• Title/Summary/Keyword: 자성 유전체

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Glutathione S-transferase polymorphism of neonatal hyperbilirubinemia in Korean neonates (한국인 신생아 황달과 Glutathione S-transferase 다형성에 관한 연구)

  • Kang, Chang Seok;Hong, Seung Su;Kim, Ji Sook;Kim, Eun Ryoung
    • Clinical and Experimental Pediatrics
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    • v.51 no.3
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    • pp.262-266
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    • 2008
  • Purpose : Glutathione S-transferase (GST) is a polymorphic supergene family of detoxification enzymes that are involved in the metabolism of numerous diseases. Several allelic variants of GSTs show impaired enzyme activity and are suspected to increase the susceptibility to diseases. Bilirubin is bound efficiently by GST members. The most commonly expressed gene in the liver is GSTM1, and GSTT1 is expressed predominantly in the liver and kidneys. To ascertain the relationship between GST and neonatal hyperbilirubinemia, the distribution of the polymorphisms of GSTT1 and GSTM1 were investigated in this study. Methods : Genomic DNA was isolated from 88 patients and 186 healthy controls. The genotypes were analyzed by polymerase chain reaction (PCR). Results : The overall frequency of the GSTM1 null was lower in patients compared to controls (P=0.0187, Odds ratio (OR) =0.52, 95% confidence interval (CI), 0.31-0.88). Also, the GSTT1 null was lower in patients compared to controls (P=0.0014, OR=0.41, 95% CI=0.24-0.70). Moreover, the frequency of the null type of both, in the combination of GSTM1 and GSTT1, was significantly reduced in jaundiced patients (P=0.0008, OR=0.31, 95% CI=0.17-0.61). Conclusion : We hypothesized that GSTM1 and GSTT1 might be associated with neonatal hyperbilirubinemia. However, the GSTT1 and GSTM1 null type was reduced in patients. Therefore the null GSTT1, null GSTM1, and null type of both in the combination of GSTM1 and GSTT1 may be not a risk factor of neonatal jaundice.

Application of RAPD Markers to Early Selection of Elite Individuals of Pinus Species for a Clonal Forest Tree Breeding Program (소나무류 육종에 있어 임의 증폭 다형 디엔에이(RAPD)지표를 이용한 우량 임목의 조기 선발)

  • Yi, Jae-Seon;Cheong, Eun-Ju;Moon, Heung-Kyu;Dale, Glenn T.;Teasdale, Robert D.
    • Journal of Forest and Environmental Science
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    • v.11 no.1
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    • pp.81-101
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    • 1995
  • Random amplified polymorphic DNA (RAPD) technology, a recent approach in molecular genetics, is much usable to select the elite trees and to maximize the genetic gain in forest tree breeding program, providing a clue to determine the genetic marker-trait correlation. This review intorduces research on bark thickness and breeding strategy in Pinus elliottii, Pinus caribaea and their hybrid by Queensland Forest Service and ForBio Research Pty Ltd, University of Queensland, which employ RAPD technology. Genetic linkage map of $F_1$ hybrids includes 186 RAPD markers and 16 linkage groups (1641 cM long in total) and 6 quantitative trait loci are located putatively for bark thickness. Following recent research results and experiences in pine breeding programs, the forseeable stages in the application and development are proposed for marker assisted selectin; stage 1-determination of species specific markers for genes controlling traits of commercial interest, and stage 2-determination of marker-allele association for specific allelic variants within pure species. As pines inherit their megagametophytes from the seed parent and zygotic embryos from both male and female parents, the determination of marker-trait correlation is possible even in embryo stage, eventually making ways for the early selection of elite individuals.

