• Korean Journal of Bronchoesophagology
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• v.2 no.1
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• pp.19-28
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• 1996

이상에서 고찰한 위식도역류의 병태를 간략히 요약하면 다음과 같다. 위액에는 염산, 펩신, 담즙산과 췌효소등을 포함하고 있어 역류된 위액은 상부 기관식도관에 자극을 주거나 손상을 줄 수 있으며 개개인의 점막 상피의 저항도와 적절한 타액의 분비는 위액에 의한 손상의 정도를 결정하는 중요한 요소로 알려져 있다. 위식도역류로 인한 많은 증상이나 소견은 두가지의 기전으로 나타나서 첫째, 역류된 위액이 직접 조직에 영향을 주거나 둘째, 간접적으로 식도 하부에 분포된 미주신경에 의한 연관자극에 의해 일어나는데 위식도역류의 증상 중 두부, 경부, 심장 및 폐장의 증상은 이들 장기에 미주신경의 일부가 같이 분포하여 일어나는 간접적인 기전이다. 하부식도괄약근(lower esophageal sphincter)의 기능은 역류를 막는 가장 중요한 요소로 알려져 있어 간헐적으로 하부식도 괄약근의 압력이 떨어지면 역류가 일어나게 된다. 정상적인 식도의 연동운동은 식도에 역류된 위내용물을 위로 제거되는데 중요하며 위식도역류 환자에서 흔히 연동운동이 저하되거나 비정상적인 연동운동을 관찰할 수 있다. 또한 위내용물이 소장으로 비워지는 시간이 연장되어 위내용물이 위내에 축적되는 것도 위식도역류의 원인의 하나로 생각된다. 이러한 위식도역류의 병태를 연구하는 것은 이 질환의 이해에 도움을 줄 것으로 생각된다.

• Childhood Kidney Diseases
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• v.12 no.2
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• pp.186-193
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• 2008

Purpose : Intrarenal reflux(IRR) is backflow of urine from the renal pelvis into the collecting ducts. IRR is the main cause of renal injury in children with vesicoureteral reflux (VUR) which leads to renal scars, hypertension, proteinuria, and chronic renal failure. The purpose of our study was to investigate the characteristics of intrarenal reflux. Method : We retrospectively reviewed the medical records of 80 patients who were diagnosed as having grades of III-V VUR from Jan. 2004 to Dec. 2006 in the department of pediatrics in Ajou University Hospital. The patients were divided into two groups according to the presence of IRR on voiding cystoureterogram and compared to each other for the possible factors associated with intrarenal reflux. Results : Among 80 VUR patients, IRR(＋) group comprised 17(21.3%) patients and 27 renal units(23.2%) and revealed younger age, higher grade of VUR, and more proteinuria compared to IRR(-) group. There were no significant difference in gender, laboratory findings and the rate of resolution in VUR or defects on renal scan between two groups. Also, intrarenal reflux mostly corresponded to the same site of photon defects on DMSA scan. Conclusion : We suggest that intrarenal reflux tends to be associated with younger age, higher grade of reflux, more proteinuria with no difference in resolution rate of VUR when compared to the VUR patients without IRR. From this study, we were able to understand the characteristics of intrarenal reflux in children with urinary tract infection.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.8 no.2
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• pp.143-149
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• 2005

Purpose: The aim of this study was to evaluate the significance of pH monitoring at two levels, hypopharynx and esophagus in gastroesophageal reflux. Methods: 29 patients with pathological gastroesophageal reflux were classified into two groups: Group I had recurrent respiratory symptoms and Group II had not recurrent respiratory symptoms. The ambulatory pH monitoring was performed at the hypopharynx and the esophagus simultaneously with two channel catheter for 18~24 hr. The pathological reflux was defined when the percent of time that pH was below 4.0 exceeding the 95th percentile of normal value. Hypopharyngeal reflux was defined as the pharyngeal pH drops below 4. Results: 39 patients were performed pH monitoring at the level of hypopharynx and esophagus for 24 hours. Among 7 patients with chronic respiratory symptom, 6 patients (85.7%) have pathological esophageal reflux. Among 32 patients without chronic respiratory symptom, 23 patients (71.8%) have pathological esophageal reflux. Thus 29 out of 39 patients (74%) have pathological esophageal reflux. In the Group I, all parameters except the longest episode showed significant differences between hypopharyngeal and esophageal pH monitoring. None of parameters showed significant differences between group I and II in the pharyngeal pH monitoring. Conclusion: Regardless of presence of respiratory symptoms, the pH monitoring at the pharyngeal level in patients with gastroesophageal reflux did not showed any differences compared with the esophageal pH monitoring. Therefore we may reconsider the usefulness of hypopharyngeal pH monitoring in patients with chronic respiratory symptoms.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.7 no.1
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• pp.48-53
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• 2004

