• Transactions of the Korean Society of Mechanical Engineers B
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• v.39 no.6
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• pp.471-475
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• 2015

Because of increasing demand, a small portable drug injector that uses osmotic pressure for its operation force is developed, and its performance is evaluated. The osmotic drug injector can be small and lightweight because it does not require heavy batteries and an actuator, unlike previous electromechanical drug injectors. Moreover, its injection pressure can be sustained longer than that of previous elastic drug injectors. The new device is composed of a drug sac, osmotic pressure chamber, semipermeable membrane, and solvent chamber. To evaluate its performance, an in-vitro experiment was designed to measure the outflow and the injection pressure with respect to time. The experimental results show that the new drug infuser can continuously deliver 20 ml drug over a period of 20 h. The maximum injecting pressure was over 400 mmHg. Which prevents backflow caused by changes in the outlet pressure resulting from changes to the position of the device and the patient's posture.

• Journal of the Microelectronics and Packaging Society
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• v.28 no.4
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• pp.51-55
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• 2021

The nurses manually carry out the intravenous therapy for the patients. Using an Arduino, the fine flow controlling device was invented to provide an ongoing patient care. The medication is injected through a peristaltic pump, and the amount of the solution is controlled with a RGB color sensor. The power of the device is supplied through the batteries. An amount of the injection is measured with LIG strain sensor fabricated by 355nm UV pulsed laser. This system will provide a better medical service.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.34 no.11
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• pp.1595-1602
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• 2010

A disposable drug infuser is used to provide drugs to patients who are not hospitalized; in this infuser, an elastic recovery force is exerted by a diaphragm made of a rubber-like materialsuch that a constant amount of drugs is provided to a patient. The drug infuser has to control the speed and amount of drugs to be released, as well as the overall duration for which they are to be administered. However, in a drug infuser with an elastic diaphragm, the infusion pressure depends on the amount of drug remaining within the infuser, and the amount of drug infused gradually decreases as the amount remaining in the infuser decreases. In this study, a finite element procedure involving the application of the fluid-structure interaction technique was developed and the performance of the elastic type disposable drug infuser was analyzed. The optimum design for ensuring that the infusion pressure remains constant throughout the duration of usage, including during infusion and discharge, was determined by this procedure.

• The KSFM Journal of Fluid Machinery
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• v.12 no.3
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• pp.31-37
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• 2009

This paper presents a implantable intrathecal drug infusion pump for pain control in cancer patients. This device consists of micropump module, drug reservoir module and control module. The micropump module using cam-follower mechanism composed of small-sized four cams and four followers. Each followers is driven by a cam and liquid is discharged by a sequential reciprocal motion of the followers. The advantage of this structure is that it allows the pump to be clean and valveless. The drug reservoir module composed of drug chamber, gas chamber and diaphragm. The control module composed of battery, wireless communication unit and controller. To design a small-sized, low power pump some analysis were performed to determine the design parameters. To verify the feasibility of the experiment, a prototype was manufactured and its operating characteristics were investigated. Experimental results were in accordance with the expected results obtained from analysis.

• The KSFM Journal of Fluid Machinery
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• v.11 no.1
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• pp.40-45
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• 2008

This paper proposes a tube pump composed of small-sized cams and followers for an implantable intrathecal drug infusion device. Each followers is driven by a cam and liquid is discharged by a sequential reciprocal motion of the followers. The advantage of this structure is that it allows the pump to be clean and valveless. To design a small-sized, low power pump some analysis were performed to determine the design parameters of the cam, follower and the tube. To verify the feasibility of the experiment, a prototype was manufactured and its operating characteristics were investigated. Experimental results were in accordance with the expected results obtained from analysis.

• Journal of Biomedical Engineering Research
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• v.36 no.6
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• pp.291-295
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• 2015

Various types of implantable drug delivery devices have attracted significant attention for several decades to improve drug bioavailability and reduce side effects, thus enhancing therapeutic efficacy and patients' compliance. However, when implanted into the body, the devices may be influenced by the changes in physiological condition, such as temperature, pH or ionic concentration. Thus, the drug release rates could be also altered concurrently. Therefore, in this work, we employed an implantable ALZET$^{(R)}$ Osmotic Pump, which has been widely used to locally deliver various therapeutic agents and examined the effect of pH, temperature and ionic concentration on its drug release rate. For this, we performed in vitro cell tests to simulate the condition of local tissues influenced by the altered drug release rates, where we used diclofenac sodium as a model drug.