• Journal of the Korean hospital association
• /
• 제21권1.2호통권191호
• /
• pp.33-48
• /
• 1992

• The Science & Technology
• /
• 제8권6호통권73호
• /
• pp.56-57
• /
• 1975

이 기사는 서울국제싸이엔스클럽 제 75차 월례오찬회에서 특강된 내용을 전문수록한 것이다. -편집부-

• The Korean Society of Law and Medicine
• /
• 제1권1호
• /
• pp.139-163
• /
• 2000

• Journal of the Korean Catholic Hospital Association
• /
• 제18권1호
• /
• pp.4-6
• /
• 1987

• The Science & Technology
• /
• 1호통권416호
• /
• pp.16-16
• /
• 2004

• Journal of Yeungnam Medical Science
• /
• 제7권2호
• /
• pp.1-11
• /
• 1990

• 한국사회복지학회:학술대회논문집
• /
• 한국사회복지학회 1993년도 추계학술대회 자료집
• /
• pp.213-233
• /
• 1993

• 보건세계
• /
• 제38권2호통권414호
• /
• pp.18-19
• /
• 1991

• Korean Journal of Transplantation
• /
• 제28권3호
• /
• pp.121-134
• /
• 2014

Current immunosuppressants have nonspecific immuosuppressive effects, and are not helpful for tolerance induction. Consequently, transplant patients cannot discontinue using them, and their nonspecific immunosuppressive effects result in many side effects, including infection and malignancy. However, most of cellular immunotherapy can have donor antigen-specific immunsuppressive effects. Therefore, cell therapy could be an alternative or adjunctive to nonspecific immunosuppressants. Polyclonal or antigen-specific Foxp3+ regulatory T cells have been actively tried for prevention of acute rejection, treatment of chronic rejection, or tolerance induction in clinical trials. Regulatory macrophages are also under clinical trials for kidney transplant patients. IL-10-secreting type 1 regulatory T cells and donor- or recipient-derived tolerogenic dendritic cells will also be used for immunoregulation in clinical trials of kidney transplantation. These cells have antigen-specific immunoregulatory effects. Mesenchymal stromal cells (MSCs) have good proliferative capacity and immunosuppressive actions independently of major histocompatibility complex; therefore, even third-party MSCs can be stored and used for many patients. Cell therapy using various immunoregulatory cells is now promising for not only reducing side effects of nonspecific immunosuppressants but also induction of immune tolerance, and is expected to contribute to better outcomes in transplant patients.

• Proceedings of the Korean Society of Embryo Transfer Conference
• /
• 한국수정란이식학회 2005년도 제5회 발생공학 국제심포지엄 및 학술대회
• /
• pp.100-100
• /
• 2005