• Korean Journal of Psychosomatic Medicine
• /
• v.22 no.1
• /
• pp.40-45
• /
• 2014

Objectives : Mild cognitive impairment(MCI) and dementia of Alzheimer's type(AD) are characterized by progressive decline of cognitive abilities and a wide range of neuropsychiatric symptoms like depression. Among various diagnostic tools of AD, many studies showed that elevated levels of serum total homocysteine are associated with increased risk of developing Alzheimer's disease, depression and other neuropsychiatric disorders. We investigated whether elevated homocysteine concentrations are associated with depressive symptoms in MCI and AD. Methods : A total of 86 patients diagnosed with MCI or AD participated. Total serum homocysteine levels in fasting blood samples were measured. We examined cognitive symptoms by MMSE-KC, Global Deterioration Scale(GDS), Clinical dementia rating(CDR) and depressive symptoms by Korean version of Geriatric Depression Scale(K-GDS). Results : The total serum homocysteine levels were significantly higher in MCI with depression than in MCI without depression. There was no significant difference in the mean homocysteine levels between AD patients with depression and AD patients without depression. The total homocysteine levels showed a negative correlation with MMSE-KC and a positive correlation with CDR, GDS. Conclusions : These findings suggest that elevated homocysteine level is a risk factor for the decline of cognitive function and depression. We found a significant relationship between elevated serum homocysteine level and depressive symptoms in MCI. But our study had several limitations, thus more research is needed to confirm this finding.

• Journal of the Institute of Electronics Engineers of Korea SP
• /
• v.49 no.1
• /
• pp.88-96
• /
• 2012

According to development of technology for media, observers try to watch the realities from images, as follows, 3D imaging has been extremely developed. 3D image gives depth in the image, observers feel in nature. Different image perception from left and right eyes make the 3D image. Anaglyph which is one of the ways to make an image of three dimensions is for obtaining an image of three dimensions by using color filter glasses. Anaglyph has a little amount of calculation and is easy to make, and it has a good point that anaglyph can be used in more wide field because it can create an image of three dimensions to the output of print like printed matter. However, the phenomenon of retinal rivalry can cause a feeling of fatigue because a difference of brightness of the left image and the right image happen. The way to reduce this problem is made by cutting down a difference of brightness. In the result, retinal rivalry can be reduced. We reduced a difference of the brightness of the left and the right image by utilizing the brightness and average of the original image to reduce retinal rivalry and we made better colors of anaglyph by using the way that we keep the hue caused by a change of brightness and supplement saturation about color distortion which is created at that time.

• Journal of Genetic Medicine
• /
• v.7 no.1
• /
• pp.45-52
• /
• 2010

Purpose: The objectives were to examine following 2 questions related to cognitive profile for the children with Williams syndrome (WS); 1) Is there a significant advantage for verbal IQ over performance IQ in WS?; 2) Is there selective impairment in visuospatial ability in the children with WS? Materials and Methods: Five children with WS with the age of $90.86{\pm}20.73$ months were compared with 12 children with Prader-Willi syndrome (PWS) or Down syndrome (DS) with comparable age and IQ. Results: All 5 children with WS showed intellectual disability whose mean scaled scores were $15.71{\pm}9.27$ in verbal subtests and $14.29{\pm}7.50$ in performance subtests, which did not show significant difference. There was no significant difference in the total sum of scaled scores of verbal subtests among WS, PWS and DS. There was no selective impairment in subtests which represented visuospatial tasks for the children with WS. However, the scaled score of object assembly was significantly lower in WS ($2.29{\pm}0.95$) compared to that of PWS ($4.75{\pm}2.77$; P <0.05). Conclusion: The general notion that the children with WS would be relatively strong in verbal function when compared with their overall cognitive function was not observed in this study. The verbal function of the children with WS was not better when compared to the children with DS or PWS. There was no selective impairment of visuospatial function in the children with WS at this age. However, the visuospatial function was significantly low in the children with WS only when compared to the children with PWS.

