• Journal of Life Science
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• v.19 no.5
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• pp.587-592
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• 2009

A dramatic morphological change of embryos occurs at peri-implantation. Maternal and embryonic cross-talk during this period, initiated by signals from embryo(s), provides signals for maternal recognition of pregnancy and establishing and maintaining the pregnancy. However, the cellular, biochemical and genetic processes that direct embryo remodeling in mammalian species are not well studied or understood. In order to identify potential genes responsible for morphological change and cross-talk between embryo and uterus, an initial EST analysis was performed. A catalog of expressed genes (Transcriptome) from the d12 peri-implanting porcine embryos was constructed. Six clones were chosen from the initial ESTs for elucidation of their expression patterns during embryogenesis in early pregnancy. A number of these genes demonstrated unique expression profiles in a tissue, cell-type, and temporal fashion, indicating dynamic regulation of embryonic and endometrial gene expressions at different stages of pregnancy. Cross-talk between the embryo and endometrium of the pregnant uterus has provided a suitable micro-environment for the embryo's rapid and dramatic morphological changing process at the peri-implantation stage.

• Journal of Korean Society of Environmental Engineers
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• v.33 no.5
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• pp.314-324
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• 2011

Algal biomass cultivated by wastewater is potentially useful resource for biodiesel production. However, little is known about algal nutrient metabolism and microbial interaction with bacteria under real municipal wastewater condition. In this work, we characterized nitrogen and phosphorus removals of municipal wastewater by a representative wastewater-growing algal population. Ankistrodesmus gracilis SAG 278-2, and analyzed its ecological interaction with wastewater bacterial communities. Compared to wastewater sludge itself, algal-bacterial co-culture improved nutrient removal. According to bacterial community analysis with 16S rRNA genes, a selective and dominant growth of a Unclassified Alcaligenaceae population resulted from algal growth in the algal-bacterial co-culture. The selectively stimulated bacterial population is phylogenetically close to Alcaligenes faecalis subsp. 5659-H, which is known to be co-present interact with algae in aquatic environment. These findings suggest that algal growth/metabolism may have effects on selection of a specific bacterial population in algal-bacterial co-cultures that can efficiently remove nutrients from municipal wastewater.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.46 no.6
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• pp.453-458
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• 2001

The Rural Development Administration (RDA) of Korea now operates a system called Rice Variety Selection Tests (RVST), which are now being implemented in eight Agricultural Research and Extension Services located in eight province RVST's objective is to provide accurate yield estimates and to select well-adapted varieties to each province. Systematic evaluation of entries included in RVST is a highly important task to select the best-adapted varieties to specific location and to observe the performance of entries across a wide range of test sites within a region. The rice yield data in RVST for ordinary transplanting in Kangwon province during 1997-2000 were analyzed. The experiments were carried out in three replications of a random complete block design with eleven entries across five locations. Additive Main effects and Multiplicative Interaction (AMMI) model was employed to examine the interaction between genotype and environment (G$\times$E) in the biplot form. It was found that genotype variability was as high as 66％, followed by G$\times$E interaction variability, 21％, and variability by environment, 13％. G$\times$E interaction was partitioned into two significant (P＜0.05) principal components. Pattern analysis was used for interpretation on G$\times$E interaction and adaptibility. Major determinants among the meteorological factors on G$\times$E matrix were canopy minimum temperature, minimum relative humidity, sunshine hours, precipitation and mean cloud amount. Odaebyeo, Obongbyeo and Jinbubyeo were relatively stable varieties in all the regions. Furthermore, the most adapted varieties in each region, in terms of productivity, were evaluated.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2005.11a
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• pp.341-344
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• 2005

최근 모바일 인터넷 기술의 발달로 인하여 시간과 공간의 제약 없이 온라인 공간을 통한 학습자 주도적이고 상호작용이 가능한 e-Learning의 학습효과에 대한 인식의 급속한 확산에 따라 다양한 기술을 이용한 효과적인 모바일 e-Learning 콘텐츠 개발이 활발하게 진행되고 있다. 그러나 기존의 학습 콘텐츠들은 대부분 학습자에게 동일한 학습 환경과 학습 내용 및 문제를 제공하고 있으며, 또한 웹의 특성상 학습진행이 주어진 절차에 따라 연결된 링크를 따라 가면서 학습을 진행하게 된다. 그러나 본 연구에서는 프로그래밍 과목에 대해 학습자가 원하는 학습 내용을 자기 학습 수준에 따라 간단한 입력으로 동적으로 직접 선택할 수 있으며, 또한 다양한 학습 환경에서 학습자가 원하는 학습내용을 대화형 유전자 알고리즘으로 선택하면서 학습할 수 있는 모바일 e-Learning 콘텐츠를 설계하고 구현하였다.

• Korean Journal of Biological Psychiatry
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• v.17 no.2
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• pp.65-69
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• 2010

Gene-environment interactions are important in pathogenesis of suicide or suicidal behavior. Twin and adoption studies and family studies show that genetic factors play a critical role in suicide or suicidal behavior. Given the strong association between serotonergic neurotransmission and suicide, recent molecular genetic studies have focused on polymorphisms of serotonin genes, especially on serotonin transporter and tryptophan hydroxylase genes. Some studies have revealed a significant interaction between s allele of the serotonin transporter gene and the risk of suicide attempt associated with childhood trauma. In addition, the polymorphism of brain-derived neurotrophic factor gene also may influence the effect of childhood trauma in relation to the risk of attempting suicide. Future studies should explore genetic and environmental factors in suicide or suicidal behavior and examine for gene and environment interaction.

