cases), dorsalis pedis flap (3 cases), local flap (3cases). The defect, mean size was $5.5{\times}5.7\;cm$, was reconstructed with rotation flap or free flap, mean size was $5.9{\times}6.0\;cm$, skin graft for remnant. The mean operation time was 310 minutes (120~540 minutes); it took 256 minutes to reconstruct by rotation flap, and 420 minutes by free flap. As oncologic results, 7 patients were no evidence of disease, 6 patients were alive with disease and 1 patient was expired by pulmonary metastasis at the time of the last follow-up. 4 patients had local recurrence and 4 pateints had distant metastases. As functional results, 14 patients were evaluated with average score of 68.8% using the system of the Musculoskeletal Tumor Society. Conclusion: The dorsalis pedis and reverse superficial sural artery rotation flap which is easy procedure, has less complication and takes short operation time, can be primarily considered to reconstruct a small defect. And the anterolateral thigh perforator flap is suitable for coverage of a large defects after wide excision of malignant soft tissue tumor in ankle and foot.

• Korean Journal of Poultry Science
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• v.41 no.3
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• pp.217-225
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• 2014

Telomeres are the ends of the eukaryotic chromosomes and consist of a tandem repetitive DNA sequence and shelterin protein complex. The function of telomere is to protect chromosome. Telomere length in somatic cells tends to decrease with organismal age due to the end replication problem. However, several factors at the genetic, epigenetic and environmental level affect telomere length. In this study, we estimated heritability of telomere length and investigated inheritance of telomeres in a chicken. Telomere length of lymphocytes was analyzed by semi-quantitative polymerase chain reaction using telomere primer and quantitative fluorescence in situ hybridization using telomeric DNA probe. In results, heritability of telomere length was estimated 0.9 at birth by offspring-parent regression analysis and was estimated 0.03 and 0.04 at 10 and 30 weeks old, respectively, by parental variance analysis. There was a significant positive correlation in telomere length between father and their offspring (r=0.348), and mother and their offspring (r=0.380). In inheritance patterns of telomere length, the influence of paternal and maternal effect on their offspring was similar. The influence of inherited telomeres on male and female progeny was also roughly alike. These results implicated that imprinting of parental telomere length was regulated by autosomal genes, not sex linked genes. In addition, telomere length of offspring at birth did not differ along with their maternal age. Thus, maternal age does not affects telomere length in their offspring at birth owing to cellular reprogramming at early embryonic stage.

• The Journal of Engineering Geology
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• v.27 no.4
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• pp.475-487
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• 2017

We performed landslide flume tests to analyze characteristics of landslide occurrence and change in the ground materials due to rainfall infiltration. The test apparatus is composed of flume, rainfall simulator, and measurement sensors and landslides were triggered by heavy rainfall (Intensity=200 mm/hr) sprinkled at the above of an artificial slope. The measurement sensors for matric suction and volumetric water content were installed with 3 sets at shallow (GL-0.2 m), middle (GL-0.4 m), and deep depth (GL-0.6 m) in the slope and the tests were performed with in-situ, loose, and dense condition of each weathered soils of granite, gneiss, and mudstone. The analyses show that surface erosion was dominant in initial time of the test due to heavy rainfall and then landslides occur following locally happened transverse tension cracks. The characteristics of landslide were both shallow failure because of a spread of wetting front induced by the rainfall infiltration and retrogressive failure. While the matric suction was decreased rapidly without any precursor in the soil saturation, the volumetric water content was increased gradually, reached its maximum value, and then decreased rapidly with landslide.

• Journal of Gastric Cancer
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• v.10 no.1
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• pp.40-44
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• 2010

The natural history of gastric cancer is unclear. We report here on a rare case of advanced gastric cancer for which we performed curative gastrectomy 78 months after the diagnosis. A 74-year-old woman with epigastric pain underwent esophagogastroscopy in January, 2000 and she was diagnosed with advanced gastric cancer. Suspicious omental cake was noted on CT. After refusing all kinds of treatment, she underwent a follow up CT scan on September, 2002, which no longer suggested omental cake. She once again refused treatment, but she visited the hospital in June, 2006 due to severe epigastric pain and a decreased oral intake. Abdominal CT showed no distant metastasis, and so radical subtotal gastrectomy with regional lymph node dissection was performed in July, 2006 and the TNM stage was T2bN1M0 (stage II).

• Journal of the Computational Structural Engineering Institute of Korea
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• v.35 no.1
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• pp.57-64
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• 2022

This study investigated the structural performance of the RC boundary beam-wall system subjected to axial loads that required lesser construction quantity and smaller floor height in comparison with the conventional RC transfer girder system. Four specimens of 1/2 scale were constructed, and their peak strengths under axial loads and failure characteristics were compared and analyzed. Test parameters included the ratio of the lower to the upper wall length, lower wall thickness, and stirrup details of the lower wall. In addition, three-dimensional nonlinear finite element analysis was performed to verify the effectiveness of the boundary beam-wall system. The peak strength of each specimen was similar to the nominal axial strength of the lower wall, indicating that the axial load was transferred smoothly from the upper to the lower wall. The contribution of the lower wall cross-section was high if the ratio of the lower to the upper wall length was small; the contribution was low if the out-of-plane eccentricity existed in the lower wall. The specimen with smaller stirrup distance and cross-ties in the lower wall showed higher initial stiffness and peak load than other specimens.