• Journal of Nutrition and Health
• /
• v.54 no.2
• /
• pp.139-151
• /
• 2021

Purpose: This study examines the correlation between fish consumption and the risk of mild cognitive impairment in the elderly living in rural areas. Methods: The Yangpyeong cohort data collected from Yangpyeong in July 2009 and August 2010 was used as the data set. Adults greater than or equal to 60 years who have completed the Korean version of the Mini-Mental State Examination (MMSE-KC) were selected for the study. After excluding participants with less than 500 kcal of energy intake (n = 2), a total of 806 adults were enrolled as the final subjects. Cognitive function was assessed using the MMSE-KC, and dietary intake was collected using the quantitative food frequency questionnaire comprising 106 foods or food groups. Results: The educational level, proportion of people who exercise, fruits and vegetable intake, and energy intake, tended to increase with fish intake among men, while increasing age resulted in decreased fish consumption. Among women, the educational level, proportion of subjects who exercise, proportion of subjects currently taking dietary supplements, fruits and vegetable intake, and energy intake, tended to increase with fish consumption, whereas increasing age showed decreasing fish consumption. Increased fish intake resulted in a higher MMSE-KC score after adjusting for the confounding variables in women (p for trend = 0.016), but no significant trend was observed between fish intake and MMSE-KC score in men. Fish intake was inversely related to the risk of mild cognitive impairment after adjusting for covariates in women (Q1 vs. Q4; odds ratio, 0.46 [0.23-0.90]; p for trend = 0.009). Conclusion: This study determined that increased fish consumption is correlated with reduced risk of mild cognitive impairment in the female elderly. Further longitudinal studies with larger samples are required to determine a causal relationship between fish intake and cognitive function.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.35 no.4
• /
• pp.402-409
• /
• 2006

This study was performed to investigate the effects of Capsosiphon fulvescens (CF) extract on serum and liver lipid metabolism in rats. Male Sprague-Dawley rats were administered 1% cholesterol and 0.25% sodium cholate to induce hypercholesterolemia and were divided into six groups. Experimental groups were administered with following diets; normal diet group (NC), high cholesterol diet group (HC), normal diet and CF extract (200 mg/kg) administered group (NC-CFL), normal diet and CF extract (400 mg/kg) administered group (NC-CFH), high cholesterol diet and CF extract (200 mg/kg) adwlinistered group (HC-CFL), and high cholesterol diet and CF extract (400 mg/kg) administered group (HC-CFH). The body weight gain and feed efficiency ratio were increased by high cholesterol diet, but gradually decreased to the corresponding level of the normal diet group by administered CF extract. The serum total cholesterol concentration of normal diet group was significantly higher than those of NC-CFL group and NC-CFH group. The concentrations of serum total cholesterol LDL-cholesterol and triglyceride and the atherogenic index .were tended to decrease in the CF extract administered groups compared with the high cholesterol diet group. However, HDL-cholesterol and phospholipid concentrations in serum decreased in the high cholesterol diet group and markedly increased by the CF extract administered groups. There were no differences in the concentrations of serum triglyceride, phopholipid, LDL-cholesterol, HDL-cholesterol and free cholesterol in normal diet groups. Concentrations of total cholesterol and triglyceride in liver and kidney were also markedly decreased in the CF administered groups. Total cholesterol and triglyceride concentrations of adipose tissue in the CF administered groups were also decreased compared with the high cholesterol diet group. In addition, there were no differences in the concentrations of liver, kidney and adipose tissue total lipid, triglyceride and total cholesterol in normal diet groups. The activities of heparin-releasable lipoprotein lipase (LPL) and total-extractable LPL in adipose tissue were increased in the high cholesterol diet group compared with the CF extract administered groups, but those of the NC -CFL group and NC-CFH group were similar to the normal diet group. Taken together, it is suggested that the extract of CF have an antiatherosclerotic effect by reducing cholesterol level of serum and liver. Furthermore, the extract of CF decreased LPL activity and triglyceride concentration, resulting in less lipid storage.

• Journal of Korean Public Health Nursing
• /
• v.26 no.3
• /
• pp.404-416
• /
• 2012

Purpose: The purpose of this study was to explore relationships among cognition, activities of daily living, and depression in persons with decreased memory. Method: Data were collected from 121 out-patients with decreased memory and analysis was performed using descriptive statistics, t-test, ANOVA, Bonferroni test, and Pearson's correlation coefficients with the SPSS/WIN 18.0 program. Result: K-MMSE was significantly increased by BADL (r=.40, p<.001), whereas K-MMSE was significantly decreased by K-IADL (r=-.51, p<.001) and K-IADL significantly decreased by BADL (r=-.51, p<.001). Conclusion: The K-MMSE of persons with decreased memory showed association with BADL and K-IADL. Management of patients complaining of decreased memory and development of nursing interventions will slow down the progression of cognitive impairment.

