• Journal of Korean Society of Coastal and Ocean Engineers
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• v.32 no.2
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• pp.95-105
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• 2020

In this study, using the CADMAS-SURF model, the characteristics of the wave pressures and the wave forces were analyzed according to the installation position of the parapet on top of the caisson, and the stability evaluation was carried out using estimated wave forces for the design wave condition. Numerical results show that adopting the rear-parapet reduces the front maximum wave pressures and wave forces, and the maximum wave pressure acting on the rear-parapet increases slightly compared to the front parapet, but the wave force acting on the rear-parapet has little effect on the stability of the breakwater due to the phase difference with the wave force acting on the front of the breakwater. In addition, impulsive wave pressures did not occur, as Yamamoto et al. (2013) pointed out the problem of the rear-parapet breakwater. As a result of the stability against sliding and overturning, it was estimated that the target safety factor of 1.2 could be secured by the self-weight of 13% less than the case of the front parapet. At this time, the maximum ground pressure was also reduced by 30%, and the applicability of the rear-parapet structure to the actual site was evaluated as high.

• Microbiology and Biotechnology Letters
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• v.42 no.2
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• pp.194-201
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• 2014

Clitocybin A is a novel anti-wrinkle cosmetic agent produced by the strain from a Korean native mushroom Clitocybe aurantiaca. In this study, fermentation, extraction, and purification conditions for a large scale production of clitocybin A were optimized, and its cytotoxicity and inhibition activity on the expression of matrix metalloproteinase-1 (MMP-1) were characterized. The mass production of anti-wrinkle agent was achieved according to the 300 L fermentation process with a fed-batch cultivation using the modified yeast-maltose (YM) broth, and a total of 12.5 kg of cell mass was obtained in a 120 L culture broth for 14 days. After extraction and purification, clitocybin A was identified by HPLC. The cytotoxicity of clitocybin A was examined by the MTT assay. When assayed at 100 and 200 ${\mu}g/ml$ concentrations, clitocybin A showed no cytotoxicity, demonstrating safety. The inhibition activity of clitocybin A on the expression of MMP-1 was examined against UV irradiation. Oleanolic acid (control group) showed a relatively low MMP-1 inhibiting activity (ca. 16.7%) at 10 ${\mu}g/ml$ and showed increased cytotoxicity at higher concentrations. In contrast, clitocybin A showed no cytotoxicity at 100 ${\mu}g/ml$, and exhibited a relatively high MMP-1-inhibiting activity (33.1%). These findings indicate that clitocybin A may be a safe and effective anti-wrinkle agent for use in functional cosmetics.

• Korean Journal of Food Science and Technology
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• v.32 no.6
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• pp.1426-1432
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• 2000

The effects of raw anchovy, salted raw anchovy (20% salt+anchovy), 6- and 12-month fermented anchovy (20% salt added) on the N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced mutagenicities were evaluated using Salmonella assay and the SOS chromotest. The methanol extracts from raw, salted and the fermented anchovy (FA) sample increased the revertants of Salmonella typhimurium TA100 at the level of $0.125{\sim}5\;mg/plate$ in Ames test. The salted raw anchovy extract induced the largest number of the revertants. All the FA extracts had comutagenic effect on the MNNG. Twelve-month FA juice exerted the lowest comutagenic activity among the FA samples. The comutagenicity of 12-month FA was due to the synergistic effect of salt and histidine which teem in FA. Thus the Ames test using histidine requiring mutant, S. typhimurium, is not appropriate to determine the mutagenicity of FA which is rich in histidine. In SOS chromotest using E coli, raw, salted and fermented anchovy extracts did not show any mutagenicity in the absence of MNNG. The raw and fermented anchovy samples blocked the SOS response of E. coli PQ37 induced by MNNG, while raw salted anchovy increased the SOS induction factor. Twelve-month FA juice showed higher antimutagenic effects than 6-month FA samples (both solid and liquid). The ripened (12-month) FA along with raw anchovy in the SOS chromotest exhibited antimutagenic activity.

