• Journal of Korean Neurosurgical Society
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• v.30 no.sup1
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• pp.120-123
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• 2001

Objectives : The present study was performed to analyze results of hydroxyurea treatment for unresectable and recurrent meningiomas as adjuvant chemotherapeutic agent. Material and Methods : Among 87 cases of meningioma patients who treated surgically between Jauary 1988 and December 1997 in our department, unresectable and recurrent cases were 4 cases. Histologically, 3 cases were meningothelial type, 1 case was angiomatous type. Tumor orgin was cerebellopontine angle(CPA) in 3 cases, cavernous sinus in 1 case. Three of 4 cases received radiation treatment. All patients received a daily dosage of 20mg/kg/day of hydroxyurea. Hematological monitorning was performed monthly and tumor measurement was assessed by MR imaging before treatment and every 6 months. Mean follow-up period was 34 months. Rerults : All cases showed no enlargement of tumor mass without any shrinkage. Trigeminal neuralgia in 1 case was improved and external herniation of brain on craniectomy site in 1 case was shrunken. None of the patients had any serious side effects. White blood cell count fell below $3000/{\mu}l$ in 1 case, but recovered 2 weeks later with cessation of medication. Conclusion : Hydroxyurea stopped cell growth by triggering the apoptotic cascade. Our preliminary data indicate that hydroxyurea provides adjuvant medical treatment in patients of unresectable and recurrent meningiomas

• Journal of Korean Neurosurgical Society
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• v.29 no.3
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• pp.324-329
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• 2000

Objective : Psychological factors may have a major influence on the outcome of treatment for back pain. We investigated the relationship between the outcome and some psychological factors, such as self-reported pain intensity, disability, sleep disturbance and fatigue. Method : The study was conducted as a survey using a questionnaire and telephone interviews. The survey included consecutive 294 patients who visited the neurosurgical out-patient department complaining of low back pain and contacted by telephone on average seven months after the first visit. Pain intensity was measured by visual analog scale, and disability was assessed by Waddell's chronic disability index. Results : The outcome of treatment for back pain was recovered in 36.7%, improved in 30.6%, almost same in 28.6%, and aggravated in 4.1%. Overall rate of improvement was 67.3%. The rate of improvement was related to the duration, patterns and intensity of the symptom, and Waddell index. It was not influenced by the doctors, special studies, and methods of treatment. When the duration was more than 6 months, there were the symptoms of both back and legs, and the self-reported Waddell index was 1-3, the rate of improvement was relatively low. Although the intensity of the pain and disability was closely related to the degree of sleep disturbance, fatigue, appetite, or indigestion, the outcome of treatment for back pain was not always bad in patients with high psychological stress. Actually the outcome of the patients who complained severe pain and disability was better than the outcome of the others. Conclusion : The outcome of the back pain can be predicted by the duration, patterns and intensity of the symptom, and Waddell index. The multidisciplinary treatment will be necessary for the patients whose expected outcome is not good to reduce not only the physical symptoms but also the psychological stress.

• Journal of Life Science
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• v.28 no.12
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• pp.1438-1447
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• 2018

We investigated the anti-inflammatory activities of various organic solvent extracts with and without Lactobacillus plantarum fermentation of Aralia continentalis Kitagawa which has hypotensive effects in addition to excitatory effects on the central nervous system. It has been used to treat arthritis, colds, neuralgia, rheumatism, and itchy skin. Our extracts were tested for their anti-inflammatory potential on NO production and the expression of inflammatory factors in lipopolysaccharide-stimulated RAW264.7 macrophages. Extracts with and without L. plantarum fermentation were prepared using water, ethanol, hexane, ethyl acetate, and butanol. The RAW264.7 cells were tested for toxicity and the anti-inflammatory activity of each extract was determined at a concentration with no toxicity to the cells. The extracts used in this study significantly inhibited both the production of NO and the mRNA expression of COX-2 and iNOS, the major inflammatory factors. The production of inflammation-related cytokines $IL-1{\beta}$, IL-6, and $TNF-{\alpha}$ was also significantly reduced. These results suggest that the extracts involving fermentation by L. plantarum can inhibit cytokines by controlling the expression of inflammatory cytokine genes. It is considered that the water, ethanol, and butanol extracts after fermentation with L. plantarum could be useful as functional natural materials with anti-inflammatory effects.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2019.10a
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• pp.5-5
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• 2019

