• Korean Journal of Psychosomatic Medicine
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• v.24 no.1
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• pp.94-101
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• 2016

Objectives : Anemia is a common problem in the management of elderly patients. Recent studies reported that anemia was associated with cognitive impairment and Alzheimer's disease. This study was aimed to analyze the differences of hemoglobin levels in Korean patients with Alzheimer's disease(AD) dementia, mild cognitive impairment(MCI), and healthy controls. Furthermore, the study also examined if any association between hemoglobin levels and cognitive functions existed. Methods : A total of 116 Korean elderly adults were participated in this study(mean age 74.67 years ; 60.3% female). The Korean version of the Mini-Mental State Examination(MMSE-K), Clinical Dementia Rating(CDR) and Global Deterioration Scale(GDS) were applied to all subjects. Hematological and related blood chemistry values were investigated. Results : We found that patients with AD dementia had significantly lower hemoglobin and hematocrit levels than MCI subjects and healthy control group. The hemoglobin levels showed a positive correlation with MMSE-K and negative correlation with CDR, GDS. Conclusions : Among Korean elderly, low hemoglobin level is associated with a cognitive impairment. This study indicates that AD is associated with anemia, and low hemoglobin levels may contribute to potentially useful clinical markers of AD. The risk factor for dementia needs to be confirmed by prospective longitudinal studies in a larger group of patients.

• Korean Journal of Food Science and Technology
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• v.53 no.6
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• pp.715-721
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• 2021

Cognitive impairment and Alzheimer's disease are serious social problems associated with the rising elderly population in Korea. 1,2,3,4,6-Penta-O-galloyl-β-ᴅ-glucopyranose (PGG) is a gallotannin isolated from medicinal plants such as Rhus chinensis. This study was performed to evaluate the effect of PGG on biomarkers related to cognitive function in human neuroblastoma SK-N-SH cells. Inhibition of acetylcholinesterase (AChE) activity is considered to be one of the main therapeutic strategies. PGG inhibited AChE activity in the test tube as well as in SK-N-SH cells. In addition, PGG induced protein and mRNA expression of brain-derived neurotrophic factor (BDNF), which is a mammalian neurotrophin that plays major roles in the development, maintenance, repair, and survival of neuronal populations. As one of the underlying molecular mechanisms that induce BDNF expression, PGG induced the activation of Ca²⁺/calmodulin (CaM)-dependent protein kinase II (CaMKII)-cAMP response element binding protein (CREB) pathway. In conclusion, PGG may be an useful material for improving cognitive function.

• 한국노년학
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• v.36 no.3
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• pp.633-648
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• 2016

This study focuses on the sleep pattern of the elderly people living in the community and its relationship to the occurrences of the depression and deterioration of the cognitive function. Our primary data is the raw data gathered by the Korean Ministry of Health and Welfare in 2008 in the National Senior Living Conditions and Well-being Needs Assessment Survey. The survey contained data from 12,087 people over 65 years of age living in the community. We have used the secondary data analysis method on this raw data to see if there exists correlation between age, gender, soundness of the sleep, total sleep time and the depression and the cognitive difficulties. Our study finds that the older a person is, the more trouble she has in sleeping. It also shows that too much sleep (in excess of 9 hours) and too little sleep (less than 6 hours) can both be linked to more occurrence of depression. Lack of restful sleep could also be linked to more frequent occurrence of depression and cognitive difficulties. Changes in the sleep pattern is not always pathological in elderly people. However, our study shows that it is important the primary health-care givers understand the role of sleep in elderly person's daily life. They should examine the elderly person's sleep pattern focusing on the quantity and the quality of sleep and develop programs suited for individuals to prevent and intervene sleep disorder.

• 재활복지
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• v.21 no.2
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• pp.247-259
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• 2017

We investigated the improvement of cognitive functions, activity of daily living (ADL), and quality of life (QoL) after hemorrhagic stroke and identified associated factors. For this research, twenty-five patients with a hemorrhagic stroke were enrolled. We measured cognitive function, activity of daily living (ADL), and quality of life (QoL) from 7 days to 12 months after onset of stroke. Then we analyzed the correlation between cognitive function and other risk factors. According to results, cognitive functions improved during 12 months with statistically significant differences. Other functions were similar to cognitive functions. Improvement of cognitive functions were correlated with age, the type of hemorrhagic stroke and Glasgow coma scale at 7 days after stroke. Overall, cognitive function in patients with hemorrhagic stroke recovered from acute to 12 months after onset of stroke. And, improvement of cognitive function at this phase were associated with age, the type of hemorrhagic stroke and GCS score at 7 days. These results would provide us an information to plan cognitive rehabilitation in patients with hemorrhagic stroke.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.12
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• pp.584-591
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• 2018

