• Title/Summary/Keyword: 자기공명영상 장치

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The Preliminary Study of Odorant Induced fMRI using an Apparatus of Smell Stimulation Controller (후취자극 제어장치를 이용한 후각 fMRI의 기초연구)

  • 강원석;백문영;이현용;신운재;정순철;민병찬;김재형;은충기;문치웅
    • Journal of Biomedical Engineering Research
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    • v.22 no.2
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    • pp.157-163
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    • 2001
  • 본 논문에서는 후취자극 제어장치를 이용하여 후각자극에 대한 인간의 뇌의 활성화 영역을 뇌기능자기공명영상(functional magnetic resonance imaging : fMRI)장치로 측정 또는 가시화하고 이의 임상적용에 대한 기초자료를 마련하고자 하였다. 우선 후각에 이상이 없고 코 수술 경험이 없는 오른손잡이 피험자 4명을 대상으로 5번에 걸쳐 Echo Plannar Imaging(EPI)에 의한 혈액산소농도의존(blood oxygen level dependent : BOLD)법을 이용하여 후각자극에 의한 뇌기능자기공명영상 실험을 수행하였다. 후각자극은 MRI 장치에서 사용할 수 있도록 제작된 후취제어장치를 사용하였으며, 제시된 향은 천연 향의 일종인 lavender-like fragrance를 사용하였다. 향의 제시는 후각의 피로도를 감안하여 3회의 휴식기관과 2회의 자극기간을 각 30초씩 번갈아 시행하였으며, 동시에 5초 간격으로 각 절편 당 30 영상을 연속적으로 획득하였다. Correlation법으로 0.4∼0.7의 문턱치(threshold)범위에서 통계 처리된 뇌의 활성화 영상은 EPI영상과 같은 부위의 T1 강조영상에 overlapping 시켰다. 호흡에 의한 artifact를 제거하기 위해 실험실에 만든 장치로 호흡을 측정하여 post-processing 할 때 반영하였다. 이렇게 얻어진 fMRI 영상의 신호변화를 관찰하여 활성 영역의 위치를 분석하였다. 그 결과 후각자극에 의해 뇌의 전두엽 피질(frontal cortex), 소뇌(cerebellum), 그리고 뇌교(pons)에서 활성화된 신호를 발견할 수 있었다. 또한, 측두엽(temporal lobe)과 뇌섬(insula)에서도 의미 있는 신호가 관찰되었다. 그러나, 일차 후각영역인 piriform cortex와 entorhinal cortex, amygdaloid complex, 그리고 이차후각영역인 orbitofrontal cotex에서는 그다지 많은 빈도로 신호가 발견되지 않았다. 결론적으로 BOLD법을 이용한 fMRI에 의하여 후각자극에 대한 뇌의 활성화영역을 관찰할 수 있었으며, 후각자극에 대한 뇌의 기능을 연구하는데 있어서 중요한 정량적 자료를 제공할 수 있다는 점을 확인할 수 있었다.

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Determination of Stereotactic Target Position with MR Localizer (자기공명영상을 이용한 두개부내 표적의 3차원적 위치결정)

  • 최태진;김옥배;주양구;서수지;손은익
    • Progress in Medical Physics
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    • v.7 no.2
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    • pp.67-77
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    • 1996
  • Purpose: To get a 3-D coordinates of intracranial target position was investicated in axial, sagittal and coronal magnetic resonance imaging with a preliminary experimented target localizer. Material and methods : In preliminal experiments, the localizer is made of engineering plastic to avoid the distrubance of magnetic field during the MR image scan. The MR localizer displayed the 9 points in three different axial tomogram. The bright signal of localizer was obtjained from 0.1~0.3% of paramagnetic gadolinium/DTPA solution in T1WI or T2WI. In this study, the 3-D position of virtual targets were examined from three different axial MR images and the streotactic position was compared to that of BRW stereotactic system in CT scan with same targets. Results: This study provided the actual target position could be obtained from single scan with MRI localizer which has inverse N-typed 9 bars. This experiment was accomplished with shimming test for detection of image distortion in MR image. However we have not found the image distortion in axial scan. The maximum error of target positions showed 1.0 mm in axial, 1.3 mm for sagittal and 1.7 mm for coronal image, respectivelly. The target localization in MR localizer was investicated with spherical virtual target in skull cadaver. Furthermore, the target position was confirmed with CRW stereotactic system showed a 1.3 mm in discrepancy. Summary : The intracranial target position was determined within 1.7 mm of discrepancy with designed MR localizer. We found the target position from axial image has more small discrepancy than that of sagittal and coronal image.