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A Study on Design and Fabrication of Quad-Band Small Antenna with MD(magneto-dielectric) material for mobile Applications (MD 매질을 이용한 이동통신용 Quad-Band 소형 안테나 설계 및 구현에 관한 연구)

  • Kim, Woo-Su;Yoon, Cheol;Oh, Soon-Soo;Kang, Suk-Youb;Park, Hyo-Dal
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.14 no.5
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    • pp.1270-1276
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    • 2010
  • In this paper, Quad-Band small antenna for GSM850, GSM900, DCS1800, DCS1900 is designed and fabricated. The antenna achieved the size reduction of over 67.9 % than the conventional PIFA(Planar Inverted-F Antenna) by using a MD(Magneto-Dielectric) material. A simple feeding microstrip line is used to feed the antenna from a $50{\Omega}$ coaxial line, which is capacitively coupled to the grounded patch structure for broadband characteristics. The impedance bandwidth the proposed antenna shows good results as broadband characteristics of 1341 MHz (801 ~ 2142 MHz) in VSWR < 3 (${\leq}\;-6\;dB$) and the gain is -6.67 ~ 4.25 dBi in the operating frequency.

Microwave Absorbing Properties of Silver-coated Ni-Zn Ferrite Spheres Prepared by Electroless Plating (무전해 도금법에 의해 제조된 은 피복 Ni-Zn Ferrite Sphere의 전파흡수특성)

  • Kim, Jong-Hyuk;Kim, Jae-Woong;Kim, Sung-Soo
    • Journal of the Korean Magnetics Society
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    • v.15 no.3
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    • pp.202-206
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    • 2005
  • The present investigation provides an electromagnetic radiation absorptive composition which comprises silver-coated ferrite microspheres dispersed in silicon rubber matrix for the aim of thin microwave absorber in GHz frequencies. Ni-Zn ferrite spheres with $50{\mu}m$ size in average were prepared by spray-drying and sintering at $1130^{\circ}C$. Conductive silver layer was plated on ferrite spheres by electroless plating. Conductive Ni-Zn ferrite sphere with uniform silver layer were obtained in the concentration of 10 g/L $AgNO_3$ per 20 g ferrite spheres. For this powder, electrical resistance is reduced as low as $10^{-2}\~10^{-3}\;\Omega$. The most sensitive material parameters with silver plating is real and imaginary parts of complex permittivity. The conductive Ni-Zn ferrite spheres have large values of dielectric constant. Due to this high dielectric constant of microspheres, matching thickness is reduced to as low as 2 mm at the frequency of 7 GHz, which is much thinner than conventional ferrite absorbers.

Single-layered Microwave Absorbers containing Carbon nanofibers and NiFe particles (탄소나노섬유와 NiFe 분말을 함유한 단층형 전자기파 흡수체)

  • Park, Ki-Yeon;Han, Jae-Hung;Lee, Sang-Bok;Kim, Jin-Bong;Yi, Jin-Woo;Lee, Sang-Kwan
    • Composites Research
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    • v.21 no.5
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    • pp.9-14
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    • 2008
  • Carbon nanofibers (CNFs) were used as dielectric lossy materials and NiFe particles were used as magnetic lossy materials. Total twelve specimens for the three types such as dielectric, magnetic and mixed radar absorbing materials (RAMs) were fabricated. Their complex permittivities and permeabilities in the range of $2{\sim}18$ GHz were measured using the transmission line technique. The parametric studios for reflection loss characteristics of each specimen to design the single-layered RAMs were performed. The mixed RAMs generally showed the improved absorbing characteristics with thinner matching thickness. One of the mixed RAMs, MD3with the thickness of 2.00 mm had the 10 dB absorbing bandwidth of 4.0 GHz in the X-band ($8.2{\sim}12.4$ GHz). It also showed very broad 10 dB absorbing bandwidth as wide as 6.0 GHz in the Ku-band ($12.0{\sim}18.0$ GHz) with the thickness tuning to 1.49 mm. The experimental results for selected several specimens were in very good agreements with simulation ones in terms of the overall reflection loss characteristics and 10 dB absorbing bandwidth.

