• Tuberculosis and Respiratory Diseases
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• v.42 no.2
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• pp.142-148
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• 1995

Background: Despite modern diagnostic, staging, and therapeutic advances, esp. with molecular biologic techniques, the 5-year survival rate of all cases of lung cancer does not exceed 15%. Also, the incidence of lung cancer of both sex in Korea is increasing year by year and the lung cancer is one of the leading causes of cancer death. Therefore, it is strongly needed to develop the new combination of treatment modalities including neoadjuvant chemotherapy and to identify tumor specific characteristics with staging or prognostic markers. Here we present the clinical significance of several biologic tumor markers to use as a prognostic markers in patients with non-small cell lung cancers. Method: The survival has correlated with the expressibility of proliferative cell nuclear antigen (PCNA), epidermal growth factor receptor(EGFR), p53 and/or blood group antigen A(BGAA) using immunohistochemistry in 46 patients with non-small cell lung cancers. Results: 1) The expression rates of PCNA, EGFR, p53 and BGAA were 80.6%, 61.3%, 45.9% and 64.3%, respectively and those were not correlated to cell types or clinical stges. 2) The expression of BGAA was correlated with better survival in median survival and in 2-year survival rate and that of PCNA was correlated with worse survival in median survival and 2-year survival rate. 3) The expression of EGFR or p53 was not valuable to predict prognosis in non-small cell lung cancers. 4) With simultaneous applications of PCNA, EGFR and p53 immunostain, the patients with 2 or more negative expressions showed better prognosis than the patients with 2 or more positive expressions. Conclusion: It is suggested that the expression of blood group antigen may be a positive prognostic factor and that of PCNA may be a negative prognostic factor. Also, the combination of expressions of PCNA, EGFR and p53 may be used as a negative prognostic factor.

• The Bulletin of The Korean Astronomical Society
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• v.42 no.2
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• pp.37.3-38
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• 2017

