• Journal of the Korean Chemical Society
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• v.19 no.4
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• pp.218-224
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• 1975

The ground state SCF IMO theory was applied to the Diels-Alder reactions of cyclopentadiene with 2-substituted acrylonitriles. The CNDO/2 MO of the separate systems, including both $\sigma$ and $\pi$ electrons, was used as starting point. The qualitative prediction of the relative reactivity was made with the calculated primary interaction energies. Here the calculated activation energies appeared to be realistic. The stereoselectivity determined by the calculated secondary interaction energies represented the endo-selectivity for all the substituents. The reason for the slightly unsymmetrical ring closure at the transition state was discussed in terms of valence inactive electron densities of the reacting atoms.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1995.04b
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• pp.440-444
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• 1995

StereoLithography는 3차원 CAD로 작성된 모델데이타를 이용하여입체조형 실물을 빠르게 제작 하는 Rapid Prototype 기술의 한 방식으로서, 감광성 수지를 자외선 Laser 광에 의해 선택적으 로 경회시켜 원하는 한 단면형상을 이룬후 적층하는 반복작업에 의해 입체 형상을 조형하는 기법 이다. Rapid Prototype 시스템은 제품개발기간 단축과 설계완성도를 높이는 목적으로 최근 산업계에서 그 활용도가 점차 증가하는 추세에 있으며, 3차원 CAD 시스템과 함께 제품개발 체제를 통합화하고 Concurrent Engineering의 실현을 위한 주요한 Tool로써 자리를 잡아가고 있다.

• KSBB Journal
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• v.17 no.6
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• pp.543-548
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• 2002

The enantioselective esterification of racemic ibuprofen catalyzed by a Candida rugosa lipase was studied according to reaction conditions such as a lipase concentration, reaction temperature, alcohol chain length and alcohol concentration. The S-(+)-ibuprofen alkyl esters prepared were converted to S-(+)-ibuprofen by hydrolysis with sulfuric acid as a catalyst. High conversions in the esterifications were obtained at 60$^{\circ}C$ and an equimolar ratio of octanol to ibuprofen. The initial reaction rate of the esterification decreased with increasing octanol concentration. Conversion and initial reaction rate increased with increasing alcohol chain length. Values of enantiomeric excess(ee) according to esterification reaction conditions did not change below 60$^{\circ}C$. On the other hand, values of conversion and ee for the chemical hydrolysis of S-(+)-ibuprofen alkyl esters were independent of alcohol alkyl chain length. Optical resolution of racemic ibuprofen was achieved by lipase catalyzed esterification and chemical hydrolysis. The separation method provided a high yield and enantioselectivity for the production of S-(+)-ibuprofen from racemic ibuprofen.

• Applied Chemistry for Engineering
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• v.19 no.5
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• pp.491-496
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• 2008

The microsomal epoxide hydrolase gene (referred to as mMCEH) of Mugil cephalus was cloned by PCR, and then inserted to pColdI and pET-21b(+) vector, respectively. The recombinant E. coli possessing the recombinant plasmids exhibited the enantioperference toward (R)-styrene oxide. When enantioselective kinetic resolutions were conducted with 20 mM racemic styrene oxide, enantiopure (S)-styrene oxide was obtained with high enantiopurity more than 99% enantiomeric excess (ee) and 24.50% yield by using the recombinant E. coli harboring pET-21b(+)/mMCEH.

• Analytical Science and Technology
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• v.5 no.3
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• pp.239-247
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• 1992

The complexations and selectivities of the 10 species of mono- and dimethylsubstituted anilinium ions with 18-crown-6 in methanol are examined at dropping mercury electrode. The stability constants of these complexes varies drastically due to the steric hindrance by the positions and numbers of methyl groups. And the analyses of the isomeric mixtures of methylanilinium, which are impossible to detect due to the overlapped peaks in normal conditions, were also accomplished by the additions of 18-crown-6 as the supporting complexing agent using the selective complexations by the steric hindrance effects. As results in case of the difference of stability, ${\Delta}log\;K$ were about 0.7~1.3, it was possible to confirm the existence of two species qualitatively. Otherwise when ${\Delta}log\;K$ were large than 1.6, the quantitative determinations of each species could be accomplished sucessfully. From these results it is deduced that the selective recongnition of the positions and numbers of methyl groups as the steric hindrance in anililniums by 18-crown-6 cause the large variation of the magnitudes of negative shift of reduction waves for guest ions in mixtures.

