• Journal of the Korea Computer Industry Society
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• v.7 no.4
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• pp.447-454
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• 2006

Imbecility, Parkinson's disease, the brain disease occurrence rate such as motor nerve disease are increasing rapidly since 1980 years, according to the Britain, the United States of America, Japan, Germany, result that investigate the spanish occurrence rate, was expose that imbecility mortality including Alzheimer's disease increased more than man case 3 triple and man and woman of brain disease mortality increases by about 50% with Parkinson's disease and motor nerve disease. <중략> first of all, courtesy call is important. So that can find out danger benevolence and occurrence danger at early stage, person arranged brain vein because examination does special Quality examination and modelling Tuesday embodying possible Cerebrovascular Ultrasonogram (brain vein supersonic waves) and prove excellency of performance from time to time. Is going to apply to brain disease patient of other disease if supplement system hereafter, and this research tried to study special quality that standardization is not producing poetic theme width directly and approach.

• The Journal of the Korea Contents Association
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• v.15 no.10
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• pp.56-65
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• 2015

The purpose of this study is to find out the possibility of the healing function of art museums in modern times with the precedent studies and to explore the healing potential specifically. There have been studies on the various healing programs regarding patients with Alzheimer, learning disability, seniors, etc. The researcher approached this study in three aspects, art appreciation, space, communication as healing potential of art museums. These findings will be able to draw more social attention on art museums. Therefore, this study will provide a new perspective on the art museums to people concerned art museums. And it will make the professionals, working for company workers, students and other people suffering under the modern stress, recognize the art museums as a place to look inside in the professionals' own mind and to heal as well as a place for culture and sophistication. These findings will be able to draw more social attention on art museums.

• Journal of Convergence for Information Technology
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• v.7 no.3
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• pp.1-12
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• 2017

The purpose of this study is to contribute to research on dementia and policy making by reviewing research trends of dementia for 15 years and it was collected from 12,588 dementia - related research data for 15 years at Google 's scalar site. The results of this study confirm that the research on dementia, one of the most common geriatric diseases, is continuously increasing. Second, research on dementia is increasing due to social influences such as government support. Third, we suggested that dementia is changing from a viewpoint of diseases to be managed at the facility and treatment of severe dementia patients to a paradigm from the viewpoint of management of mild patients and community participation. Fourth, dementia seems to be shifting from a serious and negative awareness to a social atmosphere that is accepted as a slow but manageable disease. This is changing to a dementia-friendly social environment, which is making a very positive environmental change. This study contributes to the field research by presenting the trend of domestic research on dementia.

• Journal of Oriental Neuropsychiatry
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• v.15 no.2
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• pp.141-148
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• 2004

Objective : This study is designed to assess the effects of Gongjin-dan on cognitive decline of the patients with mild Dementia of Alzheimer Type(DAT). Method : 33 patients with mild DAT were measured by using K-DRS, and after 100 days again. During 100 days the patients with mild DAT were treated with Gongjin-dan. The scores of K-DRS between before and after treatment were analyzed by paired t-Test. Result : 1. the mean age of patients was $70.3{\pm}4.1$ years (range 65 to 84 years) 2. the mean education of patients was $5.5{\pm}5.3$ years 3. the mean K-DRS score of the patients before treatment was $93.2{\pm}12.1$, and the mean K-DRS score of the patients after treatment was $114.7{\pm}14.5$. K-DRS scores after treatment was significantly different with the K-DRS scores before treatment.(t=9.907, r=.573, p<.00l) Conclusion : Treatment with Gongjin-dan for 100 days increased the cognitive ability in patients with mild DAT

• Journal of the Korean Applied Science and Technology
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• v.29 no.4
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• pp.552-560
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• 2012

Drug delivery technologies are patent protected formulation technologies that modify drug release profile, absorption, distribution, and elimination for the benefit of improving product efficacy and safety, as well as patient convenience and compliance. The most commonly used transdermal system is the skin patch using various types of technologies. Compared with other method of dosage, it is possible to use for a long term. It is also possible to stop the drug dosage are stop if the drug dosage lead to side effect. Polysaccharide, such as karaya gum and locust bean gum(LBG)/water-soluble chitosan oligomer(WSCO) were selected as base materials of TDS. Also, these polymers were characterized in terms of enhancers, tacrine contents. Among these polysaccharide, the permeation rate of karaya gum matrix was fastest in tacrine such as lipophilic drug in vitro. We used glycerin, PEG 400, and PEG 800 as enhancers. Therefore, transdermal absorption of tacrine could be improved by changing vehicle composition or by using penetration enhancers. Especially it would be anticipated that the high permeation efficacy could be obtained by using vehicle that has enhancing effect for itself and by adding enhancers to it.