우리나라의 천문 관측의 기록의 역사는 삼국시대 이전 선사시대까지 거슬러 올라간다. 선사시대에는 천문 현상을 바위나 건축 유물에 기록을 남기고 역사를 기록하기 시작한 이후에는 일반 역사 기록 속에 항상 함께 기록하고 있다. 특히 동양은 역사기록 자체가 인간이 남긴 자취뿐만 아니라 하늘과 땅에 일어나는 다양한 자연 현상도 함께 동시에 남겼다. 고대로부터 인간은 하늘과 땅과 항상 유기적인 관계를 갖는다고 믿었기 때문이다. 우리나라는 정사로서 가장 오래된 역사 기록인 삼국사기와 삼국유사에 일식, 혜성 출현, 별똥과 유성우, 달과 행성 운행, 초신성 관측 등 250회 이상의 천문 기록이 나타나며 대부분 실제로 일어났던 사실을 그대로 기록하고 있다. 그 후 고려사와 조선왕조실록에는 이루 헤아릴 수 없을 정도로 많은 천문 기록을 남기고 있다. 이러한 천문 기록뿐만 아니라 일찍부터 중국으로부터 역법을 도입하여 천체 운행을 이용하여 우리 생활에 필요한 시각법을 사용하고 달력을 제작하였다. 특히 달과 태양의 운행 원리를 파악하여 일식과 월식을 직접 추산하였다. 역법의 운용은 천체 운행의 원리를 이해하고 수학을 발전시키는데 큰 역할을 하였다. 이러한 천문 관측과 정확한 시각 체계를 유지하고 정밀한 역법을 사용하기 위해서는 끊임없이 천체를 정밀하게 관측할 필요성이 있다. 이를 위해 다양한 천문 관측기기를 개발하고 제작하였다. 천문 의기는 천체의 위치를 측정하고 천체의 운행을 이용하여 시각 체계를 유지 관리를 위해 필수불가결한 기기이다. 우리나라 천문학 발달의 네 가지 축인 천문(天文), 역법(曆法), 의상(儀象), 구루(晷漏)등은 조선 초기 세종시대 완성을 보게 되었다. 이는 단일 왕조가 이룬 업적으로 다른 문화권에서 볼 수 없을 정도의 우수한 과학 기술의 유산이다. 특히 칠정산내편과 외편의 완성은 중국의 역법에서 벗어나 독자적인 역법을 완성하려는 시도였다. 이 모든 것은 당시 이를 주도하던 세종대왕의 지도력과 천문학과 수학에 뛰어난 천문학자가 이룩한 업적이다. 그 후 조선 중기로 접어들면서 쇠퇴하다가 임진왜란과 병자호란을 겪으면서 거의 모든 과학기술의 유산이 파괴되거나 유실되었다. 조선 현종 이후에 세종시대의 유산을 복원하려는 노력 중에 중국을 통하여 서양의 천문학을 도입하게 되었다. 중국에 들어와 있던 서양 선교사들이 주도하여 중국의 역법 체계를 바꾸었다. 즉, 일식과 월식의 예측력이 뛰어난 시헌력을 만들어 사용하기 시작했다. 시헌력에는 서양의 대수학과 기하학을 이용한 다양한 수학적 기법이 사용되었다. 조선 후기에 이 시헌력을 익히기 위한 노력을 하는 과정에서 서양의 수학과 기하학을 접하게 되고 새로운 우주 체계를 도입하게 되었다. 특히 서양의 천문도와 지도 제작에 기하학의 투사법이 사용되어 복잡한 대수학적 계산을 단순화시켜 활용하였다. 조선 후기에 전문 수학자뿐만 아니라 많은 유학자들도 서양의 수학과 기하학에 깊은 관심을 갖고 연구하였다. 고천문학 전체를 조망해 볼 때 핵심은 현대의 천체물리학이 아니라 위치천문학이다. 따라서 고천문학을 연구하는데 필수적인 요소가 지구의 자전과 공전 운동에 의해서 일어나는 현상과 세차운동에 의한 효과를 정확하게 이해하고 있어야 한다. 그중에서도 구면천문학과 천체역학에 대한 원리를 알고 있는 상태에서 접근해야 한다. 고천문학의 중심인 천문(天文), 역법(曆法), 의상(儀象), 구루(晷漏) 등의 내용은 이러한 위치천문학이 그 기본 골격을 이루고 있다. 예를 들어 고려사의 천문 현상을 모아 놓은 천문지(天文志)와 일식과 월식 계산 원리가 들어있는 역지(曆志)를 연구하기 위해서는 위치천문학의 기본 개념 없이는 연구하는데 한계가 있다. 인문학을 전공하는 학자가 고천문을 연구하는데 가장 큰 걸림돌이 되는 점이 위치 천문학의 기본 개념 없이 접근하는 것이다. 심지어 조선시대 유학자들조차 저술한 많은 천문 관련 기록을 보면 상당부분 천체 운행 원리를 모르고 혼란스럽게 기록된 내용이 적지 않다. 우리나라 수학사를 연구할 경우 방정식 해법, 보간법, 삼각법, 일반 기하 원리에 대한 것을 연구하는데 큰 문제가 없다. 그러나 천문 현상이나 천문 의기 제작에 사용되는 수학은 천문 현상에 대한 원리를 모르면 접근하기 어렵게 된다. 수학사를 하더라고 기본적인 위치 천문학의 기본개념을 이해하고 있어야 폭 넓은 수학사 연구에 성과를 거둘 수 있다. 의외로 천문 현상 추산을 위해 사용되는 수학이나 기하학 원리가 수학사 연구에 중요한 요소가 된다. 더구나 한문으로 기록된 천문 내용을 한문 해독이 능숙한 학자라 하더라도 내용을 모르고 번역하면 도무지 무슨 내용인지 알아볼 수 없는 경우가 많다. 그래서 한문으로 된 천문 현상 기록이나 역법 관련 기록의 번역 내용 중에 많은 오역을 발견하게 된다. 문제는 한번 오역을 해 놓으면 몇 십 년이고 그대로 그 내용을 무비판적으로 인용하게 되고 사실로서 인정하는 오류를 범하게 된다. 이 때문에 우리 선조들이 남긴 고천문 관련 기록에 관한 이해는 우리 현대 천문학자의 역할이 대단히 크다.

• The Korean Journal of Food And Nutrition
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• v.22 no.1
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• pp.141-149
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• 2009

The elderly population in Korea is growing rapidly and their needs for long-term care has also increased. By the year 2018, our society will be approaching aged society and by 2026 it will be a super-aged society. The purpose of this study was to employ conjoint analysis to establish the relative importance of foodservice encounters in terms of determining the utility values of hospital foodservice for elderly patients. According to the results pearson's R(0.420) and Kendall's tau(0.402) statistics showed that the model fits the data well(p<0.05). The relative importance scores of hospital foodservice encounters were as follows: dietary counseling with dietetics(51.2%), foodservice personnel(48.7%), and food(0.1%). A soft cooking method(0.001) was preferred to a general cooking method(0.001), and kind foodservice personnel(0.086) were preferred to quick service(-0.086). Finally, counseling with a dietitian once a week(-0.138) was preferred to counseling twice a week (-0.276). Based on this conjoint analysis, the most preferable model for foodservice at a long-term care facility would be; soft cooking methods, kind service by foodservice personnel, and dietetic counseling once a week. Overall, a better understanding of the specific needs of our institutionalized elderly is one of the key elements that can help our long-term care system develop improved foodservice programs.

