• The Korean Journal of Nuclear Medicine
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• v.37 no.6
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• pp.341-354
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• 2003

Radioactive iodine therapy using I-131 for hyperthyroidism has been used for more than 50 years, and generally considered safe and devoid of major side effects. Appropriate patient selection criteria and clinical judgement concerning patient preparation should be employed for its optimal use. It has not been possible to resolve the trade-off between efficient definite cure of hyperthyroidism and the high incidence of post-therapy hypothyroidism. The dose of the I-131 needed to maintain euthyroid state remains an area of uncertainity and debate. Early side effects are uncommon and readily managable. Other than the need for long-term monitoring and, in most cases, lifelong thyroid hormone treatment for late adverse consequences of this treatment remains only conjectural. We have reviewed general principles and recent advances in radioiodine treatment for Graves' hyperthyroidism, specially regarding to several controversies.

• 대한핵의학회:학술대회논문집
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• 1969.12a
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• pp.1.4-2
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• 1969

• Journal of the Korean Chemical Society
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• v.15 no.6
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• pp.324-329
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• 1971

In order to evaluate the mechanism of electrolytic oxidation of iodate and to determine the optimum conditions for the electrolysis, studies were made using the cells without diaphragm and the lead peroxide anode. Results are summarized as followings: 1) Current density vs. anode potential curve by lead peroxide electrode had the different limiting current densities from platinum electrode and was more positive than platinum electrode. 2) Additions of potassium bichromate in the electrolyte contribute to maintain high current efficiency. 3) In the acid and alkaline regions, the current efficiencies decreased by reduction of iodate and discharge of hydroxyl ion, so maximum current efficiency was shown at pH 7. 4) Higher current density lowered the current efficiency in the region of 60-80% conversion of iodate. 5) Influence of the conversion on current efficiency in the region of 60-80% conversion of iodate.

• Journal of the Korean Chemical Society
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• v.25 no.3
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• pp.177-182
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• 1981

Benzoylpyridinium and lutidinium salts containing$ [MoO(NCS)_5]^{2-}$ have been synthesized. The complexes have been characterized by spectroscopic, magnetic susceptibility and conductivity studies. Benzoylpyridinium and lutidinium oxopentaisothiocyanatomolybdates(Ⅴ) arise from d-d and charge transfer transitions. The magnetic moments of the complexes are close to the spin-only values. The complex anions are mononuclear containing N-bonded $NCS^-$ ligand.

• YAKHAK HOEJI
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• v.39 no.6
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• pp.631-635
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• 1995

A series of 3, 4-dihydro-3-oxo-2H-1, 2, 4-benzothiadiazine-1, 1, dioxides with cytotoxic activity against human solid tumors is described. Synthesized compounds showed mild but broad spectrum cytotoxicity in vitro. The lipophilic substituents like alkyl, alkoxy and chloro on benzene ring increased the activity. Also hydrophobic group on 3 or 4 position of benzothiadiazine was important for the activity.

• Proceedings of the Optical Society of Korea Conference
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• 1988.06a
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• pp.135-144
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• 1988

1-GW Iodine photodissociation Laser (λ=1.315${\mu}{\textrm}{m}$)is focused to generate the continuum x-ray radiation at titanium(z=22)target. A piced of aluminum(360 )-mylar(8${\mu}{\textrm}{m}$) film is used to isolate the soft X-ray radiation emitted. Convex-xurved mica crystal spectrometer is used to obtain the soft x-ray spectra from the laser titanium target plasma and the slope of continum X-ray spectra are found to show two different different electron effective temperaturres, 0.11keV and 7.1KeV. We compare the two temperature result with the foil absorption method.

