• The Korean Journal of Applied Statistics
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• v.35 no.2
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• pp.251-263
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• 2022

Phase I clinical trial is called 'Dose finding study'. It is first step of experimenting on humans with new drugs developed through animal experiments or vitro experiments. The important area of interest in designing Phase I clinical trial is determining the dose that acceptable level to the patients and provides the greatest efficacy. In this paper, we explain about methods to determine the maximum tolerated dose using various stopping rules. The SM3, NM, Rim, J3, BSM methods are compared through simulation. And we consider how the methods might be reformed. As a result of the simulation, BSM estimated the MTD closest to the target toxicity probability. J3 method required the least number of subjects. These results are due to the feature of the stopping rules of both methods. The BSM adds 2 or 1 subject at the same dose level when there is a toxic reaction. In addition, the J3 method has a smaller number of subjects than the other methods. If the methods are improved by combining these features, MTD can be estimated more efficiently. If the total number of subjects can be reduced while using the stopping rule of the BSM, accurate estimation is possible for a small number of subjects.

• The Journal of the Korea Contents Association
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• v.22 no.3
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• pp.71-80
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• 2022

In the past, fish diseases were bacterial in aqua farms, but in recent years, the frequency of fish diseases has increased as they have become viral and mixed. Viral diseases in an enclosed space called a aqua farm have a high spread rate, so it is very likely to lead to mass death. Fast identification of fish diseases is important to prevent group death. However, diagnosis of fish diseases requires a high level of expertise and it is difficult to visually check the condition of fish every time. In order to prevent the spread of the disease, an automatic identification system of diseases or fish is needed. In this paper, in order to improve the performance of the disease identification system of Paralichthys olivaceus based on deep learning, the existing pre-processing method is compared and tested. Target diseases were selected from three most frequent diseases such as Scutica, Vibrio, and Lymphocystis in Paralichthys olivaceus. The RGB, HLS, HSV, LAB, LUV, XYZ, and YCRCV were used as image pre-processing methods. As a result of the experiment, HLS was able to get the best results than using general RGB. It is expected that the fish disease identification system can be advanced by improving the recognition rate of diseases in a simple way.

• Proceedings of the Korea Water Resources Association Conference
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• 2021.06a
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• pp.340-340
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• 2021

가뭄의 특성상 시점과 종점을 명확하게 정의하기 어렵기 때문에 기준수문량을 설정하고 부족량과 지속기간을 정의하는 것이 일반적이다. 대상 수문량은 강우나 유출량을 사용할 수 있지만, 두 성분간 지체와 감쇄효과로 인하여 빈도해석의 결과는 차이를 보일 수 밖에 없어, 사용 목적에 따라 선별적으로 적용해야 한다. 가뭄빈도해석은 강우를 기반으로 지속기간과 심도를 정의하여 빈도를 해석하는 연구가 선행되어왔지만, 기본적으로 강우의 간헐적 발생특성과 체감도의 한계가 문제로 지적되고 있다. 본 연구에서는 댐 유입량의 Run 시계열 특성을 이용하여 다양한 유황을 기준유량으로 활용하여 가뭄의 시점과 종점에 대한 가뭄사상을 추출하고 지속기간과 누적부족량을 계산하여 가뭄빈도해석의 변수로 설정하였다. 두 변수간의 복잡한 상호 관계를 해석하기 위해 Copula 함수를 이용한 이변량 가뭄빈도해석을 진행하였다. 먼저 소양강댐('74-'19) 유입량, 충주댐('86-'19) 유입량을 연구대상지역으로 설정하여, 두 유역의 유입량의 추세분석을 통해 시간의존성을 파악하였다. 유황분석에 사용되는 분위량중 평수량을 기준값으로 사용하여 각 년별 최대 지속기간과 누적부족량을 추출하였다. Copula 가뭄빈도해석을 수행하기 전에 지속기간에는 GEV, 누적 부족량에는 Log-normal 분포를 적용해 단변량 누적확률분포를 계산하여 재현기간을 도출하였다. 이변량 빈도해석에 Clayton Copula 함수를 적용하여 가뭄빈도해석을 진행하였고, Copula 이변량 재현기간과 SDF곡선을 도출하였다. Clayton Copula를 이용한 이변량 가뭄빈도해석의 결과로 소양강댐의 가장 극심한 가뭄은 1996년으로 단변량 재현기간은 지속기간 기준 9.11년, 누적부족량 기준 17.26년, Copula 재현기간은 141.19년 이며 충주댐의 가장 극심한 가뭄은 2014년으로 단변량 재현기간은 지속기간 기준 17.76년, 누적부족량 기준 18.72년, Copula 재현기간은 184.19년으로 단변량 가뭄빈도해석을 통한 재현기간보다 Copula 재현기간이 높은 결과가 도출되었다. Run 시계열을 바탕으로 한 기준유량의 임계값 기준 Event 산정과 Copula를 이용한 빈도해석은 가뭄분석에 이용되는 자료의 상관관계와 분포특성을 재현하는데 효과적인 특징이 있다. 이를 미루어 보아 Copula 함수를 이용한 가뭄빈도해석의 재현기간은 보다 현실적인 재현기간을 도출할 수 있는 것으로 판단된다. 임계값의 조정을 통해 가뭄빈도해석의 변수의 양이 늘어나면, 보다 정확도 높은 재현기간을 도출하여 수문학적 가뭄을 정의할 수 있을 것이라고 사료된다.