DMZ는 살아있는 생물다양성의 보고로 지난 60여년동안 자연적으로 재생이 일어나고 환경적인 강제 보존 영향으로 높은 생태학적인 가치가 유지되고 있으며, 최근에는 남북교류에 대한 활발한 의지로 DMZ생태자원의 남북공동활용 방안에 대한 이슈가 급부상하고 있다. 이에 본 연구진은 3년전부터 DMZ에서 자생하는 식물에 대한 조사를 진행하여 총 200여종 이상의 자생식물의 표본과 추출물들을 보유하고 있으며, 이 추출물들을 활용 in vitro 와 in vivo 평가를 통해 비임상 평가에서 유효한 효과를 나타내는 후보물질들을 다수 찾아낼 수 있었다. 그 중 조팝나무(Spiraea prunifolia var. simpliciflora)는 쌍떡잎식물 장미과에 속하는 낙엽활엽관목으로 동북아시아 지역에 널리 분포되며 우리나라에서는 중부지방에 주로 서식한다고 알려져 있다. 예로부터 해열 및 소염, 신경통완화 치료등에 이용해왔다고 알려져 있으며 그 속에는 다양한 terpenoids, flavonoid 및 phenolic 화합물이 다량 함유되어 있다고 알려져 있다. 본 연구에서는 조팝나무 추출물을 이용하여 전구지방세포에서의 지방세포분화 억제 및 관련 유전자들의 활성을 확인한 후 고지방식이로 유도된 high-fat diet mouse model을 이용하여 체지방 감소 및 내장지방감소, 간 조직내의 지방량 감소등을 확인하였으며, 혈액분석을 통해 총콜레스테롤과 고중성지방등 동맥경화와 심혈관계 질환을 유도시킬수 있는 지표들에서 억제 활성도 확인하였다. 특히 내장 지방의 경우는 Micro-CT를 통해 정밀한 분석을 진행하였고, 체지방뿐만 아니라 전체 체중감소도 나타나는 것을 확인하였다. 현재 실험을 통해 적출된 간 조직과 지방조직을 이용하여 항 비만 활성의 작용기전을 지속적으로 확인하고 있으며, 이 결과는 국제적인 연구저널에 보고되어 향후 체지방 감소 또는 항 비만 치료제로 개발되는 비임상 연구자료로 활용될 계획이다. 이미 조팝나무에 대한 연구결과는 특허로 출원이 완료되어 PCT출원까지 진행중에 있으며 개별인정형 건강기능식품 개발 기업에 기술이전이 될 예정이다. 또한 원활한 원료 수급을 위해 기초단체 소속 농업기술센터와 원료 재배 및 대량 수급에 관한 논의를 마친 상태로 접경지역 근처 농가소득 증대로도 이어지는 제품화 사례이기도 하다. 이는 접경지역에서 자생하는 원료의 활성을 과학적으로 검증하여 기업과의 연계를 통해 기초시군 단체의 농가 소득과도 연계한 우수한 제품개발 사례로 향후에도 이와 같은 연구성과가 지속적으로 도출되기를 기대해본다.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2021.04a
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• pp.40-40
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• 2021

곤달비(Ligularia stenocephala)는 쌍떡잎식물, 국화과의 다년생 초본식물로서 한국·일본·타이완·중국 등에 분포하고, 우리나라는 전남 홍도가 특산 자생지이며 주로 강원도, 경북 경주, 전북 남원 등지에서 재배되고 있다. 곤달비는 어린 부분을 생채, 데친 나물, 국거리, 튀김, 묵나물로 식용한다. 특수 성분으로는 Isopropenyl, dimethoxybenzofuran, Liguhodgsonal, Ligujapon, Ligularinone A, Ligularinone B 등이며 신경을 안정시키는 진정작용, 진통억제, 정기를 보익하고 허약함을 보하는 기능이 있고, 한방에서는 뿌리가 신경통, 유종(乳腫) 등에 쓰인다. 곤달비는 주로 시설하우스나 노동력이 많이 드는 임간에서 재배되어 생산 단가가 높아 소비활성화를 위한 가공제품을 생산하기가 힘들며, 육묘 또한 시설하우스에서 주로 이뤄지고 있다. 본 연구는 곤달비 노지육묘 파종시기별 생육특성을 구명하여 노지재배 생력화 재배기술을 확립하고자 2019년 4월부터 2020년 11월까지 전라북도농업기술원 허브산채시험장(해발 500m)에서 수행하였다. 춘파는 2019년 4월 상순, 5월 상순, 6월 상순에 각각 파종하였고 추파는 2019년 9월 상순, 중순, 하순에 파종하였다. 본포 정식은 춘파는 2019년 6월 말에, 추파는 2020년 4월 말에 식재하였으며, 파종시기별 발아율, 활착률, 생육특성, 수량성 등을 조사한 결과 파종시기별 발아율은 춘파가 35.0%로 추파 30.7%보다 높았으며, 발아 소요일수는 추파 육묘에서 8.3일로 춘파 육묘 9.3일보다 빨랐다. 파종시기별 정식시 묘소질은 춘파가 추파보다 좋은 생육상태를 보였고, 정식 후 육묘 활착률은 추파가 99.3%로 춘파 94%보다 높았고, 생존율 또한 추파 육묘에서 99.3%로 춘파 육묘 96.3%보다 높았다. 파종시기별 생육특성은 처리간 유의한 차이는 없지만 춘파에서 좀 더 좋은 생육을 보였으며, 수확량은 춘파 처리구에서 798.6kg/10a로 추파 처리 621.4kg/10a보다 높았다.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2020.12a
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• pp.72-72
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• 2020

