• 대한위암학회:학술대회논문집
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• 2003.11a
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• pp.39-43
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• 2003

• 대한위암학회:학술대회논문집
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• 2001.11a
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• pp.45-45
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• 2001

• The Journal of the Korea Contents Association
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• v.10 no.9
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• pp.251-258
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• 2010

Despite significant advance in laparoscopy, upper gastrointestinal (UGI) series is still generally carried out for preoperative localization of gastrectomy. The aim of the study was to compare the accuracy of UGI series and postoperative pathological findings in the diagnosis and localization of gastric cancer. A retrospective review was carried out for 102 patients who underwent gastrectomy between October 2007 and April 2009. Preoperative reports of UGI series were compared with postoperative pathology reports and the accuracy of the preoperative reports was calculated. Two radiographer retrospectively reviewed the analysis of UGI series. postoperative pathology reports of the surgical specimens, were compared with the preoperative reports of the location and extent of the tumor were correct in 81 case("sure", 79.4%) and incorrect in 21 case("failed, 20.6%). In 92 case UGI series revealed intestinal metaplasia (90.2%) at consensus review and these results demonstrate the limitation of the UGI series in the diagnosis of type IIb gastric cancer with size less than 1.0cm and the poor detection of gastric cancer is that the overlying mucous membrane often appears to be normal in these patients. In conclusion, UGI series is accurate the detection of the tumor localization and diagnosis of intestinal metaplasia. However, for the overcome with the limitation of UGI series should be used accurate technique for the region of the stomach. To achieve this goal, it is necessary to determine the changes of the mucus membrane of the stomach and UGI series is gaining acceptance as a standard method for preoperative gastric cancer screening.

• Journal of Gastric Cancer
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• v.9 no.3
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• pp.117-127
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• 2009

Purpose: Adequate health-related information provided by health professionals may help cancer patients overcome their uncertain situation and manage their healthcare. To provide information effectively, there is a need to understand the content of the patients' essential information. The purpose of this study was to identify recent informational needs of postoperative gastric cancer patients. Materials and Methods: Data were collected from 190 postoperative gastric cancer patients who attended the Stomach Cancer Patients' Day ceremony (18 November 2008) held by the Stomach Cancer Center of Samsung Medical Center with the use of a questionnaire which measured informational needs. A questionnaire with 37 items was comprised of domains of diagnostic tests, cancer therapy, prognosis, follow-up, sexual activity, stomach cancer-related information, and 7 single items. Results: The priorities of informational needs were the domains of prognosis, ways of healthcare during treatment (a single item), follow-up, stomach cancer-related information, cancer therapy, and diagnostic tests (in descending order). Items related to prognosis, diet, and management of their healthcare ranked in the top 10 informational need scores. As age decreased, the degree of informational needs about diagnostic tests, cancer therapy, sexual activity, and stomach cancer-related information increased. Conclusion: We suggest that prognosis-related information based on the accumulated institutional therapeutic outcomes and objective prognosis data should be incorporated in the current education program. Health professionals should provide comprehensible information content to cancer patients and caregivers and encourage patients to participate in their therapy with a more positive attitude.

• Journal of Life Science
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• v.31 no.12
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• pp.1057-1065
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• 2021

Alterations in mitochondrial DNA (mtDNA) copy numbers have been reported in patients with stomach cancer and suggested to play a role in gastric carcinogenesis or gastric cancer progression. However, changes in the levels of mitochondrial proteins or mtDNA-encoded oxidative phosphorylation (OXPHOS) proteins in gastric cancer remain unclear. In this study, we investigated mtDNA contents, mitochondrial protein levels, and mtDNA-encoded OXPHOS protein levels in gastric cancer tissues and cell lines. We correlated mtDNA copy numbers with clinicopathologic features of the gastric cancer samples used in this study and used quantitative PCR to analyze the mtDNA copy numbers of the gastric cancer tissues and cell lines. Western blot analysis was used for assessing the amounts of mitochondrial proteins and mtDNA-encoded OXPHOS proteins. Among the 27 gastric cancer samples, 22 showed a reduction in mtDNA copy numbers. The mtDNA content was increased in the other five samples relative to that in normal matched gastric tissues. Mitochondrial protein and OXPHOS protein levels were reduced in some gastric cancer tissues. However, mitochondrial protein and OXPHOS protein levels in gastric cancer cell lines were not always in line with their mtDNA contents. The mtDNA copy numbers were reduced in five gastric cancer cell lines tested in this study. In summary, this study reports a common reduction in mtDNA contents in gastric carcinoma tissues and cell lines, pointing to the possible involvement of mtDNA content alterations in tumorigenesis of the stomach.

