• Proceedings of the KTCVS Conference
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• 1998.10a
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• pp.33-34
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• 1998

• Proceedings of the KTCVS Conference
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• 1996.10a
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• pp.98-98
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• 1996

• The Korean Journal of Pharmacology
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• v.28 no.2
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• pp.163-170
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• 1992

The present study was attempted to investigate the effect of cyclobuxine (a steroidal alkaloid) on generation of reactive oxygen metablite and myocardial damage promoted by an exogenous administeration of arachidonate in ischemic-reperfused hearts. Langendorff preparation of the isolated rat heart was made ischemic condition by reducing the flow rate to 0.5 ml/min for 45 min, and then followed by normal reperfusion (7 ml/min) for 5 min. The generation of superoxide anion was estimated by measuring the SOD-inhibitable ferricytochrome C reduction. The degree of lipid peroxidation in myocardial tissue was estimated from the tissue malondialdehyde (MDA) concentration using thiobarbituric acid method. The myocardial cell damage was observed by measuring LDH released into the coronary effluent. Sodium arachidonate $(0.1\;and\;1.0\;{\mu}g/ml)$ infused during the period of oxygenated reperfusion stimulated superoxide anion production dose-dependently. The rate of arachidonate-induced superoxide anion generation was markedly inhibited by cyclobuxine $(1.0\;and\;10\;{\mu}g/ml)$. The production of malondialdehyde was increased by infusion of arachidonate. This increase was prevented by superoxide dismutase (300 U/ml) and cyclobuxine $(1.0\;and\;10\;{\mu}g/ml)$. The release of LDH was increased by sodium arachidonate was also inhibited by superoxide dismutase and cyclobuxine. In conclusion, the present results suggest that cyclobuxine inhibits the production of reactive oxygen metabolite and myocardial damages which were promoted by an administeration of arachidonate during reperfusion of ischemic hearts.

• Journal of the korean veterinary medical association
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• v.40 no.3
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• pp.227-240
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• 2004

심부전증(Heart failure)이란 심장이 조직에서 필요로 하는 산소나 영양분을 제대로 공급하지 못하는 상태로 심장 자체의 구조적 결함이외에도 혈역학(hemodynamics)에 영향을 주는 신장 질환이나 고혈압등에 의해서도 발생한다. 심장은 커다란 펌프로 혈역학적 변화에 능동적으로 대처할 능력을 가지고 있다. 하지만 이러한 혈역학의 변화를 유발하는 원인을 제거하지 않은채 장기적으로 원인이 지속할 경우, 심장, 특히 심실은 재구성(remodeling)이 일어나게되고(좌심실의 벽이 비후되고 우심실의 벽이 얇아지는 변화) 이로인하여 심장의 혈역학 변화에 따른 보상 반응은 점차 무력화 되게된다. 이로인하여, 혈액 정체에 따른 폐부종이나 복수증 및 산소 부족에 의한 허혈성 손상이 여러 장기에 나타나게 된다. 심장 질환은 불량한 예후와 치료의 제한성때문에 그동안 수의 분야에서 간과되어왔지만, 우리나라도 애완동물의 노령화가 시작되고 있고 고급 진료에 대한 축주들의 요구가 증가하고 있어서 점파 심장 질환의 진료가 늘어갈 것으로 사료된다. 따라서 본 종설에서는 심부전증에 대한 여러 가지 병리 기전과 이에 따른 치료 방법에 대해 기술하고자한다.

• Journal of the korean veterinary medical association
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• v.45 no.6
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• pp.539-543
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• 2009

심근 손상은 창상 환자에서 심장 기능에 뚜렷한 영향을 미칠 수 있지만 심각한 창상에 가려져 종종 간과됩니다. 심하지 않은 심근손상에 의한 부정맥은 스스로 치유되기도 하지만 저혈압, 쇠약, 순환부전과 같은 증상을 일으키는 부정맥은 조기에 인지하여 치료하지 않을 경우 생명을 위협할 수 있음을 잊어서는 안 될 것 같습니다.

• Journal of Chest Surgery
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• v.37 no.12
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• pp.999-1002
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• 2004

Thirteen year old boy who had been stabbed in his left chest by the knife was transferred to our department from a general hospital, because of the massive bleeding from the intercostal tube drainage. Chest X-ray showed homogeneous density in the left lung field. He was confused and his vital signs were unstable. He was moved into a operating room as soon as possible. After resuscitation, his lacerated left ventricle wound was sutured through median sternotomy. The interventricular shunt was detected with intraoperative transesophageal echocardiography. The traumatic ventricular septal defect was closed via left ventricle using Dacron patch. His postoperative course was uneventful, and he was discharged with small residual shunt.

• Journal of Chest Surgery
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• v.41 no.5
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• pp.633-635
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• 2008

Cardiac rupture after blunt chest trauma is a relatively uncommon diagnosis, and it is associated with a very high mortality rate. A 41-years-old man crashed his car into a guardrail and he was then transported to hospital. Although unstable vital signs are the most common symptoms of cardiac injury, this patient had stable vital signs. The chest CT scan showed pericardial effusion, and echocardiography did not clearly reveal cardiac tamponade, but the right atrium was slightly collapsed. Cardiac injury was suspected, and surgery was commenced for obtaining the diagnosis and treatment. A 2cm laceration at the junction of the left atrium and the lefl inferior pulmonary vein was discovered and this was repaired with $4{\sim}0$ Polypropylne monofilament sutures. We report here on the successful management of a patient with left atrial rupture following blunt chest trauma.

• The Science & Technology
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• v.33 no.8 s.375
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• pp.24-25
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• 2000

심장병 관상동맥이 막히거나 경화돼 일어나는 허혈성 심장병이 대부분으로 이 허혈성 심장병은 최근 10년 사이 10배로 늘어나 완치가 어려운 병으로 알려졌다. 심장근이 손상되면 다시 회복되거나 분열 재생되지 않기 때문이다. 그래서 최근에는 새로운 혈관을 조성해 치료를 시도하고 있는데 이런 연구를 담당한 곳이 바로 전북대 내에 자리한 심장근재생연구단이다. 이 연구단은 97년 과학기술부 지원 창의적 연구진흥사업으로 설립되어 박사후 연구원 3명을 비롯해 연구자 10여명이 새로운 치료법을 개발해 몰두하고 있다.

• Journal of Chest Surgery
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• v.11 no.4
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• pp.469-475
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• 1978

• Journal of Chest Surgery
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• v.22 no.2
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• pp.290-296
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• 1989