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Functional MRI of Language Area (언어영역의 기능적 자기공명영상)

  • 유재욱;나동규;변홍식;노덕우;조재민;문찬홍;나덕렬;장기현
    • Investigative Magnetic Resonance Imaging
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    • v.3 no.1
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    • pp.53-59
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    • 1999
  • Purpose : To evaluate the usefulness of functional MR imaging (fMRI) for language mapping and determination of language lateralization. Materials and Methods : Functional maps of the language area were obtained during word generation tasks and decision task in ten volunteers (7 right handed, 3 left-handed). MR examinations were performed at 1.5T scanner with EPI BOLD technique. Each task consisted of three resting periods and two activation periods with each period of 30 seconds. Total acquisition time was 162 sec. SPM program was used for the postprocessing of images. Statistical comparisons were performed by using t-statistics on a pixel-by- pixel basis after global normalization by ANCOVA. Activation areas were topographically analyzed (p>0.001) and activated pixels in each hemisphere were compared quantitatively by lateralization index. Results : Significant activation signals were demonstrated in 9 of 10 volunteers. Activation signals were found in the premotor and motor cortices, the inferior frontal, inferior parietal, and mid-temporal lobes during stimulation tasks. In the right handed seven volunteers, activation of language areas was lateralized to the left side. Verb generation task produced stronger activation in the language areas and higher value of lateralization index than noun generation task or decision task. Conclusion : fMRI could be a useful non-invasive method for language mapping and determination of language dominance.

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Dissociation of the semantic and syntactic processing reflected on fMRI in Korean sentences (기능적 자기공명영상에 나타난 한글 의미.통사 문장 처리의 해리)

  • Lee, Hong-Jae;Lee, Dong-Hoon;Nam, Ki-Chun;Lee, Eun-Jung;Moon, Chan-Hong;Ryoo, Jae-Wook;Na, Dong-Gyu
    • Annual Conference on Human and Language Technology
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    • 2000.10d
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    • pp.405-410
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    • 2000
  • 본 연구에서는 기능적 자기공명영상을 이용하여 한글 문장의 의미와 통사 처리에 관한 뇌의 활성화 양상을 비교함으로써 한글문장 이해의 과정에 대한 신경해부학적 증거를 찾고자 하였다. 6명의 자원자를 대상으로 문장진위판단과제를 이용하여 활성화를 유도하였다. 1.5T 초전도 자기공명영상 장치에서 EPI로 BOLD 기법을 이용하여 기능적 영상을 얻었으며 영상 후 처리는 SPM99 분석 프로그램을 이용하였다. 의미관련 통사관련 문장 모두에서 좌 우 전두회(frontal gyrus) 영역에서 활성화되었다. 의미와 통사처리 영역을 구분하기 위하여 감산법을 적용한 결과, 의미처리는 좌반구의 중측두회(middle temporal gyrus) 영역에서, 통사처리는 우반구의 하전두회(BA44) 부위에서 더 많이 활성화되었다. 의미처리에서 더 우세한 성향을 띠는 부위로 밝혀진 중측두회 영역은 의미처리시에 활성화되는 영역으로 보고하는 기존의 연구와 일치하는 결과이다. 의미와 통사 문장처리시의 뇌 활성화 양상은 뇌의 여러 영역에서 중첩되어 있기는 하지만, 특정영역에서의 차이를 보이고 있으므로, 의미와 통사처리는 다른 기전(mechanism)에 의해서 일어남을 시사해 준다.

