• Korean Journal of Acupuncture
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• 제26권1호
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• pp.111-123
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• 2009

Objective : The purpose of this study is to observe the effect of high frequency electro-acupuncture (hf-EA) at Yanglingquan(GB34) on $CCl_4$-induced liver damage in rats. Methods : The author performed several experimental items, including measurements of body weight and liver weight, hematological analysis for RBC, WBC, PLT, hemoglobin, lymphocytes, neutrophils, monocytes and biochemical assays for ALT, AST, ALP and total cholesterol in serum, and histological analysis of liver tissue. Results & Conclusion : 1. WBC level in blood was slightly reduced by acupuncture and hf-EA at GB34. 2. Lymphocyte level in blood was decreased by $CCl_4$-intoxication and significantly increased by acupuncture and hf-EA at GB34. 3. Neutrophils level in blood was slightly reduced by acupuncture and hf-EA at GB34. 4. ALT and AST in serum were reduced significantly by acupuncture and hf-EA at GB34. 5. The pathological changes of liver tissue induced by $CCl_4$ was reduced by hf-EA at GB34. 6. No significant difference was found between the effects of acupuncture and hf-EA on CCl4-induced liver damage in rats.

• Journal of Acupuncture Research
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• 제28권2호
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• pp.143-153
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• 2011

Objectives : The purpose of this study is to observe the effects of herbal acupuncture with Schizandrae Fructus solution at $GB_{34}$(Yangneungcheon) on hyperlipidemia in rats. Methods : In the present study, herbal acupuncture with Schizandrae Fructus solution was administered into hyperlipidemic mice. The author performed several experimental items to analyze the levels of various components and enzymes in serum, liver, as well as the histological changes of liver and aorta. Results : 1. In the Schizandrae Fructus herbal-acupuncture group, serum total cholesterol and Atherogenic index were significantly decreased, and the ratios of HDL to total cholesterol, and phospholipid to total cholesterol in serum were significantly increased as compared with those of the control group. 2. In the Schizandrae Fructus herbal-acupuncture group, HMG-CoA reductase activity was significantly decreased as compared with those of the control group. 3. Schizandrae Fructus herbal-acupuncture reduced deposit of lipid in the liver tissue. Conclusions : From the above results, it is suggested that Schizandrae Fructus herbal-acupuncture at $GB_{34}$ has a therapeutic effect on hyperlipidemia.

• 대한한의학회지
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• 제32권1호
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• pp.151-163
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• 2011

Objective: The purpose of this study is to observe the effects of Persicae Semen herbal-acupuncture at GB34(Yangneungcheon) on hyperlipidemia of rats caused by high-fat diet. Methods: The author performed several experiments to measure the DPPH radical scavenging activity of PS-HAS,to analyze various components and enzymes in serum and liver, and to observe the histological changes of liver and aorta. Results: 1. Persicae Semen herbal-acupuncture solution increased the DPPH radical scavenging activity in rat's liver cells. 2. In the Persicae Semen herbal-acupuncture group, compared with control group, the level of total cholesterol in serum and the ratio of total cholesterol to HDL-cholesterol decreased significantly. 3. In the Persicae Semen herbal-acupuncture group, compared with the control group, the level of glutathione in liver cells increased significantly. 4. In the Persicae Semen herbal-acupuncture group, compared with the control group, the pathological changes in liver and aorta were reduced. Conclusion: The above results suggest that Persicae Semen herbal-acupuncture at GB34 has good effects on preventing and treating hyperlipidemia.

• Korean Journal of Acupuncture
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• 제36권4호
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• pp.189-199
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• 2019

Objectives : This study aimed to investigate the effects of electroacupuncture (EA), the laser acupuncture (LA) and the combination therapy (LA+EA) in a collagenase-induced osteoarthritis rat model. Methods : Osteoarthritis rat model was induced by injection of collagenase into left lower articular cavity (50 μl to knee and 10 μl to ankle). In order to assess the anti-osteoarthritic effects of EA, the 650 nm LA and 650 nm LA+EA, the histopathological findings and plantar withdrawal responses were analyzed. Results : All of the treatment methods used in this study were effective in reducing pain. All treatment groups were effective in decreasing inflammatory cytokines of TNF-a and IL-6; the 650 nm LA and 650 nm LA+EA groups significantly reduced IL-1β. Conclusions : 650 nm LA and EA inhibit the production of collagenase-induced inflammatory mediators of osteoarthritis.