• Proceedings of the Acoustical Society of Korea Conference
• /
• 1998.06e
• /
• pp.428-431
• /
• 1998

화자 인식의 방법에서 사용되고 있는 특징 파라미터들은 음성 인식에서 사용되고 있는 특징 파라미터를 그대로 사용하고 있다. 따라서, 이를 화자 인식에 적용할 때 화자의 특성을 효과적으로 반영할 수 있어야 한다. 일반적인 화자의 특징이 고주파수 위주로 분포되어 있기 때문에 전체 스펙트럼의 고주파 영역을 강조시킬 수 있고, 또한 인간의 청각특성이 공진 주파수에 기반하여 이루어진다는 사실에 기반을 두어서 공진 주파수 위주로 강조시키는 인지 가중 필터를 인식단의 전처리로 사용하는 방법에 관한 것이다. 본 논문을 실험한 결과 전체 인식율에서는 기존의 방법보다 3.89%까지 인식율의 향상을 얻을 수 있었다. 또한 사칭자 수리율은 2.5%의 저하를 얻을 수 있었다.

• Proceedings of the Korean Society for Cognitive Science Conference
• /
• 2000.06a
• /
• pp.368-375
• /
• 2000

품사 태깅 시스템은 자연 언어 처리의 가장 기본이 되는 부분으로 상위 자연 언어 처리 분야인 구문분석, 의미분석의 전처리로 사용되거나, 기계번역, 정보검색이나 음성인식 및 합성등과 같은 많은 응용 시스템을 위해서도 필요하다. 이렇게 여러 가지 목적을 위해 품사 태깅 시스템은 존재하는데, 각각의 응용을 위해서 최적화된 태깅 시스템을 따로 구성하기도 하고, 하나의 태깅 시스템을 여러 가지 응용을 위해서 사용하기도 한다. 이때, 문제가 되는 것 중에 하나는 각 응용마다 요구하는 품사 태그 세트가 다르다는 것이다. 품사 태그세트가 고정되어 있다면 어떤 응용을 위해서는 사용되는 품사 태그세트가 너무 적어서 문제가 되고, 반대로 품사태그세트가 너무 많아서 시스템의 수행속도가 중요시되는 응용에서 성능저하의 요인이 되기도 한다. 본 논문에서는 하나의 태깅 시스템의 품사태그세트를 조절할 수 있도록 하여 몇 가지 응용시스템에 맞게 최적화 시킬 수 있는 방법론을 제시하고 실험을 통해서 시스템의 성능, 유지보수 및 시스템의 여러 리소스 관리 측면에서도 가장 효율적인 방법론임을 입증하고자 한다.

• Proceedings of the Korean Society for Cognitive Science Conference
• /
• 2000.06a
• /
• pp.26-30
• /
• 2000

문서를 대표하는 단어를 추출하는 색인어 추출은 정보검색 시스템의 질을 좌우한다. 대부분의 색인어 추출 시스템은 명사를 추출하고 있으며, 가능한 모든 명사를 추출하고 있다. 이러한 방법은 불필요한 단어가 그 문장을 대표하는 색인어로 추출될 가능성이 높으며, 이는 정보 검색 시스템의 효율을 저하시킨다. 이를 해결하기 위해 품사 태깅이나 구문 해석 단계 등을 통해 불필요한 후보를 제거할 수 있지만, 태거를 구축하거나 구문 해석을 위해서는 많은 비용과 시간이 필요하다. 본 논문에서는 구문 형태소 단위의 형태소 해석에 기반한 색인어 추출 방법을 제안한다. 구문 형태소는 통사적/의미적으로 강한 공기 관계를 가지면서 문장에서 하나의 통사적 단위나 자질의 단위로 표현되기 때문에 구문 형태소내에 포함된 단어열들은 대부분 색인어가 될 수 없다. 이러한 방법을 이용하여, 형태소 해석 결과를 이용한 색인어 추출에서 발생하는 색인 오류를 제거함으로써 색인기의 성능을 높이는 방법을 제안한다.

• Proceedings of the Korea Information Processing Society Conference
• /
• 2013.11a
• /
• pp.23-25
• /
• 2013

가상화는 이미 다양한 분야에 적용되어 컴퓨팅 효율성을 높이고 있으나 장치 가상화 과정의 빈번한 입출력으로 인한 성능 저하로 높은 장치 처리량을 요구하는 분야에는 적용이 어렵다. 이를 극복하기 위한 모델들이 제안되었으나 이전 모델들은 특별한 하드웨어를 요구하거나 불필요한 게스트 장치 처리 과정을 거치는 문제가 있다. 이에 본 논문에서는 특별한 하드웨어 환경을 요구하지 않는 소프트웨어적 기법을 제안하여 근본적인 모드전환 비용을 해결하였다. 또한 제안한 가상화 인지 소켓 모델의 프로토타입을 구현하여 성능 향상의 타당성을 입증하였다.