• Proceedings of the Korean Information Science Society Conference
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• 2004.04b
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• pp.295-297
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• 2004

유전자의 생물학적 기능을 밝히고 세포 내 상호작용을 이해하는 것은 post-genome era의 가장 중요한 작업 중 하나이다. 이러한 세포 내 상호작용은 복잡한 생화학적 네트워크를 형성하게 되며 그 중 Metabolic pathway(대사 경로)는 생물 시스템을 이해하는데 가장 중요한 부분을 차지하게 된다. 대사 경로를 분석하기 위하여 분자의 기능 및 생화학적 프로세스에 대한 정보를 데이터베이스에 저장.관리해야하고, 사용자의 다양한 질의에 대하여 관련정보를 검색하여 GUI환경에서 제공해야 한다. 이 논문은 대사 경로 정보를 객체 데이타베이스 형태로 모델링하여 구축하고, 사용자가 관심있는 정보를 SBML형태로 제공하는 대사경로 데이타베이스의 설계 및 구현에 관해 다룬다.

• Proceedings of the Korean Information Science Society Conference
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• 2005.11b
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• pp.559-561
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• 2005

본 논문은 사용자가 감각형 인터페이스를 사용하여 가상공간의 지능적인 화단을 체험, 체감 할 수 있는 시스템(Garden Alive)을 제안한다. 제안된 시스템은 카메라, 조도, 습도 센서를 갖춘 현실공간의 화단과 상호작용에 사용되는 감각형 인터페이스, 진화모듈과 감정모듈을 갖춘 인공지능 모듈, 그리고 가상식물의 성장과 반응을 보여주는 Virtual Garden으로 구성된다. 감각형 인터페이스는 카메라로 사용자의 손동작을 인식하고, 조도센서로 광량을 확인하여, 습도센서로 물의 양을 측정한다. 이러한 정보를 바탕으로 인공지능 모듈은 식물의 진화 방향과 감정상태의 변화를 결정한다. Virtual Garden은 L-system을 기반으로 제작되어 가상식물들은 실제 식물들과 유사한 형태로 성장하도록 한다. 제안된 Garden Alive에서 화단의 식물들은 각각의 개체마다. 유전자를 가지고 있어 식물의 다양성을 볼 수 있고, 빛과 수분 등의 환경요인에 따른 적합도를 평가함으로써 세대를 거듭함에 따라 진화해가는 모습을 볼 수 있다. 마지막으로 단순히 자극에 반응하는 식물이 아닌 사용자와 상호작용에 따른 식물의 감정 변화를 통해 적절한 반응을 보이는 지능적인 식물을 구현하였다. 따라서 제안된 시스템은 오락과 교육을 위한 콘텐츠, 사용자에 따른 개별적 반응을 통해 심리적인 안정을 제공할 수 있는 콘텐츠 등으로 응용될 수 있다.

• Proceedings of the Korean Society of Crop Science Conference
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• 2001.05a
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• pp.70-71
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• 2001

• Korean Journal of Microbiology
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• v.49 no.3
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• pp.215-220
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• 2013

Against environmental stresses, many bacteria utilize the alternate sigma factor RpoS that induces transcription of the specific set of genes helpful in promoting bacterial survival. Intracellular levels of RpoS are determined mainly by its turnover through proteolysis of ClpXP protease. Delivery of RpoS to ClpXP strictly requires the adaptor protein RssB. The two-component-type response regulator RssB constantly interacts with RpoS, but diverse environmental changes inhibit this interaction through modification of RssB activity, which increases RpoS levels in bacteria. This review discusses and summarizes recent findings on regulatory factors in RssB-RpoS interactions, including IraD, IraM, IraP anti-adaptor proteins of RssB and phosphorylation of N-terminal receiver domain of RssB. New information shows that the coordinated regulation of RssB activity in controlling RpoS turnover confers efficient bacterial defense against stresses.

• Journal of Life Science
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• v.34 no.3
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• pp.199-207
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• 2024

Cytochrome P450s (CYP) enzymes play a central role in the metabolism of both endogenous and xenobiotic chemical compounds. In particular, therapeutic drugs, natural products and environmental toxicants regulate expression of the tissue-specific CYP enzymes, This can cause CYP-mediated interactions among the chemical compounds such as the ingested drugs and toxicants, resulting in changes in their metabolism. This can lead to the modifications of their therapeutic and toxic effects. Intense investigations in this field throughout the last several decades have resulted in considerable progress in understanding the molecular mechanisms mediating the regulation of CYP gene expression. Now, it is well established that xenobiotic chemicals regulate the expression of specific CYP genes, and the corresponding xenobiotic-sensing receptors that mediate the expression control of specific CYP genes and their signal transduction pathways are involved in this process. This review summarizes the molecular mechanisms by which the well-known major xenobiotic-sensing receptors and other regulators affect the induction of CYP gene expression in response to exposure to various chemicals.