• Journal of the korean academy of Pediatric Dentistry
• /
• v.40 no.3
• /
• pp.203-208
• /
• 2013

Although the first case of supernumerary teeth had been documented almost 20 centuries ago, the etiology of supernumerary teeth still remains unclear. The prevalence of supernumerary teeth in the general Asian population is between 2.7% and 3.4%. The pathogenesis of supernumerary teeth has been attributed to phylogenetic reversion(atavism), splitting of the tooth bud(dichotomy theory), locally induced hyperactivity of the dental lamina and a combination of genetic and environmental factors(unified etiologic explanation). This report describes 3 cases of monozygotic twins with mesiodens who visited the pediatric dental clinic of Kyungpook national university hospital, and this is significant to support genetic factors involoved in the development of supernumerary teeth.

• The Korean Journal of Zoology
• /
• v.5 no.2
• /
• pp.5-8
• /
• 1962

한국내 수개 도시에 있는 산원에서 자료를 얻을 수 있던 15,830의 생아 및 사산의 기록을 가지고 사산의 기록을 가지고 사산율 및 쌍생아산율을 고찰하였다. 사산율은 3.525%로 일어나고 있으며 모친의 연령이 36세 이상에서는 평균 사산율보다 약 2 배에 가까운 고율을 보여주고 있다. 사산아의 성비는 생아출산의 성비보다 훨씬 높아 136.06 이었다. 산원에서의 쌍생아산도 일반쌍생아산에 비해 더 빈번히 일어나고 있다. 즉 한국인 집단의 평균 쌍생아산의 율이 0.872인데 대하여 산원에서는 1.299%를 보여주고 있다. 모친의 연령이 증가하여 감에 따라 쌍생아산의 율이 상승하는 경향은 산원의경우에서 관찰할 수있었다. 쌍생아의 성조성에 따른 비율은 대체로 일반 집단에서나 산원의 것에서나 비슷하여, 1.49 남남 ; 1.09여여 이 었다. 이는 일본의 2 : 1 : 2 나 구주인계의 0.9 ; 1 : 0.9 의 중간의 비율을 나타내고 있다. 이란성 상생아에 대한 일란성쌍생아의 비율은 산원에서 0.79 : 1 일반 집단에서 0.75 : 1 이었다. 이 율도 결국 일본의 1.5 ; 1 . 구주인계의 0.5 : 1 의 거의 중간을 나타내고있는 것이다.

• Clinical and Experimental Pediatrics
• /
• v.50 no.2
• /
• pp.182-189
• /
• 2007

Purpose : The primary purpose of this study was to evaluate the growth and neuropsychologic function following treatments for pediatric hematologic and oncologic diseases. Healthy monozygotic twins served as ideal controls for comparison to exclude possible confounding factors. Methods : Seven children treated with various hematologic and oncologic diseases were included in the study: acute lymphoblastic leukemia (ALL; n=2), Diamond-Blackfan anemia twins (n=2), and aplastic anemia (n=3). The median age at the diagnosis was 5.2 (0.3-15) years. The median duration of follow-up was 7.2 (4.9-10) years. Controls were healthy monozygotic twins. Growth was measured and the percentile channels were evaluated sequentially for patients. The K-WISC III was applied and compared in 5 pairs of patients and controls. Results : Similar growth profiles were noted for the twins. The percentiles at diagnosis was 3-10 in 3, 25-50 in 2, and 50-75 in 2 cases. All patients stayed in their growth percentiles through follow-up, except for 1 patient who became obese. For IQ tests, the mean behavioral, verbal and full scale IQ scores of patients were 88.0, 93.8, and 89.8, respectively, and those from their corresponding controls were 92.2, 97.0, and 91.7 (P>0.05). However, 2 children who were treated for ALL had lower IQ scores. Conclusion : Similar growth profiles were observed in the monozygotic twins in terms of height and weight. The IQ scores of patients were similar to those of monozygotic twins. However, prophylactic CNS-directed therapy for leukemia might adversely affect the IQ scores. A further prospective study on larger number of twins is warranted.

• 한국과학교육학회:학술대회논문집
• /
• 2008.01a
• /
• pp.130.3-130.3
• /
• 2008

• Clinical and Experimental Pediatrics
• /
• v.45 no.10
• /
• pp.1284-1288
• /
• 2002

Hyperekplexia or startle disease is a hereditary neurological disorder characterized by an abnormally exaggerated startle response to tactile, auditory and visual stimuli, together with a global muscular hypertonia and hyperactive tendon reflexes. This disease is a rare, genetically determined disorder, with an autosomal dominant inheritance with variable expression, first described by Suhren, et al. We report two cases of familial hyperekplexia, who developed hypertonia and pathologic startle response to tactile stimulation in the immediate neonatal period. The infant showed a marked improvement of the startle response and muscular hypertonia with low-dose clobazam.

• The Journal of Internal Korean Medicine
• /
• v.39 no.4
• /
• pp.772-783
• /
• 2018

The aims of this study were to use the Rydoraku test, electrogastrography, and enterotachography to examine the presence of familial gastric dysmotility among monozygotic twins and their mothers; to determine the relationship between the symptoms and the indexes of the Rydoraku test, electrogastrography, and enterotachography; and to observe the therapeutic reaction for each differential treatment between twins with familial gastric dysmotility. The same herbal medication (Banhasasim-tang extract three times/day and Sojuckkunbi-tang extract three times/day) was given to each twin, but the younger twin also underwent manual acupuncture on the CV 10, 12, and 13 points of the abdominal wall and electrical stimulation of both ST 36 points of the lower leg 2-3 times per week. Evaluation of the therapeutic effect was followed after six weeks. The presence of familial gastric dysmotility was shown in the autonomic nerve system and gastric muscle and was thought to be a common pathophysiology induced by genetic co-ownership. Only the younger twin showed any marked relief of the dyspeptic symptoms associated with improvement of pyloric sphincter function, which was induced by acupuncture treatment. The Rydoraku test, electrogastrography, and enterotachography results showed the presence of familial gastric dysmotility. Although Korean traditional medicine had no effect on the familiar gastric dysmotility associated with genetic influences, the acupuncture treatment had a beneficial effect on the secondary disorder of pyloric sphincter function, which is associated with the relief of dyspeptic symptoms.