• Proceedings of the Korean Society of Applied Pharmacology
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• 1995.04a
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• pp.116-116
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• 1995

위염(gastritis), 위궤양(gastric ulcer)은 소화기 질환중에서 가장 빈도수가 높은 질병으로 위장관 점막이 위산에 의해 소화되어 버리므로서 궤양을 형성하는 상태를 말한다. 위염 및 위궤양의 발생빈도가 높은 것에 비해 발생원인은 정확히 밝혀져 있지 않으며 대체로 공격인자와 방어인자의 불균형 즉, 공격인자의 증가나 방어인자의 약화 또는 세균에 의한 감염에 의해 발생되는 것으로 알려져 있다. 일련의 식물엑스에 대하여 항위얌 및 항궤양효능에 관한 검색을 실시하여 노두의 M？H엑스가 현저한 효과가 있음을 예지하였으므로 그에 대하여 보다 구체적인 실험을 실시하였다. 즉 MeOH 엑스를 Hexane, CHCl$_3$, BuOH로 계통적으로 추출하여 상기의 분획 및 잔사인 물분획을 제조하여 이에 대한 실험을 실시하였다.

• Journal of the Korean Society of Food Culture
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• v.5 no.3
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• pp.381-390
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• 1990

양념의 섭취는 고대 에집트 시절부터 시작되어서 현재에까지 인류의 식탁을 지켜 오고 있다. 양념의 용도는 시대에 따라서 다양화되고 있다. 고대에는 양념의 용도는 단순히 음식의 풍미를 돋구기 위해서 사용하였지만, 현대 사회로 올수록, 다양한 음식과 음료수의 맛과 향, 식품저장, 의학적 생리학적인 용도, 및 화장품 및 향수 제조를 위해서 사용한다. 세계적으로 이용되고 있는 양념의 수는 약 70여종에 이르고 있으나, 우리나라 식탁을 오르내리는 상용하는 양념의 수는 10종 내외로 본다. 그러므로 우리나라 음식 향과 맛의 단조로움을 느끼기 때문에 보다 다양한 양념의 개발이 요청된다. 최근 들어와서 고추와 마늘의 생리학적 기능이 재평가되고 있어서, 현대인의 고민인 고혈압과 이와 관련된 순환계 계통의 질병 및 암의 발병 방지 및 치료에도 효과가 있다는 보고가 되고 있다. 위궤양 및 위산분비 비정상인은 자극적인 양념인 고추나 마늘의 섭취를 금지하여 왔으나, 특별히 고추의 섭취가 이러한 상태에 있는 사람들에게 반듯이 위액분비를 자극하지 않는다는 보고도 되어 있다. 양념에 함유된 영양소의 함량으로 미루어 보면 열량 무기질의 일부 및 비타민의 일부 공급원으로 중요하다. 한국인에게 중요한 양념으로 여겨지는 고추와 마늘의 섭취량은 한국 경제가 성장함에 따라 그 섭취량이 증가되는 경향을 나타낸다.

• Korean Journal of Bronchoesophagology
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• v.1 no.1
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• pp.55-63
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• 1995

Gastroesophageal reflux is thought to be an important etiology of the various upper aerodigestive tract disease. To investigate the role of gastric acid and pepsin as an etiologic factor of laryngotracheal stenosis, and the difference of injury by synthetic gastric juice between in ciliated respiratory epithelium and in squamous epithelium, experimental study was carried out using rabbits. Mucociliary transport affected by synthetic gastric juice was also studied in dogs. Synthetic gastric juice of low pH caused serious damage and Impairment of mucociliary transport in the epithelium of the larynx and trachea. Gastric acid played major role in the mucosal damage. Squamous epithelium of vocal folds and pharynx was more resistant to synthetic gastric juice than respiratory epitheium. In conclusion, gastroesophageal reflux may be an etiologic factor in the developement of laryngotracheal stenosis, so the adequate management is necessory In patients of laryngotracheal stenosis.

