• Korean Journal of Bronchoesophagology
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• v.3 no.1
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• pp.27-36
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• 1997

초기후두암에 있어서 보존적 술식의 장점은 후두 전적출술시와 같은 국소치료효과를 얻을 수 있으면서도 후두의 생리적 기능을 최대한 보존하는데 있다. 성공적인 후두부분절제술을 위해서는 후두내에서 종양의 발생위치 및 그 확산에 대한 연부조직들의 해부학적 역할에 대한 이해가 필요하다. 과거에는 초기후두암환자에서 정상적인 목소리를 보존할 수 있다는 이점 때문에 방사선 치료가 일차적 치료요법으로 많이 시행되어 왔다. Wang 과 Wong은 성대 막양부에 국한된 병변에서 방사선치료에 대한 5년간 조절율(5-year control rate)이 92%, 전연합부를 침범한 경우가 81%, 그리고 후방으로 전파된 경우 76%로 감소된다고 보고하였다. Olofsson 등은 전연합부를 침범한 57례의 환자에서 방사선 치료를 시행하여 85.7%의 5년 생존율을 얻었으나, 57례중 15례에서 재발하여 구제수술(salvage surgery)을 시행하였고, Jesse 등$^{13)}$ 은 전연합부를 침범한 91례의 T1, T2 성문암을 방사선 치료를 시행하여 8.8%의 실패율을 보였으나 22례의 환자에서 재발하여 후에 salvage surgery를 시행하였다. 그러나 Ogura 등은 피열 연골을 침범한 79례의 환자에서 보존적 수술을 시행한 결과 6례의 환자에서 재발하여 90%의 3-years control rate를 얻을 수 있었다고 보고하였다. 이처럼 병변이 전연합부, 피열연골 혹은 후방성문하부로의 침범이 있는 경우는 방사선 치료 효과가 떨어지고, 따라서 방사선 치료에 실패할 가능성이 보다 높기 때문에 비록 방사선 치료 후 실패한 경우에서 구제 수술을 시행할 수는 있지만 후두기능을 보존하려는 궁극적인 목표를 생각할 때 보존적 수술을 우선적으로 시행하는 것이 바람직하다고 할 수 있다. Biller 등은 방사선 요법에서 실패한 성문부 종양에서는 대부분 전적출술을 시행하지만 일부는 보존적 수술을 시행할 수 있다고 보고하였다. 이들은 반대측 성문부에 종양의 침범이 없어야 하고, 전연 합으로의 파급은 있어도 가능하며 성대돌기를 제외한 피열연골이 정상이어야 하고, 종양의 성문하부로의 파급이 5mm 이내라야 하며, 연골에 침범이 없어야 하고, 성대고정이 없어야 하며, 재발 병소가 방사선요법 전의 원발병소와 상관관계가 있어야 하며, 원발병소가 후두부분적출술에 합당할 경우 보존적 술식을 시행할 수 있다고 하였다. 최근에는 다양한 후두 재건술의 발달로 보다 진행된 후두암에 대한 보존적 후두절제술들이 소개되고 있다. 단측 T3,T4 후두암 혹은 경성문암, 이상와에 위치한 암의 경우 음성만을 재건하는 후두근적출술 (near total laryngectomy)을 시행하기도 한다. 본원 이비인후과에서 1986년부터 초기성문암 51례 중 24례(47.1%)와 초기성문상암 17례 중 12례 (70.6%)에 대하여 보존적 술식을 시행하였다. 초기 성문암의 보존적 술식을 시행한 24례중, 2례(8.3%)에서 경부재발, 1례(4.2%)에서 경부재발과 동반된 폐의 원격전이가 있었으나 원발부위의 재발은 관찰되지 않았고, 술후 합병증으로 1례(4.2%)에서 후두협착, 3례(12.5%)에서 수술부위의 육아종형성, 그리고 1례(4.2%)에서 기관지염이 발생하였으나 오연으로 인한 폐렴은 발생하지 않았다. 초기성문 상암의 보존적 술식을 시행한 12례 중 1례(8.3%)에서 원발병소의 재발, 2례(16.7%)에서 경부재발이 있었으며, 술후 합병증으로 3례(16.7%)에서 오연으로 인한 폐렴의 발생이 있었지만 다른 합병증은 발생하지 않았다. 초기성문암 24례 중 재발이 나타난 3례의 환자를 제외한 21례(97.5%)와 초기성문상암 12례 중 재발이 나타난 3례의 환자를 제외한 9례 (75%)에서는 현재까지 재발소견을 보이지 않고 있다. 이러한 결과는 다른 보고자들과 유사한 결과를 보이고 있지만 아직까지 증례가 많지 않기 때문에 생존율을 얻기에는 미흡한 점이 있으며, 향후 지속적인 추적관찰이 필요할 것으로 사료된다.