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Usefulness of Dual-Echo in Steady State (DESS) Image in Chondromalacia of Knee Joint: Comparison of DESS and Turbo Spin-Echo MR Images (슬관절 연골 연화증의 진단에서의 Dual Echo in Steady State (DESS) 영상의 유용성 : 급속 스핀에코 자기공명 영상과 비교)

  • 윤삼현;하두회
    • Investigative Magnetic Resonance Imaging
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    • v.3 no.1
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    • pp.66-72
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    • 1999
  • Purpose : To evaluate the usefulness of Dual Echo in Steady State(DESS) image in the diagnosis of chondromalacia of the knee compared with turbo spin-echo MR images Materials and Methods : We included 26 patients with chondromalacia of the knee. MR imaging was obtained with a 1.5T imager. Sagittal and coronal double echo T2 weighted images(TR/TE 3000-4200/16-96msec, FOV $140-160{\times}140-160mm$, matrix size $180{\times}256$, slice thickness 4.0mm, interslice gap 0.5mm), and sagittal DESS image(TR/TE 25.4/9.0msec, flip angle $35-45^{\circ}$, FOV $150-160{\times}150-160mm,{\;}matrix{\;}size{\;}192{\times}256$, effective slice thickness 1.5mm) were obtained. Cartilage lesions were staged according to a modified scheme proposed by Outerbirdge: grade 0, normal; grade 1, softening or/and swelling; grade 2, mild surface fibrillation or/and less than 50% of cartilage thickness; grade 3, severe surface fibrillation or/and loss of more than 50% of cartilage thickness but without exposure of subchondral bone; and grade 4, complete loss of cartilage with subchondral bone exposure. Gradings were determined by two readers with consensus, and patellofemoral, medial and lateral tibiofemoral compartments were evaluated. Results : Arthroscopic findings revealed grade 1 in seven cases, grade 2 in 21 cases, grade 3 in six cases, and grade 4 in 18 cases. Sensitivity of turbo spin-echo MR image was as follows; 0%, 14%, 0%, 61% in each grade, and sensitivity of DESS image was as follows; 0%, 33%, 50%, 67%, in each grade(p=0.001). In the detection of chondromalacic lesions regardless of gradings, sensitivity, specificity and accuracy of conventional MR image were 59.6% 88.6% 78.8%, and of DESS image, 73.1% 88.4%, 82.2%(p=0.007). Conclusion : For chondromalacia of knee joints, DESS images showed higher sensitivity than turbo spin-echo MR images. Therefore, DESS images will be helpful for diagnosis of chondromalacia of knee joints.

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Basic RF Coils Used in Multi-channel RF Coil and Its B1 Field Distribution for Magnetic Resonance Imaging System (자기공명영상 촬영 장치에서 다채널 RF Coil에 이용되는 기본 구조 RF Coil의 B1 Field 분석)

  • Kim, Yong-Gwon
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.11 no.12
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    • pp.4891-4895
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    • 2010
  • RF coil is an important component of the Magnetic Resonance Imaging (MRI) system and the performance of RF coil is one of major factors for high SNR images. Sensitivity and RF field uniformity are parameters for evaluating RF coil performance. Since the B1 field is induced by RF coil, MR signal is strongly affected by RF coil structure and arrangement. In receiving MR signal, the RF coil sensitivity to MR Signal is also determined by the induced B1 field of RF coil. Therefore, the spatial distribution of B1 field must be verified. In this work, we performed computer simulation of the basic RF coil structures using Matlab and verified their sensitivity and uniformity through their B1 field distribution. This work will be useful for the advanced multi-channel RF coil design.