곤달비(Ligularia stenocephala)는 쌍떡잎식물, 국화과의 다년생 초본식물로서 한국·일본·타이완·중국 등에 분포하며, 우리나라에는 전남 홍도가 특산 자생지라고 하며 주로 강원도, 경북 경주, 전북 남원 등지에서 재배되고 있다. 곤달비는 어린 부분을 생채, 데친 나물, 국거리, 튀김, 묵나물로 식용한다. 특수 성분으로는 Isopropenyl, dimethoxybenzofuran, Liguhodgsonal, Ligujapon, Ligularinone A, Ligularinone B 등이며 신경을 안정시키는 진정작용, 진통억제, 정기를 보익하고 허약함을 보하는 기능이 있고, 한방에서는 뿌리가 신경통, 유종(乳腫) 등에 쓰인다. 곤달비는 주로 시설하우스나 노동력이 많이 드는 임간에서 재배되어 생산 단가가 높아 소비활성화를 위한 가공제품을 생산하기가 힘들다. 본 연구는 곤달비를 저비용 대량 생산을 위한 노지재배 생력화 재배기술을 확립하고자 시험을 수행하였다. 2019년 4월부터 2020년 11월까지 전라북도 농업기술원 허브산채시험장(해발 500m)에서 곤달비 노지재배를 대상으로 이랑폭 90cm, 120cm, 180cm 3처리구로 하여 시기별 생육특성, 수량성, 생리장해 등을 조사하였다. 2019년 4월 정식 후 활착률은 180cm 처리구에서 92.1%로 가장 높았고 120cm 처리에서 90.2%로 가장 낮았으며, 생존율 또한 180cm 처리구에서 87.2%로 가장 높았고 120cm 처리에서 84.4%로 가장 낮았다. 생육특성 결과 1차년도에는 초장, 엽장, 엽폭은 생육 초기부터 후기까지 90cm 처리구에서 가장 높았고, 엽수는 120cm 처리구에서 가장 많았다. 2차년에는 180cm 처리구에서 초장 61.2cm, 엽장 32.6cm, 엽폭 31.3cm, 엽수 12.7개/주로 다른 처리구에 비해 좋은 생육상태를 보였다. 이랑폭별 수확량은 180cm에서 1,073.7kg/10a로 120cm 955.7kg/10a, 90cm 923.3/kg/10a 비해 높은 수량성을 보였다. 생리장해는 2020년 3월 저온으로 인한 냉해를 출현 초기에 모든 처리구에서 받았다. 곤달비 노지재배 발생하는 병해충은 나비·나방류, 노린재류 3종류이며 그 중 점무늬병은 모든 처리구에서 30% 이상 피해가 나타났다.

• The Journal of Internal Korean Medicine
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• v.44 no.6
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• pp.1327-1336
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• 2023

This case report presents the effectiveness of Korean medicine in the treatment of occipital neuralgia. The patient with occipital neuralgia was treated with acupuncture. Acupuncture treatment was administered to the occipital nerve area, which is commonly used in occipital nerve blocks by western medicine doctors. The severity of the symptoms was assessed daily using the Numerical Rating Scale (NRS) score of pain. The patient received outpatient treatment a total of 7 times, and only received acupuncture treatment each time. According to the patient, his symptoms decreased by about 90% two days after acupuncture treatment, and the frequency and duration of the symptoms also decreased. Seven days after all acupuncture treatments, the severity of pain was reduced from NRS 6 to NRS 0. The findings of this case report suggest that treatment with Korean medicine can be an effective option for treating occipital neuralgia. Acupuncture can be a good treatment method for occipital neuralgia, along with western drug treatment and occipital nerve block.