• Proceedings of the Korea Water Resources Association Conference
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• 2012.05a
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• pp.409-413
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• 2012

아라뱃길은 다양한 수리구조물의 조작을 통하여 선박운항 및 홍수처리가 이루어지며 유입홍수량, 한강수위, 그리고 서해조위 변동과 연계하여 귤현보, 서해배수문, 체절수문, 그리고 배수펌프장 등의 대표적인 구조물 운영을 지원할 수 있는 홍수위 계산모형이 필요하다. HEC-RAS모형은 이러한 수리구조물 운영을 효과적으로 경계조건으로 반영할 수 있는 장점이 있다. 특히 서해배수문의 경우 조위변동과 내수위를 동시에 고려한 수문운영이 필요하여 Rule-script기능을 적용하여 이러한 특성을 반영하였다. 모형의 검보정을 위하여 2010년 9월 홍수사상을 적용하였으며 모형으로부터 계산된 수위값과 관측된 수위값이 서로 잘 일치함을 확인하였다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.8 no.1
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• pp.1-11
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• 2005

Purpose: The aim of this study was to evaluate the relationship between H. pylori infection and recurrent abdominal pain (RAP) in children and to evaluate the effects of eradication therapy on RAP. Methods: From January 1998 to January 2005, 166 children with RAP (61 male, 105 female) aged $10.0{\pm}3.3$ years were included. Upper gastrointestinal endoscopies were performed for all the patients. All H. pylori infected children (n=70) received the eradication therapy and were divided into two groups: Group Ia (n=52); eradicated, Group Ib (n=18); non-eradicated. H. pylori-negative children (n=96) were divided into three groups according to the medication: Group IIa (n=67); no medication, Group IIb (n=13); acid-suppressant, Group IIc (n=16); both acid-suppressant and antibiotics. Questionnaire for symptoms were asked at the first, 6th, 12th, 24th, and 36th months following the treatment (grade 0; completely resolved, grade 1; definitely improved, but there are occasional episodes of mild abdominal pain, grade 2; no change in the frequency and intensity of abdominal pain). Results: In about 90% of H. pylori positive children, RAP improved in the both H. pylori-eradicated and non-eradicated children in a follow-up survey. In about 75% of H. pylori-negative children, RAP also improved among in the three groups of patients regardless of medication. Conclusion: These results suggest that there was no correlations between improvement of RAP and eradication of H. pylori, and between improvement of RAP and medication. Consequently the reassurance that the children with RAP have no serious organic cause was important to improvement of RAP.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.31 no.4
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• pp.483-492
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• 1986

To find out the responses of plant growth, nodulation, and yield of soybean and their varietal differences to different soil pH, 16 soybean cultivars were examined under three different levels of soil pH. In general, as the soil pH decreased, plant growth, nodulation, yield and yield component and protein con-tents of grains were decreased in most of cultivars studied. But there were significant varietal differences in the responses of the characters investigated to soil pH. Jangbaegkong was evaluated as the most tolerant cultivar to acid soil, and Ulsan, Bongeui, Hwanggeumkong, and LC7852 were also relatively torelant to acid soil. There were significant correlation between soil pH and grain yield in 7 cultivars among 16, but were not in other cultivars.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.11 no.1
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• pp.87-97
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• 2000

One week survey to investigate the prevalence rate and clinical characteristics of laryngopharyngeal reflux symptoms in Korea. The subject(n=7,704 patients) was newly enrolled patients at the out patient clinic in 90 ENT departments of resident training hospitals and 11 local clinics, which were voluntarily participated in the study 1) Twenty five percent of all enrolled patients has LPR-related symptoms or clinical findings from the examination by ENT specialists. 2) Among e name of LPR-related diagnosis, globus syndrome was e most common, and follows by reflux laryngitis, and chronic laryngitis. 3) Women was more prevalent than men, and it is common in 5th, 6th, and 7th decades, which seems to be related with aging process. 4) Most popular symtoms of LPR. were globus sensation, conic throat clearing, and hoarseness of unknown origin. 5) Aggravating factors of LPR-related symptoms were tiredness, mental stress, drink alcohol, cigarettes smoking, spicy food, and drinking coffee. 6) LPR-related symptoms were more common in professional voice users. 7) In past medical history, diseases of stomach and tonsillitis were most common.