• Journal of the Korean Society of Marine Environment & Safety
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• v.14 no.1
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• pp.29-37
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• 2008

This study examined principles and techniques of efficient water quality management as well as total coastal pollutant loads and the relevant examples in the advanced countries from the viewpoints of water quality improvement and pollution control in coastal areas. The problems and improvements in an estimation of the current total pollutant loads were also pointed out. In addition, discussion was made on the relationship between total pollutant loads and environmental capacity as well as particulars requiring extensive examination on access to and study on water quality model used as prediction tool for marine environment. Furthermore, this study proposed details of and improvement plans for water quality control to be reflected and absorbed into systems and policies related to coastal water quality. In coastal areas, which are subject to total coastal pollutant loads, it is necessary to calculate pollutant loads reduction and allocation, to propose them in detail in statement in relations to new pollution sources for the corresponding projects or plans in environmental impact assessment and prior environmental review system. Also, in relations to regional plans for coastal management, the local government concerned must focus more on environmental management plan to implement data on pollution sources and pollutant loads flown into sea areas under basic jurisdiction, therefore it is required to actively respond to expansion and introduction of total coastal pollutant loads system in the future. Total coastal pollutant loads system must be expanded and executed by considering characteristics of sea area and changes in the environment of land. For pollution sources in land, the competent authorities in charge of coastal environment will need to initiatively administer supervision, monitoring activities and achieve integration and operation of the related laws by preparing legal bases for management system or adjusting the related laws.

• Journal of Korean Society of Archives and Records Management
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• v.1 no.1
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• pp.37-52
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• 2001

1. establishment and development of China archives science: With the centuries-old history of archives and archives management, early China archives science came into being in 1930s, and the research pushed forward by archives enterprise has made great achievements since then. 1.1 Expanding research fields: Foundation

• 한국지구물리탐사학회:학술대회논문집
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• 2004.08a
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• pp.104-117
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• 2004

Dmitri Donskoi, which went down during the Russo-Japanese War occurred 100 years ago, was found by using geophysical exploration techniques at the 400 m water depth of submarine valley off Jeodong of Ulleung Island. In the submarine area with the rugged seabed topography and volcanic seamounts, in particular, the reliable seabed images were acquired by using the mid-to-shallow Multibeam exploration technique The strength of corrosion (causticity) of the sunken Donskoi, measured by the electrochemical method, decreased to 2/5 compared with the original strength.

• Economic and Environmental Geology
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• v.48 no.1
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• pp.25-39
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• 2015

$CO_2$ geological storage plays an important role in reduction of greenhouse gas emissions, but there is a lack of research for CCS demonstration. To achieve the goal of CCS, storing $CO_2$ safely and permanently in underground geological formations, it is essential to understand the characteristics of them, such as total storage capacity, stability, etc. and establish an injection strategy. We perform the impedance inversion for the seismic data acquired from the Ulleung Basin in 2012. To review the possibility of $CO_2$ storage, we also construct porosity models and extract attributes of the prospects from the seismic data. To improve the quality of seismic data, amplitude preserved processing methods, SWD(Shallow Water Demultiple), SRME(Surface Related Multiple Elimination) and Radon Demultiple, are applied. Three well log data are also analysed, and the log correlations of each well are 0.648, 0.574 and 0.342, respectively. All wells are used in building the low-frequency model to generate more robust initial model. Simultaneous pre-stack inversion is performed on all of the 2D profiles and inverted P-impedance, S-impedance and Vp/Vs ratio are generated from the inversion process. With the porosity profiles generated from the seismic inversion process, the porous and non-porous zones can be identified for the purpose of the $CO_2$ sequestration initiative. More detailed characterization of the geological storage and the simulation of $CO_2$ migration might be an essential for the CCS demonstration.