• Journal of Mushroom
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• v.9 no.4
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• pp.186-189
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• 2011

The transitivity of Chemical constituents by Pleurotus ostreatus cultivated in different raw sawdusts, which are Juglans mandchurica, Cudrania tricuspidata and Lindera glauca, was investigated. The HPLC chromatography patterns on the chemical constituents of P. ostreatus showed the similar chromatography patterns in all different raw sawdusts and control sawdust. The unknown chemical constituents of P. ostreatus cultivated in the 10%, 20% mixed medium added 10 %, 20% different raw sawdusts, respectively, were increased. But the significance results in the mixed medium added 50% different raw sawdusts were not showed. The chromatography patterns of mycelia grown in media added the 80% MeOH extracts of three tree species showed the similar patterns in comparison with control mycelia. In the results, the secondary metabolites of functional media were not degrade and changed to other derivatives compounds by P. ostreatus.

• Journal of Chest Surgery
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• v.30 no.10
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• pp.991-1000
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• 1997

Closed thoracostomy with UWSD* which is the most utilized procedure in chest surgery applies general thoracic disorders, trauma and after-thoracic surgery. The University hospital was involved on operating 2341 cases of closed thoracostomy with UWSD except chest tubing after-thoracic surgery for a full six years from January, 1991 to December, 1996. The rate of men and women out of the total 2341 cases was 3.5 : 1, the distribution by age showed that men were 36.6 $\pm21.0$ years old, women were $47.0\pm20.2$ years old and so that the total were 40.0 $\pm$ 20.5 years old. As for indication, spontaneous, secondary and traumatic pneumothorax were the most common, in addition to hemothorax hemopneumothorax, hydrothorax, hydropneumothorax, empyema, chylothorax. The most indwelling period of chest tubing is between eight and fourteen days for 974 cases and the average is 13.7 $\pm$ 6.3 days, The average drainage amount immediately after thoracostomy was 537 $\pm$ 88m1, and in 694 cases(46.0%), the drain amount was 201 ~ 500 ml. The rate of right and left tubing was 52.4 47.6, in 2071 cases(88.5%), the thoracostomy was the first chance and 2210 cases(94.4%) were treated with a single tube drainage. Almost all the patients complained of tube site pain, besides tube site infection, intercostal neuralgia, loss of tube function by the pleural adhesion, intrathoracic infection, incomplete reexpansion of defective lung, hemorrhage caused by the rupture of a blood vessel, subcutaneous emphysema, lung parenchymal rupture, diaphragmatic and intraabdominal trauma, reexpansionary pulmonary edema of one side lung and cellulitis were relapsed. 84.6% of all patients recovered with only clo ed thoracostomy and the rest of patient needed additional some necessary managements and so on to have successful results. There were two deaths(0.1%), caused by reexpansionary pulmonary edema, the cellulitis were complicated by thoracostomy with UWSD on an empyema patients to come to death(due to sepsis). t UWSD = under water seal drainage

• Pediatric Infection and Vaccine
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• v.20 no.3
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• pp.161-167
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• 2013

Purpose: This study was performed to describe the clinical manifestations of hospitalized children due to varicella-zoster virus (VZV) infection Methods: This study included 40 children who were hospitalized for varicella or herpes zoster at Seoul National University Children's Hospital, 2009-2012. Diagnosis of VZV infection was confirmed by VZV PCR or culture from vesicular fluid. Medical records were reviewed to collect clinical features and outcome, antiviral treatment, history of varicella vaccination, and underlying diseases. Results: Sixteen patients with varicella and 24 patients with herpes zoster were included. Their median age was 10.5 years (16 days-19 years). Thirty-five (87.5%) patients had underlying diseases. Among 24 patients with herpes zoster, 11 patients had previous history of varicella and 1 had herpes zoster. Twenty patients (50%) had a history of varicella vaccination, and 19 immunocompromised patients had VZV infection despite of vaccination. Most (95%) patients were treated by intravenous or oral acyclovir, and no treatment failure of intravenous acyclovir was found. The median duration of fever was 4.4 days (1-10 days), and that of antiviral treatment was 12 days (7-23 days) in immunocompromised patients. Immunocompromised patients received longer duration of antiviral treatment than imunocompetent patients (P=0.014). Eleven (27.5 %) immunocompromised patients had postherpetic neuralgia, 2 (5%) had proven co-infection by Streptococcus pyogenes and Klebsiella oxytoca, and 1 (2.5%) complicated with pneumonia. Conclusion: Immunocompromised children require longer duration of treatment and are at risk of severe complication associated with VZV infection. Early initiation of antiviral therapy and close monitoring are necessary for those in immunocompromised conditions.