• Journal of the Mineralogical Society of Korea
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• v.32 no.4
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• pp.259-271
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• 2019

We evaluated mineralogical, physical property and accelerated weather resistance of cinnabar, realgar and orpiment used as cultural heritages and traditional paintings. JB and JS are sample names of cinnabar and JH and UH are sample names of orpiment and Realgar, respectively. As a result of mineralogical property evaluation, Jinsa was identified cinnabar (HgS) and there was no difference in chemical composition according to the grade. UH and JH were confirmed realgar (AsS) and orpiment (As₂S₃), respectively. The polarization characteristics such as shape and color indicate that pigments using our test were natural mineral pigment observed by polarization microscope. Especially, in the case of cinnabar, it is not easy to distinguish between natural mineral pigment and synthetic pigment. But the results of polarization microscope said that cinnabar is natural occurring mineral which have authentic mineral particle and unevenly fracture. As a result of thermal analysis, JH has a higher glass transition temperature and heat stability than UH. After accelerated weather test, cinnabar, realgar and orpiment were striking result in color change because of light degradation. Red color of cinnabar turn into black and the color of realgar and orpiment became brighter than before. JB (meta-cinnabar) is more photosensitivity and faster becoming dark than JB (cinnabar). Finally light transforms realgar (red, As₄S₄) in arsenolite (As₂O₃).

• Proceedings of the Petrological Society of Korea Conference
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• 1999.06a
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• pp.13-17
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• 1999

• 대한한약신문
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• s.122
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• pp.1-8
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• 2007

식약청장 "건의사항 합리적 방향 조화롭게 추진"/한방의료기관 한약 규격품 사용 의무화/'한약방' 의료비 연말정산자료 인터넷 제출 가능/서울지부, 긴급이사회.임시총회 개최/한약재 '주사' & '웅황' 사용 이렇게/한의학시장 개방시 중의학 잠식 우려/한의학연 최신 침구기술 공개/한약도매업무관리자 추가방안 철회 촉구/'한방 복합엑스산제' 보험급여 추진 논란/심천사혈요법 운영자 실형선고/부적합 판정을 받은 한약재/비증 이야기/신체의 일부 성형수술하면 전체 조화 깨져/명칭이 비슷하여 감별하기 어려운 한약재/지부탐방-제주지부장에게 듣는다/우리 약초를 찾아서-칡

• Economic and Environmental Geology
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• v.48 no.3
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• pp.231-240
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• 2015

A total of 93 mineral medicines are mentioned in the Chinese Bonchodogam(本草圖鑑). In Donguibogam(東醫寶鑑), 77 mineral medicines are listed, where 18 are from soil origin, 4 from gem origin, and 55 mineral medicines were originated from stone. In the Herblogy(本草學), which is the textbook used in most oriental medicine colleges in Korea, a total of 23 mineral medicines are listed. Of those, Cinnabaris, Alumen, Melanteritum, Realgar, Orpimentum, Sulfur, Lime from Donguibogam, additional eight which are Talcum, Calomelas, Minium, Calamina, Stannum, Hydrargyrum, Lithargyrum, Hydrargyrum Chloratum from Bonchodogam and Gypsum, Natrii Sulfas, Talcum, Cinnabaris, Sulfur, Arsenicum Sublimatum, Realgar, Calomelas, Minium, Calamina, Borax, Aurum, Glauberitum from Herblogy were selected as the mineral medicine applicable as external atopic dermatitis treatment. Most of the mineral medicines were generally regarded as toxic materials, and therefore, they were elaborately processed to remove toxicity before use. In accordance, it is necessary to discuss how to effectively remove toxicity from toxic mineral medicines. In addition, detoxification can be applied to those mineral medicines classified based on the index material or high content compounds, and if efficacy can be evaluated through various analytical methods, this can be applied to diverse inflammatory diseases as well as atopic dermatitis.

• The Journal of Korean Medicine
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• v.36 no.1
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• pp.9-21
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• 2015

Objectives: Realgar has been frequently used for skin disorders in history of herbal medicine. However, the efficacy of realgar has not been examined in atopic dermatitis(AD). In this study, the effects of realgar on AD were investigated, especially on pruritus and inflammation. Methods: AD lesions were induced in the shaved backs of BALB/c mice through repeated application of DNCB. The mice were treated for 11 days with 1% realgar ($100{\mu}L/day$). Histological changes in skin thickness were observed. The anti-pruritic effects of realgar were evaluated by the change in numbers of scratching behavior of mice and expression of substance P. The expressions of cytokines IL-4 and IL-6 were measured. Also, anti-inflammatory effects of realgar were examined on expressions of NF-${\kappa}B$, phospho-$I{\kappa}B{\alpha}$ and mitogen-activated protein kinases (MAPKs). Results: Realgar decreased skin thickness (both dermal and epidermal) 38% and 17% respectively, compared to positive control, DNCB group. The scratching behavior of mice was reduced by 42% and expression of substance P was significantly less. Cytokines IL-4 and IL-6 were significantly reduced by 52.6% and 77.6%, respectively. The expressions of NF-${\kappa}B$, phospho-$I{\kappa}B{\alpha}$ and MAPKs (phospho-ERK1/2, -p38 and -JNK) were significantly suppressed with marked effects on phospho-ERK1/2. Conclusions: The collective results suggest that realgar shows anti-pruritic and anti-inflammatory effects on AD. And realgar might be a potential therapeutic candidate for treatment of atopic dermatitis.

