• 월간산업보건
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• s.258
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• pp.11-14
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• 2009

살균제인 pentachloronitrobenzene(PCNB)의 직업적 노출을 위한 TLV-TWA를 0.5 mg/$m^3$으로 권고하였다. 이 수준은 간에 영향을 미치는 것을 최소화하기 위한 수준이다 피부자극과 피부 흡수에 관한 것은 증명되지 않았다. PCNB에 대한 발암가능성을 흰쥐와 생쥐를 대상으로 생물학적 검정을 한 결과, 생쥐에서 양성이었다. 이러한 결과는 생물학적 검정에 사용한 PCNB가 공업용이었고 불순물로 포함된 hexachlorobenzene에 의해 암이 유발된 것으로 확인되었다. 따라서 FCNB 물질은 발암성 유발 인자(A4;Not Classifiable as a Human Carcinogen)로 권고하였다. PCNB의 Skin, SEN notation, TLV-STEL에 관한 정보는 충분한 데이터가 확보되지 않아 제공되지 못하고 있다.

• Korean Journal of Microbiology
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• v.27 no.3
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• pp.194-200
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• 1989

The nucleotide sequence of inducible chloramphenicol acetyl-transferase(CAT) gene isolated from a small plasmid pSBK203 of Staphylococcus aureus was determined. The base sequence shows that structural gene of pSBK203-CAT encodes a protein of 213 amino acids and has a leader region which encodes a short polypeptide of 9 amino-acids in its upstream. vertical bar /sup 35/S vertical bar-Methionine labelled CAT gene product in minicell showed almost same mobility with pC194-CAT of which molecular weight is 24Kdal on polyacrylamide gel electrophoresis. Predicted amino acid sequence of pSBK203-CAT has revealed a high degree of homology with the CATs of pC194 and pC221 than those of cat-86, Tn9 and proteus mirabilis PM13.

• Proceedings of the Korea Water Resources Association Conference
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• 2019.05a
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• pp.340-340
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• 2019

지구온난화로 유발되는 기후변동성이 증가함에 따라서 정확한 수문인자의 예측은 전 세계적으로 주요 관심사항이 되고 있다. 최근에는 고성능 컴퓨터 자원의 증가로 수문기상학 연구에서 동일한 학습량에 비하여 정확도의 향상이 뚜렷한 기계학습 구조를 활용하여 위성영상 기반의 대기예측, 태풍위치 추적 및 강수량 예측 등의 연구가 활발하게 진행되고 있다. 본 연구에는 기계학습 중 시계열 분석에 널리 활용되고 있는 순환신경망(Recurrent Neural Network, RNN) 기법의 대표적인 LSTM(Long Short-Term Memory) 네트워크를 이용하여 수문인자를 예측하였다. LSTM 네트워크는 가중치 및 메모리 요소에 대한 추가정보를 셀 상태에 저장하고 시계열의 길이 조정하여 모형의 탄력적 활용이 가능하다. LSTM 네트워크를 이용한 다양한 수문인자 예측결과 RMSE의 개선을 확인하였다. 따라서 본 연구를 통하여 개발된 기계학습을 통한 수문인자 예측기술은 권역별 수계별 홍수 및 가뭄대응 계획을 능동적으로 수립하는데 활용될 것으로 판단된다. 향후 연구에서는 LSTM의 입력영역을 Bayesian 추론기법을 활용하여 구성함으로 학습과정의 불확실성을 정량적으로 제어하고자 한다.

• Journal of the Korea Society for Simulation
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• v.23 no.3
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• pp.33-40
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• 2014

Drifter is equipment which is hard to localize. Performance of prototype hasn't performed well compared to product of leading companies even though advanced foreign firm's product were dead copied. This study shows cases of approaching the factor which produces performance gap through drifter hydraulic analysis model which is core component of rock drill. Progression of procedure is following. 1) Securing reliability of the analysis model by comparing impact test result with analysis result. 2) Drawing a graph which indicates performance gap between prototype and drifter of advanced foreign firm by using analysis model. 3) Approaching the factor which produces performance gap with analysing variable of the analysis model. Software used for this analysis is SimulationX.