• Korean Journal of Cognitive Science
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• v.27 no.4
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• pp.573-597
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• 2016

Recent fMRI and EEG research for neural representations of action concepts insist that processing of action concepts evoke the simulation of sensory-motor information. Moreover, there are several behavioral studies showing that understanding of action verbs or sentences describing actions interfere or facilitate current action performance. However, it is unclear that online interaction between processing of action concepts and current action is based on the simulation of sensory-motor information, or other neural mechanisms. The present research aims to explore the underlying neural mechanism that how the perception of action language influence the performance of current action using high-spacial temporal resolution EEG and multiple source analysis techniques. For this, participants were asked to perform a cued-motor reaction task in which button-pressing hand action and pedal-stepping foot action were required according to the color of the cue, and we presented auditorily action verbs describing the responding actions (i.e., /press/, /step/, /stop/) just before the color cue and examined the interaction effect from the semantic congruency between the action verbs and the current action. Behavioral results revealed consistently a facilitatory effect when action verbs and responding actions were semantically congruent in both button-pressing and pedal-stepping actions, and an inhibitory effect when semantically incongruent in the button-pressing action condition. In the results of EEG source waveform analysis, the semantic congruency effects between action verbs and the responding actions were observed in the Wernicke's area during the perception of action verbs, in the anterior cingulate gyrus and the supplementary motor area (SMA) at the time when the motor-cue was presented, and in the SMA and primary motor cortex (M1) during action execution stage. Based on the current findings, we argue that perceived action verbs evoke the facilitation/inhibition effect by influencing the expectation and preparation stage of following actions rather than the directly activating the particular motor cortex. Finally we discussed the implication on the neural representation of action concepts and methodological limitations of the current research.

• The Journal of Society for e-Business Studies
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• v.8 no.2
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• pp.99-111
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• 2003

By virtue of diverse advantages derived from digital media, eBook is getting started to use. And many market research agencies have predicted that its market will be greatly expanded soon. But against those expectations, copyright-related problems and the difficulties of its accessing inherited from various eBook content formats become an obstacle to its diffusion. The first problems can be solved by DRM technology. And to solve the second problems, each nation has published its own content standard format. But the domestic standards are useful only the domestic level, they still leave the problems in the national level. The variety of content formats has created a demand for mechanisms that allow the exchange of eBook contents. Therefore we study the mapping relations between eBook contents for conversion. To define the mapping relations, first we extract the mapping both between eBook contents and between normal XML documents. From those mappings, we define seven mapping relations and classify them by cardinality. And we analyze the classified relations, which can be generated by automatic, or not. Using these results, we also classify the eBook content conversion as automatic, semi-automatic, and manual. Besides, we provide the conversion templates for mapping relations for automatic generation of conversion scripts. To show the feasibility of conversion templates, we apply them to the eBook content conversion. Experiment shows that our conversion templates generate the conversion scripts properly. We expected that defined mapping relations and conversion templates can be used not only in eBook content conversion , but also in normal XML document conversion.

• Journal of Wetlands Research
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• v.22 no.3
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• pp.194-199
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• 2020

Unlike in the past, the world is facing water shortages due to climate change and difficulties in simultaneously managing the risks of flooding. The Four Major Rivers project was carried out with the aim of realizing a powerful nation of water by managing water resources and fostering the water industry, and the construction period was relatively short compared to the unprecedented scale. Therefore, the prediction and analysis of how the river environment changes after the Four Major Rivers Project is insufficient. Currently, part of the construction section of the Four Major Rivers Project is caused by repeated erosion and sedimentation due to the effects of sandification caused by large dredging and flood-time reservoirs, and the head erosion of the tributaries occurs. In order to solve these problems, the riverbed maintenance work was installed, but it resulted in erosion of both sides of the river and the development of new approaches and techniques to keep the river bed stable, such as erosion and excessive sedimentation, is required. The water agent plays a role of securing a certain depth of water for the main stream by concentrating the flow so much in the center and preventing levee erosion by controlling the flow direction and flow velocity. In addition, Groyne products provide various ecological environments by forming a natural form of riverbeds by inducing local erosion and deposition in addition to the protection functions of the river bank and embankment. Therefore, after reviewing the method of determining the shape of the Groyne structure currently in use by utilizing the mobile limit flow rate and marginal reflux force, a new Critical Movement Velocity(${\bar{U}}_d$) and a new resistance coefficient formula considering the mathematical factors applicable to the actual domestic stream were developed and the measures applicable to Groyne installation were proposed.