• Journal of Broadcast Engineering
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• v.23 no.4
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• pp.511-518
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• 2018

This paper deals with improving speech intelligibility by applying binary mask to time-frequency units of speech in noise. The binary mask is set to "0" or "1" according to whether speech is dominant or noise is dominant by comparing signal-to-noise ratio with pre-defined threshold. Bayesian classifier trained with Gaussian mixture model is used to estimate the binary mask of each time-frequency signal. The binary mask based noise suppressor improves speech intelligibility only in noise condition which is included in the training data. In this paper, speaker adaptation techniques for speech recognition are applied to adapt the Gaussian mixture model to a new noise environment. Experiments with noise-corrupted speech are conducted to demonstrate the improvement of speech intelligibility by employing adaption techniques in a new noise environment.

• Korean Journal of Dental Materials
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• v.44 no.1
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• pp.61-68
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• 2017

This study evaluated the effects of various cleaning methods on the shear bond strength of zirconia ceramics after saliva contamination. Eighty zirconia disk specimens were divided into 8 groups. All groups were treated with one coat of MDP primer. All specimens (except the negative control) were contaminated with human saliva on the zirconia surface. The positive control went through the bonding procedure immediately after contamination without any cleaning procedure. With the exception of control groups, the remaining six groups were rinsed with water and either applied with MDP recoating (WATER+MDP) or without MDP recoating (WATER). While some were cleaned with a Ivoclean with MDP recoating (IVOCLEAN+MDP) or not applied with MDP recoating(IVOCLEAN), others were cleaned with a 1% NaOCl solution with MDP recoating (NaOCl+MDP) or without MDP recoating (NaOCl). The shear bond strength of all specimens were measured after being stored in distilled water at $37^{\circ}C$ for 24 hours. The data was analyzed statistically by an analysis of ANOVA, Tukey's post hoc test and Student's t-test was used to compare the shear bond strength according to the re-coating of MDP after the cleaning procedure. The positive control group showed the lowest shear bond strength value, and the WATER group and NaOCl group showed no significant difference when compared to the positive control group. The IVOCLEAN group showed significantly higher shear bond strength when compared to Water group and NaOCl group but not with the group of negative control. After rinsing with water or the NaOCl solution, the comparison of the single coating of MDP and re-coating of MDP showed different shear bond strengths but there was no significant difference to the negative control. After rinsing with Ivoclean, there was no significant difference to the negative control regardless of the recoating of MDP. In conclusion, the shear bond strength was affected by the cleansing procedure and Ivoclean was found to be effective regardless of the re-coating of MDP. When water or the NaOCl solution is used to remove surface contaminants, the re-coating of MDP provides a positive effect on cementation.

