• Proceedings of the Korea Society for Industrial Systems Conference
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• 2002.06a
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• pp.148-155
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• 2002

Multithreaded models improve the efficiency of parallel systems by combining inner parallelism, asynchronous data availability and the locality of von Neumann model. This model executes thread code which is generated by compiler and of which quality is given by the method of generation. But multithreaded models have the demerit that execution model is restricted to a specific platform. On the contrary, Java has the platform independency, so if we can translate from threads code to Java bytecode, we can use the advantages of multithreaded models in many platforms. Java executes Java bytecode which is intermediate language format for Java virtual machine. Java bytecode plays a role of an intermediate language in translator and Java virtual machine work as back-end in translator. But, Java bytecode which is translated from multithreaded models have the demerit that it is not secure. This paper, multhithread code whose feature of platform independent can execute in java virtual machine. We design and implement translator which translate from thread code of multithreaded code to Java bytecode and which check secure problems from Java bytecode.

• The Korean Journal of Nuclear Medicine Technology
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• v.18 no.1
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• pp.26-32
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• 2014

Purpose: As PET-MRI which has excellent soft tissue contrast is developed as integration system, many researches about clinical application are being conducted by comparing with existing display equipments. Because PET-MRI is actively used for head and neck cancer diagnosis in our hospital, lymph node metastasis before the patient's surgery was diagnosed and clinical usefulness of head and neck cancer PET-MRI scan was evaluated using pathological opinions and idiopathy surrounding tissue metastasis evaluation method. Materials and Methods: Targeting 100 head and neck cancer patients in SNUH from January to August in 2013. $^{18}F-FDG$ (5.18 MBq/kg) was intravenous injected and after 60 min of rest, torso (body TIM coil, Vibe-Dixon) and dedication (head-neck TIM coil, UTE, Dotarem injection) scans were conducted using $Bio-graph^{TM}$ mMR 3T (SIEMENS, Munich). Data were reorganized using iterative reconstruction and lymph node metastasis was read with Syngo.Via workstation. Subsequently, pathological observations and diagnosis before-and-after surgery were examined with integrated medical information system (EMR, best-care) in SNUH. Patient's diagnostic information was entered in each category of $2{\times}2$ decision matrix and was classified into true positive (TP), true negative (TN), false positive (FP) and false negative (FN). Based on these classified test results, sensitivity, specificity, accuracy, false negative and false positive rate were calculated. Results: In PET-MRI scan results of head and neck cancer patients, positive and negative cases of lymph node metastasis were 49 and 51 cases respectively and positive and negative lymph node metastasis through before-and-after surgery pathological results were 46 and 54 cases respectively. In both tests, TP which received positive lymph node metastasis were analyzed as 34 cases, FP which received positive lymph node metastasis in PET-MRI scan but received negative lymph node metastasis in pathological test were 4 cases, FN which received negative lymph node metastasis but received positive lymph node metastasis in pathological test was 1 case, and TN which received negative lymph node metastasis in both two tests were 50 cases. Based on these data, sensitivity in PET-MRI scan of head and neck cancer patient was identified to be 97.8%, specificity was 92.5%, accuracy was 95%, FN rate was 2.1% and FP rate was 7.00% respectively. Conclusion: PET-MRI which can apply the acquired functional information using high tissue contrast and various sequences was considered to be useful in determining the weapons before-and-after surgery in head and neck cancer diagnosis or in the evaluation of recurrence and remote detection of metastasis and uncertain idiopathy cervical lymph node metastasis. Additionally, clinical usefulness of PET-MRI through pathological test and integrated diagnosis and follow-up scan was considered to be sufficient as a standard diagnosis scan of head and neck cancer, and additional researches about the development of optimum MR sequence and clinical application are required.