• Journal of the Korean Society of Hazard Mitigation
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• v.11 no.3
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• pp.219-228
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• 2011

In this paper, the design procedure of substructure of the steel-type breakwater was described and the actual foundation design was performed for the test bed. The site investigation was executed at the Osan-port area, in Uljin, Gyeongbuk, where the steeltype detached breakwater is constructed. The foundation mainly depends on the lateral load and uplift force due to the wave force. Since the superstructure is stuck out about 9.0m from the ocean bed, the foundation must resist on the lateral force and bending moment. After considering various factors, the foundation type of this structure was determined by the steel pipe pile(${\varphi}711{\times}t12mm$). On the stability of pile foundation, the safety factors of the pile on the compressive, lateral and uplift forces were grater than the minimum factor of safety. The displacements of pile under the working load were evaluated as the values below the permissible ones. Based on the subgrade reaction method, we evaluated the relationship of subgrade reaction and displacement for the lateral and the vertical directions in the layers. The structural analyses along with the foundation were perfomed and the effect of pile foundations were compared quantitatively.

• Korean Journal of Food Science and Technology
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• v.53 no.6
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• pp.756-760
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• 2021

Frankincense has been used as a traditional medicine for treating rheumatoid arthritis, dermatitis, and muscle pain. In this study, the anti-tuberculosis effects of Frankincense were evaluated in immune responses of macrophages. Frankincense methanol extract was not cytotoxic to the host. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction assay using human macrophage (THP-1) cells did not show cytotoxic effects or morphological changes with treatments of 31.3, 62.5, and 125 ㎍/mL Frankincense methanol extract (FRM). Inhibitory effects of Frankincense methanol extract on the growth of Mycobacterium tuberculosis in human macrophages were investigated. The immune response was measured by monitoring the levels of TNF-α and IL-1β in THP-1 cells with or without M. tuberculosis infection under Frankincense methanol extract treatment. Inflammatory cytokine levels and M. tuberculosis numbers were reduced in THP-1 cells treated with Frankincense methanol extract. Therefore, Frankincense methanol extract could be used as a potential anti-tuberculosis agent.

• Journal of Applied Biological Chemistry
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• v.64 no.3
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• pp.245-251
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• 2021

Codonopsis lanceolata (Deoduk) was grown in East Asia, including Korea, China, Japan, and Russia, and the roots of C. lanceolata have been used as functional foods and traditional medicine to treat symptoms of cough, bronchitis, asthma, tuberculosis, and dyspepsia. The phytochemicals of C. lanceolata have been reported such as phenylpropanoids, polyacetylenes, saponins, and flavonoids that are involved in pharmacological effects such as anti-obesity, anti-inflammation, anti-tumor, anti-oxidant, and anti-microbial activities. Selecting marker substances of the main producing area by MS-based metabolomics analysis is important to ensure the beneficial effect of C. lanceolata without side-effects because differences in cultivated areas of plants were related not only to the safety of medicinal plants but also to changes in chemical composition and biological efficacy. In our present study, ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry combined with multivariate statistical analysis was applied to recognize the main producing area of C. lanceolata in South Korea. As a result of Principal Component Analysis and loading plot analysis of three groups, Inje (Kangwon-do), Hoengseong (Kangwon-do), and Muju (Jeonlabuk-do), several secondary metabolites of C. lanceolata including tangshenoside I, lancemaside A, and lancemaside G, were suggested as potential marker substances to distinguish the place of main producing area of C. lanceolata.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.21 no.5
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• pp.103-111
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• 2021

The purpose of this study is to study a method for preventing collisions of multiple drones in controlled airspace. As a result of the study, it was proved that it is appropriate as a method to control drone collisions after setting accurate information on the ROI (Region of Interest) area estimated based on the expected drone path and time in the control system as a method to avoid drone collision. As a result of the empirical analysis, the diameter of the flight path of the operating drone should be selected to reduce the risk of collision, and the change in the departure time and operating speed of the operating drone did not act as an influencing factor in the collision. In addition, it has been demonstrated that providing flight priority is one of the appropriate methods as a countermeasure to avoid collisions. For collision avoidance methods, not only drone sensor-based collision avoidance, but also collision avoidance can be doubled by monitoring and predicting collisions in the control system and performing real-time control. This study is meaningful in that it provided an idea for a method for preventing collisions of multiple drones in controlled airspace and conducted practical tests. This helps to solve the problem of collisions that occur when multiple drones of different types are operating based on the control system. This study will contribute to the development of related industries by preventing accidents caused by drone collisions and providing a safe drone operation environment.