• Radiation Oncology Journal
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• v.27 no.1
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• pp.29-34
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• 2009

Purpose: This study was designed to evaluate long-term results in terms of failure, survival and voice preservation after radiation therapy for early glottic cancer. Materials and Methods: From February 1988 to December 2003, 70 patients with early glottic cancer were treated with radiation therapy at Keimyung University Dongsan Medical Center. Patient age distribution was from 39 to 79 years, with a median age of 62 years. All patients had squamous cell carcinoma. According to the TNM stage, 58 patients had stage I disease, 12 patients had stage II disease; 67 patients were male. The laryngeal area was irradiated with the use of bilateral opposing fields with/without a wedge filter with 6 MV photons at a total dose of $54{\sim}70.2$ Gy in $1.8{\sim}2.2$ Gy fractions over $6{\sim}8$ weeks. We delivered a median radiation dose of 60 Gy for stage I patients and a median radiation dose of 66 Gy for stage II patients. Salvage surgery was performed in patients with local recurrence. The voice preservation rate was analyzed after all treatments including salvage surgery. Follow-up periods were from 13 to 180 months, with a median follow-up period of 77.5 months. The survival rate was analyzed by the use of the Kaplan Meier method and log rank test. A comparison of two groups was performed with the use of the chi-squared test. Results: The local control rate was 98.5% (69/70). The five-year-overall survival rate was 93.9%. The five-year disease free survival rate (5YDFS) was 84.1% and the 5YDFS after radiation and salvage surgery was 92.8%. According to stage, the 5YDFS was 93.1% and 91.7% for stage I and stage II respectively. Thirteen patients (18.5%) had local failure with 24 months of median time to local failure and nine patients received salvage surgery; however, four patients were lost to follow-up after a diagnosis of recurrence. Only two patients died due to a distant metastasis at 33 months and 71 months after radiation therapy, respectively. Nine patients died due to other diseases with a median time of 73 months. There were no severe acute or chronic complications after radiation therapy. Voice preservation was ultimately achieved in 88.5% (62/70) of patients. Conclusion: We considered that radiation therapy was effective and we achieved excellent survival and voice preservation in early laryngeal cancer. The use of radiation therapy should be the first choice for the treatment of early glottic cancer.

• Annual Conference on Human and Language Technology
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• 2007.10a
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• pp.114-121
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• 2007

한국어에 대한 음성적 유사도 비교 알고리즘은 다양한 음차표기로 사용되는 외래어에 대하여 유사도 비교에 따른 등가부류를 형성해줌으로써 정보검색의 성능을 향상시킬 수 있다. 영어 환경에서의 음성적 유사도 비교 알고리즘인 SOUNDEX 알고리즘을 기반으로 하여 개발된 KODEX는 최소한의 제약사항으로 최대한의 재현율을 보였으나, 정확도 면에서 현저한 성능 감소를 보였다. 이를 보완하여 제안된 EKODEX 알고리즘은 Metaphone 알고리즘의 개념을 도입, 부분적인 모음 정보의 사용과 'ㅇ' 음가의 정보 보존 등의 제약사항을 통해 KODEX의 정확도를 끌어올렸다. 본 연구에서 제안하는 CKODEX 알고리즘은 KODEX와 EKODEX 알고리즘을 기반으로 한 것으로, 예외사항이 많은 한국어 발음 특성에 기반하여 세부적인 규칙을 정하고, 기존 알고리즘의 조건을 수정하는 방법으로 정확률과 재현율을 보다 향상시킴으로써 사용자의 질의어에 대한 클러스터링에 보다 효과적임을 밝혔다.

• Proceedings of the Acoustical Society of Korea Conference
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• spring
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• pp.171-174
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• 2002

음성신호는 성문특성으로 인해 고주파 특성이 약화되는 경향이 있다. 이를 보상하기 위해 Pre-emphasis filter를 사용한다. 수식으로 표현하면 y(n)=s(n)-As(n-1) 와 같이 차분방정식으로 나타낼 수 있다. 여기서 A값은 보통 0.9에서 1사이의 값을 주로 사용한다. 그러나 Pre-emphasis filter는 고주파 특성을 보상하는 과정에서 극점과 같이 영점도 왜곡된다. 본 논문에서는 음성특성에 따른 LSP(Line Spectrum Pairs) 분포특성을 이용하여 영점을 보존하고 vocoder 및 coding에 필연적인 고주파 특성 혹은 저주파 특성을 강조한다.

