• Title/Summary/Keyword: 위해성평가모델

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Toxicokinetic and Toxicodynamic Models for Ecological Risk Assessment (생태위해성 평가를 위한 독성동태학 및 독성역학 모델)

  • Lee, Jong-Hyeon
    • Environmental Analysis Health and Toxicology
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    • v.24 no.2
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    • pp.79-93
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    • 2009
  • 오염물질에 대한 생태위해성평가(ecological risk assessment)를 위해서는 노출평가(exposure assessment)와 함께 생물영향에 대한 평가(effect assessment)를 수행해야 한다. 노출평가의 경우는 지화학적 과정에 대한 이해를 바탕으로 환경농도를 예측하기 위한 화학평형모델이나 다매체환경거동모델 등 다양한 평가 및 예측모델을 활용해 왔다. 이와 달리 생물영향평가는 실험실 조건에서 제한된 독성자료를 대상으로 외부노출농도에 기반한 농도-반응관계를 통계적 방법을 통해서 추정하는 '경험적 모델(empirical model)'에 주로 의존해 왔다. 최근에 와서 생체 내 잔류량을 기반으로 농도-시간-반응관계를 기술하고 예측하는 독성동태학 및 독성역학 모델(toxicokinetic-toxicodynamic model)과 같은 독성작용에 기반한 모델(processbased model)들이 개발되어 활용되고 있다. 본 논문에서는 여러 종류의 독성동태학 및 독성역학 모델을 소개하고, 이를 통계적 추론에 기반한 전통적인 독성학 모델과 비교하였다. 서로 다른 종류의 독성동태학 및 독성역학 모델로부터 도출된 노출농도-시간 -반응관계식을 비교하고, 동일 독성기작을 보이는 오염물질 그룹 내에서 미측정 오염물질의 독성을 예측할 수 있게 해주는 구조-활성관계(Quantitative Structure-Activity Relationship, QSAR) 모델을 여러 독성동태 및 독성역학모델로부터 유도하였다. 마지막으로 독성동태학 및 독성역학 파라미터를 추정하기 위한 실험계획을 제안하였고, 앞으로 독성동태학 및 독성역학 모델을 생태계 위해성평가에 활용하기 위해서 해결해야 될 연구과제를 검토하였다.

Comparative Study of Soil Risk Assessment Models used in Developed Countries (선진국의 토양위해성평가 모델 비교분석 연구)

  • An, Youn-Joo;Baek, Yong-Wook;Lee, Woo-Mi;Jeong, Seung-Woo;Kim, Tae-Seung
    • Journal of Soil and Groundwater Environment
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    • v.12 no.1
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    • pp.53-63
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    • 2007
  • Soil risk assessment models were used to determine the goals of soil remediation and to establish the soil quality standards in developed countries. Recently, Korean Ministry of Environment prepared the guideline for soil risk assessment. Soil risk assessment model applicable to Korean situation will be needed in the near future. In this study, three models for soil risk assessment were extensively compared to suggest the fundamental components that required for the soil risk assessment in Korea. The models considered in this study were CalTOX in the United States, CLEA (Contaminated Land Exposure Assessment) in the United Kingdom, and CSOIL in the Netherlands. The major exposure routes and the intake estimation equations suitable for Korean situation were suggested. The exposure routes suggested were intake of the crops, underground water, indoor outdoor soil ingestion, dust inhalation and a volatile matter inhalation. The equations for intake estimation used in CalTOX and CSOIL seem to be applicable for the calculation of the human intake in Korea.

A Study on Improvement Method of Defense Systems Interoperability Assessment based on LISI (LISI 기반의 국방 체계 상호운용성 평가 개선 방안 연구)

  • Jang, Jae-Deok;Choi, Sang-Taik;Kim, Myong-Ho;Park, Dong-Ju;Choi, Sang-Wook
    • Proceedings of the Korean Information Science Society Conference
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    • 2011.06a
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    • pp.1-4
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    • 2011
  • 본 논문은 현재 국방 체계의 상호운용성 수준을 평가하는 방법으로 사용하는 LISI 모델에 대해 개선되어야 할 내용을 제시한다. 우리 군은 국방 체계에 대해 상호운용성 수준 측정을 위해 LISI를 기반으로 한 자동화 도구를 활용하는 등 상호운용성 확보를 위해 많은 노력을 기울이고 있다. 그러나 소요제기/개념단계, 설계 단계에서 적용되는 LISI 모델에는 미흡한 점이 있다. 이를 극복하기 위해 본 논문에서는 아키텍처 구축 시 LISI를 적용하는 방법에 대해 제안한다. 상호운용성이 확보 가능한 아키텍처를 구축하기 위해 서는 LISI를 기반으로 아키텍처 대안들을 평가함으로써 향후 개발에 적용될 아키텍처가 상호운용성 요구를 달성하고 있음을 검증해야 한다. 더불어 본 논문은 LISI 모델 기반 상호운용성 평가를 위해 주요하게 고려되는 능력모델에 대한 절차(P), 응용(A), 기반구조(I), 데이터(D) 내용을 참조모델을 통해 최신화하는 방안에 대해 제안한다.