• The Korean Journal of Zoology
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• v.17 no.2
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• pp.69-80
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• 1974

The mucosubstances in the gastrointestinal mucous secreting cells of Rana rugosa were detected histochmeically during pre-hibernating, hibernating, post-hibernating and active phases. The results of the observation were as follows: 1. The mucosubstances in the gastrointestinal mucous secreting cells of active frog were strongly PAS-active in stomach, PAS-active and alcianophilic at pH 2.5 in small intestine and alcianophilic at pH 2.5 in large intestine. 2. The PAS-active mucosubstances in the gastric surface epithelial cells were increased remarkably during hibernation. 3. The alcianophilic mucosubstances at both pH 2.5 and pH 1.0 were decreased remarkably in the goblet cells of small intestine during hibernation, but a little PAS-active ones were increased. 4. The alcianophilic mucosubstances at pH 2.5 were decreased remarkably and a lttle PAS-active ones also were done in the goblet cells of large intestine during hibernation. 5. The increases of the contained quantity of mucosubstances in the gastric surface epithelial cells during hibernationi may have theeffects of preventing cohesions of gastric mucosae and suppressing activities of gastric acid and enzymes. The mucosubstances neutral acidity in the intestine during hibernation may be secreted, because of acidity being done near neutrality in its lumen, due to remarkable decrease of intestinal juices and gastric acids.

• Journal of Food Hygiene and Safety
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• v.31 no.4
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• pp.286-293
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• 2016

This study is an experiment for gastric protective effects of ursolic acid. In order to identify the effects of ursolic acid on gastrointestinal disorder, acute and chronic gastritis were also observed using HCl ethanol and indomethacin-induced gastric lesion models, respectively. As for gastric acid, it was also identified through proton pump ($H^+/K^+-ATPase$) inhibiting activity. In regards to protective factor for gastric damage, prostaglandin $E_2$ ($PGE_2$) was quantitatively analyzed. Antibacterial activity experiment was done on Helicobacter pylori (H.pylori), which is known to be the causing factor of chronic gastritis, gastric ulcer and gastric cancer. By making use of AGS cell, it was confirmed that ursolic acid was involved in apoptosis of gastric cancer cell through 4',6-diamidino-2-phenylindol (DAPI) staining and flow cytometry analysis. As a result, ursolic acid reduced gastric lesions caused by HCl ethanol and indomethacin. Ursolic acid inhibited acid secretion by inhibiting proton pump ($H^+/K^+-ATPase$), which is the gastric acid secreting enzyme involved at the final phase of gastric acid secretion. And ursolic acid was identified with gastric mucosa protection effects by increasing the concentration of $PGE_2$, a protective factor of gastric mucosa preservation. The antibacterial activity on H. pylori, which is aggressive factor in gastrointestinal disorder, ursolic acid showed inhibitory effects on H. pylori colonization. In the DAPI nuclear staining, unlike the control group, shape of the nucleus has deformed, and has been observed either shrinked cell or chromatin condensation phenomenon. In the Flow cytometry assay, confirmed the growth rate of apoptosis in a concentration-dependent manner.

• The Journal of Internal Korean Medicine
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• v.30 no.1
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• pp.191-199
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• 2009

Objectives : The aim of this study was to evaluate the therapeutic effect of acupuncture and herbal medicine in patients who had hvpoactivity of the gastric vagus nerve and pyloric valve disturbance simultaneously with function dyspepsia by bowel sounds analysis. Methods : Bowel sounds of 10 patients (male 1, female 9) were recorded and their % of bowel sound (%BS) and ratio of dominant frequency (DF) were analyzed before and after treatment. Hypoactivity of the gastric vagus nerve was considered if % BS was <6%. and pyloric valve disturbance was accepted if DF ratio (e.g.. postprandial DF/fasting DF) was <1. Electroacupuncture at Zusanli (ST36, 3Hz, 30 minutes) and manual acupuncture at other meridian points were applied daily for 2 weeks. Herbal medicine, Pyengwi-san. was administered to all patients (100cc, 3 times/day). Results : DF ratio significantly increased from $0.93\pm0.06$ to $1.06\pm0.04$ after treatment for 2 weeks (p=0.005). 9 of 10 patients were improved to DF ratio>1. %BS also increased from $2.97\pm1.17%$ to $4.49\pm4.27%$. not significantly. 3 patients showed a remarkable elevation, and their %BS reached >6% of normal value. Conclusions : Combined effect of electroacupuncture at Zusanli (ST36), manual acupuncture. and Pyengwi-san was shown effective in the improvement of pyloric valve disturbance more than hypoactivity of gastric vagus nerve on patients with functional dyspepsia.