Analysis of Learning Effects MRI Education Content based on Virtual Reality (가상현실 기반 MRI 교육 콘텐츠 학습효과 분석)

  • Jung-Hun Lee;Jae-Goo Shim
    • Journal of the Korean Society of Radiology
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    • v.17 no.5
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    • pp.775-782
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    • 2023
  • In order to overcome practical limitations in installing, managing and operating MRI machines with expensive equipment, this study developed and utilized virtual reality (VR) experience education by combining virtual reality (VR) with magnetic resonance imaging devices. The Students who experienced virtual reality-based educational systems were surveyed to identify possible side effects during the experience and self-directed learning ability and academic self-efficacy surveys were conducted to analyze the impact of virtual reality-based practice on learning. In the analysis of the self-directed learning ability survey there was no difference in the average between the student group who experienced education and the student group who did not but there was a significant difference in the average for each group. Virtual Reality-based practical education is expected to provide an efficient practice system by providing new learning methods and opportunities for education that can be repeated anytime, anywhere regardless of time and space.

A Study of the Effect of Acoustic Noise Attenuator on Auditory Functional MRI (소음 감쇠기를 이용한 청각의 뇌기능 자기공명영상)

  • Kim, S.H.;Kim, I.S.;Lee, J.J.;Park, J.A.;Lee, Y.J.;Yeo, J.R.;Bae, S.J.;Lee, S.H.;Chang, Y.
    • Investigative Magnetic Resonance Imaging
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    • v.9 no.2
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    • pp.134-139
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    • 2005
  • Purpose : To evaluate the usefulness of acoustic noise attenuator on auditory fMRI examination. Materials and methods : The acoustic noise attenuator consists of mask, earmuff and silicon earplug. The soft polyurethane sheet and polyurethane form , which has a good soundproof characteristic were used for mask and earmuff. Auditory fMRI experiments of 500 Hz pure tone stimulation were performed in three different cases; first all of mask, earmuff and earplug, secondly earmuff and earplug only and finally without attenuator in 4 normal hearing volunteers. For data acquisition, BOLD MR imaging technique was employed at a 1.5T MR scanner equipped with high performance gradient system. The raw data were analyzed using a SPM-99 analysis software and the activation maps were obtained. Results : In case of all items of acoustic attenuator used, the results revealed that activation was focused on primary auditory area. When only earmuff and earplug were used, the results showed that the activation spread over primary auditory and secondary associative areas. Last, when no device used, only weak activation was observed on the right auditory cortex. Conclusion : It is expected that the acoustic noise attenuator, which consists of earplugs, earmuffs and mask, is a very useful device in auditory fMRI study.

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"세계적인 뇌과학 R&D 기지 만들터"

  • Sim, Jae-U
    • The Science & Technology
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    • no.9 s.424
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    • pp.20-22
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    • 2004
  • "이제 미지의 영역은 뇌뿐입니다. 영상장치의 수준에 따라 각국의 연구성과는 달라질 겁니다." PET(양전자 방출 단층촬영 장치)를 세계 최초로 개발, 뇌영상 연구분야의 세계 3대 석학 가운데 한 사람으로 꼽히는 UC어바인 조장희(68) 교수는 쩌렁쩌렁한 목소리에 기백이 넘쳤다. 고희를 앞둔 나이가 무색할 정도였다. 한국과학기술원과 광주과학기술원의 초빙 석좌교수 시절(1978~98년)의 거침없는 성격은 변함이 없었고, 뇌과학의 미래에 대한 그의 확신은 여전했다. 조 교수는 자신의 마지막 연구 인생을 조국에서 불태울 수 있는 기회를 잡았다. 가천의대가 조 교수를 영입해 370억 원을 들여 최첨단 뇌과학연구소를 세우기로 한 것이다. 조 교수에게는 15년간 연봉 30만 달러를 보장하는 파격적인 조건을 제시했다. 조 교수가 맡게 될 뇌과학영상연구소는 뇌 속에서 벌어지는 미세한 현상을 손바닥 보듯 들여다볼 수 있는 방법과 장치를 개발하게 된다. 가장 우선적인 목표는 MRI(자기공명 영상장치)와 PET를 합친 영상장치의 세계 최초 개발이다.

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