• Journal of the Korean Geotechnical Society
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• v.22 no.4
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• pp.11-19
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• 2006

For the last decade, the hi-directional testing method has been advantageous over the conventional pile load testing method in many aspects. However, because the hi-directional test uses a loading mechanism entirely different from that of the conventional pile load testing method, many investigators and practicing engineers have been concerned that the hi-directional test would give inaccurate results, especially about the pile head settlement behavior. Therefore, a hi-directional load test and the conventional top-down load test were executed on 1.5 m diameter cast-in-situ concrete piles at the same time and site. Strain gauges were placed on the piles. The two tests gave similar load transfer curves at various depth of piles. However, the top-down equivalent curve constructed from the hi-directional load test results predicted the pile head settlement under the pile design load to be about one half of that predicted by the conventional top-down load test. To improve the prediction accuracy of the top-down equivalent curve, a simple method that accounts for the pile compression is proposed. It was also shown that the strain gauge measurement data from the hi-directional load test could reproduce almost the same top-down curve.

• Journal of Korean Society of Transportation
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• v.19 no.3
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• pp.115-131
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• 2001

The Purpose of this study is to develop a simulation model for large-scale network with interrupted flow as well as uninterrupted flow. The Cell Transmission(CT) theory is used to simulate traffic flow. Flow transition rules have been newly developed to simulate traffic flows at merging and diverging sections, and signalized intersections. In the model, it is assumed that dynamic OD table is exogenously given. Simulation results for toy network shows that the model can explain queue dynamics not only in signalized intersections of urban arterials, but also in merging and diverging sections of freeway. In case study, the model successfully simulated traffic flows of 145,000 vehicles on CBD network of city of Seoul with 74 traffic zones, 133 signalized intersections among 395 nodes and 1110 links.

• Journal of the Korea Concrete Institute
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• v.19 no.3
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• pp.265-273
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• 2007

The most common structural system for apartment buildings in Korea is adopted to combine structural systems: for example, a moment-resisting frame will be used for lower stories and bearing wall system for the upper stories. This type of buildings have soft and/or weak stories in lower stories, and it may lead to collapse of those buildings during the large earthquake. Reversed cyclic load tests were conducted to estimate the performance and behavioral characteristics of deep beam and exterior column Joints. Experimental parameter is the amount of transverse reinforcement (designed by ACI code and Sheikh's procedure). The results of this study are as follows: (1) The required transverse reinforcement of column designed by Sheikh's procedure requires 2.9 times larger than that designed by ACI procedure. Large amount of transverse reinforcement increase the ductility of the column. (2) Most of the lateral drift in the column is due to the flexural deformation in the joint and plastic hinge region and up-lift rotation. (3) Transverse reinforcement in the exterior column shall be required not only in the hinge region but also in the joint.

• Journal of Chest Surgery
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• v.37 no.4
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• pp.349-355
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• 2004

Non-small cell lung cancer (NSCLC) with invasion of mediastinal structures is classified as stage IIIB, and has been considered surgically unresectable However, in a selected group of these patients, better results after surgical resection compared to non-surgical group have been reported. The aim of this study is to evaluate the role of surgical resection in treatment of mediastinal T4 NSCLC. Material and Method: Among 1067 patients who underwent surgical intervention for non-small cell lung cancer from Aug 1987 to Dec 2001 in Korea cancer center hospital, 82 patients had an invasion of T4 mediastinal structures (7.7%). Resection was possible in 63patients (63/82 resectability 76.8%). Their medical records in Data Base were reviewed, and they were followed up completely until Jun 2002. Surgical results and prognostic factors of NSCLC invading mediastinal structures were evaluated retrospectively. Result Lung cancer was resected completely in 52 patients (63.4%, 52/82). Lung resection was lobectomy (or more) in 14, pneumonectomy in 49. The mediastinal structures invaded by primary tumor were great vessel (61.9%), heart (19%), vagus nerve (9.5%), esophagus (7.9%), and vertebral body (7.9%). Nodal status was N0 in 11, N1 in 24, and N2 in 28 (44.4%). Neoadjuvant therapy was done in 6 (9.5%, 5 chemotherapy, 1 radiotherapy), and adjuvant therapy was added in 44 (69.8%, 15 chemotherapy, 29 radiotherapy) in resection group (n=63). Complication was occurred in 23 (31.7%), and operative mortality was 9.5% in resection group. Median and 5 year overall survival including operative mortality was 18.1 months and 21.7% in resection group (n=63), 6.2months and 0% in exploration only group (n=19, p=.001), 39 months and 32.9% in N2 (-) resection group (n=35), and 8.8 months and 8.6% in N2 (+) resection group (n=28, p=.007). The difference of overall survival by mediastinal structure was not significant. Conclusion: The operative risk of NSCLC invading mediastinal structures was high but acceptable, and long-term result of resection was favorable in selected group. Aggressive resection is recommended in well selected pateints with good performace and especially N2 (-) NSCLC with mediastinal invasion.

• Journal of Yeungnam Medical Science
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• v.11 no.1
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• pp.72-81
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• 1994

Total 55 patients with nonsmall cell lung cancer treated with radiation therapy at Department of Therapeutic Radiology, Yeungnam University Hospital, between May-1 1986 and April-30 1993 were retrospectively analyzed by clinical characteristics, failure patterns, follow up duration and survival ratio according to prognostic factors. Obtained results were as follows : 1. Male to female ratio was 17.3 2. Sixth and seventh decades were predominant age group. 3. The patients were 8 in stage I-II, 34 in stage IIIA, 13 in stage IIIb, respectively. 4. Forty five patients out of 55 were squamous cell carcinoma. 5. Primary tumor were originated from upper lobe bronchi predominantly. 6. The size of the primary tumor, lymph node involvement and the degree of differentiation were important in evaluation of prognosis. 7. In conclusion, for patients with poor prognostic factors systemic chemotherapy and multidisciplinary approach were recommended for better treatment outcome and improvement of survival.