Purpose: Besides interferencence of esophageal motor function by the nasogastric tube, a decline of the positive gastro-esophageal pressure gradient caused by intermittent positive pressure ventilation seems to have a major role in the pathogenesis of gastroesophageal reflux (GER) in mechanically ventilated preterm infants. The aim of this study was to determine the incidence of GER and associated risk factors in mechanically ventilated preterm infants. Methods: Twenty four hour esophageal pH monitorings were performed using a antimony electrode on 11 mechanically ventilated preterm infants in Neonatal Intensive Care Unit in Pusan National University Hospital. We evaluated the following reflux parameters; reflux index, reflux episodes/hour, reflux episodes ${\geq}5min/hour$, duration of longest episode, and percent episodes ${\geq}5min$. Patients were considered to have significant GER if more than 2 among 5 parameters were satisfied. Results: The mean gestational age of the patients was 30.9 weeks, mean birth weight was 1,568 g, and mean age at the time of pH monitoring was 2.8 days. Significant GER was detected in 4 patients (36.4%). There was no relationship between the incidence of GER and gestational age, birth weight, postnatal age, or the ventilator settings. Conclusion: The incidence of GER in mechanically ventilated preterm infants was similar, compared with other previous studies. Associated risk factors of GER in these patients were not detected. Therefore, mechanical ventilation in preterm infants does not seem to be the high risk factor of GER.

• 학교보건
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• s.25
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• pp.50-53
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• 2004

소아 요로감염이 있을시 방광요관역류가 흔히 관찰되며 만성 신우 신염과 방광요관역류와 깊은 관계가 있는 것이 알려져 있다. 발열을 동반하는 소아 요로감염시 D MSA 신주사에서 급성 신우신염의 뚜렷한 소견이 있더라도 방광요관역류가 발견되지 않는 경우가 더 많다. 하지만 신장에 신 반흔이 있을 경우에는 흔히 방광요관역류가 관찰 된다. 소아 요로감염의 처치는 신 반흔의 형성을 막는데 그 궁극적 목적이 있다 하겠다. 신생아시기 심한 방광요관역류에서 요로감염이 없이 신 이형성증으로 인한 신 반흔이 관찰되기도 한다.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1996.04a
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• pp.84-84
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• 1996

인후두 이상감각을 주소로 내원한 환자들에서 주요한 원인 중의 하나로 위식도 역류가 관련되어 있다고 보고되고 있다. 이에 저자들은 이학적 검사 및 Esophagogram을 시행하여 기질적 원인을 배제한 후 인두신경증으로 진단받은 50명과 정상 대조군 30명을 이용하여 다음과 같은 결과를 얻었다. 1) 식도내압 검사상 상부식도압과 하부식도압에서 인두신경중 환자군과 대조군에서 유의한 차이는 없었다(UES : P = 0.56, LES P = 0.98). 2) 24시간 보행성 식도 pH검사에서 환자군과 대조군에서 앙와위시와 기립시 각각의 총역류 횟수, pH 4 미만으로 내려가는 역류횟수, 백분율, 5분이상 지속된 역류횟수, 최장역류시간 등을 비교한 바 양군간의 유의한 차이를 발견할 수 있었다(P<0.05). 3) 50명의 인두신경증 환자중 DeMester Scoring에 의해 의식도 역류 질환으로 진단받은 사람은 12명(24%)으로 위식도 역류가 인두신경증의 중요한 원인이 될 수 있음을 보여주었다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.2 no.2
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• pp.139-146
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• 1999

