• Journal of the Society of Cosmetic Scientists of Korea
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• v.40 no.1
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• pp.45-54
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• 2014

Lipopolysaccharide (LPS)-induced inflammatory responses in the HaCaT keratinocyte cell line produce proinflammatory cytokines, such as interleukin-1${\alpha}$(IL-1${\alpha}$), tumor neurosis factor-${\alpha}$ (TNF-${\alpha}$), interleukin-6 (IL-6), and interleukin- 8 (IL-8) and also increase the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandins E2 (PGE2). In this study, we developed new natural ingredients for cosmetics that inhibit the pro-inflammatory responses induced by LPS in HaCaT cells. The mixture of Sorbus commixta (SC), Urtica dioica (UD), Phyllostachys nigra (PN), and Rhus semialata gall (RS) extracts blocked the increase of TNF-${\alpha}$ IL-1${\alpha}$ IL-6, and IL-8. The increase of COX-2, iNOS, and PGE2 were also blocked by it. Finally, the mixture inhibited skin irritation induced by sodium lauryl sulfate (SLS), when applied on skin through IQ chamber$^{(R)}$. In conclusion, these results show that the mixture of SC, UD, PN, and RS can be used as a primary ingredient to alleviate skin irritation when cosmeceutical products are developed for sensitive skin.

• Journal of Biosystems Engineering
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• v.4 no.1
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• pp.58-66
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• 1979

동력경운기용 두류의 무경운 파종기에 부착하여 사용하는 구절기중에서 소요견인력이 작고 구절작업정도가 양호한 구절기의 개발을 위한 기초자료를 얻기 위하여 구동식 토조에 인공강토를 채우고 원판형 및 호우형 구절기의 소요견인력과 이에 영향을 미치는 인자들의 관계를 구명코자 실내모형 확험을 실시하여 다음과 같은 결과를 얻었다. 원판형 구절기에 대하여 직경별로 조립각을 $8^{\circ}$ 와 $16^{\circ}$, 경심을 3 cm 와 6cm로 변화시키면서 2.75cm/sec의 속도로 견인력을 측정한 결과 원판의 직경이 약 28cm인 경우에 견인력이 최소로 나타났고, 직경이 이보다 크거나 작은 때는 견인력이 증가하는 경향을 나타냈으며 비저항도 대체로 비슷한 경향이었으나 원판의 직경이 약 30cm 일 때 최소로 나타났다. 종자파종의 심도조절을 목적으로 작구심(3cm 및 6 cm)과 견인력과의 관계를 조사하였던바, 경심과 견인력과의 관계는 거의 직선적인 변화를 나타냈으며 견인력에 영향을 미치는 인자중에서 경심의 영향이 가장 컸음을 알 수 있었다. 일반적으로 조립각 미 주행속도에 별 영향없이 경심 3cm 및 6 cm 공히 견인력은 직경 약 28 cm에서 , 비저항은 약 30cm에서 최소의 값을 나타내었다. 파종기의 작업성능과 관계가 깊은 주행속도 및 파시의 조절을 목적으로 원판의 조립각과 주행속도가 견인력에 미치는 영향을 조사했던 바, 조립각과 주행속도가 증가함에 따라 모두 견인력이 증가하는 경향을 나타내었으나 견인력에 미치는 영향은 주행속도가 더욱 크게 나타났다. 원판형 구절기와 호우형 구절기를 비교하기 위하여 쐐기각이$16^{\circ}$ 이고 리프트 각이 $20^{\circ}$ 인 호우형 구절기와 조건이 비슷한 조립각$16^{\circ}$ 의 원판형 구절기의 견인특성을 비교한 결과 직경 30cm 인 원판형의 경우는 비저항이 0.35-0.5kg/$cm^2$인데 비해 호우형의 경우는 0.71-1.02kg/$cm^2$로 나타나 호우형의 견인저항력이 평균 2 배정도 크게 나타났고 작구상태고 원판형의 경우보다 불량하였다.