• The Journal of Natural Sciences
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• v.19 no.1
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• pp.45-55
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• 2008

Alzheimer's disease is charaterized by the acetylcholine depletion, amyloid b-protein aggregation and neurofibrillary tangles. The prevention of the breakdown of acetylcholine by acetylcholinesterase (AChE) inhibitor has the best clinically therapeutic efficacy for Alzheimer's disease patients. To develop new antidementia alternative drugs or nutraceuticals, methanol extracts of Sorghum bicolor was screened from various extracts of cereals and legumes as a potent AChE inhibitor-containing extract in previous paper. In this paper, physicochemical properties of the methanol extracts was investigated. The methanol extracts was soluble by water, methanol and DMSO and had 215 nm and 282nm of maximum absorption spectra. It was also stable at 20-$100^{\circ}C$ and pH 2.0-10.0 for 1 hr. Test product was prepared by using methanol extracts from Sorghum bicolor and changes of its quality during storge at $20^{\circ}C$ and $40^{\circ}C$ were investigated. It was very stable for 8 weeks at $40^{\circ}C$.

• Journal of The Korean Dental Society of Anesthesiology
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• v.11 no.2
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• pp.146-152
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• 2011

Background: Elderly patients with progressive dementia including Alzheimer's disease (AD) are more and more often scheduled to undergo general anesthesia for various pathologies including dental problem. But, there is high risk of deterioration of underlying mental diseases and other co-morbidities. So it is important to implement preventive strategies and take adequate measures to minimize negative perioperative events in these patients. Methods: We reviewed the 17 cases of 11 patients with AD who underwent ambulatory general anesthesia for dental treatment at the clinic for the disabled in Seoul National University Dental Hospital. Results: The mean age was 68 (57-81) years. All of them were diagnosed with AD and some had hypertsnsion, bronchiectasis, urinary incontinence. For anesthesia induction, 3 cases (1 patient) was needed physical restraint, but others showed good or moderate cooperation. Drugs used for anesthesia induction was thiopental (11 cases), propofol (3 cases) and sevoflurane (3 cases). All patients received nasotracheal intubation without difficulties. Mean total anesthetic time was 3 hour 44 min ${\pm}$ 60 min and staying time at PACU was 83 ${\pm}$ 34 min. All the patients except one who showed hypertension discharged without any complication. There was no death or long term hospitalization because of severe complications. Conclusions: If general anesthesia is needed, pertinent diagnostic tests and workup about other medical problems, and appropriate anesthetic planning are essential for safety.

• Journal of Biomedical Engineering Research
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• v.39 no.6
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• pp.237-242
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• 2018

$^{18}F$-fludeoxyglucose PET (FDG-PET) can help finding an abnormal metabolic activity in brain. In this study, we evaluated an efficiency of volume- and cortical surface-based analysis which were used to determine whether standardized uptake value ratio (SUVR) of FDG-PET was different among Alzheimer's disease (AD), mild cognitive impairment (MCI), and healthy control (HC). Each PET image was rigidly co-registered to the corresponding magnetic resonance imaging (MRI) using mutual information. All voxels of the co-registered PET images were divided by the mean FDG uptake of the cerebellum cortex which was thresholded by partial volume effect (>0.9). Also, the SUVR value of each vertex was linearly interpolated from volumetric SUVR image which was thresholded by gray matter partial volume effect (>0.1). Lobar mean values were calculated from both volume- and cortical surface-based SUVRs. Statistical analysis was conducted to compare two measures for AD, MCI and HC groups. Even though the results of volume (SUVR_vol) and cortical surface-based SUVR (SUVR_surf) analysis were not significantly different from each other, the latter would be better for detecting group differences in SUVR of PET.

• Journal of the Korea Convergence Society
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• v.12 no.2
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• pp.327-336
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• 2021

It is important to prevent progression of mild cognitive impairment (MCI) to Alzheimer's disease or other dementia. This study was conducted to investigate cognitive-based intervention and its effectiveness for the older patients with MCI through systematic review. Data search was conducted in September 2020, using the Korea Research Information Service (Riss) and KoreaMed. After selection of literatures according to the predefined inclusion criteria, a total of 12 articles were included. It is revealed that the cognitive-based intervention for the older adults with MCI was found to have a positive effect on the various factors including cognitive function, depression, physical health status, quality of life, and communication. However, it is difficult to draw a definite conclusion due to the various intervention strategies and instruments used. Thus, based on the results of this study, we suggest more studies to verify the effectiveness of such programs.

• Journal of Oriental Neuropsychiatry
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• v.31 no.4
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• pp.301-314
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• 2020

Objectives: The purpose of this study was to provide clinical evidence to support the use of herbal medicine combined with western medicine for BPSD. Methods: Studies were identified by searching CNKI, Pubmed, EMBASE, Cochrane Library, SCIENCEON, RISS, KMbase, KISS, OASIS. Literature searches of Chinese, English, and Korean databases were performed. Two authors independently extracted the data and evaluated the quality of each study. Results: The literature search identified 203 articles. Of these, 7 were selected for the analysis. The risk of bias in most studies was unclear. The most frequently used diagnostic tools were the NINCDS-ADRDA and DSM-IV. The most commonly used results indicator was NPI. In 6 of the 7 papers, combination treatment (herbal & Western medicine) was statistically significantly more effective than single treatment (Western medicine alone) for BPSD. No significant adverse events were reported. Conclusions: Herbal medicine in combination with Western medicine is more effective for treating BPSD than Western medicine alone. However, the quality of the studies used in this study was uncertain and the sample size was too small. Based on the findings of this study, more high-quality clinical trials are needed to confirm the efficacy of combination treatment.