A Study on Electromagnetic Properties in OPC Mortar with Different Chloride Content (염화물을 혼입한 OPC 모르타르의 전자기 특성에 대한 연구)

  • Kwon, Seung-Jun;Na, Ung-Jin;Feng, M.Q.
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.28 no.4A
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    • pp.565-571
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    • 2008
  • Recently, the evaluation technique using NDT (Nondestructive Technique : NDT) is widely utilized because it makes little damage on RC (Reinforced Concrete : RC) structures. The techniques using electromagnetic properties (EM properties) are also attempted for the evaluation of the performance of concrete which is nonmetallic. For the economic manufacturing of concrete material, sea-sand is often used as aggregate, however, chloride ion in concrete has direct effects on steel corrosion and EM properties. In this study, OPC mortar specimens with 5 different chloride amount (0.0, 0.6, 1.2, 2.4, and $3.6kg/m^3$) and 3 different water-cement ratios (45%, 55%, and 65%) are prepared in order to investigate the EM properties corresponding to concrete properties. The EM properties of conductivity and dielectric constant are measured in the frequency range over 0.2~20 GHz. To facilitate the comparison of EM properties with chloride content, average values are taken respectively for the conductivity and dielectric constant measured over the 5~20 GHz frequency range. According to the results of this experiment, dielectric constant and conductivity are increased with lower W/C ratio and larger amount of chloride content.

Clonal Variation of Flowering in Pinus thunbergii Seed Orchard (해송 채종원(採種園)에서 개화특성(開花特性)의 클론 변이(變異))

  • Han, Sang-Urk;Choi, Wan-Yong;Chang, Kyong-Hwan;Kim, Tae-Su;Song, Jeong-Ho
    • Journal of Korean Society of Forest Science
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    • v.90 no.6
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    • pp.717-724
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    • 2001
  • This study was conducted in an attempt to quantify some traits that may be involved in the reproductive process of Pinus thunbergii. During the past 6 years (1995-2000), we surveyed flowering patterns of 60 P. thunbergii clones in a seed orchard which was established in Anmyon-do, 1979. From this survey, we estimated clonal contributions of male and female flowers and sexual asymmetry. Among 60 clones, 18 clones (30%) accounted for 0.37 (1999)~0.46 (1995) of clonal contribution in female flowers and 0.44 (1999)~0.57 (1995) of clonal contribution in male flowers. As compared with the previous reports in other pine species, more clones made contributions to reproductive process in P. thunbergii seed orchard. The relative effective population numbers for females (v♀) varied from 0.59 (1995) to 0.91 (1999) and those for males ( v♂) were between 0.56 (1995) and 0.83 (1998) at gamete level. This showed that the female gametes effectively contribute to the reproductive process more than did the male gametes. The relative effective population numbers at clonal level ($v_b$) were in the range of 0.72 (1995) and 0.93 (1999). More than 73% of the total clones showed values of 0.4~0.6 ($0.5{\pm}0.1$) in maleness index. The values averaged over all the clones were temporally variable with the range of 73% in 1996 and 100% in 2000. The degree of sexual asymmetry ($A_s$) ranged from 0.09 to 0.26. These values were relatively low when compared with those of other trees, suggesting that P. thunbergii seed orchard remains a high level of homogeneity in the number of male and female. All of the various types of effective population numbers were positively correlated with each other while they were negatively correlated with the degree of sexual asymmetry.

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Fabrication of Ba-, Pb-electronic ceramics by powder prepartion of wet chemical method (습식화학적 분말합성법에 의한 Ba-, Pb-계 전자세라믹스의 제조)