• Journal of the Korean Society of Radiology
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• v.11 no.3
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• pp.109-115
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• 2017

The purpose of this study was to evaluate the clinical efficacy of 128 MDCT (multi-detector computed tomography) for reducing the CareDose 4D dose and comparing the image quality with the fixed tube current technique. For this purpose, we conducted the phantom and clinical studies to evaluate the exposure dose and image of the subject before and after applying the CareDose 4D system in abdominal examination using 128 MDCT. In the phantom study, ROI (Region of interest) was located at the center, 3, 6, 9, 12 o'clock, into two groups: group A without CareDose 4D and Group B applied were measured. In the clinical study, ROI was located at the liver 8 segments, divided into two groups too. The measured items were CT number, noise, and dose length product (DLP) dose. The result of CTDIvol (CT Dose Index volume) measurements in phantom and clinical studies were lower than those before CareDose 4D application, and dose and effective dose were also measured lower (p<.05). There was no difference in CT number before and after application (p>.05). In conclusion, using CareDose 4D, we can obtain optimal image information without deteriorating image quality while reducing patient dose.

• The Korean Journal of Nuclear Medicine Technology
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• v.16 no.1
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• pp.12-16
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• 2012

Purpose : In conventional PET image reconstruction, iterative reconstruction methods such as OSEM (Ordered Subsets Expectation Maximization) have now generally replaced traditional analytic methods such as filtered back-projection. This includes improvements in components of the system model geometry, fully 3D scatter and low noise randoms estimates. SharpIR algorithm is to improve PET image contrast to noise by incorporating information about the PET detector response into the 3D iterative reconstruction algorithm. The aim of this study is evaluation of SharpIR reconstruction method in PET/CT. Materials and Methods: For the measurement of detector response for the spatial resolution, a capillary tube was filled with FDG and scanned at varying distances from the iso-center (5, 10, 15, 20 cm). To measure image quality for contrast recovery, the NEMA IEC body phantom (Data Spectrum Corporation, Hillsborough, NC) with diameters of 1, 13, 17 and 22 for simulating hot and 28 and 37 mm for simulating cold lesions. A solution of 5.4 kBq/mL of $^{18}F$-FDG in water was used as a radioactive background obtaining a lesion of background ratio of 4.0. Images were reconstructed with VUE point HD and VUE point HD using SharpIR reconstruction algorithm. For the clinical evaluation, a whole body FDG scan acquired and to demonstrate contrast recovery, ROIs were drawn on a metabolic hot spot and also on a uniform region of the liver. Images were reconstructed with function of varying iteration number (1~10). Results: The result of increases axial distance from iso-center, full width at half maximum (FWHM) is also increasing in VUE point HD reconstruction image. Even showed an increasing distances constant FWHM. VUE point HD with SharpIR than VUE point HD showed improves contrast recovery in phantom and clinical study. Conclusion: By incorporating more information about the detector system response, the SharpIR algorithm improves the accuracy of underlying model used in VUE point HD. SharpIR algorithm improve spatial resolution for a line source in air, and improves contrast recovery at equivalent noise levels in phantoms and clinical studies. Therefore, SharpIR algorithm can be applied as through a longitudinal study will be useful in clinical.

• KIPS Transactions on Computer and Communication Systems
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• v.12 no.7
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• pp.227-234
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• 2023

Measuring heart rate variability by deep breathing and using this to evaluate the autonomic nervous system is a well-known method widely used in various clinical fields. In hospitals, expensive equipment is installed and managed by experts for this purpose. This paper discusses an app we developed that can easily test the autonomic nervous system by deep breathing anytime, anywhere using a smartphone, and then reviews experiments performed to verify the results. The experiments were conducted in the clinical room of the Department of Neurology at Soonchunhyang University Cheonan Hospital on eight volunteers. We tested the autonomic nervous systems of the volunteers first with an electromyography device installed in the hospital and then with the app under identical conditions. We performed a correlation analysis on the results of these two methods using the Pearson method, and this yielded a very high correlation of 0.98.