Purpose: The aim of this study was to evaluate the clinical significance of 24 hour pH monitoring in the pediatric patients with recurrent vomiting or regurgitation. Methods: We performed 24 hour pH monitoring on 87 pediatric patients with recurrent vomiting or regurgitation using GastrograpH with glass electrode. The pathologic GER was determined by the reflux index (RI). RIs>10% were considered positive in patients <1 year of age, whereas RIs of >5% were positive in other age groups. We evaluated the mean and standard deviation of the reflux parameters between physiologic and pathologic GER groups, and also compared the reflux indices of each group with respect to time zones of the day. Results: Pathologic GER was found in 32 of 87 patients (36.8%), and the age incidence included 32.5% in infants <6 months old, 13.3% in infants aged 6 months-1 year old, 61.5% in children aged 1~2 years old, 14.3% in children aged 2~3 years old and 66.7% in children >3 years old. In physiologic GER patients, the RI was $3.7{\pm}2.9%$ for the patients <1 year old (group A), and $1.8{\pm}1.5%$ for those ${\geq}1$ year old (group B) which was statistically significant between the 2 age groups (p=0.02). The number of long refluxes more than 5 minutes was significantly increased (p=0.03) in group A ($1.7{\pm}1.9$) than in group B ($0.8{\pm}1.0$). The duration of the longest reflux was significantly longer (p=0.007) in group A ($604{\pm}551$ sec) than in group B ($275{\pm}296$ sec). In pathologic GER patients, the RI was $17.7{\pm}11.6%$ for the patients <1 year old and $7.8{\pm}2.9$ for those ${\geq}1$ year old. The number of long refluxes of more than 5 minutes were $8.9{\pm}4.6$ and $3.2{\pm}1.8$, and the duration of the longest reflux were $1955{\pm}2190$ sec and $1093{\pm}706$ sec for each age group. In both physiologic and pathologic GER patients, there was no significant difference of RI among the time zones of the day. Conclusion: Pathologic GER was found in 36.8% of patients. There was significant difference of RI between those <1 year old and those ${\geq}1$ year old in physiologic GER patients. There was no significant difference of RI among the time zones of the day in both pathologic and physiologic groups. In our study, the frequency of pathplogic GER was too much higher in age group of 1~2 years old (61.5%) than in group of 6 months-1 year old (13.3%), which means that further study is needed to determine the pathologic criteria of RI (Vandenplas criteria is >5%) in the age group of 1~2 years old.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.6 no.1
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• pp.17-23
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• 2003

Purpose: The aim of this study was to determine clinical significance of dual-probe esophageal pH monitoring and to compare four pH monitoring parameters between proximal and distal esophagus in pathological gastroesophageal reflux disease with recurrent respiratory symptoms. Methods: Among the thirty-four patients who were performed 24 hr pH monitoring, seventeen patients with pathological distal reflux were classified into two groups: Group I (n:12) had recurrent respiratory symptoms and Group II (n:5) hadn't recurrent respiratory symptoms. The ambulatory dual-probe esophageal pH monitoring was performed for 18~24 hr. A pathologic GER was defined when reflux index (percent of the investigation time a pH<4) exceeded the 95th percentile of normal value. Results: Among the sixteen patients with recurrent respiratory symptoms, twelve patients (75%) have pathological distal reflux. Whereas among the eighteen patients without recurrent respiratory symptom, five patients (28%) have pathological distal reflux. In the Group I, the significant differences between proximal and distal esophageal pH recordings persisted for all parameters, but didn't persist in group II except for longest episode. Comparing esophageal pH four parameters between group I and group II at the proximal esophageal site, all parameters didn't show statistically significant differences. Conclusion: Regardless of respiratory symptoms, patients with pathological distal reflux didn't show statistically significant differences in the all parameters at the proximal esophageal site. Therefore we may reconsider usefulness of dual probe pH meter in patients with recurrent respiratory symptoms.

• The Korean Journal of Nuclear Medicine
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• v.34 no.2
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• pp.135-143
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• 2000

Purpose: As vesicoureteral reflux (VUR) could lead to renal functional deterioration when combined with urinary tract infection, we need to decide whether operative anti-reflux treatment should be performed at the time of diagnosis of VUR. Predictive value of radioisotope voiding cystography (RIVCG) for renal outcome was tested. Materials and Methods: In 35 children (18 males, 17 females), radiologic voiding cystoure-thrography (VCU), RIVCG and DMSA scan were performed. Change in renal function was evaluated using the follow-up DMSA scan, ultrasonography, and clinical information. Discriminant analysis was performed using individual or integrated variables such as reflux amount and extent at each phase of voiding on RIVCG, in addition to age, gender and cortical defect on DMSA scan at the time of diagnosis. Discriminant function was composed and its performance was examined. Results: Reflux extent at the filling phase and reflux amount and extent at postvoiding phase had a significant prognostic value. Total reflux amount was a composite variable to predict prognosis. Discriminant function composed of reflux extent at the filling phase and reflux amount and extent at postvoiding phase showed better positive predictive value and specificity than conventional reflux grading. Conclusion: RIVCG could predict renal outcome by disclosing characteristic reflux pattern during various voiding phases.