• Applied Chemistry for Engineering
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• v.31 no.2
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• pp.187-192
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• 2020

(2S,3R)-3-hydroxyhomoserine lactone (HSL) has been used as a key intermediate for the synthesis of various biologically active compounds. In this study, we demonstrated an efficient synthesis of HSL via anti selective dihydroxylation of a protected vinyl glycine analog with an oxabicyclo[2.2.2]octyl orthoester (OBO) ester group. Because the acyclic conformation of the substrate was efficiently controlled by the bulky OBO ester group, a diastereoselectivity of > 10 : 1 was obtained in the dihydroxylation reaction without the use of a chiral reagent. By using this result, the target compound 1 can be obtained from commercially available N-Cbz-L-serine 2 in seven steps with an overall yeid of 34%. This result could be applied to the stereoselective synthesis of biologically active molecules containing a vicinal amino diol moiety.

• Journal of the Korean Chemical Society
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• v.46 no.4
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• pp.393-397
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• 2002

• Applied Chemistry for Engineering
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• v.25 no.4
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• pp.392-395
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• 2014

(2S,3S,4S)-3,4-Dihydroxyglutamic acid (DHGA), a biologically active ${\alpha},{\beta}$-dihydroxy-${\gamma}$-amino acid, was efficiently synthesized from a readily available D-serine derivative in 30% overall yield over 11 steps. The key stereoselective $OsO_4$-catalyzed dihydroxylation reaction controlled by an N-diphenylmethylene group on the amino group of ${\gamma}$-amino-${\alpha},{\beta}$-unsaturated (Z)-ester successfully introduced the diol moiety of the intermediate 5a in 86% with more than 10 : 1 diastereomeric ration. Then it was in turn successfully converted to the desired target compound, (2S,3S,4S)-3,4-DHGA, via simple oxidation and hydrolysis in a highly stereoselective manner and a higher yield than the previous syntheses. This result strongly supports that our synthetic methodology of stereoselective $OsO_4$-catalyzed dihydroxylation should be useful in stereoselctive synthesis of various bioactive compounds with an amino diol moiety.

• KSBB Journal
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• v.16 no.6
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• pp.562-567
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• 2001

Aspergillus niger LK harboring the enantioselective epoxide hydrolase (EHase) activity was isolated, and enantioselectivity of EHase was tested for various racemic aromatic epoxides. The gene encoding epoxide hydrolase was cloned from cDNA library generated by reverse transcriptase-polymerase chain reaction of the isolated total mRNA. Sequence analysis showed that the cloned gene encodes 398 amino acids with a deduced molecular mass of 44.5 kDa. Database comparison of the amino acid sequence reveals that it is similar to fungal EHase, whereas the sequence identity with bacterial EHase is very low. Recombinant expression of the cloned EHase in Escherichia coli BL21 yielded an active EHases, which can offer a potential biocatalyst for the production of chiral epoxides.

• 한국HCI학회:학술대회논문집
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• 2006.02a
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• pp.830-835
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• 2006

본 연구에서는 바둑을 응용하여, 모바일에서 가능한 6면체 게임으로 구현 하였다. 기존의 바둑과 같은 룰과 비슷한 내용의 게임으로서 모바일 버튼의 단순 조작만으로 가능한 게임이다. 게임에 사용되는 6면체 바둑판과 바둑돌들은 PHOSHOP을 이용하여 3차원 모양의 객체로 생성하였다. 프로그래밍은 SKT GENX기반으로 구현하였다. 기존의 바둑판은 가로 세로 교차된19줄이 평면에 그려져 있으나, 6면체 바둑판은 한 평면에 가로 세로 5줄이 주사위 모양의 6표면에 연결되어있다. 대국 시의 모바일 화면 인터페이스는 바둑판의 6면 중 3면을 동시에 보이는 입체도와 6면을 펼친 전개도가 있다. 입체도는 모바일 버튼 조작에 의해 6면을 상하좌우 회전이 가능하도록 하였다. 입체도와 전개도는 동시에 보는 것을 기본으로 하나 사용자 선택에 의해 두 그림의 크기 위치 등이 다양하게 가능하도록 제공하고 있다. 바둑돌의 착점방식은 모바일 버튼 조작에 의해 커서의 이동으로 가능하다. 게임은 네트워크를 이용한 사람과 사람이 가능하도록 약식으로 구현하였다. 게임의 내용은 6면의 입체적 상황을 고려하면서 작전을 세워야 하므로 기존의 평면바둑에 비해 좀더 고난도의 사고와 전략을 요구하는 게임이다. 그리고 6면체 바둑게임은 모바일 스크린환경에서 기존의19줄 평면바둑이 문제시 될 수 있는 가독성과, 한 게임에 사용되는 시간에 대해서 유리한 요인으로 실용화의 가능성을 제시하고자 한다.