• Communications for Statistical Applications and Methods
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• v.2 no.1
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• pp.13-21
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• 1995

선형모형에서 오차가 대칭인 분포를 따르는지 또는 한쪽으로 치우친(skewed distribution)분포를 따르는지 검정하는 문제를 다루었다. 또 이러한 검정과정을 분석의 예비단계로 하는 회귀계수의 추정방법에 대해서 연구하고, 모의실험을 통해서 회귀계수 추정법들의 효율을 비교하였다.

• The Korean Journal of Applied Statistics
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• v.29 no.4
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• pp.595-611
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• 2016

We use nonlinear regression models (such as the Hill Model) when we analyze data in toxicology and/or pharmacology. In nonlinear regression models an estimator of parameters and estimation of measurement about uncertainty of the estimator are influenced by the variance structure of the error. Thus, estimation methods should be different depending on whether the data are homoscedastic or heteroscedastic. However, we do not know the variance structure of the error until we actually analyze the data. Therefore, developing estimation methods robust to the variance structure of the error is an important problem. In this paper we propose a method to estimate parameters in nonlinear regression models based on a preliminary test. We define an estimator which uses either the ordinary least square estimation method or the iterative weighted least square estimation method according to the results of a simple preliminary test for the equality of the error variance. The performance of the proposed estimator is compared to those of existing estimators by simulation studies. We also compare estimation methods using real data obtained from the National Toxicology program of the United States.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.14
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• pp.87-90
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• 1973

Optimum plot shape and size in a uniformity trial in the newly founded experimental farm of KAERI were determined for seed yield with the basic units consisted of 2.5m $\times$ 0.6m plot. Various plot sizes and shapes were made by combination of the basic units. Coefficients of variations for yield were 21% in local branch type variety Kumkang-Dairip and 20% in the introduced branchless type variety Clark. This result indicates that the field in the new experimental farm is appropriate for soybean yield trials when adequate number of replications are employed in the field experiment. In general, C. V. values were gradually decreased with increase of plot sizes. Although the data were not consistant, the errors for the long narrow plots tend to have somewhat smaller than for the square shape plots. A sharp decrease in C.V. value was found from the $4.5\textrm{m}^2$ plot in the variety Kumkang-Dairip and from the $6\textrm{m}^2$ plot in the variety Clark. These results imply that 5-$6\textrm{m}^2$ plot could be used for yield trials in early generations of hybrid progenies. 2.5-5m long plot with 3-4 replications will be practical for yield trials in the early hybrid generations. The C.V. values with 7.5m long plot was about 16% in both varieties and 15.3% in 10m plot. These results indicate that 7.5-10m plot with 3-4 replications could be employed in accurate yield test in the advanced generations.

• Journal of Acupuncture Research
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• v.23 no.1
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• pp.15-23
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• 2006

목적 : 경사계와 각도기로 경추, 요추 및 견관절의 운동 범위를 반복 측정하여 두 도구의 측정자내 신뢰도 우위를 추정하여 보고자 하였다. 방법 : 각 관절에 별다른 증상이 없는 104명의 학생들을 대상으로 경추, 요추 및 견관절의 능동 운동 범위를 경사계와 각도기로 각 도구 당 2회씩 측정하였다. 측정하기 바로 전에, 한 명의 교육자가 경사계와 각도기를 이용한 경추, 요추 및 견관절의 운동 범위 측정 방법을 교육하였다. 104명은 두 명 씩 쌍을 이룬 후 각도기, 경사계, 각도기, 경사계를 이용하는 순서로 서로의 경추, 요추 및 견관절의 운동 범위를 측정하였다. 결과 : 견관절의 수평 외전과 외회전에서 경사계의 측정값이 각도기의 측정값보다 통계적으로 의미 있게 안정적으로 반복되었다(P<0.05, 독립 이 표본 t-검정). 결론 : 견관절의 운동 범위 측정에 있어서 경사계가 각도기보다 높은 측정자내 신뢰도를 가지는 것으로 추정되어, 경사계와 각도기의 신뢰도를 급간내 상관 계수(intraclass correlation coefficient)를 이용하여 비교해보는 연구의 예비 조사로서 실시된 이번 연구의 결과는 향후 시행될 연구에 있어서 견관절의 운동 범위 측정에 보다 집중적인 연구를 진행할 수 있는 근거를 마련하였다.

• Journal of dental hygiene science
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• v.12 no.1
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• pp.71-77
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• 2012

Sex Hormones exert significant influence in body physiology throughout life. Some reports suggested increased sex hormone levels correlate with an increased prevalence of gingivitis. The objectives of this pilot study are to(1) address the link between menstrual cycle and MMP-9, MMP-8, IL-$1{\beta}$ of gingival crevicular fluid during 4 weeks and (2) discuss the major biomarker of periodontal status. 7 female and 3 male volunteer who didn't have smoking habit, medical and dental disease after informed consent, were seen twice a week for 4 weeks. GCF samples were collected and GCF levels of MMP-9, MMP-8, IL-$1{\beta}$ were measured by enzyme-linked immunosorbent assay. The GCF levels of MMP-9, MMP-8, IL-$1{\beta}$ had fluctuation according to menstrual cycle, but the changes of those were not significant by Friedman matched samples test. There is no difference between female and male subjects by Mann-Whitney U test. The correlation of MMP-8, MMP-9 and IL-$1{\beta}$ showed strong by Spearman correlation(0.644-0.945). This study confirms menstrual cycle doesn't influence the periodontium of healthy female subjects.

• Journal of Korean Society of Forest Science
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• v.87 no.3
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• pp.422-428
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• 1998

Polymerase chain reaction(PCR)-based inter-simple sequence repeats(I-SSR) markers were analyzed in 48 megagametophytes of a single tree of Abies koreana $W_{ILS}$. Nineteen of the 35 primers, screened with 6 megagametophyte DNA and produced the clearest amplification products in the preliminary experiment, were used for PCR with 48 megagametophyte DNAs sampled from a single tree. On the basis of the chi-square test, a total of 51 amplicons, amplified by the 19 primers, were revealed to be segregated according to the Mendelian ratio(i.e., 1 : 1 segregation ratio) in the 48 megagametophytes at 5% significance level. Based on the linkage analysis, the observed 51 Mendelian loci turned out to be unlinked each other, which suggested that they are evenly distributed in the genome. However, majority of RAPD markers are known to belong to the independent linkage blocks, which frequently results in the amplification of RAPD markers from the restricted regions of the genome. Owing to the nature of even distribution of the 51 loci observed in this study, the I-SSR markers could give better resolution of estimating genetic diversity from the whole genome than RAPD markers. And I-SSR markers are also more suitable than RAPD markers for reconstructing phylogenetic relationship by a cladistic method which requires to fulfil the assumption of independent evolution of the different characters.