• Journal of Life Science
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• v.34 no.7
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• pp.520-530
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• 2024

Tumor suppressor genes (TSGs) play a crucial role in maintaining cellular homeostasis. When the function of these genes is lost, it can lead to cellular plasticity that drives the development of various cancers, including small-cell lung cancer (SCLC), which is known for its aggressive nature. SCLC is primarily driven by numerous loss-of-function mutations in TSGs, often involving genes that encode epigenetic regulators. These mutations pose a significant therapeutic challenge as they are not directly targetable. However, understanding the molecular changes resulting from these mutations might provide insights for developing tumor intervention strategies. We propose that despite the heterogeneous genomic landscape of SCLC, the effects of mutations in patient tumors converge on a few critical pathways that drive malignancy. Specifically, alterations in epigenetic regulators lead to transcriptional dysregulation, pushing mutant cells toward a highly plastic state that makes them immune evasive and highly metastatic. This review will highlight studies showing how an imbalance of epigenetic regulators with opposing functions leads to the loss of immune recognition markers, effectively hiding tumor cells from the immune system. Additionally, we will discuss the role of epigenetic regulators in maintaining neuroendocrine features and how aberrant transcriptional control promotes epithelial-to-mesenchymal transition during tumor development. Although these pathways seem distinct, we emphasize that they often share common molecular drivers and mediators. Understanding the connection among frequently altered epigenetic regulators will provide valuable insights into the molecular mechanisms underlying SCLC development, potentially revealing preventive and therapeutic vulnerabilities for SCLC and other cancers with similar mutations.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2011.04a
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• pp.489-492
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• 2011

장대레일 궤도의 부동구간에서 발생되는 과도한 축력은 혹서기 궤도의 좌굴을 유발시켜 주행하는 열차의 안정성을 위협할 수 있다. 궤도 제원을 제외한 압축응력과 관련된 레일온도 인자, 궤도 강성과 관련된 도상저항력, 궤도의 초기결함인 궤도틀림과 같은 인자들은 기후조건, 궤도 운영조건, 유지관리조건 등에 의해 임의적으로 변동되는 불확실성이 높은 궤도 매개변수이다. 그러므로 장대레일 궤도의 좌굴은 불확실성이 높은 현상임을 알 수 있다. 따라서 궤도 매개변수들의 불확실성 및 임의성을 합리적으로 고려하기 위해서는 확률론적 접근방법의 적용이 필수적이라 할 수 있다. 본 논문에서는 기존 본 연구진에 의해 개발된 장대레일 궤도의 좌굴확률 평가시스템을 이용하여 장대레일 축력을 산정하기 위한 필수요소인 중립온도의 확률분포 특성에 따른 좌굴 안정성을 분석하였다.

• Clinical and Experimental Pediatrics
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• v.50 no.4
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• pp.376-380
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• 2007

Purpose : Febrile seizures occur in childhood associated with a febrile illness not caused by infections of the central nervous system. Provoked seizures are identified with seizures in association with infections that do not usually affect the brain such as gastroenteritis, except criteria for other febrile seizures in this study. We studied seizures provoked by minor extracranial infections, to contrast them with febrile and provoked seizures. Methods : We retrospectively studied one hundred and twenty children with provoked and febrile seizures who visited Chungbuk National University hospital from January, 2000 to December, 2004. Among these children, 36 patients were determined as provoked seizures and 84 patients as febrile seizures. We compared the distribution of minor infections between the patients with provoked seizures and those with febrile seizures, and studied risk factors of subsequent unprovoked seizures after febrile and provoked seizures associated with minor infections. Results : We analyzed the records of 120 children aged from 1 month to 15 years. The common etiologies of minor infections were gastroenteritis and respiratory infections. In the group of febrile seizures, there was a significantly greater proportion of patients with respiratory infections (58.3%) and a lesser proportion of those with gastroenteritis (25.0%). But there was a higher incidence of gastroenteritis (50.0%) in the provoked group. Comparing the distribution of etiologies between the patients with provoked seizures and those with febrile seizures seemed a significant difference. But, there were no difference between the provoked seizures and febrile seizures in the risk for subsequent unprovoked seizures. Conclusion : In conclusion, the leading cause except brain involvement is gastroenteritis in patients with provoked seizures, and respiratory infection in those with febrile seizures. Thus we need prompt recognition of, and medical attention given to, seizures associated with minor infections.