• Proceedings of the Korea Water Resources Association Conference
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• 2022.05a
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• pp.245-245
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• 2022

최근 국내 기후변화에 따른 국지성 집중호우로 인한 시간당 강우량의 증가로 도로부 유출량의 증가와 배수관거에서의 내수배제 불량에 따른 도심지 내수침수 피해가 증가함에 따라 이를 해결하기 위한 우수유출저감시설이 설치되고 있다. 그러나 대단위의 지하 저류시설의 지속적인 설치는 과밀화된 도심지에서 설치 지하공간의 구조적인 한계 및 적정 설치 위치의 미확보 등의 다양한 문제가 발생하여 저류시설의 침수저감 효과에 대한 추가적이고 새로운 저류시설에 대한 연구가 필요한 실정이다. 이에 내수 침수 저감 및 배수 능력 향상을 위한 도로 배수시설과 연계된 도로 측구부 저류시스템 구축이 필요하다. 이를 위해 역류 방지 및 노면수 저류 빗물받이에 적용되는 부력식 역류차단장치를 개발하였으며, 역류차단장치의 최적 형상 개발을 위해서 기존 빗물받이 연결관과의 통수능 비교 및 분석이 필요한 실정이다. 따라서 본 연구에서는 기존 빗물받이 연결관 및 연결관 내에 역류차단장치가 적용된 역류차단 빗물받이의 흐름분석을 위해 Fluent 모형을 이용하여 3차원 수치모의를 수행하였다. 수치모의 구성으로는 전체 형상을 40×50cm의 빗물받이 유입부와 50×50cm의 빗물받이로 결정하고 격자는 빗물받이 내부의 복잡한 3차원 흐름을 모의하기 위해 1.2~2mm 크기로 생성하였다. 다상유동 해석을 위해 VOF(Volume of Fluid)방법을 적용하였고, 수치해석 방법으로는 비정상류, 난류 모형으로는 SST k-𝜔모형을 적용하였다. 해석조건으로는 김정수(2021) 등이 제시한 4차선 기준 설계빈도별(5~30년) 빗물받이 유입유량을 산정하여 빗물받이 유입조건으로 선정하였으며, 빗물받이와 연결관에서의 통수능력 분석 조건으로는 빗물받이에 기존 연결관이 부착된 조건과 연결관 내에 역류차단장치가 설치되어 역류차단장치가 개방된 조건에서의 통수능을 비교하였으며, 역류상황을 가정한 연결관에서의 통수능을 비교하기 위하여 역류차단장치의 개폐정도를 15도(통수단면 33%감소) 닫힌 상태 및 30도(통수단면 67% 감소) 닫힌 상태 조건을 대상으로 빗물받이와 연결관에서의 흐름을 모의하였다. 수치모의 결과 역류차단장치의 계폐조건에 상관없이 5년 빈도유입량 조건에서는 완전 배수가 되었으며, 개폐조건 15도에서는 10년 빈도의 유입량에서는 완전 배수가 되었으나 20년 빈도 이상의 유입량 조건에서 빗물받이 유입부로의 역류가 발생하였으며, 개폐조건 30도에서는 5년 빈도 이상 유입량 조건에서 빗물받이 유입부로 역류가 발생하는 것으로 나타났다. 특히, 30년 빈도 이상의 유입량부터는 빗물받이 연결관 내에 역류차단장치 개페조건과 관계없이 빗물받이 유입부로의 역류로 인한 도로 침수가 발생하기 때문에 유휴공간인 도로 측구부를 저류공간으로 활용할 수 있는 도로 측구부 저류시스템의 구축은 필수적이라고 판단되며, 유량 조건에 따른 빗물받이 내부 와 흐름과 유출부에서의 유속 변화 특성을 확인하였다. 그러므로 측구 저류조 개발 형상과 연결한 3차원 흐름의 구현 및 분석에 Fluent 모형의 적용이 가능하다고 판단된다.