• Journal of Food Hygiene and Safety
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• v.31 no.2
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• pp.113-118
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• 2016

Proprotein convertase subtilisin/kexin type 9 (PCSK9), is a protein mainly secreted by a liver. The PCSK9 plays an important role in low density lipoprotein (LDL) metabolism acting as a repressor of LDL receptor through transportation of the LDLR to the lysosome for degradation. Thus, the PCSK9 inhibitor suppresses PCSK9-regulated degradation of the LDL receptor as a LDL-lowering medicine. However, little is known about the role of PCSK9 in the reproductive system. Therefore, in the present study, we investigated Pcsk9 expression in male reproductive tracts including penises, prostates and testes using rats in response to their diets between a normal diet and a high-fat diet with cholesterol. Based on our previous study, the high-fat diet elevates concentration of total cholesterol and LDL in serum whereas it reduces the concentration of plasma high density lipoprotein (HDL). In addition, it dramatically affects to morphological changes of the male reproductive organs. Consistent with these results, the expression of Pcsk9 was substantially decreased in the penile tissues (P < 0.001) from rats fed a high fat diet as compared to a normal diet. Moreover, it slightly reduced in the prostate and testes (P < 0.05) of rats in response to a high fat diet. Localization of Pcsk9 was predominantly detected in urethral epithelium of penises, cylinder-shaped cells of prostate glands, and spermatogonia, spermatocytes and spermatid of testes of rats. Collectively, results of current study provide invaluable insights into the Pcsk9 gene with respect to its tissue- and cell-specific expression by a high fat diet with cholesterol.

• Animal Systematics, Evolution and Diversity
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• v.20 no.2
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• pp.215-223
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• 2004

Two species of the heptageniid mayfly genus Thalerosphyrus Eaton, T. vietnamensis (Dang) and T. separatus n. sp., are described from Vietnam. Thalerosphyrus separatus can be distinguished by the basally detached posterolateral expansions of pronotum in larva and by the Y -shaped penes in male adult. Their larval and adult stages are described with line-drawings of diagnostic characters. Their diagnoses, distributions, habitat and ecological data, and taxonomic remarks are provided.

• 대한미세수술학회:학술대회논문집
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• 1992.11a
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• pp.80-81
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• 1992

• Journal of Ginseng Research
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• v.21 no.2
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• pp.98-103
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• 1997

On the precontracted rabbit cavernosal muscle strips with phenylephrine ($5\ast10^{-6}$M), Increasing concentrations of acetylcholine (10-7, 10-6, 10-5, 10-4M) showed relaxation effect dose-dependently in control group ($10^{-7}$M : 15.32%, $10^{-6}$M : 35.44%, 10-5M : 59.45%, 10-4M : 76.54%). After 3 months administering Korean red ginseng, the relaxation action of acetylcholine was significantly increased ($10^{-7}$M : 34.18%, $10^{-6}$M : 56.35%, $10^{-5}$M : 75.33%, $10^{-4}$M : 89.86%). Relaxation effect of Korean red ginseng was significantly increased after 3 months administering Korean red ginseng. Intracavernous pressure response to electrostimulation wan 107.52 cm$H_2O$ in control group and significantly increased to 138.34 cm $H_2O$ after 3 month administering Korean red ginseng. With these results, we can confirm that long-term administration of Korean red ginseng enhances the erectly capacity and that its action is mediated by endothelium derived relaxing factor and peripheral neurophysiologic enhancement.

• The Monthly Diabetes
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• s.253
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• pp.34-35
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• 2010

50대 중반인 회사원 김 모 씨는 10년 전 당뇨병을 진단받았다. 요즘 그에게 말 못 할 고민이 생겼다. 아내와의 잠자리가 예전 같지 않다는 것. 어느 날부턴가 발기가 잘 되지 않더니 어렵사리 발기가 되도 오랫동안 유지되지 못했다. 처음에는 피곤해서 그러려니 하고 넘겼지만 그러기를 몇 번, 이제는 아내 볼 면목도 서지 않는다. 어딘가 털어놓을 곳도 마땅치 않고 남자로서 자존심 상하는 게 이만 저만이 아니다. 몇날 며칠 고민을 거듭하던 끝에 용기를 내 비뇨기과를 찾았다. 병원에서 찾은 김 씨는 발기부전에 대한 여러 가지 검사를 받았다. 기본적인 소변검사 및 혈액검사를 통해 남성호르몬 검사와 시청각 발기유발검사, 복합 초음파 검사 등이 실시되었다. 검사 결과 김 씨는 당뇨합병증으로 인해 음경의 신경과 말초 혈관에 이상이 생긴 것이 발견됐다. 바쁘게 생활하다 보니 식사조절이나 운동을 꾸준하게 실천하지 못해 혈당관리에도 신경을 쓰지 못하고 있었다.