• The Journal of Korean Society for Radiation Therapy
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• v.23 no.1
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• pp.59-66
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• 2011

Purpose: Investigation of the clinical use of tangential fields technique using TOMO direct in comparison to conventional LINAC based radiation therapy after breast partial mastectomy. Materials and Methods: Treatment plans were created for 3 left-sided breast cancer patients who had radiation therapy after breast partial mastectomy by using wedged tangential fields technique, field in field technique (FIF), TOMO Direct, TOMO Direct intensity modulated radiation therapy (IMRT) under the normalized prescription condition ($D_{90%}$: 50.4 Gy/28 fx within CTV). Dose volume histogram (DVH) and isodose curve were used to evaluate the dose to the clinical target volume (CTV), organ at risk (OAR). We compared and analyzed dosimetric parameters of CTV and OAR. Dosimetric parameters of CTV are $D_{99}$, $D_{95}$, Dose homogeneity index (DHI: $D_{10}/D_{90}$) and $V_{105}$, $V_{110}$. And dosimetric parameters of OAR are $V_{10}$, $V_{20}$, $V_{30}$, $V_{40}$ of the heart and $V_{10}$, $V_{20}$, $V_{30}$ of left lung. Results: Dosimetric results of CTV, the average value of $D_{99}$, $D_{95}$ were $47.7{\pm}1.1Gy$, $49.4{\pm}0.1Gy$ from wedged tangential fields technique (W) and FIF (F) were $47.1{\pm}0.6Gy$, $49.2{\pm}0.4Gy$. And it was $49.2{\pm}0.4$ vs. $48.6{\pm}0.8Gy$, $49.9{\pm}0.4$ vs. $49.5{\pm}0.3Gy$ Gy for the TOMO Direct (D) and TOMO Direct IMRT (I). The average value of dose homogeneity index was W: $1.1{\pm}0.02$, F: $1.07{\pm}0.02$, D: $1.03{\pm}0.001$, I: $1.05{\pm}0.02$. When we compared the average value of $V_{105}$, $V_{110}$ using each technique, it was the highest as $34.6{\pm}9.3%$, $7.5{\pm}7.9%$ for wedged tangential fields technique and the value dropped for FIF as $16.5{\pm}14.8%$, $2.1{\pm}3.5%$, TOMO direct IMRT as $7.5{\pm}8.3%$, $0.1{\pm}0.1%$ and the TOMO direct showed the lowest values for both as 0%. Dosimetric results of OAR was no significant difference among each technique. Conclusion: TOMO direct provides improved target dose homogeneity over wedged tangential field technique. It is no increase the amount of normal tissue volumes receiving low doses, as oppose to IMRT or Helical TOMO IMRT. Also, it simply performs treatment plan procedure than FIF. TOMO Direct is a clinical useful technique for breast cancer patients after partial mastectomy.

• Journal of the Korean GEO-environmental Society
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• v.5 no.2
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• pp.41-49
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• 2004

In this study, a newly modified soil nailing technology named as the SPN (Spiral Pipe Nailing) system, is developed to self drilling method can apply to ground which is hard to keep shape of bore hole. And limit equilibrium analysis with simplified trial wedge method while length ratio and bond ratio being altered was performed to evaluate slope stability considered of tensile strength and bending stiffness. Also, using $FLAC^{2D}$ program, superiority of the SPN system was compared to the GSN (General Soil Nailing) system about an example section. And effects of various factors related to the design of the SPN system, such as the type of drilling method and the bit, are examined throughout a series of the displacement-controlled field pull-out tests. As a result, the SPN system is better than the GSN system in slope stability because of having larger bending stiffness, tensile strength and unit skin friction. And results of simplified trial wedge method are similar to results of TALREN 97 program, commercial limit equilibrium analysis computer software, about an example section. Consequently, it will find out of that the SPN system reduce displacements and settlements in down excavation process as well as to increase the global stability.