Study on the Methodology of the Microbial Risk Assessment in Food (식품중 미생물 위해성평가 방법론 연구)

  • 이효민;최시내;윤은경;한지연;김창민;김길생
    • Journal of Food Hygiene and Safety
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    • v.14 no.4
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    • pp.319-326
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    • 1999
  • Recently, it is continuously rising to concern about the health risk being induced by microorganisms in food such as Escherichia coli O157:H7 and Listeria monocytogenes. Various organizations and regulatory agencies including U.S.FPA, U.S.DA and FAO/WHO are preparing the methodology building to apply microbial quantitative risk assessment to risk-based food safety program. Microbial risks are primarily the result of single exposure and its health impacts are immediate and serious. Therefore, the methodology of risk assessment differs from that of chemical risk assessment. Microbial quantitative risk assessment consists of tow steps; hazard identification, exposure assessment, dose-response assessment and risk characterization. Hazard identification is accomplished by observing and defining the types of adverse health effects in humans associated with exposure to foodborne agents. Epidemiological evidence which links the various disease with the particular exposure route is an important component of this identification. Exposure assessment includes the quantification of microbial exposure regarding the dynamics of microbial growth in food processing, transport, packaging and specific time-temperature conditions at various points from animal production to consumption. Dose-response assessment is the process characterizing dose-response correlation between microbial exposure and disease incidence. Unlike chemical carcinogens, the dose-response assessment for microbial pathogens has not focused on animal models for extrapolation to humans. Risk characterization links the exposure assessment and dose-response assessment and involve uncertainty analysis. The methodology of microbial dose-response assessment is classified as nonthreshold and thresh-old approach. The nonthreshold model have assumption that one organism is capable of producing an infection if it arrives at an appropriate site and organism have independence. Recently, the Exponential, Beta-poission, Gompertz, and Gamma-weibull models are using as nonthreshold model. The Log-normal and Log-logistic models are using as threshold model. The threshold has the assumption that a toxicant is produce by interaction of organisms. In this study, it was reviewed detailed process including risk value using model parameter and microbial exposure dose. Also this study suggested model application methodology in field of exposure assessment using assumed food microbial data(NaCl, water activity, temperature, pH, etc.) and the commercially used Food MicroModel. We recognized that human volunteer data to the healthy man are preferred rather than epidemiological data fur obtaining exact dose-response data. But, the foreign agencies are studying the characterization of correlation between human and animal. For the comparison of differences to the population sensitivity: it must be executed domestic study such as the establishment of dose-response data to the Korean volunteer by each microbial and microbial exposure assessment in food.

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초고온가스로 흑연 노심 구조 건전성

  • Kim, Eung-Seon
    • Journal of the KSME
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    • v.55 no.10
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    • pp.36-39
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    • 2015
  • 이 글에서는 초고온가스로 노심 흑연 구조물의 신뢰성 평가 관련 이해를 돕기 위해 원자력급 흑연의 일반적인 특성, 흑연 구조물의 파손 평가 모델 및 이론, ASME 응력 평가 모델에 대해 기술하고자 한다.

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A Proposal of Evaluation of Large Language Models Built Based on Research Data (연구데이터 관점에서 본 거대언어모델 품질 평가 기준 제언)

  • Na-eun Han;Sujeong Seo;Jung-ho Um
    • Journal of the Korean Society for information Management
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    • v.40 no.3
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    • pp.77-98
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    • 2023
  • Large Language Models (LLMs) are becoming the major trend in the natural language processing field. These models were built based on research data, but information such as types, limitations, and risks of using research data are unknown. This research would present how to analyze and evaluate the LLMs that were built with research data: LLaMA or LLaMA base models such as Alpaca of Stanford, Vicuna of the large model systems organization, and ChatGPT from OpenAI from the perspective of research data. This quality evaluation focuses on the validity, functionality, and reliability of Data Quality Management (DQM). Furthermore, we adopted the Holistic Evaluation of Language Models (HELM) to understand its evaluation criteria and then discussed its limitations. This study presents quality evaluation criteria for LLMs using research data and future development directions.

Web Accessibility Evaluation Model Development for Specific user group based on WCAG 2.0 (WCAG2.0 기반의 특정 사용자 집단을 위한 웹 접근성 평가 모델 개발)