• Clinical and Experimental Reproductive Medicine
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• v.13 no.2
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• pp.181-185
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• 1986

To estimate the penile blood flow changes during artificial with erection intracorporeal papaverine injection, we injected 99 m Technitium-Human Serum Albumin via antecubital vein simultaneously and calculate the radioisotope activity of the penis using computerized Gamma Camera. We classified the results into 3 groups according to the transit time, erection persistent time and venous index in 67 impotence patients. We defined the arteriogenic impotence with the delayed transit time (more than 600 seconds) in 13 patients and venogenic with the shortened erection persistant time (less than 200 seconds) and decreased venous index (less than 0.8) in 11 patients. The rest of them (43 patients) were regarded as equivocal impotence, probably nonvasculogenic or psychogenic.

• The Journal of Korean Society for Radiation Therapy
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• v.21 no.1
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• pp.9-15
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• 2009

Purpose: We evaluated the device that was created for maintaining the patient's setup and protecting the testicles from scattered radiation during treatment of carcinoma of the penis. Materials and Methods: The phantom testicles were made of vaseline cotton gauze and the device consisted of 5 mm of acryl box and 4 mm of lead shielding. $3{\times}3\;cm^2$, $4{\times}4\;cm^2$, $5{\times}5\;cm^2$, $6{\times}6\;cm^2$, $7{\times}7\;cm^2$ field sizes were used for this study and measurement was made at 4, 5, 6, 7, 8, 10 cm from the lower edge of the field for 10 times with lead shielding and without the shielding respectively. 200 cGy was delivered using 6 MV photons. Results: The scatted radiation without lead shielding at 4, 5, 6, 7, 8, 10 cm from the lower edge of the field were 14.8-4.7 cGy with $3{\times}3\;cm^2$, 15.7-5.2 cGy with $4{\times}4\;cm^2$, 17.6-5.5 cGy with $5{\times}5\;cm^2$, 19.9-6.6 cGy with $6{\times}6\;cm^2$, 22.2-7.6 cGy with $7{\times}7\;cm^2$ and the measured dose without lead shielding were 7.1-2.6 cGy with $3{\times}3\;cm^2$, 8.9-3.6 cGy with $4{\times}4\;cm^2$, 12.3-4.8 cGy with $5{\times}5\;cm^2$, 14.6-5.0 cGy with $6{\times}6\;cm^2$ and 21.1~6.4 cGy with $7{\times}7\;cm^2$. As shown above, the scatted radiation decreased after using lead shielding. Depending of the range of field sizes, the resulting difference between without shielding values and with shielding values were: 7.8-1.1 cGy at 4 cm, 5.1-1.2 cGy at 5 cm, 3.8-1.1 cGy at 6 cm, 3.4-1.7 cGy at 7 cm, 2.8-1.7 cGy at 8 cm, 2.4-2.5 cGy at 9 cm and 2.1-1.8 cGy at 10 cm. In the situation as described above, the range in values depending on the distance was 7.8-1.1 cGy with $3{\times}3\;cm^2$, 6.9-1.6 cGy with $4{\times}4\;cm^2$, 5.3-0.8 cGy with $5{\times}5\;cm^2$, 5.3-1.5 cGy with $6{\times}6\;cm^2$ and 1.1-1.8 cGy with $7{\times}7\;cm^2$. Conclusion: Using the device we created to shield the testicles from scattered radiation during treatment of carcinoma of the penis, we have found that scattered radiation to the testicles is decreased by the phantom testicles, and by increasing the distance between the testicles and penis.

• Journal of the Korean Institute of Landscape Architecture
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• v.43 no.1
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• pp.82-95
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• 2015

This study is intended to obtain a guideline for creating a therapeutic garden soundscape in a psychiatric hospital by analyzing the psychological and physiological effects of auditory components on mental patients. The subjects were 27 inpatients at a psychiatric institute located in Jeollabuk-do. They were recommended by their doctors and had been diagnosed with mild cases of schizophrenia. The survey was carried out in October 2011. With regard to the study, the subjects listened to single sounds(the sound of flowing water, birdsong, wind chimes and music) and 4 sounds composed of some of these, and then Electroencephalography(EEG) and psychological effects were measured. The moving water sound was perceived as pleasing and revitalizing and the birdsong as sonorous and delightful. When designing a healing garden in a psychiatric hospital, the vitality of sound should be considered. In comparison to other single sounds, water sounds were highly preferred and had greater effects on psychological vitality. Music sounds had a significant effect on enhancing tranquility while water sounds affected on both psychological vitality and tranquillity. When comparing single sounds with combined sounds, single sounds such as running water for vitality and music for tranquility had a greater psychological effect than combined sounds. In terms of combined sound preferences, the combination of water and bird sounds had higher preference rates. Generally, combined sounds including water tended to have higher preference rates. The physiological effects of single sounds showed that music had a greater therapeutic effect than natural sounds such as water sounds and birdsong in promoting tranquility. As for combined sounds adopted to enhance physiological tranquility, it is most appropriate to combine music and birdsong or music and water sounds. However, a single music sound is more effective than combined sounds. Overall, analyses of both psychological and physiological reactions showed music and water sounds to be most calming while water sounds promoted the greatest vitality.