• Journal of the Korean Chemical Society
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• v.26 no.6
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• pp.383-388
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• 1982

$Mo_2O_4Cl_2$$(X-py)_4{\cdot}2H_2$O and $(X-pyH)_4$[$Mo_2O_4(NCS)_6)$]${\cdot}H_2$O have been prepared. The infrared, electronic and reflectance spectra, molar conductances and magnetic susceptibility data of complexes are reported. $Mo_2O_4Cl_2$$(X-py)_4{\cdot}2H_2$O (X-py were 3-and 4-cyanopyridine, nicotinamide, 3,5-lutidine and 2-amino-4-picoline) were obtained by hydrolysis of the corresponding substituted pyridinium oxopentachloromolybdates(Ⅴ). Addition of water and substituted pyridines to molybdenum(Ⅴ)-thiocyanate ethylacetate extract yielded brown compounds, $(X-pyH)_4$[$Mo_2O_4(NCS)_6)$]${\cdot}H_2$O where X-py were pyridine, ${\alpha}$, 3-bromopyridine 3,5-lutidine, 3-benzoylpyridine and 4-acetylpyridine. Binuclear, $Mo_2O_4Cl_2(X-py)_4{\cdot}2H_2$ prepared from hydrolysis of $(X-pyH)_2[MoOCl_5]{\cdot}H_2O$ were diamagnetic and nonelectrolytes. The anion of $(X-pyH)_4$[$Mo_2O_4(NCS)_6)$]${\cdot}H_2$O was formulated as dimer and electrolyte.

• Journal of the Korean Chemical Society
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• v.46 no.1
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• pp.26-36
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• 2002

A solid-state reaction of $MoO_3$ with as-synthesized H-SAPO-34 generated paramagnetic Mo(V) species. The dehydration resulted in weak Mo(V) species, and subsequent activation resulted in the formation of Mo(V) species such as $Mo(V)_{5c}$ and $Mo(V)_{6c}$ that are characterized by ESR. The data of ESR and ESEM show the oxomolybdenum species, to be $(MoO_2)^+$ or $(MoO)^{3+}$. The $(MoO_2)^+$ species seems to be more probable. Since H-SAPO-34 has a low framework negative charge, $(MoO)^{3+}$ with a high positive charge can not be easily stabilized. A solution reaction between the solution of silico-molybdic acid and calcined H-SAPO-34 resulted in only $(MoO_2)^+$ species. A rhombic ESR signal is observed on adsorption of $D_2O$, $CD_3OH$, $CH_3Ch_2OD$ and $ND_3$. The Location and coordination structure of Mo(V) species has been determined by three-pulse electron spin-echo modulation data and their simulations. After the adsorption of methanol, ethylene, ammonia, and water for MoH-SAPO-34, three molecules, one molecule, one and one molecule, respectively, are directly coordinated to $(MoO_2)^+)$.

• Journal of the Korean Chemical Society
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• v.33 no.3
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• pp.281-286
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• 1989

The redox properties of benzophydroxamic acid (Hben) and its oxovanadium complex, $VO(Ben)_2$ has been studied by the use of polarograpy and cyclic voltammetry. The radical anions of Hben seem to be generated in acetone. The wave at -0.05V vs. Ag/AgCl electrode might be attributed to the formation of radical anion and the wave at -1.78V vs. Ag/AgCl electrode might be attributed the formation of radical dianion. The $VO(Ben)_2$ exhibits one oxidation wave at + 0.55V and two reduction waves at -0.15V and -1.30V vs. Ag/AgCl electrode; the oxidation is reversible one electron process $(VO(ben)_2 {\rightleftharpoons} VO(ben)^+ + e)$. The reduction wave at -0.15V is quasireversible and is arised from the formation of radical anion,$VO(Ben)_2^-$. The second reduction wave at -1.30V is irreversible and this reduction process produces vanadium(III). This oxygen containing ligand of Hben seems to reduce the stability of + 4 oxidation state of vanadium while the sulfur or nitrogen donor of the ligands stabilize the + 4 oxidation state of vanadium when comparisons are made among several oxovanadium complexes.

• Analytical Science and Technology
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• v.22 no.4
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• pp.345-353
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• 2009

The new anti-impotency analogue was identified in food source. Detection of this analogue was accomplished through screening of food samples by liquid chromatography/photodiode array detector. The spectrum pattern of analogue compound was similar to that observed for hongdenafil which was analogue of sildenafil. This new compound was isolated and purified using the liquid-liquid extraction, thin layer chromatography, column chromatography and preparative HPLC. And then those structure were identified using analytical instruments such as HPLC/PDA, LC/MS/MS and NMR. The compound was given a name to oxohongdenafil which was replaced with acetyl oxoethylpiperazinyl residue instead of sulfonyl piperazine group of sildenafil. The regulation for the abovementioned analogue, oxohongdenafil, was established by Standard of Korean food code.