• Conservation Science in Museum
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• v.2
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• pp.9-17
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• 2000

This is a case study of conservation treatment of the textiles and costumes excavated from Soonchun Park's tomb in Eumsung, North Chungcheong province. When excavated, the objects were found fairly wet and badly smelled since they decayed in wooden coffin. They were wet-treated with deionized water to remove dirt and dried at room temperature, during which the objects were blocked and flattened to keep them in shape. Silk crepeline was under-layed and stitched to the damaged areas with silk-hair threads. Each costume was individually stored in a tray made of paulownia wood and flat textiles were rolled up in paper cylinders with 6 and 10 cm in diameter. Thymol was used to prevent microorganisms.

• The Journal of the Acoustical Society of Korea
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• v.13 no.6
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• pp.91-97
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• 1994

In speech processing, the waveform codings are concerned with simply preserving the waveform of signal through a redundancy reduction process. In the case of speech synthesis, the waveform codings with high quality are mainly used to the synthesis by analysis. Because the parameters of this coding are not classified as both excitation and vocal tract, it is difficult to apply the waveform coding to the synthesis by rule. Thus, in order to apply the waveform coding to synthesis by rule, it is necessary to alter the pitches. In this paper, we proposed a new pitch alteration method that can change the pitch period in waveform coding by dividing the speech signals into the vocal tract and excitation parameters. This method is a time-frequency domain method preserving the phase component of the waveform in time domain and the magnitude component in frequency domain. Thus, it is possible that the waveform coding is carried out the synthesis by rule in speech processing. In case of using the algorithm, we can obtain spectrum distortion with $2.94\%$. That is, the spectrum distortion is decreased more $5.06\%$ than that of the pitch alteration method in time domain.

• Journal of the Korean Applied Science and Technology
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• v.38 no.6
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• pp.1568-1576
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• 2021

Here, we conducted the study on the possibility of using FK-13, a short analog of human-derived antibacterial peptide LL-37, as a cosmetic preservative to discover a natural cosmetic preservative that is safe for human body. For the purpose, FK-13 composed of 13 amino acids was synthesized by solid-phase peptide synthesis, and purified using reversed phase-high performance liquid chromatography (RP-HPLC). The purity and molecular weight were confirmed by liquid chromatography-mass spectrometry (LC-MS) analysis. FK-13 showed high antimicrobial activity on the three gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis, and Staphylococcus epidermidis), the three gram-negative bacteria (Escherichia coli, Salmonella typhimurium, and Pseudomonas aeruginosa), and also even the fungus Candida glabrata. FK-13 had a broad spectrum of antibacterial activity, showing a suitability as a cosmetic preservative. In addition, FK-13 showed high thermostability and higher antibacterial activity in a comparative test with existing natural herbal cosmetic and chemical preservatives. Therefore, as FK-13 is a safe material and has high antibacterial activity at a low concentration, it is likely to be applied as a peptide natural cosmetic preservative that can replace existing chemical preservatives.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 1999.06b
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• pp.41-44
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• 1999

최근, 방송기술의 발전이 날로 그 속도가 빨라지고 있다. 기존의 아날로그 방송에서 요즘은 디지털 방송으로 전환되는 것이 그 예이다. 방송의 디지털화는 영상 및 음성의 질을 높이고 방송 자료의 영구보존 및 검색에 뛰어난 장점을 가지고 있다. 반면 하드웨어의 복잡도가 높아지고 그 응용 소프트웨어가 부족한 형편이다. 본 논문에서는 MPEG-2로 압축된 영상 데이터에서 원영상 레벨의 복원과 재압축 없이 압축 비트열내 특징정보를 추출 및 간단하게 조작하여 간단하게 움직이는 오브젝트에 모자이크 효과를 적용하였다.