• Journal of Yeungnam Medical Science
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• v.23 no.1
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• pp.52-61
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• 2006

Background: Korean ginseng (KG) has been used as a general tonic, and for voiding dysfunction for a long time in oriental society. However, scientific basic studies on the use of KG, have been rare, especially for voiding and erectile dysfunction. This study was performed to investigate the effects of KG on voiding and erectile function by examining the effects of total saponin (TS) on the bladder, urethral and penile cavernosal smooth muscle. Materials and methods: To examine the effects of TS, NewZeland white rabbits were used to obtain tissue strips from the smooth muscle of the bladder, proximal urethra and corpus cavernosum. Adult Sprague Dawley rats were used to examine the changes in urodynamic findings and penile erection after administration of TS. Results: In proximal urethral strips, the rate of relaxation of the proximal urethra was increased from $9.0{\pm}2.9$ to $33.7{\pm}4.8%$ in a dose-dependent manner when the concentration of TS was added accumulatively from 0.25 mg/ml to 4.0 mg/ml (p<0.05). However, no significant response was observed in the bladder strips within these concentration ranges. For the corpus cavernosal strips, the rate of relaxation ranged from $5.8{\pm}2.1$ to $36.7{\pm}5.8%$, increasing in a dose-dependent manner when TS was increased from 1.0 mg/ml to 4.0 mg/ml (p<0.05). After administration of 0.1 ml of TS (32 mg/ml) in the rat, the bladder pressure was $37.5{\pm}8.5$ mmHg at $52.1{\pm}7.0$ sec. during isovolumetric bladder contraction, showing no significant differences from $35.7{\pm}7.8mmHg$ and $50.7{\pm}7.2$ sec, respectively, before treatment. However, when 0.1 ml of TS (32 mg/ml) was administered, the relative reduction of urethral pressure was $6.9{\pm}0.5mmHg$ at $62{\pm}7.5$ sec, which was significantly higher compared to $4.6{\pm}1.1mmHg$ at $45{\pm}10$ sec before treatment (p<0.05). For the cavernosal injection study, the change in intracavernosal pressure (${\Delta}ICP$) was examined after administering 0.1 ml of TS. The cumulative additions of TS at concentrations from 0.5 mg/ml to 32 mg/ml increased ${\Delta}ICP$ from $1.3{\pm}0.5$ to $21.3{\pm}7.8mmHg$ in a dose-dependent manner (p<0.05). The duration of tumescence was from $0.3{\pm}0.1$ to $5.2{\pm}0.2$ min, showing dose-dependent increase (p<0.05). Furthermore, the cumulative addition of TS at concentrations from 0.5 mg/ml upto 32 mg/ml did not cause any significant change in systemic blood pressure. Conclusion: These results suggest that ginseng improves voiding functions, which is mainly achieved by TS relaxing the proximal urethra, the most important part of the bladder outlet function. In addition, ginseng safely induced a penile erection hemodynamically by relaxing the corpus cavernosum.

• Korean Journal of Pharmacognosy
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• v.38 no.3 s.150
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• pp.239-244
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• 2007

The herbal formulation (KH-204) mainly consisted of the fruits of Lycium chinense, Cornus officinalis, Rubus coreanus, Cuscuta chinensis and Schizandra chinensis. We investigated the effects of this herbal formulation on the penile erection and corpus cavernosum of spontaneous hypertensive male Rats (SHR). We used male SHR aged 16 weeks as a model of hypertension. The treatment groups received once a day oral doses KH-204 100 and 300 mg/kg per day for 4 weeks. Distilled water was administered in the control group. To investigate the penile erection, intracavernosal pressure (ICP) and mean arterial pressure (MAP) were recorded in all groups. We analyzed the distribution of NOS by immunohistochemical staining and the expression of nNOS, eNOS concentration in the isolated corpus cavernosum by western blotting. In the control group, ICP/MAP ratio was $14.9{\pm}1.4%$ after pelvic nerve stimulation. ICP/MAP ratio was markedly increased in the treatment group with KH-204 100, 300 mg/kg, compared with control group. Immunohistochemical staining for NOS showed that eNOS and nNOS was stained as brown color. Compared with the control group, NOS activities of KH-204 100, 300 mg/kg were increased significantly. Also the penile expression levels of nNOS, eNOS in KH-204 100, 300 mg/kg treatment group were more increased significantly than control group by western blotting. This study showed that KH-204 enhances the penile erection and the level of eNOS and nNOS expression of penile corpus cavernosum of male SHR.