• Journal of Gastric Cancer
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• v.6 no.2
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• pp.114-119
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• 2006

Purpose: The purpose of this study is to determine whether it is possible to evaluate patients with pN2 or pN3 early gastric cancer (EGC) as being in an advanced stage before and during the operation. Materials and Methods: 4,430 patients underwent a gastrectomy for cancer from 1990 to 2003. Eight of the 552 patients with EGC included pN2 or pN3. The estimated clinical and surgical stage before and during the operation were compared to the pathological results, and a follow-up of progression was done. Results: The patients were evenly distributed among all age groups with seven men and one woman. The pre-operative estimate of T1 by CT was 25% (2/8). In the main, the cT stage was over estimated. The estimate of over N2 was 50% (4/8). One patient was preoperatively staged as la sT1 during operation was 57.1% (4/7), and the estimate of over N2 was 67% (4/6). Two patients were intraoperatively evaluated as Ia. Only one patient survived over 5 years, and the mean survival of these patients was 15 months $(95%\;Cl:\;0{\sim}35.5)$. Conclusion: It was generally possible to evaluate patients with EGC of over pN2 as being in an advanced stage before and during the operation. Although very rare (2/552, 0.04%), there were EGC patients whose stages were not predictable at all. Therefore, more precise preoperative and intraoperative staging methods are warranted.

• Proceedings of the KAIS Fall Conference
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• 2009.05a
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• pp.123-127
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• 2009

본 논문은 국내 일부지역 주민의 건강행태가 위암발생에 영향을 미치는 요인들을 규명하기 위해 시행하였다. 이를 위해 서울에 소재한 한 종합병원에 위암관련 검진을 받기 위해 내원한 환자로 조직병리검사상 위암으로 확진받은 91명을 환자군으로 선정하였다. 대조군도 환자군과 동일한 기간, 동일한 병원 내과에 내원하여 동일한 방법으로 검진한 결과 위암에 속하지 않는 것으로 진단된 환자군과 연령, 성별에 대해 짝짓기하여 선정된 91명이었다. 자료수집은 2008년 12월 20일부터 2009년 1월 30일까지 설문과 면접조사의 방법을 병행하여 진행하였다. 연구결과 첫째, 취미활동량은 취미활동을 전혀 하지 않는 군에 비해 일일 평균 300kcal 미만 또는 그 이상의 열량을 소모하는 군에서 교차비가 각각 0.27과 0.33으로 위암발생 위험을 유의하게 감소시켰다(P<0.05). 둘째, 음주경험이 없는 군에 비해 있는 군(OR=1.85, 95% Cl=1.02-3.36), 총 음주기간이 30년 이상인 경우(OR=5.91, 95% Cl=1.78-19.95)에서 유의하게 높았다. 셋째, 탄음식을 주 3회 이상 섭취할 경우(OR=4.85 95% Cl=1.61-9.84), 짠음식의 섭취빈도가 주 3회 이상인 경우(OR=1.49 95% Cl=0.26-0.91) 위암발생과 유의하게 관련되었다. 넷째, 다중 로지스틱 회귀분석결과 위암발생에 영향을 미치는 요인은 월평균소득, 10년 전 BMI, 취미활동량, 알코올 섭취량, 탄류 및 짠류 섭취였다. 이러한 연구결과를 토대로 적당한 취미활동이 육체적 활동량의 증가뿐만 아니라 건강행동변화를 유도하여 결과적으로 위암예방 효과를 높일 수 있을 것이라 본다.

• The Korean Journal of Applied Statistics
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• v.34 no.2
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• pp.255-266
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• 2021

The purpose of this study is to compare the effects of treatment on stage III stomach cancer data obtained from the SEER program of the National Cancer Institute and to identify the significant risk factors for the survival rates of stage III stomach cancer. Since the proportional hazards assumption was violated for treatment, we used the restricted mean survival time as an alternative to the proportional hazards model. The restricted mean survival time was estimated using pseudo-observations, and the effects of treatment were compared using a test statistic based on the estimated restricted mean survival times. We conducted the regression analysis using a generalized linear model to investigate the significant predictors for the restricted mean survival time of patients with stage III stomach cancer. We found that there was a significant difference between the restricted mean survival times of treatment groups. Age at diagnosis, race, substage, grade, tumor size, surgery, and treatment were significant predictors for the restricted mean survival time of patients with stage III stomach cancer. Surgery was the most significant predictor for increasing the restricted mean survival time of patients with stage III stomach cancer.

• 대한위암학회:학술대회논문집
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• 2005.04a
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• pp.22-22
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• 2005

• 대한위암학회:학술대회논문집
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• 2005.04a
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• pp.20-20
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• 2005