• Korean Journal of Psychosomatic Medicine
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• v.22 no.1
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• pp.40-45
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• 2014

Objectives : Mild cognitive impairment(MCI) and dementia of Alzheimer's type(AD) are characterized by progressive decline of cognitive abilities and a wide range of neuropsychiatric symptoms like depression. Among various diagnostic tools of AD, many studies showed that elevated levels of serum total homocysteine are associated with increased risk of developing Alzheimer's disease, depression and other neuropsychiatric disorders. We investigated whether elevated homocysteine concentrations are associated with depressive symptoms in MCI and AD. Methods : A total of 86 patients diagnosed with MCI or AD participated. Total serum homocysteine levels in fasting blood samples were measured. We examined cognitive symptoms by MMSE-KC, Global Deterioration Scale(GDS), Clinical dementia rating(CDR) and depressive symptoms by Korean version of Geriatric Depression Scale(K-GDS). Results : The total serum homocysteine levels were significantly higher in MCI with depression than in MCI without depression. There was no significant difference in the mean homocysteine levels between AD patients with depression and AD patients without depression. The total homocysteine levels showed a negative correlation with MMSE-KC and a positive correlation with CDR, GDS. Conclusions : These findings suggest that elevated homocysteine level is a risk factor for the decline of cognitive function and depression. We found a significant relationship between elevated serum homocysteine level and depressive symptoms in MCI. But our study had several limitations, thus more research is needed to confirm this finding.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.9 no.2
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• pp.165-173
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• 1998

Objectives：This study was conducted to compare the cognitive characteristics and visual-motor coordination ability of children with Asperger’s disorder and with those of children with PDD NOS. Methods：27 children(13 in AS group and 14 in PDD NOS group) were individually assessed using the K-WISC and BGT, and the results of those tests were analyzed. Results：The mean FSIQ of the AS group was significantly higher than that of the PDD NOS group. There was also a large discrepancy between VIQ and PIQ in the PDD NOS, while there was not significant discrepancy in the AS. The AS was distinguished from PDD NOS group by significantly higher scores in Vocabulary and Comprehension subscales and lower score in Block design. Also, when compared with the PDD NOS, the AS showed more difficulties in visual-motor coordination. Conclusion：The AS showed relatively good verbal and learning ability, while the PDD NOS relatively superior ability in visuospatial function and visual-motor coordination. The findings indicated that the K-WISC and BGT might be useful assessment tool to differentiate the AS from PDD NOS.

• Journal of Korea Entertainment Industry Association
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• v.14 no.8
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• pp.295-303
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• 2020

The purpose of this study was to find out whether the cognitive function, depression, and health promotion lifestyle changes are maintained or improved through the dementia prevention program when applying the dementia prevention program along with the daily life management program to the elderly with mild cognitive impairment. The study was conducted from April 1 to August 9, 2019, and 30 elderly people with mild cognitive impairment who participated in the dementia prevention program at the Dementia Safty Center in Seoul were studied. The study found that cognitive function (MMSE-DS) and health promotion lifestyle (HPLP-II) were maintained and improved compared to control groups in the experimental group that voluntarily implemented daily life management programs along with dementia prevention programs, and that depression (SF-GDS) decreased. Therefore, based on the results of this study, in future studies, we hope to develop a variety of voluntary daily life management programs to maintain and improve the effectiveness of the dementia prevention program for a long period of time. I hope that the prospective study will be done.