• Proceedings of the Korean Information Science Society Conference
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• 2011.06c
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• pp.180-183
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• 2011

본 논문에서는 진단 검사 의학 분야에서 통계적 지식이나 도구사용능력이 부족한 임상의학자들을 위해 개발된 통계적 데이터 분석 시스템을 소개한다. 개발된 시스템은 질병진단에 필요한 다중 바이오마커 데이터를 Luminex장비를 통하여 측정한 후, 분석이 용이한 형태로 변환하는 시각화 기술과 데이터에 내재된 패턴을 찾아내어 유용한 지식을 생성하는 데이터 마이닝 기술을 포함한다. 주요 모듈로는 마커선택, 데이터 시각화, 마커 평가 모듈로 구성되며 MATLAB을 기반으로 개발되었다.

• Korean Journal of Clinical Laboratory Science
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• v.51 no.4
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• pp.420-427
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• 2019

Scrub typhus is a fever-related disease that is commonly diagnosed during the autumn season. The number of patients affected by this disease continues to increase every year. However, the cause of the disease and the regional differences of its incidence are poorly understood. This study examined the epidemiological features and regional differences in the incidence of scrub typhus. The monthly incidence of cases from all reports rose to more than 90% during the fall season (October~December). Based on the analysis of the 18,851 cases in the epidemiological investigation, 14,777 (78.4%) and 4,074 (21.6%) cases occurred in high and low occurrence areas, respectively. Moreover, there were more female cases than male cases (males: 7,233 [38.4%]; females: 11,618 [61.6%]; P< 0.001). The clinical symptoms, including fever, chills, myalgia, and eschar of the body, were noted in 16,688 (89.1%), 11,533 (61.2%),11,439 (60.7%), and 6,005 (45.4%) cases, respectively. The incidence rates were higher for Gyeongnam, Jeonam, Jeonbuk, and Chungnam provinces. The areas with a high occurrence of scrub typhus were consistent with the areas experiencing a high distribution of Leptotrombidium scutellare. The incidence of scrub typhus has been rising owing to the increasing population of ticks due to global warming and increased agricultural and outdoor activities. Thus, continuous management of patients and preventive environmental measures are needed to control this disease.

• Science of Emotion and Sensibility
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• v.6 no.3
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• pp.55-62
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• 2003

Patients with schizophrenia have thinking disorders such as delusion or hallucination, because they have a deficit in the ability which to systematize and integrate information. therefore, they cannot integrate or systematize visual, auditory and tactile stimuli. In this study, we suggest a virtual reality system for the assessment of cognitive ability of schizophrenia patients, based on the brain multimodal integration model. The virtual reality system provides multimodal stimuli, such as visual and auditory stimuli, to the patient, and can evaluate the patient's multimodal integration and working memory integration abilities by making the patient interpret and react to multimodal stimuli, which must be remembered for a given period of time. the clinical study showed that the virtual reality program developed is comparable to those of the WCST and the SPM.

• Proceedings of the Korea Information Processing Society Conference
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• 2007.05a
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• pp.1487-1490
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• 2007