• Magazine of the Korea Concrete Institute
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• v.9 no.3
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• pp.127-135
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• 1997

In this study, the wedge splitting tcst (WST) was carried out for the fatigue wack growth behavior of concrete. Selected test variables were concrete compressive strength of 28, 60 and 118 MI%, and stress ratio with 2 levels (6. 13%). In oder to make the designed stress ratio, the maximum and thr minimum fatigue loading level were 75-85% and 5- 10% of ultimate static load, respectively. Fatigue testing was preceded by crack mout.h opening displacement (CMOI)) compliance calibration tcst, and then the fatigue crack growth was computed by crack lcngth vs. (lMOI) compliance relations acquisited by the CMOD compliance calibration technique. To evaluate thc validity of CMOD compliancc calibration techniquc, the crack length p~mlicted by this method was cornpard with the crack length by linear elastic fracture mechanics(LEFIbl) and dyeing test. On the basis of the experimental results, a LRFhl-based c.mpirica1 model for f'at,igue crack growth rate(da/dN-AKI relationships) was presented. The fat,igut. crack growth ratc increased with the strength of concwtc. It appcars that t.he da/tiN-AKI relationships was influenced by stress ratio, however, the effect is diminished with an increase of strength. The comparisons between CblOl) compliance calibration technique anti the other. methods gave the validity of' ('MOD compliance calibration technique for the LZXT.

• Applied Biological Chemistry
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• v.50 no.4
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• pp.295-303
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• 2007

A preliminary diet experiment utilizing Jerusalem artichoke's inulin, lotus leaf powder, nettle powder and eucalyptus powder extract indicated that combining all four elements gave the most effective result. Therefore, a study was conducted to evaluate the effectiveness of combined diet for weight loss. In this study, Sprague-Dawley, male white rats about 200 g in weight was fed with high fat diet for 8 weeks in order to induce obesity followed by 4 week administration of combined diet to look into the effect of the diet. After a total of 12 weeks of feeding, factors relevant to weight, blood, and lipid metabolism by liver in the body were researched and histologic change was examined with optical microscope. In terms of weight change, both high fat diet group and regular diet group gained weight from high fat diet for 8 weeks compared to normal group. Then, for another 4 weeks, while normal group and high fat diet group kept gaining weight, combined diet group which was provided with high fat diet for 8 weeks, lost weight to the normal group level after 3 week administration of diet. However, after the 4th week of administration, the group weighted significantly less than the normal group and the efficiency of diet also significantly dropped. In the biochemical analysis of blood, total cholesterol, LDL-cholesterol, triglyceride, glucose, GOT, GPT, ${\gamma}-GTP$ and creatine showed significant increase in high fat diet group and there was no significant difference between diet group and normal group except for GPT, ${\gamma}-GTP$ and creatine. In the biochemical analysis of liver, there was significant increase in LDL-cholesterol, triglyceride of high fat diet group compared to normal group, while there was no significant difference in term of total cholesterol and HDL-cholesterol. Compared to normal group, diet group had higher HDL-cholesterol, while total cholesterol dropped significantly. There was no significant difference in terms of LDL-cholesterol and triglyceride. Besides, in high fat diet group, observation of histologic change in liver and change in ultrastructure showed volume increase of hepatic cell and severe fatty degeneration in hepatic cell around hepatic vein. However in diet group, like normal group, no pathological change was observed in terms of cytoplasm, nucleus and capillary in hepatocyte and the alignment of hepatocyte had regularity thanks to the administration of combined diet. Therefore, combined diet utilizing Jerusalem artichoke's inulin, lotus leaf powder, nettle powder and eucalyptus powder was proven to be an effective measure to prevent and improve obesity as a result of abnormal adipose deposition.

• Proceedings of the Korean Society of Medical Physics Conference
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• 2003.09a
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• pp.65-65
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• 2003