• Korean Journal of Psychosomatic Medicine
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• v.5 no.1
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• pp.89-96
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• 1997

This study was designed to determine whether cognitive impairment was evident in patients with SLE. Also, it aimed to examine the association of cognitive impairment with other clinical variables. The subjects consisted of 20 patients with mildly active SLE and 20 healthy controls. Methods : A total of 20 SLE patients and 20 normal controls completed a computerized neuropsychological test battery using Vienna Test System. These included Cognitrone test, Continuous attention test, Corsi block tapping test, Standard progressive matrices. Also, neuro-behavioral cognitive status examination was done. The symptom severity of depression was measured with Beck Depression Inventory, Hamilton Depression Rating Scale, and current medications were documented. Disease activity was rated using the SLE diasease activity index (SLEDAI). Results : SLE patients had poorer performance than normal controls on the tests of Cognitrone, attention, nonverbal IQ and memory, independent of age, education, disease activity, steroid use and depression status. Conclusion : Cognitive dysfunction was not uncommon in ambulatory SLE patients as measured by standardized neuropsychological tests. It seemed to occur independently of various clinical variables. These findings would suggest that cognitive dysfunction in SLE may be explained by reflecting subclinical central nervous system(CNS) involvement, rather than coexisting psychological distress due to chronic illness or side effect of medication.

• Journal of the Korea Convergence Society
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• v.12 no.2
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• pp.327-336
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• 2021

It is important to prevent progression of mild cognitive impairment (MCI) to Alzheimer's disease or other dementia. This study was conducted to investigate cognitive-based intervention and its effectiveness for the older patients with MCI through systematic review. Data search was conducted in September 2020, using the Korea Research Information Service (Riss) and KoreaMed. After selection of literatures according to the predefined inclusion criteria, a total of 12 articles were included. It is revealed that the cognitive-based intervention for the older adults with MCI was found to have a positive effect on the various factors including cognitive function, depression, physical health status, quality of life, and communication. However, it is difficult to draw a definite conclusion due to the various intervention strategies and instruments used. Thus, based on the results of this study, we suggest more studies to verify the effectiveness of such programs.

• The Journal of the Convergence on Culture Technology
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• v.9 no.2
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• pp.67-71
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• 2023

The purpose of this study is to investigate the effect of a community-based cognitive stimulation program on cognitive function and subjective memory in the elderly with mild cognitive impairment. This study was applied by selecting 15 users who understood the purpose of this study and agreed to participate in the shelter program for more than 3 months from April 2019 to August 2019 at the D Dementia Center in G located, Gyeonggi-do. The program consisted of a total of 36 cognitive stimulation programs 3 times a week a total of 3 months. Cognitive stimulation program stimulates cognitive function through various activities such as orientation reinforcement, cognitive training, recall, music, art, and physical play, and is used for the purpose of improving social function. It consists of folk songs, percussion instruments, national gymnastics, dance, games, and traditional games. As a result of the cognitive stimulation program, the average cognitive function increased by 2.13 points from 26.33 points before implementation to 28.46 points after implementation, and a statistically significant result was obtained (p=0.000). Subjective memory decreased by 3.53 points from the average of 7.13 points before the cognitive stimulation program was implemented to 3.60 points after the implementation, and a statistically significant result was obtained (p=0.000). It can be confirmed that this works. Dementia is leading to a cost burden, and congnitive function decreases the aqulity of life. It brings various burdens. It is necessary to study cognitive stimulation programs applied to various environments in the future.

• Proceedings of the Korean Society of Computer Information Conference
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• 2022.07a
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• pp.307-310
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• 2022

4차 산업혁명의 기술이 발전함에 따라 세계는 눈부시게 발전하고 있다. 그러나 그와 동시에 어르신들의 치매로 인한 사회적 비용의 증가로 발생하는 문제점 또한 무시하지 못할 수준에 이르렀다. 이에 조기에 치매를 선별하여 예방하는 것이 중요시되었으며 다양한 연구기관에서는 빠르고 쉽게 치매의 전 단계인 경도인지장애를 선별하고자 여러 선별 검사지를 제작하여 경도인지장애 선별을 통한 치매를 예방하는 데 노력하는 중이다. 하지만 다양한 상황으로 각각의 효율성이 경도인지장애 선별에 대한 기대에 미치지 못하고 있다. 그리하여 본 연구는 기존에 개발된 경도인지장애 선별지 들을 비교 분석 및 코로나 상황에 적합하게 비대면 방식으로 경도인지장애 선별이 가능하도록 보다 효율적으로 개선하였으며 이를 IoT 기기에 접목하였다. 또한 IoT 기기는 어르신들의 경도인지장애 선별검사에 대한 부담감을 줄이고자 친근한 인형 형태로 개발하였으며 상호작용을 위한 기능 제작을 통하여 마음 돌봄 서비스를 구현하였다.