  • Kim, Cho-Yi;Hong, So-Yeon;Kim, So-Ra;Han, Hyuk-Soo
    • Proceedings of the Korea Information Processing Society Conference
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    • 2009.11a
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    • pp.417-418
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    • 2009
  • 웹이 대중화되면서, 사용자 계층도 어린이, 노인, 장애인 등으로 다양해졌다. 인지적, 신체적 특징에 상관없이 모든 사람에게 동등한 웹 기회를 제공하고 있는가를 나타내는 지표가 웹 접근성이다. 웹 사이트들이 특정 수준의 웹 접근성을 준수하도록 유도하기 위해 W3C(World Wide Web Consourtium)의 WAI(Web Accessiability Initiative)는 웹 콘텐츠 접근성 가이드라인 WCAG (Web Content Accessibility Guideliens)를 개발하였다. 현재, WCAG2.0까지 발표된 가이드라인은, 4개의 원칙(Principle), 12개의 지침(Guideline), 그리고 61개의 성공기준(Success Criteria)으로 구성 되어 있다. 평가자들은 WCAG2.0에서 제시하는 성공 기준에 맞춰, 웹 사이트가 웹 접근성을 어느 수준으로 준수하고 있는지 평가한다. 하지만, WCAG2.0을 기준으로 웹 사이트를 평가할 경우, 성공기준의 준수여부는 평가가 가능하지만, 특정 사용자 집단의 특성을 반영한, 우선순위가 포함되지 않아, 특정 사용자 집단을 위한 개선 사항을 도출하는데 어려움이 있다. 이에, 본 논문에서는 이러한 점을 고려하여 WCAG2.0 기반의, 특정 사용 집단을 위한 웹 접근성 평가 모델을 제안한다. 사용자 특성에 따라 성공지침들의 중요도가 달라 질 수 있으므로, AHP 기법을 활용하여 성공지침들의 상대적 중요도를 평가하고, 우선순위화 하였다. 평가 모델의 효용성을 입증하기 위해, 특정 사용집단으로 노인 집단을 선정하여, 웹 접근성 평가 모델을 개발하였다.

Suitability Assessment for Agriculture of Soils Adjacent to Abandoned Mining Areas Using Different Human Risk Assessment Models (인체 위해성평가 모델을 이용한 폐광산 주변 농경지 적합성 평가)

  • Lee, Jun-Su;Kim, Young-Nam;Kim, Kye-Hoon
    • Korean Journal of Soil Science and Fertilizer
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    • v.43 no.5
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    • pp.674-683
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    • 2010
  • The current study was performed to examine the agricultural suitability of the cultivated upland nearby abandoned mining areas in Korea using three different scientific risk assessment models of Korea, USA and UK. For this, three mining sites DM, MG and KS were selected among 687 abandoned mines through preliminary risk assessment. A wide range of parameters were obtained through analysis of both soil and crop samples from the selected areas for heavy metal concentration and questionnaires to the communities along with the selected mining sites. Heavy metal concentration in soil samples was lower than the values previously reported by the Ministry of Environment (ME, 2002). However, both As and Cd concentration in the soil samples exceeded the concern level for agricultural area of the Soil Environment Conservation Act. Judging from the contaminant criteria for the crops, only Zn level in pepper, soybean and corn from the mining area DM exceeded the criteria whereas As, Cd, $Cr^{6+}$, Cu, Hg, Ni, Pb did not exceed the criteria. It was demonstrated that there would be human health risk by Pb accumulated in crops from both mining areas MG and KS when estimated by the risk assessment models of Korea and USA. Against it, results of the risk assessment model of UK showed human health risk by Pb in the crops from all study areas.

A Study for Design and Implementation of Open Source Software Maturity and Applicability Assessment Model(OSMAAM) for OSS Proliferation (오픈소스 소프트웨어 활성화를 위한 성숙도 및 적용성 평가 모델(OSMAAM)의 설계 및 구현에 관한 연구)

  • Jung, Yunjae;Oh, Seung Woon;Kim, Hyeong Chae;PARK, JIN HONG;Kim, Keun Dong
    • Informatization Policy
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    • v.20 no.1
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    • pp.85-109
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    • 2013
  • This study presents a model and its implementation methodology assessing not only maturity but also applicability in order to increase the practical usage of open source software(OSS). Since this model measures applicability which can not be assessed by the previous models, it is able to support users in many ways when they introduce OSS for the first time, replace commercial software with OSS, and compare OSS with commercial software. For the purpose of design and implementation of this model, we presented a methodology with 7 phases and conducted a survey to evaluate the appropriateness and reliability of the model. In addition, we proved the practical usability of the model by providing a practical example assessing maturity and applicability of OSS in the area of the infra category on the basis of the methodology. In the future, not only general users but also officers in charge of informatization will be able to select optimal OSS by using this model for industrial application. Therefore, the result of this research is expected to greatly contribute to OSS promotion policy.

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Cloud Model based Efficiency Evaluation of Asset (클라우드 모델 기반의 자산 효율성 평가)

  • Choi, Hanyong
    • Journal of Digital Convergence
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    • v.17 no.12
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    • pp.229-234
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    • 2019
  • The software market has diversified service needs due to the expansion of the mobile market. To this end, the company intends to produce various apps by extending to the design domain based on the structured architectural assets of the domain market. In this study, we propose an evaluation model that can evaluate the efficiency for servicing assets that reflect the domain characteristics of architecture based on cloud. Based on the characteristics of ISO/IEC 25010 quality model of SQuaRE Series, a software evaluation standard, evaluation model sub-features for evaluating the efficiency of cloud-based asset data were constructed. When the architectural assets were designed as composite assets, they were designed to provide the flexibility of the evaluation model by applying the mandatory and optional evaluation elements of the sub-features that weighted the evaluation items according to the characteristics of the design domain.