목적 : 방사선치료기술이 날로 발전함에 따라 방사선치료계획시스템에 대한 주기적인 정도관리의 필요성은 증대하고 있으나, 국내 실정에 적합한 표준화된 정도관리절차서가 없는 실정이다. 따라서 본 연구에서는 방사선치료계획용 시스템에 대한 정도관리용 고체팬톰을 제작하여 주기적인 정도관리 활용 및 절차서를 제시하고자 한다. 대상 및 방법 : 체윤곽 보정을 위한 삼각기둥 모형 (30cm$\times$30cm$\times$5cm, 30cm$\times$15cm$\times$5$\times$) 및 정형ㆍ부정형, 불균질 측정이 가능한 물등가고체팬톰을 제작하였고, 컴퓨터단층촬영(AcQsim)을 통해 영상을 얻었으며, RTPS(AcQplan)에 입력하여 영상 내 기준점에서의 선량값을 계산하였다. RTPS를 통해 계산된 값의 평가를 위해 동일한 조건하에서 각 기준점에 대한 실제 측정을 이온함을 이용하여 측정하였다. 평가 항목으로는 정방형 조사면, 부정형 조사면, 쐐기 조사면, 불균질 물질 보정, 사방향 조사 등에 대해서 알고리즘별로 수행하였다. 결과 : RTPS를 이용하여 계산된 값과 실제 측정한 값을 비교하여 RTPS의 정확성을 평가한 결과로 합성의 불확도 허용 기준 (3%), 선속 중심축 상에서의 허용 기준 (2%) 등, 선진 각국 및 각 학회에서 권고하고 있는 허용 범위 내에서 잘 일치하였다. 결론 : RTPS는 측정된 심부선량과 선량분포 등 물리적인 인자에 의존하는 제한성이 있고, 실제로 선량계산 알고리즘과 기하학적 변화에 따라 계산값과 측정값 간에 차이가 발생할 수 있었다. 실제 인체의 체윤곽 불균일성과 불균질성을 모사한 팬톰을 제작하여 이용함으로써 다양한 RTPS간의 비교를 통한 치료 선량의 정확성을 평가하고, 방사선 치료의 원활하고 정확한 수행을 위해 실용적이고, 보편적인 치료계획 시스템의 정도관리 방법과 절차서를 수립하는데에 유용할 것으로 사료된다.

• Tuberculosis and Respiratory Diseases
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• v.59 no.3
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• pp.326-329
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• 2005

A case of 51-year-old woman with a malignant solitary pulmonary nodule (SPN) that exhibited no growth over a period of 4 years is reported. Surgical wedge resection revealed an adenocarcinoma upon intra-operative frozen examination. The operation was completed with a right upper lobectomy and complete lymphadenectomy. The authors recommend an early surgical procedure for any SPNs due to risk factors for developing lung cancer.

• Journal of the Society of Naval Architects of Korea
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• v.29 no.4
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• pp.87-97
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• 1992

Of various design factors affecting icebreaking capability of an icebreaker, the stem angle(i.e., angle between bow stem and ice sheet) is the most important one under continuous icebreaking operation. This study focuses on the relationship between the bow stem angle of an icebreaker and its icebreaking capability. Considering relatively high loading-rate conditions with typical advancing speed of 3 to 4 knots, the material properties and deformation characteristics of sea ice are regarded as entirely elastic and brittle. In this paper the interaction process of icebreaker with level ice is simplified as a beam of finite length supported by Winkler-type elastic foundation simulating water buoyancy. The wedge type ice beam is loaded by the vertical impact forces due to the inclined bow stem of icebreaking vessels. The numerical model provides locations of maximum bending moment where extreme tensile stress arises and also possible fracture occurs. The model can predict a characteristic length of broken ice sheet upon the given environmental and design parameters.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.1B
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• pp.1-6
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• 2006

Amount of coastal ground water discharge(CGD) of surficial aquifer via coastlines of Nakdong River watershed, Seomjin River watershed, Youngsan River watershed and Keum River watershed is estimated. Compared to other major hydrological components, such as evapo-transpiration and river discharge, CGD is not so large in the amount. However, it is important since coastal ground water can be developed relatively free of environmental impact on downstream area and since most of coastal areas currently suffers water shortage. Regional groundwater investigation data and assessment based on Darcy's law are used for estimating coastal groundwater discharge. In this work the amount of CGD across the coastlines of the four rivers is estimated as 1.8 billion cubic meter per year and that is about 2.3 percentage of total amount of annual precipitation. Nakdong River watershed is most appropriate region in view of developing groundwater.