• The Journal of the Convergence on Culture Technology
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• v.9 no.4
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• pp.331-335
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• 2023

As the viscosity of the blood increases, the blood becomes more sticky and difficult to flow, so the possibility of thrombosis increases and the probability of ischemic cerebral infarction increases. The importance of measuring blood viscosity has recently been emphasized for the prevention of circulatory system diseases, and the need for a viscometer capable of easily and accurately measuring blood viscosity has emerged. In this study, the measured values of a viscosity standard solution and an artificial blood by a parallel-plate viscometer ARS-Medi were compared with the those by Ares-G2 of TA instrument, which is internationally recognized for its accuracy and reliability. The viscosity of N44 standard solution, which is a Newtonian solution, was almost perfectly matched between the two instruments at all shear rates. In the case of an artificial blood, which is a non-Newtonian solution, the measured values between the two instruments showed a difference of about 10% at the lowest shear rate 1 rad/s; however, at a clinically significant shear rate of 10 rad/s or higher, the measured values between them were consistent within the error range. We expect that ARS-Medi, a newly developed parallel-plate viscometer for blood, using disposable plates, will be very useful in clinical practice as it improves the convenience and hygiene of blood viscosity measurement.

• The Journal of the Convergence on Culture Technology
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• v.9 no.2
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• pp.171-179
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• 2023

Due to man-made climate change, global abnormal weather phenomena have occurred, increasing disasters. Major developed countries(military) are preparing for disasters caused by extreme weather appearances. However, currently, disaster prevention plans and facilities have been implemented based on the frequency and intensity method based on statistical data, it is not enough to prepare for disasters caused by frequent extreme weather based on probability basis. The U.S. and British forces have been the fastest to take research and policy approaches related to climate change and the threat of disaster change, and are considering both climate change mitigation and adaptation. The South Korean military regards the perception of disasters to be storm and flood damage, and there is a lack of discussion on extreme weather and disasters due to climate change. In this study, the process of establishing disaster management systems in developed countries(the United States and the United Kingdom) was examined, and the response policies of each country(military) were analyzed using literature analysis techniques. In order to maintain tight security, our military should establish a response policy focusing on sustainability and resilience, and the following three policy approaches are needed. First, it is necessary to analyze the future operational environment of the Korean Peninsula in preparation for the environment that will change due to climate change. Second, it is necessary to discuss climate change 'adaptation policy' for sustainability. Third, it is necessary to prepare for future disasters that may occur due to climate change.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.30 no.3B
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• pp.257-267
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• 2010

A flood event can be characterized by three attributes such as peak discharge, total flood volume, and flood duration, which are correlated each other. However, the amount of peak discharge is only used to evaluate the flood events for the hydrological plan and design. The univariate analysis has a limitation in describing the complex probability behavior of flood events. Thus, the univariate analysis cannot derive satisfying results in flood frequency analysis. This study proposed bivariate flood frequency analysis methods for evaluating flood events considering correlations among attributes of flood events. Parametric distributions such as Gumbel mixed model and bivariate gamma distribution, and a non-parametric model using a bivariate kernel function were introduced in this study. A time series of annual flood events were extracted from observations of inflow to the Soyang River Dam and the Daechung Dam, respectively. The joint probability distributions and return periods were derived from the relationship between the amount of peak discharge and the total volume of flood runoff. Applicabilities of bivariate flood frequency analysis were examined by comparing the return period acquired from the proposed bivariate analyses and the conventional univariate analysis.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.16 no.5
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• pp.338-346
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• 2023

During isometric elbow flexion, forearm length should be an important factor to determine not only joint torque but also maximum endurance time (MET), when the forearm is perpendicular to the direction of the force. The purpose of this paper is to examine the effect of forearm length as an additional factor on empirical models of MET such as an exponential model and a power model during isometric elbow flexion. Thirty volunteers participated in our experiment to measure factor variables such as circumferences and lengths of their upper and lower arms. Their METs were measured according to the percent of maximum voluntary contraction intensity (%MVC). For the multiple linear regression model of ln(MET) using these measurements, significant variables could be observed in %MVC and forearm lengths (P<0.05). The empirical models were assessed by these models using forearm length as the additional factor. Mean absolute deviations (MAD) between the measured METs amd the two empirical models were about 19.4 [s], but MAD using models applied forearm lengths were reduced to about 16.2 [s]. The correlation coefficients and intraclass correlation coefficients were about 0.87, but those applied forearm lengths were increased to about 0.91. These results demonstrated that forearm length was a significant additional factor to the empirical model.