• Korean Journal of Acupuncture
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• 제27권3호
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• pp.25-46
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• 2010

Objective & Methods : The purpose of this study is to observe the effects of herbal- acupuncture with Achyranthis Radix(AR-HA) at GB34(Yangleungchean) on hyperlipidemia in rats. The author performed several experimental items to analyze the levels of various components and enzymes in serum and liver, as well as the histological changes of liver and aorta. Results : 1. Achyranthis Radix herbal acupuncture solution increased DPPH radical scavenging activity and HMG-CoA reductase inhibition rate in rat liver cells. 2. AR-HA at GB34 decreased the level of serum total cholesterol, and increased the ratios of HDL-cholesterol to total cholesterol, phospholipid to total cholesterol in hyperlipidemic rat. 3. AR-HA at GB34 decreased the hepatic HMG-CoA reductase activity in hyperlipidemic rat. 4. AR-HA at GB34 increased the hepatic GSH level in hyperlipidemic rat. Conclusion : From the above results, it is suggested that AR-HA at GB34 has a therapeutic effect on hyperlipidemia.

• Korean Journal of Acupuncture
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• 제25권2호
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• pp.211-224
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• 2008

Objectives : To investigate the effect of electro-acupuncture (EA) at GB34 on hepatotoxicity in $CCl_4$-intoxicated rats. Methods : Rats were injected with $CCl_4$ and treated with acupuncture or 2 Hz electro-acupuncture (EA) at left GB34 three times a week for 10 weeks. A non-acupoint in left gluteal area was selected as a sham point. To estimate the effects of EA on hepatotoxicity in rats, body weight, liver weight and liver index were measured, and biochemical assays for serum ALT, AST, ALP and total cholesterol, and hematological analysis for RBC, WBC, PLT, hemoglobin, lymphocytes, neutrophils and monocytes, and histology analysis of liver tissue were performed. Results : 1. Lymphocyte level in blood was significantly decreased by $CCl_4$-intoxication and significantly increased by acupuncture and 2 Hz EA at left GB34. 2. Neutrophill and monocyte level in blood was increased by $CCl_4$-intoxication and significantly reduced by acupuncture and 2 Hz EA at left GB34. 3. Acupuncture and 2 Hz EA at left GB34 significantly reduced serum ALT and AST which were increased by $CCl_4$-intoxication. 4. EA at GB34 significantly reduced serum ALT and AST as compared with EA at sham point in $CCl_4$-intoxicated rat. 5. No significant difference was found between the effects of acupuncture and that of 2 Hz EA on $CCl_4$-induced liver damage in rats. Conclusions : 2 Hz EA at GB34 has hepatoprotective effects on $CCl_4$-induced liver damage in rats and the point-specificity of GB34 may be involved in these effects.

• 동의신경정신과학회지
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• 제14권1호
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• pp.133-139
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• 2003

본 증례는 약물부작용으로 인한 이차성 파킨슨 중에서 설(舌), 하악(下顎), 수부(手部)에 진전(震顫)증상이 나타난 환자를 풍담(風痰)으로 인한 진전(震顫)증상으로 보고 척담탕(滌痰湯)을 투여하고, 합곡(合谷), 태충(太衝), 중완(中脘), 풍륭(豊隆), 염천(廉泉), 족삼리(足三里), 양릉천(陽陵泉), 풍지(風池), 백회(百會) 위주의 침(鍼)치료를 병행하여 치료한 결과, 빠른 증상회복을 보였던 예이다. 이런 결과는 약물부작용으로 인한 이차성 파킨슨증을 치료하는 기초적 자료가 될 것이며, 약물회피요법을 단독으로 시행하는 경우와 한의학적 치료를 병행하는 경우의 치료효과에 대한 비교분석을 포함하여 향후 객관적이고 지속적인 연구가 필요하 리라 사료된다.