• The Journal of the Korea Contents Association
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• v.11 no.4
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• pp.273-282
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• 2011

This study was to investigate the effect of improve forelimb sensorimotor function and neurotrophic factor(GAP-43) expression when differing an application time of tDCS in ischemic brain injury rat model(pre, $1^{st}$, $7^{th}$, $14^{th}$). Focal ischemic brain injury was induced in 80 Sprague-Dawley rats through middle cerebral artery occlusion(MCAO) by 'Longa' method. And then experimental groups were randomly divided into four groups; GroupI: MCAO induction, GroupII: application of tDCS(10 min) after MCAO induction, GroupIII: application of tDCS(20 min) after MCAO induction, GroupIV: application of tDCS(30 min) after MCAO induction. Modified limb placing test and single pellet reaching test were performed to test forelimb sensorimotor function. And the histological examination was also observed through the immunohistochemistric response of GAP-43(growth-associated protein-43) in the cerebral cortex. In modified limb placing test, groupIII(p<0.05) showed significantly improve than the other groups on $14^{th}$). day. In single pellet reaching test, groupIII(p<0.01) and groupIV(p<0.05) significantly improved on $14^{th}$) day. And in immunohistochemistric response of GAP-43, group III showed significantly positive response than the other groups on $14^{th}$ day. These results suggest that the intensity(0.1 mA)/time(20 min) condition of tDCS application has a significant impact on the sensorimotor functional recovery in focal ischemic brain injury rat models.

• The Journal of Korean Academy of Prosthodontics
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• v.9 no.1
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• pp.79-83
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• 1969

1) 가능(可能)한한 조직(組織)이 변형(變形)되지 않아야 한다. 2) Atmospheric pressure를 이용(利用)하기 위(爲)하여 peripheral border 에 있어서의 조직변형(組織變形)이 필요(必要)한 경과(境過)는 그 정도(程度)가 eiastic force가 retentive force 보다 크지 않도록 최소한(最小限)으로 해야 한다. 3) Denture base와 조직(組織)의 원형간(原形間)에는 접촉(接觸)이 밀접(密接)해야 한다. 그래야 saliva의 film 균일(均一)하고 얇게 될 수 있다. 4) Atmospheric pressure는 denture의 retention과 중요(重要)한 연관성이 있으므로 physiologic seal area를 형성(形成)해 주는 것이 유리(有利)하다. 5) Ridge의 형태(形態)도 denture의 retention 대(對)한 하나의 중요(重要)한 인자(因子)이다. 6) Denture에 의(依)해서 피개(被蓋)되는 면적(面積)은 retention에 관계(關係)되는 한 인자(因子)로써 피개면적(被蓋面積)이 클수록 유지력(維持力)이 커진다. 7) Saliva의 viscosity도 retention의 한 인자(因子)가 된다. 8) Friction은 retention의 한 인자(因子)가 될수는 있으나 병인적(病因的)인 증상(症狀)을 유발(誘發)할수 있으므로 이용(利用)해서는 않된다.

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2003.11a
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• pp.562-571
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• 2003

A series of factors such as sampling, pretreatment measurement, volume estimation which induces uncertainty of the calculated radioactivity in liquid effluent released from a nuclear power plant were analyzed. It is innately impossible to estimate exact error of the calculated radioactivity, since most of the input parameters are determined by a single measurement and true value of the released radioactivity cannot be known. In this paper, a systematic model to calculate uncertainty of the released liquid radioactivity was developed based upon the guidance report published by the ISO in 1993, and the model was applied to a set of hypothetical batch release conditions. As a result, the Priority of each input parameter was turned out to be (1) wastewater volume, (2) sample volume, and (3) measured radioactivity of the sample. In addition, probability distribution of the released radioactivity was simulated by Monte Carlo method combining the probability distribution of each input parameter It was shown that the radioactivity released to the environment, which has been reported as a single value, has a certain form of probability distribution.