• Environmental and Resource Economics Review
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• v.33 no.2
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• pp.113-133
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• 2024

Variable renewable energy (VRE) such as solar and wind power is the main sources of achieving carbon net zero, but it undermines the stability of power supply due to high variability and uncertainty. Energy storage system (ESS) can not only reduce the curtailment of VRE by load shifting but also contribute to stable power system operation by providing ancillary services. This study analyzes how the allocation of ESS resources between load shifting and ancillary service can contribute to maximizing the efficiency of power supply in a situation where the problems caused by VRE are becoming more and more serious. A stochastic power system optimization model that can realistically simulate the variability and uncertainty of VRE was applied. The analysis time point was set to 2023 and 2036, and the optimal resource allocation strategy and benefits of ESS by varying VRE penetration levels were analyzed. The analysis results can be largely summarized into the following three. First, ESS provides excellent functions for both load shifting and ancillary service, and it was confirmed that the higher the reserve price, the more limited the load shifting and focused on providing reserve. Second, the curtailment of VRE can be a effective substitute for the required reserve, and the higher the reserve price level, the higher the curtailment of VRE and the lower the required amount of reserve. Third, if a reasonable reserve offer price reflecting the opportunity cost is applied, ESS can secure economic feasibility in the near future, and the higher the proportion of VRE, the greater the economic feasibility of ESS. This study suggests that cost-effective low-carbon transition in the power system is possible when the price signal is correctly designed so that power supply resources can be efficiently utilized.

• Clinical and Experimental Pediatrics
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• v.49 no.1
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• pp.46-50
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• 2006

Purpose : Intradermal BCG vaccine has not well been accepted by pediatric practitioners due to BCG lymphadenitis. Therefore, this study was undertaken to find out the incidence of lymphadenitis following intradermal BCG vaccination and its clinical outcome. Methods : One thousand and fifty infants, who received intradermal BCG(French 1173 P2, Korea Tuberculosis Association) vaccination in the Well Baby Clinic of Hanyang University Hospital from July 2001 to January 2004, were included in the study. Severe local reactions at the injection site and any mass noted on surrounding areas were reported to, and evaluated by, pediatricians. Surgical procedures, either surgical resection or needle aspiration, were recommended when lymph nodes progressed to suppurate without regression. Results : Twenty infants(1.9 percent) developed lymphadenitis 2 to 8 months following vaccination. The incidence of BCG lymphadenitis was significantly higher in infants born with intrauterine period of <38 weeks and birth weight of <2,700 g. The lymph nodes became suppurative in 7/17 infants (41.2 percent) and four infants required surgical procedures with which the rate for the requirement of surgical procedures among intradermal BCG vaccinnes approximated to be 0.45 percent. There was no correlation between the size of lymph nodes and suppuration, however surgical procedures were required significantly more often for lymph nodes of greater than 3 cm in diameter. Conclusion : The incidence of BCG lymphadenitis following intradermal BCG(French 1173 P2, Korea Tuberculosis Association) vaccinations would be more than 1.9 percent, when considering cases of lymphadenits not reported. More efforts need to be paid to decrease the incidence of BCG lymphadenitis in order to promote intradermal BCG vaccination in Korea.

• Journal of Korean Society of Environmental Engineers
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• v.39 no.5
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• pp.255-264
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• 2017

To evaluate the water quality changes in agricultural reservoir covered with floating photovoltaic solar-tracking systems, the water quality variations with time and depth were monitored on both six sites for light blocking zones and four sites for light penetration zones after the installation of floating photovoltaic solar-tracking systems in Geumgwang reservoir at Anseong-si, Kyeonggi province. For one year with 16 monitoring events, water quality parameters [i.e., water temperature, pH, dissolved oxygen (DO), chlorophyll-a (Chl-a), and blue-green algae (BGA)] were monitored at depths of 0.3 m, 1 m, 3 m, and 5 m, while chemical oxygen demand (COD), total nitrogen (TN), and total phosphorus (TP) were monitored at depths of 0.3 m. Statistically, the difference in all water quality parameters was not significantly different (p > 0.05) at the level of significance of 0.05. Based on these results, the water quality data from light blocking zones (site 1~6) and light penetration zones (site 7~10) were clustered, and were compared with time and depth. As a result, the difference in water temperature, pH, DO, COD, TN, TP, Chl-a, and BGA between light blocking zones and light penetration zones was not significant (p > 0.05) with different time and depth. For Chl-a and BGA, some data from light blocking zones greater than light penetration zones were temporary observed due to the severe drought, low water storage rate, and over growth of periphyton. However, this temporal phenomenon did not impact the water quality. Considering the small water surface area (${\leq}0.5%$) covered by floating photovoltaic solar-tracking systems, the mixing effect of whole Geumgwang reservoir caused by Ekman current and continuous discharge were more dominant than the effect of reduced solar irradiance. Further study is warranted to monitor the changes in water quality and aquatic ecosystems with greater water surface area covered by floating photovoltaic solar-tracking systems for a long time.