This study was conducted to determine the levels of cognitive impairment (MMSE-K) among centenarians, and to reveal their association with related variables. The study subjects were 268 centenarians who received medical check-ups from the National Health Insurance Corporation during the period of 2016-2017. The levels of cognitive impairment were significantly reduced among females as well as those living with spouses and children, lower monthly income, lower BMI and individuals who engaged in smoking and alcohol consumption without regular exercise relative to their respective counterparts. The risk of definitive cognitive impairment in study subjects was significantly higher among women (ORs=9.85, 95% CI=2.88-33.59) than men and was lower in obese group (ORs=0.25, 95% CI=0.07-0.86) than in low weight groups, as well as in non-smoking (ORs=0.30, 95% CI=0.10-0.83) than smoking groups. The factors influencing the cognitive impairment of study subjects were sex, living status, monthly income, BMI and smoking status. Taken together, these results suggest that the levels of cognitive impairments among centenarians differed significantly in response to socio-demographic characteristics and health related variables. Especially, the levels of cognitive impairments decreased among those with poor health related variables such as smoking, alcohol consumption and regular exercise.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.46 no.6
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• pp.19-25
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• 2009

The performance of a cognitive radio system with cooperative diversity which includes the direct and indirect path is analysed. The selection relay cooperation which selects the best relay, the relay with the best received signal-to-noise ratio(SNR) in destination node, is considered and derived the performance degradation caused by the CSI(Channel State Information) delay analytically. Numerical examples show that the cooperative diversity which have the direct and the indirect paths effectively improves the system performance in Rayleigh fading; the performance improves 4.4 dB with 1/10 of SNR of the indirect path. And the system performance is more degraded with the less frequency acquisition probability and with the high CSI delay.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.11C
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• pp.1095-1101
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• 2007

For the cognitive radio (CR) systems sharing the spectrum with narrowband primary devices, this paper presents a fractional bandwidth (FBW) mode utilizing a variable portion of the system band to avoid the interference to or from the primary devices. For the method, the preamble and FBW mode detection algorithm are provided to obtain the FBW mode information during the synchronization. Simulation results in wireless regional area network (WRAN) environments reveal that the FBW mode can be detected reliably without any deterioration of the synchronization performance.

• Journal of the Korea Computer Graphics Society
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• v.20 no.4
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• pp.1-7
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• 2014

The volume rendering has become an important technique in many applications along with hardware development. Understanding and perception of volume visualization benefit from visual cues which are available from shading. Better visual cues can be obtained from global illumination models but it's huge amount of computation and extra GPU memory need cause a lack of interactivity. In this paper, in order to improve visual cues on volume rendering, we propose an image space occlusion shading model which requires no additional resources.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2013.10a
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• pp.206-208
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• 2013

The fact that the gigantic and luxurious cruise, Titanic, sank into the cold winter sea causing 1,490 casualties in 1912 resulted in discussing safety of life at sea international and Korea has adopted and operated the GMDSS to keep up with those international endeavors to decrease the number of tragic accidents at sea, However, all GMDSS equipment is making a monotonous beep sound when receiving a distress, emergency, safety and even general message so that it might contribute to lowering ship operators' cognitive abilities as well as being dull of safety precautions. So, I'd like to render great services for saving even one person by considering developing an automatic audio alarm device which allows people to respond in a prompt manner as soon as they hear an audion alarm such as a shipwreck.

• Journal of The Korean Society of Integrative Medicine
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• v.4 no.3
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• pp.49-59
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• 2016

Purpose : The study was aimed to evaluate the improvement of cognitive and hand functions after the application of a complex rehabilitation intervention program on patients with mild cognitive impairment (MCI) and dementia who were living a regional community from. Methods : Subjects who were living in a regional sanatorium or who were outpatients of a community health center were enrolled from 2012. 2 to 2013.2 All subjects were enforced 8 cycles of a complex rehabilitation intervention program including RON dance, physical activity using therabands, reality awareness training, space retrieval training and handicraft activities. Results : There were significant improvement in LOTCA-G cognitive function and JTHFT hand function test after the application of a complex rehabilitation intervention program. Conclusion : The result shows a significant improvement in cognitive and hand functions after the application of a complex rehabilitation intervention program in patients with MCI and dementia. Therefore the authors suggest the vast studies of the cognitive function program development and hand function vitalization by the application of a complex rehabilitation intervention program.