디지털 위성방송의 시작과 더불어 본격적인 데이터 방송의 시대가 열렸다. 데이터방송이 시작 되면서 데이터방송용 양방향 콘텐츠에 대한 수요가 급속하게 증가하고 있다. 하지만 양방향 콘텐츠 개발에 필요한 저작 도구 및 검증 시스템은 아주 초보적인 수준에 머물러 있는 것이 현실이다. 그러나 방송의 특성상 콘텐츠 상에서의 오류는 방송 사고에까지 이를 수 있는 심각한 상황이 연출 될 수 있다. 본 연구 팀은 이러한 DTV 콘텐츠 개발 요구에 부응하여, 개발자의 콘텐츠 개발 및 사업자 또는 기관에서의 콘텐츠 검증이 원활이 이루어 질수 있도록 하는 양방향 콘텐츠 검증 시스템을 개발 중이다. 양방향 콘텐츠 검증 시스템은 Java 컴파일러, 디버거, 미들웨어, 가상머신, 그리고 IDE 등으로 구성된다. 본 논문에서 제시한 자바 컴파일러는 양방향 콘텐츠 검증 시스템에서 데이터 방송용 자바 애플리케이션(Xlet)을 컴파일하여 에뮬레이팅 하거나 런타임 상에서 디버깅이 가능하도록 하는 바이너리형태의 class 파일을 생성한다. 이를 위해 Java 컴파일러는 *.java 파일을 입력으로 받아 어휘 분석과 구문 분석 과정을 거친 후 SDT(syntax-directed translation)에 의해 AST(Abstract Syntax Tree)를 생성한다. 클래스링커는 생성된 AST를 탐색하여 동적으로 로딩 되는 파일들을 연결하여 AST를 확장한다. 의미 분석과정에서는 확장된 AST를 입력으로 받아 참조된 명칭의 사용이 타당한지 등을 검사하고 코드 생성이 용이하도록 AST를 변형하고 부가적인 정보를 삽입하여 ST(Semantic Tree)를 생성한다. 코드 생성 단계에서는 ST를 입력으로 받아 이미 정해 놓은 패턴에 맞추어 Bytecode를 출력한다.ovoids에서도 각각의 점들에 대한 선량을 측정하였다. SAS와 SSAS의 직장에 미치는 선량차이는 실제 임상에서의 관심 점들과 가장 가까운 25 mm(R2)와 30 mm(R3)거리에서 각각 8.0% 6.0%였고 SAS와 FWAS의 직장에 미치는 선량차이는 25 mm(R2) 와 30 mm(R3)거리에서 각각 25.0% 23.0%로 나타났다. SAS와 SSAS의 방광에 미치는 선량차이는 20 m(Bl)와 30 mm(B2)거리에서 각각 8.0% 3.0%였고 SAS와 FWAS의 방광에 미치는 선량차이는 20 mm(Bl)와 30 mm(B2)거리에서 각각 23.0%, 17.0%로 나타났다. SAS를 SSAS나 FWAS로 대체하였을 때 직장에 미치는 선량은 SSAS는 최대 8.0 %, FWAS는 최대 26.0 %까지 감소되고 방광에 미치는 선량은 SSAS는 최대 8.0 % FWAS는 최대 23.0%까지 감소됨을 알 수 있었고 FWAS가 SSAS 보다 차폐효과가 더 좋은 것으로 나타났으며 이 두 종류의 shielded applicator set는 부인암의 근접치료시 직장과 방광으로 가는 선량을 감소시켜 환자치료의 최적화를 이룰 수 있을 것으로 생각된다.)한 항균(抗菌) 효과(效果)를 나타내었다. 이상(以上)의 결과(結果)로 보아 선방활명음(仙方活命飮)의 항균(抗菌) 효능(效能)은 군약(君藥)인 대황(大黃)의 성분(成分) 중(中)의 하나인 stilbene 계열(系列)의 화합물(化合物)인 Rhapontigenin과 Rhaponticin의 작용(作用)에 의(依)한 것이며, 이는 한의학(韓醫學) 방제(方劑) 원리(原理)인 군신좌사(君臣佐使) 이론(理論)에서 군약(君藥)이 주증(主症)에 주(主)로 작용(作用)하는 약물(藥物)이라는 것을 밝혀주는 것이라고

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.11 no.1
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• pp.91-99
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• 2000

Objectives：Present study developed the computerized ADHD Diagnostic System(ADS) in order to diagnose ADHD and evaluate treatment effect of it, and conducted a standardization study for ADS. Methods：The normative group was composed of 847 children and adolescents between the age of 5 and 15(boy 429, girl 418) living in the areas of Seoul, Kyunggi-do, and Kangwon-do. 30 ADHD children with age ranged 7 to 9 years were participated present study to evaluate the validity of ADS. To establish the norms for diagnosing ADHD, the means and standard deviations of normative group were used to calculate T-scores for each age group. Results：The reliability coefficient of ADS(Cronbach's ${\alpha}$) was .85. There were significant differences in the measures of ADS except commission error between the normal and the ADHD groups. Three factors were extracted through factor analysis of ADS, which were labelled 'inattention', 'slow information processing' and 'impulsivity'. Discriminant analysis showed that ADS significantly discriminate the normal and the ADHD groups. Percentage of correct classification by ADS variables was 96.7%. Conclusion：These results put together strongly support the reliability and validity of ADS as a diagnostic instrument for ADHD.