• The Journal of the Korea Contents Association
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• v.21 no.9
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• pp.176-183
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• 2021

Digital medical technology is very effective and at the same time faces the challenge of protecting privacy. However, for contact tracking and exposure notification apps in COVID-19 environment, there is always a trade-off between privacy measures and the effectiveness of the app's use. Today, many countries have developed and used contact tracking and exposure notification apps in various forms to prevent the spread of COVID-19, but the suspicion of digital surveillance (digital panopticon) is unavoidable. Therefore, this study aims to identify the factors of personal information infringement and dissatisfaction through text mining analysis by extracting user reviews of "Self-Quarantine Safety Protection" in Korea. As a result of the text mining analysis, we derived four groups, 'Address recognition error', 'Exit warning error', 'Access error', and 'App. program error'. Since 'Address recognition error' and 'Exit warning error' can give the app users a strong perception that they are keeping under surveillanc by the app, transparent management of personal information protection and consent procedures related to personal information collection are required. In addition, if the other two groups are not corrected immediately due to an error in an app function or a program bug, the complaints of users can be maximized and a protest against the monitor can be raised.

• Journal of Korean Society of Forest Science
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• v.110 no.4
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• pp.711-723
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• 2021

During the COVID-19 pandemic, social distancing affected daily life and leisure activities, including forest recreational activities. This study identified changes in people's participation in forest recreational activities and factors affecting their participation. It collected data from 1,000 samples through an online survey and analyzed it using a binary logit model with interaction terms. It was observed that there were decreases in the participation in visits to urban parks and green areas, outdoor activities in forests and mountains, and trips to mountain villages after the COVID-19 outbreak. People in their 40s, 50s, and 60s were more likely to decrease their participation in all kinds of forest recreational activities than those in their 20s. Moreover, higher household income earners were more likely to decrease their involvement in outdoor activities in forests and mountains. With respect to the place of residence, the residents in the Seoul metropolitan area were less likely to decrease their participation in trips to mountain villages than those outside this area. Thus, this study suggests that online forest recreation information services and forest management are needed to meet the demands of forest recreation for young generations and diversify the function of forests and rural areas as a safe leisurely space.

• Journal of Physiology & Pathology in Korean Medicine
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• v.32 no.6
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• pp.384-395
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• 2018

The aim of this study was to investigate whether a novel formulation of an herbal extracts has an inhibitory effect on obesity. To determine its anti-obesity effects, we performed anti-obesity-related experiments in vitro and in vivo. Thus, our present study was carried out to evaluate the anti-obesity effect of herbal extracts using a high fat diet (HFD)-induced obese mouse model and 3T3-L1 adipose cells. The effects of each herbal extracts on lipid accumulation in 3T3-L1 cells were examined using Oil Red O staining. Results showed that treatment with each herbal extracts at $10{\sim}100{\mu}g/ml$ had no effect on cell morphology and viability. Without evidence of toxicity, herbal extracts treatment decreased lipid accumulation compared with the untreated adipocytes controls as shown by the lower absorbance of Oil Red O stain. Futhermore, compared with control-differentiated mature adipocytes, each herbal extracts significantly inhibited lipid accumulation in mature 3T3-L1 adipocytes. In the HFD-fed obese mice, body weight, liver weight and white adipose tissue weights were significantly reduced by mixture of herbal extracts administration in mouse skin. Futhermore, we found that mixture of herbal extracts administration suppressed serum triglyceride (TG), and total cholesterol (TCHO) in HFD-induced obese mouse model. The mixture of herbal extracts of permeability was estimated by measuring the transepithelial electrical resistance (TEER) value in pig skin. The optimized formulations of herbal extracts (Test 3 formulation) showed skin permeation. However, test 1 formulation containing essential oil as enhancer showed maximum skin permeation. After confirming the enhanced skin permeability, in vivo studies were performed to assess whether skin irritation potential on the basis of a primary irritation index (PII) in rabbit skin. Reactions were scored for erythema/edema reactions at 24 h, 48 h and 72 h post-application. It was concluded that the test 1 formulation was not irritation (PII = 0). The present study suggests that the test 1 formulation might be of therapeutic interest with respect to the treatment of obesity.