  • 이병우;오근호
    • Proceedings of the Korea Association of Crystal Growth Conference
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    • 1996.06b
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    • pp.259-279
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    • 1996
  • 최근 정보·전자산업의 발전으로 고 신뢰성 전자재료에 대한 수요가 증대되고 있으며 이러한 첨단산업의 기반의 될 신소재 중 전자세라믹스가 차지하는 비중이 그 대부분을 차지하고 있으며 이에 대한 수요와 기대가 점점 커지고 있다. 이러한 전자세라믹스는 유전재료, 자성재료, 압전재료, 도전성 재료 등으로 나뉘게 된다. 어떠한 분류에 들어가든 그 조성은 금속의 산화물 형태가 일반적이며 미세한 분말의 성형체를 소결(sintering) 함으로써 최종제품으로 완성된다. 이러한 전잣라믹스가 최근 요구되는 고 신뢰성, 고 밀도화를 달성하기 위해선 원료 분말 제조단계부터 제어가 필요하다. 원료분말의 균일·균질성과 그 입도는 소결특성 뿐만아니라 전기적 특성에도 큰 영향을 미치기 때문이다. 세라믹스의 분말제조 방법 중 일반적으로 사용되는 방법으로는 고상 산화물을 혼합하여 하소(calcination)한 후 분쇄하는 '고상합성법'과 금속의 염 또는 alkoxide 용액을 이용하여 화학적으로 제조하는 '습식 화학적 합성법'이 있다. 고상합성법은 합성온도가 높고 기계적 분쇄와 혼합에 의존하므로 균일·균질성이 떨어지고 분말크기를 1㎛ 이하로 만들기 힘들다. 반면에 습식화학적 합성법은 기계적인 분쇄와 혼합에선 얻을 수 없는 원자 혹은 분자단위의 균일한 혼합과 submicron 이하의 미세한 분말을 얻을 수 있다. 따라서 이러한 습식 화학적 합성으로 얻은 분말을 사용하면 미세한 입자의 특성으로 인해 소결온도를 낮출 수 있으며 균일한 미세구조와 균질한 조성을 갖게되어 기계적·전기적 물성증진도 가져올 수 있게 된다. 습식 화학적 분말합성법은 전술하였듯이 alkoxide의 가수분해를 이용하는 sol-gel 법과 금속의 염(salt) 용액을 이용하여, 화학적으로 화합물 침전을 얻거나 또는 공침전물(coprecipitate) 형태의 분말을 얻는, 침전법으로 나뉠 수 있다. 침전법의 근본원리는 pH 및 pCO3 등에 따른 이온종의 용해도 차이를 이용하는 것으로써 각 이온종에 따른 solubility product(ksp)를 이용하여 설명된다. 본 연구에서는 침전법을 사용한 Ba-, Pb-계 전자세라믹스의 분말합성에 대한 이론적 고찰과 공정개발 및 실험을 통한 물성증진 효과에 대해 알아보았다. 본 실험상의 전자세라믹스 조성은 강유전체, 세라믹반도체, 압효과에 대해 알아보았다. 본 실험상의 전자세라믹스 조성은 강유전체, 세라믹 반도체, 압전재료로 널리 사용되는 BaTiO3, PZT(PbZrO3-PbTiO3)와 수직 자기기록매체로 큰 가능성이 있으며 hard ferrite로 널리쓰이는 Ba-feerite(BaFe12O19)로써 수산화물 형태의 침전에 대한 기구(mechanism)와 물성에 대해 살펴보았다. 이러한 침전법에 의한 분말합성 과정에는 소결체의 물성에 영향을 미치는 pH 조절제나 원료에서 혼입될 수 있는 Na+, K+, Cl-, SO4- 등의 제거(washing 혹은 filtering)가 필수적이다. 그러나 침전법에서 얻게 되는 분말은 매우 미세하여 colloid를 형성하게 되며, 이러한 colloid 상태의 미세한 침전입자가 filtering media에 끼이게 되어 견고하면서도 상당한 부피를 가지는 filter cake을 형성하기 때문에 filtering에 많은 시간과 다량의 filtering agent (본 실험의 경우엔 증류수)가 필요하게 된다. 따라서 이러한 문제점을 해결하기 위하여 colloid 상태의 침전물을 얼렸다 녹이는 freezing process를 개발, 적용하여 그 원리 및 효과, 그로인한 분말형태를 관찰하여 보았다.

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