• Tuberculosis and Respiratory Diseases
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• v.39 no.1
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• pp.7-14
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• 1992

Background: Cognitive deficit by hypoxia and/or hypercapnia is one of neuropsychological impairments frequently observed in patients with chronic obstructive pulmonary disease (COPD). The degree of cognitive deficit is variable among patients with similar level of hypoxia and/or hypercapnia, although a cause of this individual difference is well not known. COPD can be divided into two characteristic clinical entities including predominant emphysema and predominant bronchitis. This study was designed to evaluate the individual difference in cognitive deficit respond to hypoxia and/or hypercapnia in patients with COPD. Method: Sixteen patients with COPD (9 emphysema-dominant and 7 bronchitis-dominant) participated in this study. On admission arterial blood gas analysis and trail-making B (TMB) test for the evaluation of cognitive function were done in all patients. Mean TMB scores and the correlations between TMB scores and arterial blood gases were compared between two clinical groups. Results: 1) Mean TMB scores and arterial blood gases between two clinical groups were not different. 2) There was a tendency to be higher TMB score in hypoxemia, acidemia, and hypercapnia. However these findings were not statistically significant. 3) In emphysema-dominant group, $PaCO_2$ was mostly well correlated with TMB score (r=0.693). 4) In bronchitis-dominant group, arterial pH was mostly well correlated with TMB score (r=-0.526). Conclusion: Our data suggest that the individual difference in cognitive deficit respond to hypoxia and/or hypercapnia in patients with COPD may be dependent on their clinical entities, and arterial blood gases mostly well correlated with cognitive function that may be different according to their clinical entities.

• Journal of Korean Physical Therapy Science
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• v.1 no.2
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• pp.275-287
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• 1994

For the purpose of promotion mental health in the elderly lived small city, a personal interview was conducted for 150 elderlies aged 65 years or more in the Kyungpook Andong city between 29th of August and 9th of September, 1994. The major findings were as follows; 1. The variables related depression were chronic disease, level of physical ability, smoking habits(pack/day) and school education. 2. The variables related cognitive impairment were level of physical ability, age, sex and chronic disease. It was revealed by this study, the female elderlies who had beend not educated and had chronic disease were higher depression or cognitive impairment. so the prospective research with these variables is need.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.12
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• pp.584-591
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• 2018

This study was conducted to determine the levels of cognitive impairment (MMSE-K) among centenarians, and to reveal their association with related variables. The study subjects were 268 centenarians who received medical check-ups from the National Health Insurance Corporation during the period of 2016-2017. The levels of cognitive impairment were significantly reduced among females as well as those living with spouses and children, lower monthly income, lower BMI and individuals who engaged in smoking and alcohol consumption without regular exercise relative to their respective counterparts. The risk of definitive cognitive impairment in study subjects was significantly higher among women (ORs=9.85, 95% CI=2.88-33.59) than men and was lower in obese group (ORs=0.25, 95% CI=0.07-0.86) than in low weight groups, as well as in non-smoking (ORs=0.30, 95% CI=0.10-0.83) than smoking groups. The factors influencing the cognitive impairment of study subjects were sex, living status, monthly income, BMI and smoking status. Taken together, these results suggest that the levels of cognitive impairments among centenarians differed significantly in response to socio-demographic characteristics and health related variables. Especially, the levels of cognitive impairments decreased among those with poor health related variables such as smoking, alcohol consumption and regular exercise.