• Journal of Conservation Science
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• v.36 no.6
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• pp.549-561
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• 2020

This study aimed to assess the performance and life of nine natural mineral dancheong pigments: Seokganju, Jinsa, Hwangto, Jahwang, Wunghwang, Seokrok, Noerok, Seokcheong, and Baekto. The design of the accelerated weathering test considered the domestic climate characteristics and the location of Dancheong. Outdoor weathering tests were conducted at the Research Institute in Daejeon and the Sungnyemun Gate in Seoul to confirm the field reproducibility of the accelerated weathering test. Monitoring of the physical changes in pigments through accelerated and outdoor weathering tests are based on ultraviolet exposure dose. Despite small cracks at the beginning of the tests, the monitoring showed that Seokganju and Baekto had no marked physical changes, but the surface cracks of Jinsa and Seorok continue to expand. Hwangto and Noerok were marked with water or were resin stained, and the particles of Jahwang, Wunghwang, and Seokcheong had lost their luster. Despite the absolute difference in color change in each test, the final chromaticity change patterns of pigments were similar in that the color difference between Baekto and Noerok was below five, and Jina was above 28. The physical and surface color pigment changes were more concentrated in outdoor weathering tests than in accelerated tests, and the Seoul site was more intense than the Daejeon site. This is because outdoor weathering tests are exposed to severe variations of temperature and moisture or deposition of dust particles and, in the case of Seoul, the site is more exposed to the external environment than the Daejeon site.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.2
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• pp.365-372
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• 2002

The mineral medicines mean a sort of mineral or rock for medical treatment and natural material using their chemical components and physical properties. In this study, it was apprehended the mineralogical characteristics of As-bearing group mineral medicines. The extraction test is an vitro test system for predicting the bioavailability of the major and minor elements from mineral medicines and incorporates gastrointestinal tract parameters representative of a human(including stomach and small intestinal pH, stomach mixing time and velocity). The results of the extraction test are used for reaction path modeling in human body. Reaction path modeling in human body can predict digestion with gastric juice as well as bioavailability, speciation. Also, it can predict accumulation of arsenic as pH condition. As the results of the extraction test for digestion, the amounts of Fe extraction was the highest, followed by As, Ca, Ni. In addition, as the results of the reaction path modeling between arsenic compounds and gastric juice using thermodynamic data, when absorbed, major species are followed by H₃As₃S/sub 6/(aq), As₃S/sub 6/ (aq), AsO/sup +/, H₂As₃S/sup 6-/, H₂AsO/sup 3-/, HAs₃S6/sup 2-/, HAsO/sub 3//sup 2-/ and AsO/sub 3//sup 3-/. Specifically the concentration of H₃As₃S/sub 6/(aq) is the highest. As pH increases, the concentration of H₂AsO/sup 3-/, HAsO/sub 3//sup 2-/, HAsO/sub 3//sup 3-/, HAs₃S/sub 6//sup 2-/, H₂As₃S/sup 6-/, and H₃As₃S/sub 6/ increases, whereas the concentration of H₃As₃S/sub 6/ and AsO/sup +/ decreases. On the results of this study, it is able to find out effective and toxic components of poisonous arsenic group of mineral medicines and expected to be widely used for the development of new medicines.

• Journal of Conservation Science
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• v.32 no.3
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• pp.403-416
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• 2016

Mineral composition and content of 22 Korean Dancheong pigment products were obtained by Rietveld quantitative analysis. Jubosa, Hwang, Seokrok, Seokcheong and Hobun consist of pure cinnabar, orpiment, malachite, azurite and calcite (or aragonite), respectively. Whereas Seokganju, Hwangto, Noerok, Lapis lazuli, Baekto and Cockie hobun mainly consist of hematite, goethite, celadonite, lazurite, kaolin mineral and portlandite, respectively. And they all consist of soil minerals (quartz, feldspar, sericite and vermiculite) and filler minerals in the industry field (calcite, gypsum and anhydrite) at a different content. Quantitative XRD proved more useful method to determined exact mineral composition and content than chemical or microscopical data. If this method utilize for specification of natural pigment product, it is considered to be applicable in restoration technology and conservation science field.

• Journal of Conservation Science
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• v.31 no.4
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• pp.443-455
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• 2015

To verifying the stability of Natural pigments for Dancheong which is available on the market was carried out as light resistance and gas corrosion test. In this particular case, we will confirm the characteristics of the only pigments except of Dancheong technique and influence of substance. Medium using for coloring are animal glue and synthetic resin that widely used for Dancheong in currently. Selected to artificial light source is a xenon arc lamp, contaminated gas is nitrogen dioxide gas in experiment. Degree of degradation of pigment were compared by measuring the degree of color change. The result of light resistance test, mineral pigments were good; color is green and blue type, soil pigments also good; color is yellow ocher, white clay, red clay etc. Gamboge, unghwang, cinnabar, red lead were confirmed not good. The result of gas corrosion test, most of the natural pigments were good condition except the red lead. Generally, animal glue samples had better than a synthetic resin samples.