• Journal of Marine Life Science
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• v.3 no.2
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• pp.51-58
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• 2018

Variations in water temperature are known to affect almost every part of fish physiology. The rise in water temperature due to climate change can physically damage fish. This study was conducted to evaluate the health status of the Atlantic salmon (Salmo salar) at high water temperature (20℃) than the optimum water temperature (15℃). Liver tissue exerts important metabolic functions in thermal adaptation. Therefore, liver tissue was used in this study. The evaluation method is to develop the biomarker gene using NGS RNAseq analysis and to examine the expression pattern using RT-qPCR analysis. The NGS RNAseq analysis revealed 1,366 differentially expressed genes, among which 880 genes were increase expressed and 486 genes were decrease expressed. The biomarker genes are such as heat shock protein 90 alpha (Hsp90α), heat shock protein 90 beta (Hsp90β) and cytochrome P450 1A (CYP1A). The selected genes are sensitive to changes in water temperature through NGS RNAseq analysis. Expression patterns of these genes through RT-qPCR were similar to those of NGS RNAseq analysis. The results of this study can be applied to other fish species and it is considered to be useful industrially.

• Korean Journal of Biological Psychiatry
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• v.15 no.4
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• pp.275-287
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• 2008

Depression and coronary artery disease are both highly prevalent diseases. Many previous studies suggest that depression is a common comorbid condition in patients with coronary artery disease and has a significant negative impact on the onset, course, and prognosis of coronary artery disease. However, the exact mechanisms that underlie the association between these two diseases remain unclear. Pathophysiologic mechanisms that may explain the effect of depression on coronary artery disease include hypercoagulability, hypothalamus-pituitary-adrenal axis and autonomic nervous system dysregulation, altered inflammatory response. On the contrary, pathophysiologic mechanisms in coronary artery disease that affect depression are less well known. It is also suggested that both diseases may share a common genetic vulnerability. The authors reviewed the literature on the pathophysiologic relationships of depression and coronary heart disease.

• The Journal of Engineering Geology
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• v.32 no.2
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• pp.257-270
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• 2022

This study evaluated the hydraulic factors contributing to the decreasing groundwater levels across Jeju island. Time-series data for groundwater level, precipitation, and groundwater usage and information on land use were acquired, and the correlations among them were analyzed to evaluate the causes of the decreasing groundwater. The effects of precipitation and groundwater usage on the fluctuations of groundwater level were quantified using response surface analysis and sensitivity analysis, and methods for groundwater quantity management by region were proposed. The results showed that the rate of groundwater decrease in the western region was larger than that in the eastern region. For the eastern region, the influence of precipitation was large and the rate of decrease in the groundwater level was relatively small. The geological formation of this part of the island and continuous seawater intrusion suggest that although the absolute amount of groundwater extracted for use was large, the decrease in the groundwater level was not seen to be great due to an increase in pressure by seawater intrusion. Overall, precipitation and groundwater usage had the greatest effect on the amount of groundwater in the western region, and thus their data would be most useful for informing groundwater management, whereas other factors (e.g., sea level and the location of the freshwater-seawater transition zone) must be considered when understanding Jeju's eastern region. As the characteristics of groundwater level fluctuations in the eastern and western regions are distinct, an optimal management plan for each region should be proposed to ensure the efficient management of groundwater quantity.