• Journal of Acupuncture Research
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• 제23권3호
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• pp.143-153
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• 2006

Introduction : This study was designed to evaluate the effect of acupuncture on Unified Parkinson's Disease Rating Scale (UPDRS) and Heart Rate Variability (HRV) of patients with Parkinson's disease Methods: Subjects were voluntarily recruited through newspaper and internet advertisement. All the subjects were confirmed as idiopathic parkinson's disease by a neurologist. Acupuncture was applied 2 times a week for four weeks by oriental medical doctor at Kyung-hee University hospital. Acupuncture points used were GB34 and LR3. The patient's symptoms were assessed before and after 4 weeks of treatment by UPDRS and HRV. HRV was measured for 5 minutes before and after 4 weeks of treatment. Results : The results were as follows; 1. In both groups, UPDRS scores were significantly improved after 4 weeks compared to the pre-treatment 2. After 4 weeks of treatment UPDRS score differences between the two groups were insignificant 3. After 4 weeks of treatment HRV parameter scores showed statistically insignificant differences between the two groups. SDNN parameters of the Experimental group were significantly increased. Conclusion : This study suggests that acupuncture treatments can be applicable to improve symptoms in the patients with idiopathic Parkinson's disease. Further study on the acupuncture and HRV in the patients with Parkinson's disease is recommended.

• Journal of Acupuncture Research
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• 제32권2호
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• pp.65-75
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• 2015

Objectives : The purpose of this study was to investigate the effects of warm needling at $GB_{30}{\cdot}GB_{34}$ on Complete Freund's Adjuvant(CFA)-induced rheumatoid arthritis in rats. Methods : Arthritis was induced by injecting CFA subcutaneously into the left knee joint and paw. Acupuncture(AT) and warm needling(W-AT0.5, W-AT1.0) were injected at $GB_{30}{\cdot}GB_{34}$, every other day for a total of 5 times beginning on day 10 after the CFA injection. Thereafter, external shape, paw edema, serum aminotransferase and anti-inflammatory factors were assessed, and hematological and histological observations were made. Results : In paw edema volume all 3 groups(AT, W-AT0.5, W-AT1.0) showed significant decrease compared to the CFA control group. In TNF-${\alpha}$ and IL-6, all 3 groups showed significant decrease compared to CFA control group. In AST and ALT all 3 groups showed no significant change. In IL-$1{\beta}$, W-AT0.5 and W-AT1.0, groups showed significant decrease compared to the CFA control group. Leucocyte, erythrocyte and thrombocyte, all 3 groups showed no significant change. In histological observations, all 3 groups were similar to the intact group in terms of synoviocyte, cartilage lacuna and cartilage cells. Conclusions : The results suggest that warm needling at $GB_{30}{\cdot}GB_{34}$, has the effect of suppressing inflammation of CFA-induced rheumatoid arthritis in rats.

• Korean Journal of Acupuncture
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• 제25권4호
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• pp.119-132
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• 2008

Objectives : To compare the effects of low-frequency electro-acupuncture (EA) stimulation at left and right GB34s on hepatotoxicity in $CCl_4$-intoxicated rats. Methods : Rats were injected with $CCl_4$ and treated with 2 Hz electro-acupuncture (EA) at left and right GB34s for 15 minutes 3 times per week, for 10 weeks. Holder group, injected with $CCl_4$ and strained in a cylinder for same period as the EA group, was established to compare the hepatotoxicity against the two electroacupuncture groups. To estimate the effects of EA on hepatotoxicity in rats, body weight, liver weight and liver index were measured. Biochemical assays for serum ALT, AST, ALP and total cholesterol ; hematological analysis for RBC, WBC, PLT, hemoglobin, lymphocytes, neutrophils and monocytes ; and histology analysis of liver tissue were also performed. Results : Lymphocyte level in blood was significantly decreased by $CCl_4$-intoxication, and increased by low-frequency electroacupuncture applied on both left and right GB34s. Low-frequency EA applied on right and left GB34s significantly reduced serum ALT and AST, both of which had been increased by $CCl_4$-intoxication. Conclusion : Low-frequency electroacupunctures at both left and right GB34s have hepatoprotective effects on $CCl_4$-induced liver damage in rats. However, no significant differences were found between the effects of EAs at left and right GB34s.